Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats

Biological Psychiatry

Volumn 76, Issue 3, 2014, Pages 213-222

  Russell, Shayla E ^a   Rachlin, Anna B ^a   Smith, Karen L ^a   Muschamp, John ^a   Berry, Loren ^b   Zhao, Zhiyang ^b   Chartoff, Elena H ^a  

^a MCLEAN HOSPITAL   (United States)

^b AMGEN INC   (United States)

Author keywords

c Fos; dynorphin; female; intracranial self stimulation; pharmacokinetics; stress

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; CORTICOTROPIN RELEASING FACTOR; DYNORPHIN; ESTROGEN; KAPPA OPIATE RECEPTOR; PROTEIN C FOS;

ADULT; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN REGION; CASTRATED FEMALE; CASTRATED MALE; COMPARATIVE STUDY; DEPRESSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; ESTRUS CYCLE; FEMALE; GONADECTOMY; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; MALE; MAXIMUM PLASMA CONCENTRATION; MEDIAL FOREBRAIN BUNDLE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SELF STIMULATION; SENSITIVITY ANALYSIS; SEX DIFFERENCE; STRIA TERMINALIS; TIME TO MAXIMUM PLASMA CONCENTRATION; AGONISTS; ANIMAL; BLOOD; DRUG EFFECTS; ELECTROSTIMULATION; LIMBIC SYSTEM; METABOLISM; NERVE CELL; REWARD; SPRAGUE DAWLEY RAT;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANIMALS; DEPRESSION; ELECTRIC STIMULATION; FEMALE; LIMBIC SYSTEM; MALE; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, KAPPA; REWARD; SELF STIMULATION; SEX FACTORS;

EID: 84904044356     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.07.042     Document Type: Article

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