Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2

Cell Metabolism

Volumn 20, Issue 1, 2014, Pages 85-102

  Gurzov, Esteban N ^a   Tran, Melanie ^a   Fernandez Rojo, Manuel A ^a   Merry, Troy L ^a   Zhang, Xinmei ^a   Xu, Yang ^b,c   Fukushima, Atsushi ^a   Waters, Michael J ^d   Watt, Matthew J ^a   Andrikopoulos, Sofianos ^e   Neel, Benjamin G ^b,c   Tiganis, Tony ^a  

^a MONASH UNIVERSITY   (Australia)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MESSENGER RNA; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; SOMATOMEDIN; STAT5 PROTEIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; GROWTH HORMONE; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; STAT1 PROTEIN; STAT1 PROTEIN, MOUSE; STAT3 PROTEIN; STAT3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME INACTIVATION; FEMALE; GROWTH HORMONE RELEASE; INSULIN RESISTANCE; LIPOGENESIS; LIVER; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEATOSIS; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; LIPID DIET; LIVER CELL; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; CELLS, CULTURED; DIET, HIGH-FAT; FEMALE; GLUTATHIONE PEROXIDASE; GROWTH HORMONE; HEPATOCYTES; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; OXIDATIVE STRESS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR;

EID: 84904035083     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.05.011     Document Type: Article

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