Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function

Toxicology and Applied Pharmacology

Volumn 279, Issue 2, 2014, Pages 198-210

  Jiang, Xin ^a,b   Bai, Yang ^a,b   Zhang, Zhiguo ^a,b   Xin, Ying ^b,c   Cai, Lu ^a,b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b University of Louisville School of Medicine   (United States)

^c JILIN UNIVERSITY   (China)

Author keywords

Endoplasmic reticulum stress; Nrf2; Oxidative damage; Sulforaphane; Testicular apoptosis; Type 1 diabetes

Indexed keywords

ACTIN; CASPASE 12; CASPASE 3; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYTOPROTECTIVE AGENT; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LIPID PEROXIDE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM STRESS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INSULIN DEPENDENT DIABETES MELLITUS; INTERSTITIUM; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RNA ISOLATION; SEMINIFEROUS TUBULE; SPERMATOCYTE; SPERMATOGONIUM; TESTIS WEIGHT; UPREGULATION; WESTERN BLOTTING;

ENDOPLASMIC RETICULUM STRESS; NRF2; OXIDATIVE DAMAGE; SULFORAPHANE; TESTICULAR APOPTOSIS; TYPE 1 DIABETES;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CYTOPROTECTION; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; INFLAMMATION MEDIATORS; ISOTHIOCYANATES; MALE; MICE; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TESTIS; TIME FACTORS; UP-REGULATION;

EID: 84903892521     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.06.009     Document Type: Article

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