Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice

Journal of Immunology

Volumn 160, Issue 11, 1998, Pages 5294-5299

  Szalai, Alexander J ^a,d   Van Ginkel, Frederik W ^b   Dalrymple, Static A ^c   Murray, Richard ^c   McGhee, Jerry R ^b   Volanakis, John E ^a  

^a Division of Clinical Immunology and Rheumatology   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d Center for Palliative Care   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; TESTOSTERONE;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ARTICLE; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TISSUE INJURY; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; C-REACTIVE PROTEIN; DRUG COMBINATIONS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; SERUM AMYLOID P-COMPONENT; SEX FACTORS; TESTOSTERONE; TRANSGENES;

EID: 0032101932     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Kushner, I. 1982. The phenomenon of the acute phase response. Ann. NY Acad. Sci. 389:39.
2. Won, K., S. P. Campos, and H. Baumann. 1993. Experimental systems for studying hepatic acute phase response. In Acute Phase Proteins: Molecular Biology, Biochemistry, and Clinical Applications. A. Mackiewicz, I. Kushner, and H. Baumann, eds. CRC Press, Inc., Boca Raton, FL, p. 255.
3. Luster, M. I., D. R. Germolec, T. Yoshida, F. Kayama, and M. Thompson. 1994. Endotoxin-induced cytokine gene expression and excretion in the liver. Hepatology 19:480.
4. Kushner, I., and A. Mackiewicz,. 1993. The acute phase response: an overview. In Acute Phase Proteins: Molecular Biology, Biochemistry, and Clinical Applications. A. Mackiewicz, I. Kushner, and H. Baumann, eds. CRP Press, Boca Raton, FL, p. 3.
5. Baumann, H., G. P. Jahreis, and K. K. Morella. 1990. Interaction of cytokine- and glucocorticoid-response elements of acute phase plasma protein genes. J. Biol. Chem. 265:22275.
6. Baumann, H., and J. Gauldie. 1990. Regulation of the hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol. Biol. Med. 7:147.
7. Osmand, A. P., B. Friedenson, H. Gewurz, R. H. Painter, T. Hofmann, and E. Helton. 1977. Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins). Proc. Natl. Acad. Sci. USA 74:739.
8. Gewurz, H., X.-H. Zhang, and T. F. Lint. 1995. Structure and function of the pentraxins. Curr. Opin. Immunol. 7:54.
9. Agrawal, A., J. M. Kilpatrick, and J. E. Volanakis. 1993. Structure and function of human C-reactive protein. In Acute Phase Proteins: Molecular Biology, Biochemistry, and Clinical Applications. A. Mackiewicz, I. Kushner, and H. Baumann, eds. CRP Press, Boca Raton, FL, p. 79.
10. Bodmer, B., and R. Siboo. 1977. Isolation of mouse C-reactive protein from liver and serum. J. Immunol. 118:1086.
11. Whitehead, A. S., K. Zahedi, M. Rits, R. F. Mortensen, and J. M. Lelias. 1990. Mouse C-reactive protein: generation of complementary DNA clones, structural analysis, and induction of messenger RNA during inflammation. Biochem. J. 266:59.
12. Siboo, R., and E. Kulisek. 1978. A fluorescent immunoassay for the quantification of C-reactive protein. J. Immunol. Methods 23:59.
13. Le, P. T., M. T. Muller, and R. F. Mortensen. 1982. Acute phase reactants of mice. I. Isolation of serum amyloid P-component (SAP) and its induction by a monokine. J. Immunol. 129:665.
14. Zhang, D., S.-L. Jiang, D. Rzewnicki, D. Samols, and I. Kushner. 1995. The effect of interleukin-1 on C-reactive protein expression in Hep 3B cells is exerted at the transcriptional level. Biochem. J. 310:143.
15. Depraetere, S., J. Willems, and M. Joniau. 1991. Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6. Agents Actions 34:369.
16. Toniatti, C., R. Arcone, B. Majello, M. Ganter, G. Arpaia, and G. Ciliberto. 1990. Regulation of the human C-reactive protein gene: a major marker of inflammation and cancer. Mol. Biol. Med. 7:199.
17. Ganter, U., R. Arcone, C. Toniatti, G. Morrone, and G. Ciliberto. 1989. Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J. 8:3773.
18. Ganapathi, M K., D. Rzewnicki, D. Samols, S.-L. Jiang, and I. Kushner. 1991. Effect of combinations of cytokines and hormones on synthesis of serum A amyloid and C-reactive protein in Hep 3B cells. J. Immunol. 147:1261.
19. Un, B.-F., N.-O. Ku, K. Zahedi, A. S. Whitehead, and R. F. Mortensen. 1990. IL-1 and IL-6 mediate increased production and synthesis by hepatocytes of acute-phase reactant mouse serum amyloid P-component (SAP). Inflammation 14:297.
20. Ciliberto, G., R. Arcone, E. F. Wagner, and U. Rüther. 1987. Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J. 6:4017.
21. Murphy, C., J. Beckers, and U. Rüther. 1995. Regulation of the human C-reactive protein gene in transgenic mice. J. Biol. Chem. 270:704.
22. Szalai, A. J., D. E. Briles, and J. E. Volanakis. 1995. Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J. Immunol. 155:2557.
23. Weinhold, B., A. Bader, V. Polis, and U. Rüther. 1997. Interteukin-6 is necessary, but not sufficient, for induction of the human C-reactive protein gene in vivo. Biochem. J. 325:617.
24. Dalrymple, S. A., L. A. Lucian, R. Slattery, T. McNeil, D. M. Aud, S. Fuchino, F. Lee, and R. Murray. 1995. Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect. Immun. 63:2262.
25. Nunomura, W., Y. Takakuwa, and T. Higashi. 1994. Changes in serum concentration and mRNA level of rat C-reactive protein. Biochim. Biophys. Acta 1227: 74.
26. Kilpatrick, J. M., J. F. Kearney, and J. E. Volanakis. 1982. Demonstration of calcium-induced conformational change(s) in C-reactive protein by using monoclonal antibodies. Mol. Immunol. 19:1159.
27. Volanakis, J. E., W. L. Clements, and R. E. Schrohenloher. 1978. C-reactive protein: purification by affinity chromatography and physicochemical characterization. J. Immunol. Methods 23:285.
28. Taktak, Y. S., and B. Stenning. 1992. Solid phase enzyme immunoassays for the quantification of serum amyloid P (SAP) and complement component 3 (C3) proteins in acute-phase mouse sera. Horm. Metab. Res. 24:371.
29. Geiger, T., T. Andus, J. Klapproth, T. Hirano, T. Kishimoto, and P. C. Heinrich. 1988. Induction of rat acute-phase proteins by interleukin 6 in vivo. Eur. J. Immunol. 18:717.
30. Nonaka, M., H. Kimura, Y. D. Yell, S. Yokoyama, K. Nakayama, and M. Takahaski. 1986. Identification of the 5′-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes. Proc. Natl. Acad. Sci. USA 83:7883.
31. Ogata, R. T., and D. S. Sepich. 1985. Murine sex-limited protein: complete cDNA sequence and comparison with murine fourth complement component J. Immunol. 135:4239.
32. Ogata, R. T., and N. E. Zepf. 1991. The murine Slp gene: additional evidence that sex-limited protein has no biologic function. J. Immunol. 147:2756.
33. Passmore, H. C., and D. C. Shreffler. 1971. A sex-limited serum protein variant in the mouse: hormonal control of phenotypic expression. Biochem. Genet. 5:201.
34. Georgatsou, E., P. Bourgarel, and T. Meo. 1993. Male-specific expression of mouse sex-limited protein requires growth hormone, not testosterone. Proc. Natl. Acad. Sci. USA 90:3626.
35. Tannenbaum, G. S., and J. B. Martin. 1976. Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 98:562.
36. Millard, W. J., D. M. O'Sullivan, T. O. Fox, and B. M. Joseph. 1987. Sexually dimorphic patterns of growth hormone secretion in rats. In The Episodic Secretion of Hormones. W. F. Crowley and J. G. Rofler, eds. John Wiley and Sons, Inc., New York, p. 287.
37. Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Köhler. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368:339.
38. Poli, V., R. Balena, E. Fattori, A. Markatos, M. Yamamoto, H. Tanaka, G. Ciliberto, G. A. Rodan, and F. Costantini. 1994. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 13:1189.
39. Fattori, E., M. Cappelletti, P. Costa, C. Sellitto, L. Cantoni, M. Carelli, R. Faggioni, G. Fantuzzi, P. Ghezzi, and V. Poli. 1994. Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 180:1243.
40. Libert, C. N. Takahashi, A. Cauwels, P. Brouckaert, H. Bluethmann, and W. Fiers. 1994. Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality. Eur. J. Immunol. 24:2237.
41. Heinrich, P. C., J. V. Castell, and T. Andus. 1990. Interleukin-6 and the acutephase response. Biochem. J. 265:621.
42. Arcone, R., G. Gualandi, and G. Ciliberto. 1988. Identification of sequences responsible for acute-phase induction of human C-reactive protein. Nucleic Acids Res. 16:3195.
43. Li, S.-P., T.-Y. Liu, and N. D. Goldman. 1990. cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression. J. Biol. Chem. 265:4136.
44. Zhang, D., M. Sun, D. Samols, and I. Kushner. 1996. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J. Biol. Chem. 271:9503.
45. Ramji, D. P., A. Vitelli, F. Tronche, R. Cortese, and G. Ciliberto. 1993. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBPδ/NF-IL6β, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res. 21:289.
46. Wegenka, U. M., J. Buschmann, C. Lütticken, P. C. Heinrich, and F. Horn. 1993. Acute phase response factor, a nuclear factor binding to acute phase response elements, is rapidly activated by interleukin-6 at the posttranslational level. Mol. Cell. Biol. 13:276.
47. Gabay, C., B. Genin, G. Mentha, P. B. Iynedjian, P. Roux-Lombard, and P.-A. Guerne. 1995. IL-1 receptor antagonist (IL-1Ra) does not inhibit the production of C-reactive protein or serum amyloid A protein by human primary hepatocytes: differential regulation in normal and tumour cells. Clin. Exp. Immunol. 100:306.
48. Smith, J. W., and T. L. McDonald. 1992. Production of serum amyloid A and C-reactive protein by HepG2 cells stimulated with combinations of cytokines or monocyte conditioned media: the effects of prednisolone. Clin. Exp. Immunol. 90:293.