Apocynin improves insulin resistance through suppressing inflammation in high-fat diet-induced obese mice

Mediators of Inflammation

Volumn 2010, Issue , 2010, Pages

  Zhu, Da Long ^a   Meng, Ran ^a   Bi, Yan ^a   Yang, Dong Hui ^a   Wang, Ya Ping ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOCYNIN; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 6; LEPTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; ACETOPHENONE DERIVATIVE; ANTIOXIDANT; AUTACOID; CCL2 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; PRIMER DNA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DIET RESTRICTION; FOOD INTAKE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; BLOOD; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; FAT INTAKE; GENETICS; GLUCOSE BLOOD LEVEL; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY;

MUS;

ACETOPHENONES; ADIPOSE TISSUE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BASE SEQUENCE; BLOOD GLUCOSE; CHEMOKINE CCL2; DIETARY FATS; DISEASE MODELS, ANIMAL; DNA PRIMERS; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; INFLAMMATION MEDIATORS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; LIVER; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; OBESITY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79954987219     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2010/858735     Document Type: Article

References (52)

1. James P. T., Rigby N., Leach R., The obesity epidemic, metabolic syndrome and future prevention strategies European Journal of Cardiovascular Prevention and Rehabilitation 2004 11 1 3 8 (Pubitemid 38388918)
2. Shoelson S. E., Lee J., Goldfine A. B., Inflammation and insulin resistance Journal of Clinical Investigation 2006 116 7 1793 1801 (Pubitemid 44033299)
3. Tilg H., Moschen A. R., Insulin resistance, inflammation, and non-alcoholic fatty liver disease Trends in Endocrinology and Metabolism 2008 19 10 371 379
4. Xu H., Barnes G. T., Yang Q., Tan G., Yang D., Chou C. J., Sole J., Nichols A., Ross J. S., Tartaglia L. A., Chen H., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Journal of Clinical Investigation 2003 112 12 1821 1830 (Pubitemid 38063705)
5. Kang J. H., Tsuyoshi G., Han I. S., Kawada T., Kim Y. M., Yu R., Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet Obesity 2010 18 4 780 787
6. Tilg H., Moschen A. R., Inflammatory mechanisms in the regulation of insulin resistance Molecular Medicine 2008 14 3-4 222 231 (Pubitemid 351481853)
7. Leclercq I. A., Farrell G. C., Sempoux C., Pea A. D., Horsmans Y., Curcumin inhibits NF- B activation and reduces the severity of experimental steatohepatitis in mice Journal of Hepatology 2004 41 6 926 934 (Pubitemid 39575659)
8. Cai D., Yuan M., Frantz D. F., Melendez P. A., Hansen L., Lee J., Shoelson S. E., Local and systemic insulin resistance resulting from hepatic activation of IKK- and NF- B Nature Medicine 2005 11 2 183 190 (Pubitemid 40321354)
9. Arkan M. C., Hevener A. L., Greten F. R., Maeda S., Li Z. W., Long J. M., Wynshaw-Boris A., Poli G., Olefsky J., Karin M., IKK- links inflammation to obesity-induced insulin resistance Nature Medicine 2005 11 2 191 198 (Pubitemid 40321355)
10. Hotamisligil G. S., Shargill N. S., Spiegelman B. M., Adipose expression of tumor necrosis factor- : direct role in obesity-linked insulin resistance Science 1993 259 5091 87 91 (Pubitemid 23036092)
11. Kamei N., Tobe K., Suzuki R., Ohsugi M., Watanabe T., Kubota N., Ohtsuka-Kowatari N., Kumagai K., Sakamoto K., Kobayashi M., Yamauchi T., Ueki K., Oishi Y., Nishimura S., Manabe I., Hashimoto H., Ohnishi Y., Ogata H., Tokuyama K., Tsunoda M., Ide T., Murakami K., Nagai R., Kadowaki T., Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance Journal of Biological Chemistry 2006 281 36 26602 26614 (Pubitemid 44401869)
12. Bastard J. P., Maachi M., van Nhieu J. T., Jardel C., Bruckert E., Grimaldi A., Robert J. J., Capeau J., Hainque B., Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro Journal of Clinical Endocrinology and Metabolism 2002 87 5 2084 2089 (Pubitemid 34521492)
13. Murthy S. N., Desouza C. V., Bost N. W., St. Hilaire R.-C., Casey D. B., Badejo A. M., Dhaliwal J. S., McGee J., McNamara D. B., Kadowitz P. J., Fonseca V. A., Effects of salsalate therapy on recovery from vascular injury in female zucker fatty rats Diabetes 2010 59 12 3240 3246
14. Hopps E., Noto D., Caimi G., Averna M. R., A novel component of the metabolic syndrome: the oxidative stress Nutrition, Metabolism and Cardiovascular Diseases 2010 20 1 72 77
15. Ho E., Bray T. M., Antioxidants, NF B activation, and diabetogenesis Proceedings of the Society for Experimental Biology and Medicine 1999 222 3 205 213
16. Campo G. M., Avenoso A., Campo S., Nastasi G., Traina P., D'Ascola A., Rugolo C. A., Calatroni A., The antioxidant activity of chondroitin-4-sulphate, in carbon tetrachloride-induced acute hepatitis in mice, involves NF- B and caspase activation British Journal of Pharmacology 2008 155 6 945 956
17. Shapiro H., Ashkenazi M., Weizman N., Shahmurov M., Aeed H., Bruck R., Curcumin ameliorates acute thioacetamide-induced hepatotoxicity Journal of Gastroenterology and Hepatology 2006 21 2 358 366
18. Bruck R., Aeed H., Avni Y., Shirin H., Matas Z., Shahmurov M., Avinoach I., Zozulya G., Weizman N., Hochman A., Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats Journal of Hepatology 2004 40 1 86 93 (Pubitemid 38064716)
19. Kamigaki M., Sakaue S., Tsujino I., Ohira H., Ikeda D., Itoh N., Ishimaru S., Ohtsuka Y., Nishimura M., Oxidative stress provokes atherogenic changes in adipokine gene expression in 3T3-L1 adipocytes Biochemical and Biophysical Research Communications 2006 339 2 624 632 (Pubitemid 41739713)
20. Uchida Y., Ohba K. I., Yoshioka T., Irie K., Muraki T., Maru Y., Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway Journal of Biological Chemistry 2004 279 6 4075 4083 (Pubitemid 38198991)
21. Sakurai T., Kitadate K., Nishioka H., Fujii H., Kizaki T., Kondoh Y., Izawa T., Ishida H., Radk Z., Ohno H., Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages Journal of Nutritional Biochemistry 2010 21 1 47 54
22. Sakurai T., Nishioka H., Fujii H., Nakano N., Kizaki T., Radak Z., Izawa T., Haga S., Ohno H., Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes Bioscience, Biotechnology and Biochemistry 2008 72 2 463 476 (Pubitemid 351353659)
23. Hougee S., Hartog A., Sanders A., Graus Y. M. F., Hoijer M. A., Garssen J., Van Den Berg W. B., Van Beuningen H. M., Smit H. F., Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice European Journal of Pharmacology 2006 531 13 264 269 (Pubitemid 43202245)
24. Viakov D., Pekarov M., Crhk T., Bcsaiov M., Matiaovic J., Lojek A., Kubala L., Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin. Immunobiology. In press
25. Pechnov O., Jendekov L., Vrankov S., Effect of chronic apocynin treatment on nitric oxide and reactive oxygen species production in borderline and spontaneous hypertension Pharmacological Reports 2009 61 1 116 122
26. Picchi A., Gao X., Belmadani S., Potter B. J., Focardi M., Chilian W. M., Zhang C., Tumor necrosis factor- induces endothelial dysfunction in the prediabetic metabolic syndrome Circulation Research 2006 99 1 69 77 (Pubitemid 44297057)
27. Weber C., Erl W., Pietsch A., Strobel M., Ziegler-Heitbrock H. W. L., Weber P. C., Antioxidants inhibit monocyte adhesion by suppressing nuclear factor- B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals Arteriosclerosis and Thrombosis 1994 14 10 1665 1673
28. Mller A. A., Reiter S. A., Heider K. G., Wagner H., Plant-derived acetophenones with antiasthmatic and anti-inflammatory properties: inhibitory effects on chemotaxis, right angle light scatter and actin polymerization of polymorphonuclear granulocytes Planta Medica 1999 65 7 590 594 (Pubitemid 29503222)
29. Muijsers R. B. R., van Ark I., Folkerts G., Koster A. S., van Oosterhout A. J. M., Postma D. S., Nijkamp F. P., Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice British Journal of Pharmacology 2001 134 2 434 440 (Pubitemid 32989142)
30. Lafeber F. P. J. G., Beukelman C. J., van den Worm E., Van Roy J. L. A. M., Vianen M. E., Van Roon J. A. G., Van Dijk H., Bijlsma J. W. J., Apocynin, a plant-derived, cartilage-saving drug, might be useful in the treatment of rheumatoid arthritis Rheumatology 1999 38 11 1088 1093 (Pubitemid 29537328)
31. Barbieri S. S., Cavalca V., Eligini S., Brambilla M., Caiani A., Tremoli E., Colli S., Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms Free Radical Biology and Medicine 2004 37 2 156 165 (Pubitemid 38760252)
32. Winiarska K., Grabowski M., Rogacki M. K., Inhibition of renal gluconeogenesis contributes to hypoglycaemic action of NADPH oxidase inhibitor, apocynin. Chemico-Biological Interactions. In press
33. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I., Increased oxidative stress in obesity and its impact on metabolic syndrome Journal of Clinical Investigation 2004 114 12 1752 1761 (Pubitemid 40385531)
34. Thallas-Bonke V., Thorpe S. R., Coughlan M. T., Fukami K., Yap F. Y. T., Sourris K. C., Penfold S. A., Bach L. A., Cooper M. E., Forbes J. M., Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C- -dependent pathway Diabetes 2008 57 2 460 469
35. Edlund J., Fasching A., Liss P., Hansell P., Palm F., The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney Diabetes/Metabolism Research and Reviews 2010 26 5 349 356
36. Olukman M., Orhan C. E., Celenk F. G., Ulker S., Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions Journal of Diabetes and Its Complications 2010 24 6 415 423
37. Hayashi T., Juliet P. A. R., Kano-Hayashi H., Tsunekawa T., Dingqunfang D., Sumi D., Matsui-Hirai H., Fukatsu A., Iguchi A., NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction Diabetes, Obesity and Metabolism 2005 7 4 334 343 (Pubitemid 40916575)
38. Yokota T., Kinugawa S., Hirabayashi K., Matsushima S., Inoue N., Ohta Y., Hamaguchi S., Sobirin M. A., Ono T., Suga T., Kuroda S., Tanaka S., Terasaki F., Okita K., Tsutsui H., Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice American Journal of PhysiologyHeart and Circulatory Physiology 2009 297 3 H1069 H1077
39. Schenk S., Saberi M., Olefsky J. M., Insulin sensitivity: modulation by nutrients and inflammation Journal of Clinical Investigation 2008 118 9 2992 3002
40. Wellen K. E., Hotamisligil G. S., Inflammation, stress, and diabetes Journal of Clinical Investigation 2005 115 5 1111 1119 (Pubitemid 40629025)
41. Kopp H. P., Kopp C. W., Festa A., Krzyzanowska K., Kriwanek S., Minar E., Roka R., Schernthaner G., Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 6 1042 1047 (Pubitemid 36713558)
42. Considine R. V., Sinha M. K., Heiman M. L., Kriauciunas A., Stephens T. W., Nyce M. R., Ohannesian J. P., Marco C. C., Mckee L. J., Bauer T. L., Caro J. F., Serum immunoreactive-leptin concentrations in normal-weight and obese humans New England Journal of Medicine 1996 334 5 292 295 (Pubitemid 26033933)
43. Tilg H., Moschen A. R., Adipocytokines: mediators linking adipose tissue, inflammation and immunity Nature Reviews Immunology 2006 6 10 772 783 (Pubitemid 44453463)
44. Antuna-Puente B., Feve B., Fellahi S., Bastard J. P., Adipokines: the missing link between insulin resistance and obesity Diabetes and Metabolism 2008 34 1 2 11
45. Luo N., Liu J., Chung B. H., Yang Q., Klein R. L., Timothy Garvey W., Fu Y., Macrophage adiponectin expression improves insulin sensitivity and protects against inflammation and atherosclerosis Diabetes 2010 59 4 791 799
46. Akira S., Taga T., Kishimoto T., Interleukin-6 in biology and medicine Advances in Immunology 1993 54 1 78 (Pubitemid 23289250)
47. Hart B. A., Simons J. M., Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drug Biotechnology Therapeutics 1992 3 3-4 119 135
48. Pandey A., Kour K., Bani S., Suri K. A., Satti N. K., Sharma P., Qazi G. N., Amelioration of adjuvant induced arthritis by apocynin Phytotherapy Research 2009 23 10 1462 1468
49. Roy A. K., Transcription factors and aging Molecular Medicine 1997 3 8 496 504 (Pubitemid 127499163)
50. Schreck R., Rieber P., Baeuerle P. A., Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-αB transcription factor and HIV-1 EMBO Journal 1991 10 8 2247 2258 (Pubitemid 21905698)
51. Clark R. A., Valente A. J., Nuclear factor kappa B activation by NADPH oxidases Mechanisms of Ageing and Development 2004 125 10-11 799 810 (Pubitemid 39482408)
52. Brar S. S., Kennedy T. P., Sturrock A. B., Huecksteadt T. P., Quinn M. T., Murphy T. M., Chitano P., Hoidal J. R., NADPH oxidase promotes NF- B activation and proliferation in human airway smooth muscle American Journal of PhysiologyLung Cellular and Molecular Physiology 2002 282 4 L782 L795