BACE1 inhibitors: A head group scan on a series of amides

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4239-4243

  Woltering, Thomas J ^a   Wostl, Wolfgang ^a   Hilpert, Hans ^a   Rogers Evans, Mark ^a   Pinard, Emmanuel ^a   Mayweg, Alexander ^a   Göbel, Martin ^a   Banner, David W ^a   Benz, Jörg ^a   Travagli, Massimiliano ^b   Pollastrini, Martina ^b   Marconi, Guido ^b,c   Gabellieri, Emanuele ^b   Guba, Wolfgang ^a   Mauser, Harald ^a   Andreini, Matteo ^b   Jacobsen, Helmut ^a   Power, Eoin ^b,d   Narquizian, Robert ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Siena Biotech SpA   (Italy)

^c Autifony Srl ^*  (Italy)

^d Dundalk Co   (Ireland)

Author keywords

Alzheimer's disease; BACE1; Inhibitors pKa; P gp

Indexed keywords

2 AMINO 1,3 OXAZINE; AMIDE; BETA SECRETASE 1; BETA SECRETASE 1 INHIBITOR; BETA SECRETASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; OXAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; PH;

ALZHEIMER DISEASE; AMIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BINDING SITES; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879605451     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.003     Document Type: Article

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