How it's made: Organisational effects of hormones on the developing brain

Journal of Neuroendocrinology

Volumn 22, Issue 7, 2010, Pages 736-742

  McCarthy, M M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Androgens; GABA; Oestrogens; Prostaglandins; Sexual differentiation; TNF

Indexed keywords

4 AMINOBUTYRIC ACID; ANDROGEN; ESTROGEN; FOCAL ADHESION KINASE; GLUTAMIC ACID; PAXILLIN; PROSTAGLANDIN; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; ESTRADIOL; SEX HORMONE;

BRAIN DEVELOPMENT; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; DENDRITIC SPINE; FEMALE; FEMINIZATION; GONAD; HORMONE ACTION; HORMONE RESPONSE; MALE; NONHUMAN; PERINATAL DEVELOPMENT; PREOPTIC AREA; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; SEX DIFFERENTIATION; SEXUAL BEHAVIOR; SEXUAL DEVELOPMENT; SYNAPTOGENESIS; VIRILIZATION; ANIMAL; BRAIN; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; HUMAN; HYPOTHALAMUS; METABOLISM; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; BRAIN; CELL DEATH; CELL SURVIVAL; ESTRADIOL; GLUTAMIC ACID; GONADAL STEROID HORMONES; HUMANS; HYPOTHALAMUS; PREOPTIC AREA; SEX CHARACTERISTICS; SIGNAL TRANSDUCTION; SYNAPSES;

EID: 77954153103     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2010.02021.x     Document Type: Review

References (38)

1. Morris JA, Jordan CL, Breedlove SM. Sexual differentiation of the vertebrate nervous system. Nat Neurosci 2004, 7:1034-1039.
2. Wallen K. Hormonal influences on sexually differentiated behavior in nonhuman primates. Front Neuroendocrinol 2005, 26:7-26.
3. Breedlove SM. Sexual differentiation of the human nervous system. Annu Rev Psychol 1994, 45:389-418.
4. Hines M. Sexual differentiation of human brain and behavior. Hormones, Brain and Behavior 2002, 425-462. Pfaff D. ed, London, Academic Press
5. Phoenix CH, Goy RW, Gerall AA, Young WC. Organizing action of prenatally administered testosterone proprionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 1959, 65:369-382.
6. DonCarlos LL, Handa RJ. Developmental profile of estrogen receptor mRNA in the preoptic area of male and female neonatal rats. Brain Res Dev Brain Res 1994, 79:283-289.
7. Lephart ED. A review of brain aromatase cytochrome P450. Brain Res Rev 1996, 22:1-26.
8. Davis EC, Popper P, Gorski RA. The role of apoptosis in sexual differentiation of the rat sexually dimorphic nucleus of the preoptic area. Brain Res 1996, 734:10-18.
9. Tsukahara S. Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats. Neurosci Lett 2008, 432:58-63.
10. Tsukahara S, Kakeyama M, Toyofuku Y. Sex differences in the level of Bcl-2 family proteins and caspase-3 activation in the sexually dimorphic nuclei of the preoptic area in postnatal rats. J Neurobiol 2006, 66:1411-1419.
11. Krishnan S. Central role of TRAF-interacting protein in a new model of brain sexual differentiation. Proc Natl Acad Sci USA 2009, 106:16692-16697.
12. Searles RV. Sex differences in GABA turnover and glutamic acid decarboxylase (GAD(65) and GAD(67)) mRNA in the rat hypothalamus. Brain Res 2000, 2:11-19.
13. Waters EM, Simerly RB. Estrogen induces caspase-dependent cell death during hypothalamic development. J Neurosci 2009, 29:9714-9718.
14. Bos CL. Prostanoids and prostanoid receptors in signal transduction. Int J Biochem Cell Biol 2004, 36:1187-1205.
15. Chandrasekharan NV, Simmons DL. The cyclooxygenases. Genome Biol 2004, 5:241.
16. Amateau SK, McCarthy MM. Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior. Nat Neurosci 2004, 7:643-650.
17. Regan JW. EP2 and EP4 prostanoid receptor signaling. Life Sci 2003, 74:143-153.
18. Wright CL, Burks SR, McCarthy MM. Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates. Dev Neurobiol 2008, 68:1406-1419.
19. Snyder EM. Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression. J Biol Chem 2005, 280:16962-16968.
20. Wright CL, McCarthy MM. Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. J Neurosci 2009, 29:13274-13282.
21. Pfaff DW. Cellular and molecular mechanisms of female reproductive behaviors. Physiology of Reproduction 1994, 107-220. Knobil ENeill JD. eds, New York, NY, Raven Press
22. Mong JA, Glaser E, McCarthy MM. Gonadal steroids promote glial differentiation and alter neuronal morphology in the developing hypothalamus in a regionally specific manner. J Neurosci 1999, 19:1464-1472.
23. Todd BJ, Schwarz JM, McCarthy MM. Prostaglandin-E2: a point of divergence in estradiol-mediated sexual differentiation. Horm Behav 2005, 48:512-521.
24. Schwarz JM. Estradiol induces hypothalamic dendritic spines by enhancing glutamate release: a mechanism for organizational sex differences. Neuron 2008, 58:584-598.
25. Schwarz JM, McCarthy MM. The role of neonatal NMDA receptor activation in defeminization and masculinization of sex behavior in the rat. Horm Behav 2008, 54:662-668.
26. Ivankovic-Dikic I. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat Cell Biol 2000, 2:574-581.
27. Girault JA. FAK and PYK2/CAKbeta in the nervous system: a link between neuronal activity, plasticity and survival? Trends Neurosci 1999, 22:257-263.
28. Speert DB. Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation? Endocrinology 2007, 148:3391-3401.
29. Dohler KD, Hancke JL, Srivastava SS, Hofmann C, Shryne JE, Gorski RA. Participation of estrogens in female sexual differentiation of the brain; neuroanatomical, neuroendocrine and behavioral evidence. Prog Brain Res 1984, 61:99117.
30. Bakker J, Baum MJ. Role for estradiol in female-typical brain and behavioral sexual differentiation. Front Neuroendocrinol 2008, 29:1-16.
31. Arnold AP, Rissman EF, De Vries GJ. Two perspectives on the origin of sex differences in the brain. Ann NY Acad Sci 2003, 1007:176-188.
32. McCarthy MM, Konkle AT. When is a sex difference not a sex difference? Front Neuroendocrinol 2005, 26:85-102.
33. Woolley CS. Effects of estrogen in the CNS. Curr Opin Neurobiol 1999, 9:349-354.
34. Shors TJ, Miesegaes G. Testosterone in utero and at birth dictates how stressful experience will affect learning in adulthood. Proc Natl Acad Sci USA 2002, 99:13955-13960.
35. Wald C, Wu C. Biomedical research. Of mice and women: the bias in animal models. Science 2010, 327:1571-1572.
36. Chanda ML, Mogil JS. Sex differences in the effects of amiloride on formalin test nociception in mice. Am J Physiol Regul Integr Comp Physiol 2006, 291:R335-R342.
37. McCarthy GM, de Vries MJ, Forger NG. Sexual differentiation of the brain: mode, mechanisms and meaning. Hormones, Brain and Behavior 2009, 1707-1744. Pfaff EW, Etgen AM, Fahrbach SERubin RT. eds, San Diego, CA, Academic Press
38. Amateau SK, McCarthy MM. A novel mechanism of dendritic spine plasticity involving estradiol induction of prostglandin-E2. J Neurosci 2002, 22:8586-8596.