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Volumn 393, Issue 1-2, 2014, Pages 143-151

Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained

Author keywords

AMPK; IL 6; Inflammation; Liver; Type 2 diabetes

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; METFORMIN; STAT3 PROTEIN; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; ANTIINFLAMMATORY AGENT; GLUCOSE BLOOD LEVEL; RIBONUCLEOTIDE;

EID: 84904045056     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.06.014     Document Type: Article
Times cited : (19)

References (64)
  • 1
    • 80053430193 scopus 로고    scopus 로고
    • Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
    • Akerfeldt M.C., Laybutt D.R. Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes 2011, 60:2506-2514.
    • (2011) Diabetes , vol.60 , pp. 2506-2514
    • Akerfeldt, M.C.1    Laybutt, D.R.2
  • 2
    • 33751501694 scopus 로고    scopus 로고
    • Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle
    • Al-Khalili L., Bouzakri K., Glund S., Lonnqvist F., Koistinen H.A., Krook A. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle. Mol. Endocrinol. 2006, 20:3364-3375.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 3364-3375
    • Al-Khalili, L.1    Bouzakri, K.2    Glund, S.3    Lonnqvist, F.4    Koistinen, H.A.5    Krook, A.6
  • 3
    • 0035131190 scopus 로고    scopus 로고
    • Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation (correction of activation) in the liver
    • Alonzi T., Maritano D., Gorgoni B., Rizzuto G., Libert C., Poli V. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation (correction of activation) in the liver. Mol. Cell. Biol. 2001, 21:1621-1632.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1621-1632
    • Alonzi, T.1    Maritano, D.2    Gorgoni, B.3    Rizzuto, G.4    Libert, C.5    Poli, V.6
  • 5
    • 0021126053 scopus 로고
    • Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type
    • Begue J.M., Guguen-Guillouzo C., Pasdeloup N., Guillouzo A. Prolonged maintenance of active cytochrome P-450 in adult rat hepatocytes co-cultured with another liver cell type. Hepatology 1984, 4:839-842.
    • (1984) Hepatology , vol.4 , pp. 839-842
    • Begue, J.M.1    Guguen-Guillouzo, C.2    Pasdeloup, N.3    Guillouzo, A.4
  • 6
    • 0029744043 scopus 로고    scopus 로고
    • Insulin modulates STAT3 protein activation and gene transcription in hepatic cells
    • Campos S.P., Wang Y., Baumann H. Insulin modulates STAT3 protein activation and gene transcription in hepatic cells. J. Biol. Chem. 1996, 271:24418-24424.
    • (1996) J. Biol. Chem. , vol.271 , pp. 24418-24424
    • Campos, S.P.1    Wang, Y.2    Baumann, H.3
  • 7
    • 84883428628 scopus 로고    scopus 로고
    • Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet
    • Cansby E., et al. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. Fed. Proc. 2013, 27:3660-3671.
    • (2013) Fed. Proc. , vol.27 , pp. 3660-3671
    • Cansby, E.1
  • 8
    • 33750859187 scopus 로고    scopus 로고
    • Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    • Carey A.L., et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 2006, 55:2688-2697.
    • (2006) Diabetes , vol.55 , pp. 2688-2697
    • Carey, A.L.1
  • 9
    • 14544271907 scopus 로고    scopus 로고
    • AMP-activated protein kinase: balancing the scales
    • Carling D. AMP-activated protein kinase: balancing the scales. Biochimie 2005, 87:87-91.
    • (2005) Biochimie , vol.87 , pp. 87-91
    • Carling, D.1
  • 11
    • 0031759744 scopus 로고    scopus 로고
    • Hormonal regulation of liver fatty acid-binding protein in vivo and in vitro: effects of growth hormone and insulin
    • Carlsson L., Nilsson I., Oscarsson J. Hormonal regulation of liver fatty acid-binding protein in vivo and in vitro: effects of growth hormone and insulin. Endocrinology 1998, 139:2699-2709.
    • (1998) Endocrinology , vol.139 , pp. 2699-2709
    • Carlsson, L.1    Nilsson, I.2    Oscarsson, J.3
  • 13
    • 0020822437 scopus 로고
    • Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes
    • Clayton D.F., Darnell J.E. Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol. Cell. Biol. 1983, 3:1552-1561.
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 1552-1561
    • Clayton, D.F.1    Darnell, J.E.2
  • 14
    • 77954274018 scopus 로고    scopus 로고
    • Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice
    • Davis R.C., et al. Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes 2010, 59:1616-1625.
    • (2010) Diabetes , vol.59 , pp. 1616-1625
    • Davis, R.C.1
  • 15
    • 0036720342 scopus 로고    scopus 로고
    • Muscle-derived interleukin-6: mechanisms for activation and possible biological roles
    • Febbraio M.A., Pedersen B.K. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. Fed. Proc. 2002, 16:1335-1347.
    • (2002) Fed. Proc. , vol.16 , pp. 1335-1347
    • Febbraio, M.A.1    Pedersen, B.K.2
  • 16
    • 1942533537 scopus 로고    scopus 로고
    • Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate
    • Gervois P., Kleemann R., Pilon A., Percevault F., Koenig W., Staels B., Kooistra T. Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate. J. Biol. Chem. 2004, 279:16154-16160.
    • (2004) J. Biol. Chem. , vol.279 , pp. 16154-16160
    • Gervois, P.1    Kleemann, R.2    Pilon, A.3    Percevault, F.4    Koenig, W.5    Staels, B.6    Kooistra, T.7
  • 17
    • 33744976813 scopus 로고    scopus 로고
    • Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells
    • Hattori Y., Suzuki K., Hattori S., Kasai K. Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension 2006, 47:1183-1188.
    • (2006) Hypertension , vol.47 , pp. 1183-1188
    • Hattori, Y.1    Suzuki, K.2    Hattori, S.3    Kasai, K.4
  • 18
    • 0032562458 scopus 로고    scopus 로고
    • Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection
    • Homan R., Anderson M.K. Rapid separation and quantitation of combined neutral and polar lipid classes by high-performance liquid chromatography and evaporative light-scattering mass detection. J. Chromatogr. B Biomed. Sci. Appl. 1998, 708:21-26.
    • (1998) J. Chromatogr. B Biomed. Sci. Appl. , vol.708 , pp. 21-26
    • Homan, R.1    Anderson, M.K.2
  • 19
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 20
    • 84866939632 scopus 로고    scopus 로고
    • Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance
    • Huang L., Kirschke C.P., Lay Y.A., Levy L.B., Lamirande D.E., Zhang P.H. Znt7-null mice are more susceptible to diet-induced glucose intolerance and insulin resistance. J. Biol. Chem. 2012, 287:33883-33896.
    • (2012) J. Biol. Chem. , vol.287 , pp. 33883-33896
    • Huang, L.1    Kirschke, C.P.2    Lay, Y.A.3    Levy, L.B.4    Lamirande, D.E.5    Zhang, P.H.6
  • 22
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    • Iglesias M.A., Ye J.M., Frangioudakis G., Saha A.K., Tomas E., Ruderman N.B., Cooney G.J., Kraegen E.W. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes 2002, 51:2886-2894.
    • (2002) Diabetes , vol.51 , pp. 2886-2894
    • Iglesias, M.A.1    Ye, J.M.2    Frangioudakis, G.3    Saha, A.K.4    Tomas, E.5    Ruderman, N.B.6    Cooney, G.J.7    Kraegen, E.W.8
  • 25
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern P.A., Ranganathan S., Li C., Wood L., Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2001, 280:E745-E751.
    • (2001) Am. J. Physiol. Endocrinol. Metab. , vol.280
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 26
    • 84862817442 scopus 로고    scopus 로고
    • Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models
    • Kim Y.D., Kim Y.H., Cho Y.M., Kim D.K., Ahn S.W., Lee J.M., Chanda D., Shong M., Lee C.H., Choi H.S. Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models. Diabetologia 2012, 55:1482-1494.
    • (2012) Diabetologia , vol.55 , pp. 1482-1494
    • Kim, Y.D.1    Kim, Y.H.2    Cho, Y.M.3    Kim, D.K.4    Ahn, S.W.5    Lee, J.M.6    Chanda, D.7    Shong, M.8    Lee, C.H.9    Choi, H.S.10
  • 27
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover P.J., Zimmers T.A., Koniaris L.G., Mooney R.A. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003, 52:2784-2789.
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 28
    • 66149110793 scopus 로고    scopus 로고
    • An inhibitor of interleukin-6 trans-signalling, sgp130, contributes to impaired acute phase response in human chronic liver disease
    • Lemmers A., et al. An inhibitor of interleukin-6 trans-signalling, sgp130, contributes to impaired acute phase response in human chronic liver disease. Clin. Exp. Immunol. 2009, 156:518-527.
    • (2009) Clin. Exp. Immunol. , vol.156 , pp. 518-527
    • Lemmers, A.1
  • 29
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long Y.C., Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Invest. 2006, 116:1776-1783.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 30
    • 44249124486 scopus 로고    scopus 로고
    • Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response
    • Mansouri R.M., Bauge E., Staels B., Gervois P. Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response. Endocrinology 2008, 149:3215-3223.
    • (2008) Endocrinology , vol.149 , pp. 3215-3223
    • Mansouri, R.M.1    Bauge, E.2    Staels, B.3    Gervois, P.4
  • 31
    • 79954987219 scopus 로고    scopus 로고
    • Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice
    • Meng R., Zhu D.L., Bi Y., Yang D.H., Wang Y.P. Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice. Mediators Inflamm. 2010, 2010:858735.
    • (2010) Mediators Inflamm. , vol.2010 , pp. 858735
    • Meng, R.1    Zhu, D.L.2    Bi, Y.3    Yang, D.H.4    Wang, Y.P.5
  • 32
    • 84888377946 scopus 로고    scopus 로고
    • Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes
    • Mukumoto H., Takahashi Y., Ando M., Nishikawa M., Takakura Y. Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type II diabetes. Mol. Pharm. 2013, 10:3812-3821.
    • (2013) Mol. Pharm. , vol.10 , pp. 3812-3821
    • Mukumoto, H.1    Takahashi, Y.2    Ando, M.3    Nishikawa, M.4    Takakura, Y.5
  • 33
    • 77957653461 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)
    • Nerstedt A., Johansson A., Andersson C.X., Cansby E., Smith U., Mahlapuu M. AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3). Diabetologia 2010, 53:2406-2416.
    • (2010) Diabetologia , vol.53 , pp. 2406-2416
    • Nerstedt, A.1    Johansson, A.2    Andersson, C.X.3    Cansby, E.4    Smith, U.5    Mahlapuu, M.6
  • 34
    • 84878933932 scopus 로고    scopus 로고
    • Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes
    • Nerstedt A., Cansby E., Amrutkar M., Smith U., Mahlapuu M. Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. Mol. Cell. Endocrinol. 2013, 375:68-78.
    • (2013) Mol. Cell. Endocrinol. , vol.375 , pp. 68-78
    • Nerstedt, A.1    Cansby, E.2    Amrutkar, M.3    Smith, U.4    Mahlapuu, M.5
  • 35
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park E.J., Lee J.H., Yu G.Y., He G., Ali S.R., Holzer R.G., Osterreicher C.H., Takahashi H., Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6    Osterreicher, C.H.7    Takahashi, H.8    Karin, M.9
  • 36
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan A.D., Manson J.E., Rifai N., Buring J.E., Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001, 286:327-334.
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 38
    • 0028226196 scopus 로고
    • Soluble receptors for cytokines and growth factors: generation and biological function
    • Rose-John S., Heinrich P.C. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 1994, 300(Pt 2):281-290.
    • (1994) Biochem. J. , vol.300 , Issue.PART 2 , pp. 281-290
    • Rose-John, S.1    Heinrich, P.C.2
  • 39
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V., Nagaev I., Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J. Biol. Chem. 2003, 278:45777-45784.
    • (2003) J. Biol. Chem. , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 40
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D., Carling D., Stout R.D., Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 2008, 181:8633-8641.
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 41
    • 17144474893 scopus 로고    scopus 로고
    • Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
    • Sakamoto K., Goransson O., Hardie D.G., Alessi D.R. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E310-E317.
    • (2004) Am. J. Physiol. Endocrinol. Metab. , vol.287
    • Sakamoto, K.1    Goransson, O.2    Hardie, D.G.3    Alessi, D.R.4
  • 42
    • 0020697026 scopus 로고
    • Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats
    • Salhanick A.I., Konowitz P., Amatruda J.M. Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats. Diabetes 1983, 32:206-212.
    • (1983) Diabetes , vol.32 , pp. 206-212
    • Salhanick, A.I.1    Konowitz, P.2    Amatruda, J.M.3
  • 43
    • 0023691651 scopus 로고
    • Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6
    • Satoh T., Nakamura S., Taga T., Matsuda T., Hirano T., Kishimoto T., Kaziro Y. Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 1988, 8:3546-3549.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3546-3549
    • Satoh, T.1    Nakamura, S.2    Taga, T.3    Matsuda, T.4    Hirano, T.5    Kishimoto, T.6    Kaziro, Y.7
  • 44
    • 84862729680 scopus 로고    scopus 로고
    • Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6
    • Scheele C., Nielsen S., Kelly M., Broholm C., Nielsen A.R., Taudorf S., Pedersen M., Fischer C.P., Pedersen B.K. Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6. PLoS ONE 2012, 7:e39657.
    • (2012) PLoS ONE , vol.7
    • Scheele, C.1    Nielsen, S.2    Kelly, M.3    Broholm, C.4    Nielsen, A.R.5    Taudorf, S.6    Pedersen, M.7    Fischer, C.P.8    Pedersen, B.K.9
  • 45
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn J.J., Klover P.J., Nowak I.A., Mooney R.A. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 2002, 51:3391-3399.
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 46
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • Senn J.J., Klover P.J., Nowak I.A., Zimmers T.A., Koniaris L.G., Furlanetto R.W., Mooney R.A. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J. Biol. Chem. 2003, 278:13740-13746.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Zimmers, T.A.4    Koniaris, L.G.5    Furlanetto, R.W.6    Mooney, R.A.7
  • 47
    • 37449022587 scopus 로고    scopus 로고
    • Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy
    • Serrano A.L., Baeza-Raja B., Perdiguero E., Jardi M., Munoz-Canoves P. Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metab. 2008, 7:33-44.
    • (2008) Cell Metab. , vol.7 , pp. 33-44
    • Serrano, A.L.1    Baeza-Raja, B.2    Perdiguero, E.3    Jardi, M.4    Munoz-Canoves, P.5
  • 49
    • 0022000618 scopus 로고
    • Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes
    • Steward A.R., Dannan G.A., Guzelian P.S., Guengerich F.P. Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol. Pharmacol. 1985, 27:125-132.
    • (1985) Mol. Pharmacol. , vol.27 , pp. 125-132
    • Steward, A.R.1    Dannan, G.A.2    Guzelian, P.S.3    Guengerich, F.P.4
  • 51
    • 0032101932 scopus 로고    scopus 로고
    • Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice
    • Szalai A.J., van Ginkel F.W., Dalrymple S.A., Murray R., McGhee J.R., Volanakis J.E. Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice. J. Immunol. 1998, 160:5294-5299.
    • (1998) J. Immunol. , vol.160 , pp. 5294-5299
    • Szalai, A.J.1    van Ginkel, F.W.2    Dalrymple, S.A.3    Murray, R.4    McGhee, J.R.5    Volanakis, J.E.6
  • 52
    • 0023575852 scopus 로고
    • Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression
    • Taga T., Kawanishi Y., Hardy R.R., Hirano T., Kishimoto T. Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J. Exp. Med. 1987, 166:967-981.
    • (1987) J. Exp. Med. , vol.166 , pp. 967-981
    • Taga, T.1    Kawanishi, Y.2    Hardy, R.R.3    Hirano, T.4    Kishimoto, T.5
  • 53
    • 0024393839 scopus 로고
    • Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
    • Taga T., Hibi M., Hirata Y., Yamasaki K., Yasukawa K., Matsuda T., Hirano T., Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989, 58:573-581.
    • (1989) Cell , vol.58 , pp. 573-581
    • Taga, T.1    Hibi, M.2    Hirata, Y.3    Yamasaki, K.4    Yasukawa, K.5    Matsuda, T.6    Hirano, T.7    Kishimoto, T.8
  • 55
    • 2942628012 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    • Ueki K., Kondo T., Kahn C.R. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol. Cell. Biol. 2004, 24:5434-5446.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 5434-5446
    • Ueki, K.1    Kondo, T.2    Kahn, C.R.3
  • 56
    • 3142723189 scopus 로고    scopus 로고
    • Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
    • Ueki K., Kondo T., Tseng Y.H., Kahn C.R. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc. Natl. Acad. Sci. USA 2004, 101:10422-10427.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10422-10427
    • Ueki, K.1    Kondo, T.2    Tseng, Y.H.3    Kahn, C.R.4
  • 58
    • 79959236073 scopus 로고    scopus 로고
    • Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1
    • Wallerstedt E., Sandqvist M., Smith U., Andersson C.X. Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1. Mol. Cell. Biochem. 2011, 352:47-55.
    • (2011) Mol. Cell. Biochem. , vol.352 , pp. 47-55
    • Wallerstedt, E.1    Sandqvist, M.2    Smith, U.3    Andersson, C.X.4
  • 60
    • 23044499225 scopus 로고    scopus 로고
    • Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt
    • Weigert C., Hennige A.M., Brodbeck K., Haring H.U., Schleicher E.D. Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am. J. Physiol. Endocrinol. Metab. 2005, 289:E251-E257.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Weigert, C.1    Hennige, A.M.2    Brodbeck, K.3    Haring, H.U.4    Schleicher, E.D.5
  • 62
    • 0033821518 scopus 로고    scopus 로고
    • The influence of improved glycaemic control with insulin and sulphonylureas on acute phase and endothelial markers in Type II diabetic subjects
    • Yudkin J.S., Panahloo A., Stehouwer C., Emeis J.J., Bulmer K., Mohamed-Ali V., Denver A.E. The influence of improved glycaemic control with insulin and sulphonylureas on acute phase and endothelial markers in Type II diabetic subjects. Diabetologia 2000, 43:1099-1106.
    • (2000) Diabetologia , vol.43 , pp. 1099-1106
    • Yudkin, J.S.1    Panahloo, A.2    Stehouwer, C.3    Emeis, J.J.4    Bulmer, K.5    Mohamed-Ali, V.6    Denver, A.E.7
  • 64
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001, 108:1167-1174.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1


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