Thiamine is a substrate of organic cation transporters in Caco-2 cells

European Journal of Pharmacology

Volumn 682, Issue 1-3, 2012, Pages 37-42

  Lemos, Clara ^a,b   Faria, Ana ^a,c   Meireles, Manuela ^a   Martel, Fátima ^a   Monteiro, Rosário ^a   Calhau, Conceição ^a  

^a University of Porto   (Portugal)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Caco 2 cell; Organic cation; Thiamine; Uptake

Indexed keywords

ALKALINE PHOSPHATASE; AMILORIDE; AMPROLIUM; CARRIER PROTEIN; CHEMICAL COMPOUND; CHLORIDE ION; CLONIDINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DECYNIUM22; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER; OXYTHIAMINE; PROGESTERONE; PROTEIN THT2; PROTEIN THTR1; PROTEIN TYROSINE PHOSPHATASE; SEROTONIN; SODIUM ION; THIAMINE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CELL PH; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; EXTRACELLULAR PH; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TIME;

AMILORIDE; AMPROLIUM; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DESIPRAMINE; ENZYME INHIBITORS; FLUOXETINE; HUMANS; HYDROGEN-ION CONCENTRATION; ORGANIC CATION TRANSPORT PROTEINS; OXYTHIAMINE; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN BINDING; SEROTONIN; SODIUM CHLORIDE; THIAMINE;

EID: 84859099760     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.02.028     Document Type: Article

References (38)

1. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
2. A.E. Busch, U. Karbach, D. Miska, V. Gorboulev, A. Akhoundova, C. Volk, P. Arndt, J.C. Ulzheimer, M.S. Sonders, C. Baumann, S. Waldegger, F. Lang, and H. Koepsell Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine Mol. Pharmacol. 54 1998 342 352
3. C. Calhau, F. Martel, C. Hipolito-Reis, and I. Azevedo Effect of thiamine on 3H-MPP+ uptake by Caco-2 cells Pharmacol. Res. 48 2003 579 584
4. F. Delie, and W. Rubas A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: advantages and limitations of the Caco-2 model Crit. Rev. Ther. Drug Carrier Syst. 14 1997 221 286
5. G.A. Diaz, M. Banikazemi, K. Oishi, R.J. Desnick, and B.D. Gelb Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome Nat. Genet. 22 1999 309 312
6. P.K. Dudeja, S. Tyagi, R.J. Kavilaveettil, R. Gill, and H.M. Said Mechanism of thiamine uptake by human jejunal brush-border membrane vesicles Am. J. Physiol. Cell Physiol. 281 2001 C786 C792
7. P.K. Dudeja, S. Tyagi, R. Gill, and H.M. Said Evidence for a carrier-mediated mechanism for thiamine transport to human jejunal basolateral membrane vesicles Dig. Dis. Sci. 48 2003 109 115
8. B. Dutta, W. Huang, M. Molero, R. Kekuda, F.H. Leibach, L.D. Devoe, V. Ganapathy, and P.D. Prasad Cloning of the human thiamine transporter, a member of the folate transporter family J. Biol. Chem. 274 1999 31925 31929
9. E. Fabian, and I. Elmadfa Nutritional situation of the elderly in the European Union: data of the European Nutrition and Health Report (2004) Ann. Nutr. Metab. 52 Suppl 1 2008 57 61
10. T. Frank, K. Czeche, R. Bitsch, and G. Stein Assessment of thiamin status in chronic renal failure patients, transplant recipients and hemodialysis patients receiving a multivitamin supplementation Int. J. Vitam. Nutr. Res. 70 2000 159 166
11. V. Ganapathy, S.B. Smith, and P.D. Prasad SLC19: the folate/thiamine transporter family Pflugers Arch. 447 2004 641 646
12. D. Grundemann, G. Liebich, N. Kiefer, S. Koster, and E. Schomig Selective substrates for non-neuronal monoamine transporters Mol. Pharmacol. 56 1999 1 10
13. R. Hayeshi, C. Hilgendorf, P. Artursson, P. Augustijns, B. Brodin, P. Dehertogh, K. Fisher, L. Fossati, E. Hovenkamp, T. Korjamo, C. Masungi, N. Maubon, R. Mols, A. Mullertz, J. Monkkonen, C. O'Driscoll, H.M. Oppers-Tiemissen, E.G. Ragnarsson, M. Rooseboom, and A.L. Ungell Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories Eur. J. Pharm. Sci. 35 2008 383 396
14. E. Keating, C. Lemos, R. Monteiro, I. Azevedo, and F. Martel The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT Life Sci. 76 2004 103 119
15. E. Keating, C. Lemos, I. Azevedo, and F. Martel Characteristics of thiamine uptake by the BeWo human trophoblast cell line J. Biochem. Mol. Biol. 39 2006 383 393
16. H. Koepsell, K. Lips, and C. Volk Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications Pharm. Res. 24 2007 1227 1251
17. H. Koike, and G. Sobue Alcoholic neuropathy Curr. Opin. Neurol. 19 2006 481 486
18. N. Kumar Neurologic presentations of nutritional deficiencies Neurol. Clin. 28 2010 107 170
19. V. Labay, T. Raz, D. Baron, H. Mandel, H. Williams, T. Barrett, R. Szargel, L. McDonald, A. Shalata, K. Nosaka, S. Gregory, and N. Cohen Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness Nat. Genet. 22 1999 300 304
20. U. Laforenza, M.N. Orsenigo, and G. Rindi A thiamine/H+ antiport mechanism for thiamine entry into brush border membrane vesicles from rat small intestine J. Membr. Biol. 161 1998 151 161
21. C.O. Lengyel, S.J. Whiting, and G.A. Zello Nutrient inadequacies among elderly residents of long-term care facilities Can. J. Diet. Pract. Res. 69 2008 82 88
22. F. Martel, C. Calhau, and I. Azevedo Characterization of the transport of the organic cation [3H]MPP + in human intestinal epithelial (Caco-2) cells Naunyn Schmiedebergs Arch. Pharmacol. 361 2000 505 513
23. F. Martel, D. Grundemann, C. Calhau, and E. Schomig Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters Naunyn Schmiedebergs Arch. Pharmacol. 363 2001 40 49
24. F. Martel, E. Keating, C. Calhau, and I. Azevedo Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms Biochem. Pharmacol. 63 2002 1565 1573
25. J.E. Morley Nutrition and the brain Clin. Geriatr. Med. 26 2010 89 98
26. A. Olsen, J. Halkjaer, C.H. van Gils, B. Buijsse, H. Verhagen, M. Jenab, M.C. Boutron-Ruault, U. Ericson, M.C. Ocke, P.H. Peeters, M. Touvier, M. Niravong, M. Waaseth, G. Skeie, K.T. Khaw, R. Travis, P. Ferrari, M.J. Sanchez, A. Agudo, K. Overvad, J. Linseisen, C. Weikert, C. Sacerdote, A. Evangelista, D. Zylis, K. Tsiotas, J. Manjer, B. van Guelpen, E. Riboli, N. Slimani, and S. Bingham Dietary intake of the water-soluble vitamins B1, B2, B6, B12 and C in 10 countries in the European Prospective Investigation into Cancer and Nutrition Eur. J. Clin. Nutr. 63 Suppl 4 2009 S122 S149
27. A. Rajgopal, A. Edmondnson, I.D. Goldman, and R. Zhao SLC19A3 encodes a second thiamine transporter ThTr2 Biochim. Biophys. Acta 1537 2001 175 178
28. G. Rindi, and U. Laforenza Thiamine intestinal transport and related issues: recent aspects Proc. Soc. Exp. Biol. Med. 224 2000 246 255
29. H.M. Said, A. Ortiz, C.K. Kumar, N. Chatterjee, P.K. Dudeja, and S. Rubin Transport of thiamine in human intestine: mechanism and regulation in intestinal epithelial cell model Caco-2 Am. J. Physiol. 277 1999 C645 C651
30. H.M. Said, K. Balamurugan, V.S. Subramanian, and J.S. Marchant Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine Am. J. Physiol. Gastrointest. Liver Physiol. 286 2004 G491 G498
31. N. Saito, M. Kimura, A. Kuchiba, and Y. Itokawa Blood thiamine levels in outpatients with diabetes mellitus J. Nutr. Sci. Vitaminol. (Tokyo) 33 1987 421 430
32. A. Seithel, J. Karlsson, C. Hilgendorf, A. Bjorquist, and A.L. Ungell Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells Eur. J. Pharm. Sci. 28 2006 291 299
33. V. Soukoulis, J.B. Dihu, M. Sole, S.D. Anker, J. Cleland, G.C. Fonarow, M. Metra, E. Pasini, T. Strzelczyk, H. Taegtmeyer, and M. Gheorghiade Micronutrient deficiencies an unmet need in heart failure J. Am. Coll. Cardiol. 54 2009 1660 1673
34. Subramanya, S.B., Subramanian, V.S., Said, H.M., Chronic alcohol consumption and intestinal thiamin absorption: effects on physiological and molecular parameters of the uptake process. Am J Physiol Gastrointest Liver Physiol 299, G23-31.
35. C.M. Tallaksen, H. Bell, and T. Bohmer The concentration of thiamin and thiamin phosphate esters in patients with alcoholic liver cirrhosis Alcohol Alcohol. 27 1992 523 530
36. P.J. Thornalley, R. Babaei-Jadidi, H. Al Ali, N. Rabbani, A. Antonysunil, J. Larkin, A. Ahmed, G. Rayman, and C.W. Bodmer High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease Diabetologia 50 2007 2164 2170
37. J.A. Wooley Characteristics of thiamin and its relevance to the management of heart failure Nutr. Clin. Pract. 23 2008 487 493
38. S. Yee In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth Pharm. Res. 14 1997 763 766