-
1
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan, D., et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646-74.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
-
2
-
-
41749100127
-
Pancreatic cancer
-
Maitra, A., et al. (2008) Pancreatic cancer. Annu Rev Pathol, 3, 157-88.
-
(2008)
Annu Rev Pathol
, vol.3
, pp. 157-188
-
-
Maitra, A.1
-
3
-
-
84875228204
-
Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
-
Ino, Y., et al. (2013) Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br J Cancer, 108, 914-23.
-
(2013)
Br J Cancer
, vol.108
, pp. 914-923
-
-
Ino, Y.1
-
4
-
-
84892763014
-
Prognostic impact of hyaluronan and its regulators in pancreatic ductal adenocarcinoma
-
Cheng, X.B., et al. (2013) Prognostic impact of hyaluronan and its regulators in pancreatic ductal adenocarcinoma. PLoS One, 8, e80765.
-
(2013)
PLoS One
, vol.8
-
-
Cheng, X.B.1
-
5
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano, P.P., et al. (2012) Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell, 21, 418-29.
-
(2012)
Cancer Cell
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
-
6
-
-
84871157346
-
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
Gut
-
Jacobetz, M.A., et al. (2013) Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut, 62, 112-20.
-
(2013)
, vol.62
, pp. 112-120
-
-
Jacobetz, M.A.1
-
7
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K.P., et al. (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science, 324, 1457-61.
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
8
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty, G.L., et al. (2011) CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science, 331, 1612-6.
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
-
9
-
-
78149298209
-
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha
-
Kraman, M., et al. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science, 330, 827-30.
-
(2010)
Science
, vol.330
, pp. 827-830
-
-
Kraman, M.1
-
10
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani, S.R., et al. (2003) Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell, 4, 437-50.
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
-
11
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre, A.J., et al. (2003) Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev, 17, 3112-26.
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
-
12
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani, S.R., et al. (2005) Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell, 7, 469-83.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
-
13
-
-
33847419143
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
-
Guerra, C., et al. (2007) Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell, 11, 291-302.
-
(2007)
Cancer Cell
, vol.11
, pp. 291-302
-
-
Guerra, C.1
-
14
-
-
84863012865
-
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
-
Collins, M.A., et al. (2012) Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest, 122, 639-53.
-
(2012)
J Clin Invest
, vol.122
, pp. 639-653
-
-
Collins, M.A.1
-
15
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying, H., et al. (2012) Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell, 149, 656-70.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
-
16
-
-
31544467540
-
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
-
Hruban, R.H., et al. (2006) Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations. Cancer Res, 66, 95-106.
-
(2006)
Cancer Res
, vol.66
, pp. 95-106
-
-
Hruban, R.H.1
-
17
-
-
84860112131
-
What we have learned about pancreatic cancer from mouse models
-
Perez-Mancera, P.A., et al. (2012) What we have learned about pancreatic cancer from mouse models. Gastroenterology, 142, 1079-92.
-
(2012)
Gastroenterology
, vol.142
, pp. 1079-1092
-
-
Perez-Mancera, P.A.1
-
18
-
-
84903976231
-
The Secret Origins and Surprising Fates of Pancreas Tumors
-
Carcinogenesis
-
Bailey, J.M., et al. (2014) The Secret Origins and Surprising Fates of Pancreas Tumors. Carcinogenesis.
-
(2014)
-
-
Bailey, J.M.1
-
19
-
-
35148814410
-
Dynamics of the immune reaction to pancreatic cancer from inception to invasion
-
Clark, C.E., et al. (2007) Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res, 67, 9518-27.
-
(2007)
Cancer Res
, vol.67
, pp. 9518-9527
-
-
Clark, C.E.1
-
20
-
-
84894098516
-
Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
-
Gut
-
Stromnes, I.M., et al. (2014) Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity. Gut.
-
(2014)
-
-
Stromnes, I.M.1
-
21
-
-
84879850236
-
Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis
-
Sanford, D.E., et al. (2013) Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis. Clin Cancer Res, 19, 3404-15.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3404-3415
-
-
Sanford, D.E.1
-
22
-
-
33749317518
-
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
-
Hiraoka, N., et al. (2006) Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res, 12, 5423-34.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5423-5434
-
-
Hiraoka, N.1
-
23
-
-
19944426790
-
Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma
-
Ryschich, E., et al. (2005) Control of T-cell-mediated immune response by HLA class I in human pancreatic carcinoma. Clin Cancer Res, 11, 498-504.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 498-504
-
-
Ryschich, E.1
-
24
-
-
33846434093
-
The terminology issue for myeloid-derived suppressor cells
-
Gabrilovich, D.I., et al. (2007) The terminology issue for myeloid-derived suppressor cells. Cancer Res, 67, 425; author reply 426.
-
(2007)
Cancer Res
, vol.67
-
-
Gabrilovich, D.I.1
-
25
-
-
84884556145
-
History of myeloid-derived suppressor cells
-
Talmadge, J.E., et al. (2013) History of myeloid-derived suppressor cells. Nat Rev Cancer, 13, 739-52.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 739-752
-
-
Talmadge, J.E.1
-
26
-
-
84862150896
-
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
-
Bayne, L.J., et al. (2012) Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell, 21, 822-35.
-
(2012)
Cancer Cell
, vol.21
, pp. 822-835
-
-
Bayne, L.J.1
-
27
-
-
84862147254
-
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
-
Pylayeva-Gupta, Y., et al. (2012) Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer cell, 21, 836-47.
-
(2012)
Cancer cell
, vol.21
, pp. 836-847
-
-
Pylayeva-Gupta, Y.1
-
28
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich, D.I., et al. (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nature reviews. Immunology, 9, 162-74.
-
(2009)
Nature reviews. Immunology
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
-
29
-
-
54049134747
-
Subsets of myeloid-derived suppressor cells in tumor-bearing mice
-
Youn, J.I., et al. (2008) Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol, 181, 5791-802.
-
(2008)
J Immunol
, vol.181
, pp. 5791-5802
-
-
Youn, J.I.1
-
30
-
-
54849440346
-
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicincyclophosphamide chemotherapy
-
Diaz-Montero, C.M., et al. (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicincyclophosphamide chemotherapy. Cancer Immunol Immunother, 58, 49-59.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 49-59
-
-
Diaz-Montero, C.M.1
-
31
-
-
84866537713
-
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
-
Cancer immunology, immunotherapy: CII
-
Porembka, M.R., et al. (2012) Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer immunology, immunotherapy: CII.
-
(2012)
-
-
Porembka, M.R.1
-
32
-
-
84899505520
-
A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma
-
Sanford, D.E., et al. (2013) A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma. J Cancer Ther, 4, 797-803.
-
(2013)
J Cancer Ther
, vol.4
, pp. 797-803
-
-
Sanford, D.E.1
-
33
-
-
25844526684
-
Central tolerance: learning self-control in the thymus
-
Hogquist, K.A., et al. (2005) Central tolerance: learning self-control in the thymus. Nat Rev Immunol, 5, 772-82.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 772-782
-
-
Hogquist, K.A.1
-
34
-
-
2442484053
-
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
-
Sakaguchi, S. (2004) Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol, 22, 531-62.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
-
35
-
-
43049103779
-
Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection
-
discussion 854-6
-
Witkiewicz, A., et al. (2008) Expression of indoleamine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection. J Am Coll Surg, 206, 849-54; discussion 854-6.
-
(2008)
J Am Coll Surg
, vol.206
, pp. 849-854
-
-
Witkiewicz, A.1
-
36
-
-
84872079174
-
Indoleamine 2,3-dioxygenase affects the aggressiveness of intraductal papillary mucinous neoplasms through Foxp3+CD4+CD25+ T cells in peripheral blood
-
Ikemoto, T., et al. (2013) Indoleamine 2,3-dioxygenase affects the aggressiveness of intraductal papillary mucinous neoplasms through Foxp3+CD4+CD25+ T cells in peripheral blood. Pancreas, 42, 130-4.
-
(2013)
Pancreas
, vol.42
, pp. 130-134
-
-
Ikemoto, T.1
-
38
-
-
4644265937
-
Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma
-
Akasaki, Y., et al. (2004) Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma. J Immunol, 173, 4352-9.
-
(2004)
J Immunol
, vol.173
, pp. 4352-4359
-
-
Akasaki, Y.1
-
39
-
-
34548804503
-
Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma
-
Bergmann, C., et al. (2007) Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. Cancer Res, 67, 8865-73.
-
(2007)
Cancer Res
, vol.67
, pp. 8865-8873
-
-
Bergmann, C.1
-
40
-
-
77951626075
-
Regulatory T cells in cancer
-
Mougiakakos, D., et al. (2010) Regulatory T cells in cancer. Adv Cancer Res, 107, 57-117.
-
(2010)
Adv Cancer Res
, vol.107
, pp. 57-117
-
-
Mougiakakos, D.1
-
41
-
-
0036721629
-
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
-
Liyanage, U.K., et al. (2002) Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. Journal of immunology, 169, 2756-61.
-
(2002)
Journal of immunology
, vol.169
, pp. 2756-2761
-
-
Liyanage, U.K.1
-
42
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang, C.T., et al. (2004) Role of LAG-3 in regulatory T cells. Immunity, 21, 503-13.
-
(2004)
Immunity
, vol.21
, pp. 503-513
-
-
Huang, C.T.1
-
43
-
-
78449296907
-
IL-35-mediated induction of a potent regulatory T cell population
-
Collison, L.W., et al. (2010) IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol, 11, 1093-101.
-
(2010)
Nat Immunol
, vol.11
, pp. 1093-1101
-
-
Collison, L.W.1
-
44
-
-
0020047427
-
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells
-
North, R.J. (1982) Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J Exp Med, 155, 1063-74.
-
(1982)
J Exp Med
, vol.155
, pp. 1063-1074
-
-
North, R.J.1
-
45
-
-
21144454780
-
Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response
-
Ercolini, A.M., et al. (2005) Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response. J Exp Med, 201, 1591-602.
-
(2005)
J Exp Med
, vol.201
, pp. 1591-1602
-
-
Ercolini, A.M.1
-
46
-
-
15944410592
-
Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
-
Lutsiak, M.E., et al. (2005) Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood, 105, 2862-8.
-
(2005)
Blood
, vol.105
, pp. 2862-2868
-
-
Lutsiak, M.E.1
-
47
-
-
0037174674
-
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
-
Dudley, M.E., et al. (2002) Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science (New York, NY), 298, 850-4.
-
(2002)
Science (New York, NY)
, vol.298
, pp. 850-854
-
-
Dudley, M.E.1
-
48
-
-
20244366111
-
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
-
Dudley, M.E., et al. (2005) Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol, 23, 2346-57.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2346-2357
-
-
Dudley, M.E.1
-
49
-
-
70350496784
-
Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
-
Rech, A.J., et al. (2009) Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells. Ann N Y Acad Sci, 1174, 99-106.
-
(2009)
Ann N Y Acad Sci
, vol.1174
, pp. 99-106
-
-
Rech, A.J.1
-
50
-
-
84861175955
-
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients
-
134ra62
-
Rech, A.J., et al. (2012) CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci Transl Med, 4, 134ra62.
-
(2012)
Sci Transl Med
, vol.4
-
-
Rech, A.J.1
-
51
-
-
34247504608
-
Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro
-
Mahnke, K., et al. (2007) Depletion of CD4+CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro. Int J Cancer, 120, 2723-33.
-
(2007)
Int J Cancer
, vol.120
, pp. 2723-2733
-
-
Mahnke, K.1
-
52
-
-
84903938973
-
Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-alpha gene therapy for pancreatic cancer
-
Aida, K., et al. (2013) Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-alpha gene therapy for pancreatic cancer. Cancer Sci.
-
(2013)
Cancer Sci
-
-
Aida, K.1
-
53
-
-
63149148047
-
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer
-
Tan, M.C., et al. (2009) Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. Journal of immunology, 182, 1746-55.
-
(2009)
Journal of immunology
, vol.182
, pp. 1746-1755
-
-
Tan, M.C.1
-
54
-
-
84887081136
-
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans
-
Sugiyama, D., et al. (2013) Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci U S A, 110, 17945-50.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 17945-17950
-
-
Sugiyama, D.1
-
55
-
-
54049151564
-
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation
-
Chen, W., et al. (2008) The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. J Immunol, 181, 5396-404.
-
(2008)
J Immunol
, vol.181
, pp. 5396-5404
-
-
Chen, W.1
-
56
-
-
77958050577
-
Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
-
Royal, R.E., et al. (2010) Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. Journal of immunotherapy, 33, 828-33.
-
(2010)
Journal of immunotherapy
, vol.33
, pp. 828-833
-
-
Royal, R.E.1
-
57
-
-
84883207410
-
Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer
-
Le, D.T., et al. (2013) Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer. J Immunother, 36, 382-9.
-
(2013)
J Immunother
, vol.36
, pp. 382-389
-
-
Le, D.T.1
-
58
-
-
84884206864
-
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
-
Delgoffe, G.M., et al. (2013) Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature, 501, 252-6.
-
(2013)
Nature
, vol.501
, pp. 252-256
-
-
Delgoffe, G.M.1
-
59
-
-
35649009802
-
Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer
-
Muller, M.W., et al. (2007) Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer. Int J Cancer, 121, 2421-33.
-
(2007)
Int J Cancer
, vol.121
, pp. 2421-2433
-
-
Muller, M.W.1
-
60
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce, J.A., et al. (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer, 9, 239-52.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
-
61
-
-
84884236200
-
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-kappaB and MMPs
-
Liou, G.Y., et al. (2013) Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-kappaB and MMPs. J Cell Biol, 202, 563-77.
-
(2013)
J Cell Biol
, vol.202
, pp. 563-577
-
-
Liou, G.Y.1
-
62
-
-
79952724783
-
Intratumor T helper type 2 cell infiltrate correlates with cancerassociated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
-
De Monte, L., et al. (2011) Intratumor T helper type 2 cell infiltrate correlates with cancerassociated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer. J Exp Med, 208, 469-78.
-
(2011)
J Exp Med
, vol.208
, pp. 469-478
-
-
Monte, D.L.1
-
63
-
-
0032482337
-
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
-
Ridge, J.P., et al. (1998) A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature, 393, 474-8.
-
(1998)
Nature
, vol.393
, pp. 474-478
-
-
Ridge, J.P.1
-
64
-
-
0032482356
-
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
-
Bennett, S.R., et al. (1998) Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature, 393, 478-80.
-
(1998)
Nature
, vol.393
, pp. 478-480
-
-
Bennett, S.R.1
-
65
-
-
34249722182
-
Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation
-
French, R.R., et al. (2007) Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation. Blood, 109, 4810-5.
-
(2007)
Blood
, vol.109
, pp. 4810-4815
-
-
French, R.R.1
-
66
-
-
84876424760
-
Macrophage regulation of tumor responses to anticancer therapies
-
De Palma, M., et al. (2013) Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell, 23, 277-86.
-
(2013)
Cancer Cell
, vol.23
, pp. 277-286
-
-
Palma, D.M.1
-
67
-
-
84873468174
-
Targeting tumor-infiltrating macrophages decreases tumorinitiating cells, relieves immunosuppression, and improves chemotherapeutic responses
-
Mitchem, J.B., et al. (2013) Targeting tumor-infiltrating macrophages decreases tumorinitiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res, 73, 1128-41.
-
(2013)
Cancer Res
, vol.73
, pp. 1128-1141
-
-
Mitchem, J.B.1
-
68
-
-
84903938974
-
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase
-
Oncogene
-
Weizman, N., et al. (2013) Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase. Oncogene.
-
(2013)
-
-
Weizman, N.1
-
69
-
-
84880747672
-
Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance
-
Zitvogel, L., et al. (2013) Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity, 39, 74-88.
-
(2013)
Immunity
, vol.39
, pp. 74-88
-
-
Zitvogel, L.1
-
70
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
Biankin, A.V., et al. (2012) Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature, 491, 399-405.
-
(2012)
Nature
, vol.491
, pp. 399-405
-
-
Biankin, A.V.1
-
71
-
-
84875490185
-
Cancer genome landscapes
-
Vogelstein, B., et al. (2013) Cancer genome landscapes. Science, 339, 1546-58.
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
-
72
-
-
84877982642
-
Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling
-
Cifola, I., et al. (2013) Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling. PloS one, 8, e63597.
-
(2013)
PloS one
, vol.8
-
-
Cifola, I.1
-
73
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
Govindan, R., et al. (2012) Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell, 150, 1121-34.
-
(2012)
Cell
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
-
74
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F.S., et al. (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med, 363, 711-23.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
75
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian, S.L., et al. (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. The New England journal of medicine, 366, 2443-54.
-
(2012)
The New England journal of medicine
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
76
-
-
3543060047
-
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
-
Thomas, A.M., et al. (2004) Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med, 200, 297-306.
-
(2004)
J Exp Med
, vol.200
, pp. 297-306
-
-
Thomas, A.M.1
-
77
-
-
84890281217
-
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
-
Feig, C., et al. (2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A, 110, 20212-7.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 20212-20217
-
-
Feig, C.1
-
78
-
-
84890192723
-
Re-adapting T cells for cancer therapy: from mouse models to clinical trials
-
Stromnes, I.M., et al. (2014) Re-adapting T cells for cancer therapy: from mouse models to clinical trials. Immunological reviews, 257, 1-20.
-
(2014)
Immunological reviews
, vol.257
, pp. 1-20
-
-
Stromnes, I.M.1
-
79
-
-
84055217292
-
IL-12 triggers a programmatic change in dysfunctional myeloidderived cells within mouse tumors
-
Kerkar, S.P., et al. (2011) IL-12 triggers a programmatic change in dysfunctional myeloidderived cells within mouse tumors. J Clin Invest, 121, 4746-57.
-
(2011)
J Clin Invest
, vol.121
, pp. 4746-4757
-
-
Kerkar, S.P.1
-
80
-
-
84877845953
-
IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner
-
Liu, R.B., et al. (2013) IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad Sci U S A, 110, 8158-63.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 8158-8163
-
-
Liu, R.B.1
-
81
-
-
17144404527
-
Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
-
Bachem, M.G., et al. (2005) Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology, 128, 907-21.
-
(2005)
Gastroenterology
, vol.128
, pp. 907-921
-
-
Bachem, M.G.1
-
82
-
-
84886780808
-
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
-
Ene-Obong, A., et al. (2013) Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology, 145, 1121-32.
-
(2013)
Gastroenterology
, vol.145
, pp. 1121-1132
-
-
Ene-Obong, A.1
-
83
-
-
84902435628
-
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
-
Rhim, A.D., et al. (2014) Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma. Cancer Cell.
-
(2014)
Cancer Cell
-
-
Rhim, A.D.1
-
84
-
-
80053577336
-
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression
-
1497, e1-14
-
Froeling, F.E., et al. (2011) Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-beta-catenin signaling to slow tumor progression. Gastroenterology, 141, 1486-97, 1497 e1-14.
-
(2011)
Gastroenterology
, vol.141
, pp. 1486-1497
-
-
Froeling, F.E.1
-
85
-
-
84855562506
-
Nuclear receptors as modulators of the tumor microenvironment
-
Sherman, M.H., et al. (2012) Nuclear receptors as modulators of the tumor microenvironment. Cancer Prev Res (Phila), 5, 3-10.
-
(2012)
Cancer Prev Res (Phila)
, vol.5
, pp. 3-10
-
-
Sherman, M.H.1
-
86
-
-
84877825407
-
Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer
-
Iclozan, C., et al. (2013) Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer immunology, immunotherapy: CII, 62, 909-18.
-
(2013)
Cancer immunology, immunotherapy: CII
, vol.62
, pp. 909-918
-
-
Iclozan, C.1
-
87
-
-
80655127773
-
Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats
-
Abramovitch, S., et al. (2011) Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. Gut, 60, 1728-37.
-
(2011)
Gut
, vol.60
, pp. 1728-1737
-
-
Abramovitch, S.1
-
88
-
-
84876928036
-
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
-
Ding, N., et al. (2013) A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell, 153, 601-13.
-
(2013)
Cell
, vol.153
, pp. 601-613
-
-
Ding, N.1
-
89
-
-
84887459688
-
A nonclassical vitamin D receptor pathway suppresses renal fibrosis
-
Ito, I., et al. (2013) A nonclassical vitamin D receptor pathway suppresses renal fibrosis. J Clin Invest, 123, 4579-94.
-
(2013)
J Clin Invest
, vol.123
, pp. 4579-4594
-
-
Ito, I.1
-
90
-
-
55949135598
-
Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma
-
Cohen, S.J., et al. (2008) Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma. Pancreas, 37, 154-8.
-
(2008)
Pancreas
, vol.37
, pp. 154-158
-
-
Cohen, S.J.1
-
91
-
-
79958250916
-
FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells
-
Lee, H.O., et al. (2011) FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer, 11, 245.
-
(2011)
BMC Cancer
, vol.11
, pp. 245
-
-
Lee, H.O.1
-
92
-
-
84880656055
-
Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
-
Tran, E., et al. (2013) Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia. J Exp Med, 210, 1125-35.
-
(2013)
J Exp Med
, vol.210
, pp. 1125-1135
-
-
Tran, E.1
-
93
-
-
84882636722
-
Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
-
Schuberth, P.C., et al. (2013) Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells. J Transl Med, 11, 187.
-
(2013)
J Transl Med
, vol.11
, pp. 187
-
-
Schuberth, P.C.1
-
94
-
-
66149150580
-
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
-
Azab, A.K., et al. (2009) CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood, 113, 4341-51.
-
(2009)
Blood
, vol.113
, pp. 4341-4351
-
-
Azab, A.K.1
-
95
-
-
84255170450
-
PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment
-
Obermajer, N., et al. (2011) PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment. Cancer Res, 71, 7463-70.
-
(2011)
Cancer Res
, vol.71
, pp. 7463-7470
-
-
Obermajer, N.1
-
96
-
-
4043055316
-
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
-
Phillips, R.J., et al. (2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest, 114, 438-46.
-
(2004)
J Clin Invest
, vol.114
, pp. 438-446
-
-
Phillips, R.J.1
-
97
-
-
79957624520
-
Fibrocytes: emerging effector cells in chronic inflammation
-
Reilkoff, R.A., et al. (2011) Fibrocytes: emerging effector cells in chronic inflammation. Nat Rev Immunol, 11, 427-35.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 427-435
-
-
Reilkoff, R.A.1
-
98
-
-
1842509856
-
Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma
-
Devine, S.M., et al. (2004) Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J Clin Oncol, 22, 1095-102.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1095-1102
-
-
Devine, S.M.1
-
99
-
-
84902469661
-
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
-
Ozdemir, B.C., et al. (2014) Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell.
-
(2014)
Cancer Cell
-
-
Ozdemir, B.C.1
-
100
-
-
79951677394
-
Fate mapping of IL-17-producing T cells in inflammatory responses
-
Hirota, K., et al. (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nature immunology, 12, 255-63.
-
(2011)
Nature immunology
, vol.12
, pp. 255-263
-
-
Hirota, K.1
-
101
-
-
0034684279
-
Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition
-
Theocharis, A.D., et al. (2000) Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition. Biochim Biophys Acta, 1502, 201-6.
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 201-206
-
-
Theocharis, A.D.1
-
102
-
-
0030820092
-
Hyaluronan: its nature, distribution, functions and turnover
-
Fraser, J.R., et al. (1997) Hyaluronan: its nature, distribution, functions and turnover. J Intern Med, 242, 27-33.
-
(1997)
J Intern Med
, vol.242
, pp. 27-33
-
-
Fraser, J.R.1
-
103
-
-
0018718903
-
Interstitial fluid pressure: capsule, free fluid, gel fluid, and gel absorption pressure in subcutaneous tissue
-
Brace, R.A., et al. (1979) Interstitial fluid pressure: capsule, free fluid, gel fluid, and gel absorption pressure in subcutaneous tissue. Microvasc Res, 18, 217-28.
-
(1979)
Microvasc Res
, vol.18
, pp. 217-228
-
-
Brace, R.A.1
-
104
-
-
84904269126
-
Interstitial pressure and vascular collapse in pancreas cancer: fluids and solids, measurement and meaning
-
in press
-
DelGiorno, K.E., et al. (2014) Interstitial pressure and vascular collapse in pancreas cancer: fluids and solids, measurement and meaning. Cancer Cell, in press.
-
(2014)
Cancer Cell
-
-
DelGiorno, K.E.1
-
105
-
-
0019826493
-
Progress toward resolving the controversy of positive Vs. negative interstitial fluid pressure.
-
Brace, R.A. (1981) Progress toward resolving the controversy of positive Vs. negative interstitial fluid pressure. Circ Res, 49, 281-97.
-
(1981)
Circ Res
, vol.49
, pp. 281-297
-
-
Brace, R.A.1
-
106
-
-
0034894250
-
Rheology of sodium hyaluronate under physiological conditions
-
Krause, W.E., et al. (2001) Rheology of sodium hyaluronate under physiological conditions. Biomacromolecules, 2, 65-9.
-
(2001)
Biomacromolecules
, vol.2
, pp. 65-69
-
-
Krause, W.E.1
-
107
-
-
84872611820
-
Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
-
Provenzano, P.P., et al. (2013) Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br J Cancer, 108, 1-8.
-
(2013)
Br J Cancer
, vol.108
, pp. 1-8
-
-
Provenzano, P.P.1
-
108
-
-
0026786660
-
Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse
-
Boucher, Y., et al. (1992) Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res, 52, 5110-4.
-
(1992)
Cancer Res
, vol.52
, pp. 5110-5114
-
-
Boucher, Y.1
-
109
-
-
0000318041
-
Pulsatile Pressures in the Microcirculation of Frog's Mesentery
-
Wiederhielm, C.A., et al. (1964) Pulsatile Pressures in the Microcirculation of Frog's Mesentery. Am J Physiol, 207, 173-6.
-
(1964)
Am J Physiol
, vol.207
, pp. 173-176
-
-
Wiederhielm, C.A.1
-
110
-
-
0017373031
-
Interstitial fluid pressure in rats measured with a modified wick technique
-
Fadnes, H.O., et al. (1977) Interstitial fluid pressure in rats measured with a modified wick technique. Microvasc Res, 14, 27-36.
-
(1977)
Microvasc Res
, vol.14
, pp. 27-36
-
-
Fadnes, H.O.1
-
111
-
-
0023481357
-
Transport of molecules across tumor vasculature
-
Jain, R.K. (1987) Transport of molecules across tumor vasculature. Cancer Metastasis Rev, 6, 559-93.
-
(1987)
Cancer Metastasis Rev
, vol.6
, pp. 559-593
-
-
Jain, R.K.1
-
112
-
-
0001439035
-
A concept of negative interstitial pressure based on pressures in implanted perforated capsules
-
Guyton, A.C. (1963) A concept of negative interstitial pressure based on pressures in implanted perforated capsules. Circ Res, 12, 399-414.
-
(1963)
Circ Res
, vol.12
, pp. 399-414
-
-
Guyton, A.C.1
-
113
-
-
0031785806
-
Technology and application of ultraminiature catheter pressure transducers
-
Zimmer, H.G., et al. (1998) Technology and application of ultraminiature catheter pressure transducers. Can J Cardiol, 14, 1259-66.
-
(1998)
Can J Cardiol
, vol.14
, pp. 1259-1266
-
-
Zimmer, H.G.1
-
114
-
-
27644537720
-
A simple method for measuring interstitial fluid pressure in cancer tissues
-
Ozerdem, U., et al. (2005) A simple method for measuring interstitial fluid pressure in cancer tissues. Microvasc Res, 70, 116-20.
-
(2005)
Microvasc Res
, vol.70
, pp. 116-120
-
-
Ozerdem, U.1
-
115
-
-
0036819199
-
Mammalian hyaluronan synthases
-
Itano, N., et al. (2002) Mammalian hyaluronan synthases. IUBMB Life, 54, 195-9.
-
(2002)
IUBMB Life
, vol.54
, pp. 195-199
-
-
Itano, N.1
-
116
-
-
0030832062
-
Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture
-
Agren, U.M., et al. (1997) Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture. Free Radic Biol Med, 23, 996-1001.
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 996-1001
-
-
Agren, U.M.1
-
117
-
-
38049066579
-
Hyaluronan in tissue injury and repair
-
Jiang, D., et al. (2007) Hyaluronan in tissue injury and repair. Annu Rev Cell Dev Biol, 23, 435-61.
-
(2007)
Annu Rev Cell Dev Biol
, vol.23
, pp. 435-461
-
-
Jiang, D.1
-
118
-
-
33746040501
-
Hyaluronan fragments: an information-rich system
-
Stern, R., et al. (2006) Hyaluronan fragments: an information-rich system. Eur J Cell Biol, 85, 699-715.
-
(2006)
Eur J Cell Biol
, vol.85
, pp. 699-715
-
-
Stern, R.1
-
119
-
-
80053947868
-
High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation
-
Maharjan, A.S., et al. (2011) High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation. PLoS One, 6, e26078.
-
(2011)
PLoS One
, vol.6
-
-
Maharjan, A.S.1
-
120
-
-
0034663808
-
Oligosaccharides of hyaluronan are potent activators of dendritic cells
-
Termeer, C.C., et al. (2000) Oligosaccharides of hyaluronan are potent activators of dendritic cells. J Immunol, 165, 1863-70.
-
(2000)
J Immunol
, vol.165
, pp. 1863-1870
-
-
Termeer, C.C.1
-
121
-
-
33745840859
-
Hyaluronan fragments act as an endogenous danger signal by engaging TLR2
-
Scheibner, K.A., et al. (2006) Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol, 177, 1272-81.
-
(2006)
J Immunol
, vol.177
, pp. 1272-1281
-
-
Scheibner, K.A.1
-
122
-
-
74249106459
-
Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes
-
Campo, G.M., et al. (2010) Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes. Biochimie, 92, 204-15.
-
(2010)
Biochimie
, vol.92
, pp. 204-215
-
-
Campo, G.M.1
-
123
-
-
34548727522
-
Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells
-
Bollyky, P.L., et al. (2007) Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells. J Immunol, 179, 744-7.
-
(2007)
J Immunol
, vol.179
, pp. 744-747
-
-
Bollyky, P.L.1
-
124
-
-
70149120971
-
Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells
-
Bollyky, P.L., et al. (2009) Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells. J Leukoc Biol, 86, 567-72.
-
(2009)
J Leukoc Biol
, vol.86
, pp. 567-572
-
-
Bollyky, P.L.1
-
125
-
-
79956352407
-
ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors
-
Bollyky, P.L., et al. (2011) ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors. Proc Natl Acad Sci U S A, 108, 7938-43.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7938-7943
-
-
Bollyky, P.L.1
-
126
-
-
3042697038
-
Hyaluronan: from extracellular glue to pericellular cue
-
Toole, B.P. (2004) Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer, 4, 528-39.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 528-539
-
-
Toole, B.P.1
-
127
-
-
84866430581
-
Detection and clinical significance of CD44v6 and integrin-beta1 in pancreatic cancer patients using a triplex real-time RT-PCR assay
-
Zhou, G., et al. (2012) Detection and clinical significance of CD44v6 and integrin-beta1 in pancreatic cancer patients using a triplex real-time RT-PCR assay. Appl Biochem Biotechnol, 167, 2257-68.
-
(2012)
Appl Biochem Biotechnol
, vol.167
, pp. 2257-2268
-
-
Zhou, G.1
-
128
-
-
84896489722
-
Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice
-
Li, L., et al. (2014) Antibody Against CD44s Inhibits Pancreatic Tumor Initiation and Postradiation Recurrence in Mice. Gastroenterology.
-
(2014)
Gastroenterology
-
-
Li, L.1
-
129
-
-
80053631995
-
Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis
-
Du, Y.C., et al. (2011) Receptor for hyaluronan-mediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proc Natl Acad Sci U S A, 108, 16753-8.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 16753-16758
-
-
Du, Y.C.1
-
130
-
-
0028822237
-
Quantitative analysis of collagen and collagen subtypes I, III, and V in human pancreatic cancer, tumor-associated chronic pancreatitis, and alcoholic chronic pancreatitis
-
Imamura, T., et al. (1995) Quantitative analysis of collagen and collagen subtypes I, III, and V in human pancreatic cancer, tumor-associated chronic pancreatitis, and alcoholic chronic pancreatitis. Pancreas, 11, 357-64.
-
(1995)
Pancreas
, vol.11
, pp. 357-364
-
-
Imamura, T.1
-
131
-
-
77957221459
-
Dynamic interplay between the collagen scaffold and tumor evolution
-
Egeblad, M., et al. (2010) Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol, 22, 697-706.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 697-706
-
-
Egeblad, M.1
-
132
-
-
58849097668
-
Imaging intratumoral convection: pressure-dependent enhancement in chemotherapeutic delivery to solid tumors
-
Gade, T.P., et al. (2009) Imaging intratumoral convection: pressure-dependent enhancement in chemotherapeutic delivery to solid tumors. Clin Cancer Res, 15, 247-55.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 247-255
-
-
Gade, T.P.1
-
133
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff, D.D., et al. (2013) Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med, 369, 1691-703.
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
-
134
-
-
84878396462
-
Macropinocytosis of protein is an amino acid supply route in Rastransformed cells
-
Commisso, C., et al. (2013) Macropinocytosis of protein is an amino acid supply route in Rastransformed cells. Nature, 497, 633-7.
-
(2013)
Nature
, vol.497
, pp. 633-637
-
-
Commisso, C.1
-
135
-
-
33846916208
-
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
-
Infante, J.R., et al. (2007) Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol, 25, 319-25.
-
(2007)
J Clin Oncol
, vol.25
, pp. 319-325
-
-
Infante, J.R.1
-
136
-
-
84903938967
-
SPARC independent drug delivery and antitumour effects of nabpaclitaxel in genetically engineered mice
-
Gut
-
Neesse, A., et al. (2013) SPARC independent drug delivery and antitumour effects of nabpaclitaxel in genetically engineered mice. Gut.
-
(2013)
-
-
Neesse, A.1
-
137
-
-
84880658054
-
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
-
Neesse, A., et al. (2013) CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A, 110, 12325-30.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 12325-12330
-
-
Neesse, A.1
-
138
-
-
33745454902
-
The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer
-
Skandalis, S.S., et al. (2006) The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer. Biochim Biophys Acta, 1760, 1217-25.
-
(2006)
Biochim Biophys Acta
, vol.1760
, pp. 1217-1225
-
-
Skandalis, S.S.1
-
139
-
-
0033563208
-
Elevated levels of peritumoral chondroitin sulfate are predictive of poor prognosis in patients treated by radical prostatectomy for early-stage prostate cancer
-
Ricciardelli, C., et al. (1999) Elevated levels of peritumoral chondroitin sulfate are predictive of poor prognosis in patients treated by radical prostatectomy for early-stage prostate cancer. Cancer Res, 59, 2324-8.
-
(1999)
Cancer Res
, vol.59
, pp. 2324-2328
-
-
Ricciardelli, C.1
-
140
-
-
4444259183
-
Pancreatic tumor cells influence the composition of the extracellular matrix
-
Peer Review 32
-
Koninger, J., et al. (2004) Pancreatic tumor cells influence the composition of the extracellular matrix. Biochem Biophys Res Commun, 322, 943-9. Peer Review 32
-
(2004)
Biochem Biophys Res Commun
, vol.322
, pp. 943-949
-
-
Koninger, J.1
-
141
-
-
0035118911
-
Versican accumulation in human prostatic fibroblast cultures is enhanced by prostate cancer cell-derived transforming growth factor beta1
-
Sakko, A.J., et al. (2001) Versican accumulation in human prostatic fibroblast cultures is enhanced by prostate cancer cell-derived transforming growth factor beta1. Cancer Res, 61, 926-30.
-
(2001)
Cancer Res
, vol.61
, pp. 926-930
-
-
Sakko, A.J.1
-
142
-
-
70349916021
-
Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer
-
Ryschich, E., et al. (2009) Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. Pancreas, 38, 804-10.
-
(2009)
Pancreas
, vol.38
, pp. 804-810
-
-
Ryschich, E.1
-
143
-
-
0029088680
-
De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells
-
Santra, M., et al. (1995) De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc Natl Acad Sci U S A, 92, 7016-20.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7016-7020
-
-
Santra, M.1
-
144
-
-
0033572612
-
In vitro growth inhibition of ovarian cancer cells by decorin: synergism of action between decorin and carboplatin
-
Nash, M.A., et al. (1999) In vitro growth inhibition of ovarian cancer cells by decorin: synergism of action between decorin and carboplatin. Cancer Res, 59, 6192-6.
-
(1999)
Cancer Res
, vol.59
, pp. 6192-6196
-
-
Nash, M.A.1
-
145
-
-
84866901074
-
Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer
-
van der Zee, J.A., et al. (2012) Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer. Br J Cancer, 107, 1153-8.
-
(2012)
Br J Cancer
, vol.107
, pp. 1153-1158
-
-
van der Zee, J.A.1
-
146
-
-
84872611820
-
Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
-
Provenzano, P.P., et al. (2013) Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. British journal of cancer, 108, 1-8.
-
(2013)
British journal of cancer
, vol.108
, pp. 1-8
-
-
Provenzano, P.P.1
-
147
-
-
84863691378
-
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
-
Singh, M., et al. (2012) Modeling and predicting clinical efficacy for drugs targeting the tumor milieu. Nat Biotechnol, 30, 648-57.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 648-657
-
-
Singh, M.1
-
148
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy, T., et al. (2011) FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med, 364, 1817-25.
-
(2011)
N Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
-
149
-
-
84893029048
-
Albumin-bound paclitaxel plus gemcitabine in pancreatic cancer
-
Von Hoff, D.D., et al. (2014) Albumin-bound paclitaxel plus gemcitabine in pancreatic cancer. N Engl J Med, 370, 479-80.
-
(2014)
N Engl J Med
, vol.370
, pp. 479-480
-
-
Von Hoff, D.D.1
|