Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function

American Journal of Physiology - Endocrinology and Metabolism

Volumn 307, Issue 1, 2014, Pages

  Wang, Yonggang ^a,b   Zhang, Zhiguo ^b,c   Guo, Weiying ^b,c   Sun, Weixia ^b,c   Miao, Xiao ^b,d   Wu, Hao ^b,d   Cong, Xianling ^a   Wintergerst, Kupper A ^e   Kong, Xiangbo ^a   Cai, Lu ^b  

^a CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^b University of Louisville School of Medicine   (United States)

^c THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^d THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^e KOSAIR CHILDREN'S HOSPITAL   (United States)

Author keywords

High fat diet; Male germ cell death; Nuclear factor (erythroid derived 2) like 2; Sulforaphane; Type 2 diabetes

Indexed keywords

CASPASE 3; CASPASE 8; INSULIN; PROTEIN BAX; PROTEIN BCL 2; STREPTOZOCIN; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, MOUSE; SULFORAFAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GERM CELL; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; MALE; MITOCHONDRION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORCHITIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEMINIFEROUS TUBULE; SEMINIFEROUS TUBULE EPITHELIUM; SIGNAL TRANSDUCTION; SPERMATID; SPERMATOGONIUM; TESTIS CELL; TESTIS WEIGHT; UPREGULATION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TESTIS; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; ISOTHIOCYANATES; MALE; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; TESTIS; TREATMENT OUTCOME; UP-REGULATION;

EID: 84903644519     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00702.2013     Document Type: Article

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