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Volumn 24, Issue 15, 2014, Pages 3618-3621
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Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase
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Author keywords
Acetylcholinesterase; Alzheimer disease; Chemical biology; Lipoxygenase; Oxazine
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Indexed keywords
1,2 OXAZINE DERIVATIVE;
2 [(2 ACETYL 6,6 DIMETHYL 4 PHENYL 5,6 DIHYDRO 2H 1,2 OXAZIN 3 YL)METHYL] 1H ISOINDOLE 1,3(2H) DIONE;
ACETYLCHOLINESTERASE;
ARACHIDONATE 5 LIPOXYGENASE;
NEOSTIGMINE;
UNCLASSIFIED DRUG;
2 [(ACETYL 6,6 DIMETHYL 4 PHENYL 5,6 DIHYDRO 2H 1,2 OXAZIN 3 YL)METHYL] 1H ISOINDOLE 1,3(2H) DIONE;
CHOLINESTERASE INHIBITOR;
LIPOXYGENASE INHIBITOR;
2-((2-ACETYL-6,6-DIMETHYL-4-PHENYL-5,6-DIHYDRO-2H-1,2-OXAZIN-3-YL)METHYL)-1H-ISOINDOLE-1,3(2H)-DIONE;
MOLECULAR LIBRARY;
OXAZINE DERIVATIVE;
PHTHALIMIDE DERIVATIVE;
ALZHEIMER DISEASE;
ARTICLE;
BLOOD BRAIN BARRIER;
COMPUTER MODEL;
CONTROLLED STUDY;
DRUG SYNTHESIS;
ENZYME ACTIVE SITE;
IC 50;
LIPOPHILICITY;
MOLECULAR DOCKING;
NONHUMAN;
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;
CHOLINESTERASE INHIBITION;
CONCENTRATION RESPONSE;
DRUG PENETRATION;
DRUG POTENCY;
DRUG PROTEIN BINDING;
DRUG SCREENING;
ENZYME INHIBITION;
IC50;
CHEMICAL STRUCTURE;
CHEMISTRY;
DOSE RESPONSE;
METABOLISM;
MOLECULAR LIBRARY;
PHARMACOLOGY;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
ACETYLCHOLINESTERASE;
ARACHIDONATE 5-LIPOXYGENASE;
CHOLINESTERASE INHIBITORS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
LIPOXYGENASE INHIBITORS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
OXAZINES;
PHTHALIMIDES;
SMALL MOLECULE LIBRARIES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84903975823
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2014.05.040 Document Type: Article |
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Times cited : (26)
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References (27)
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