Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis

Fertility and Sterility

Volumn 80, Issue SUPPL. 2, 2003, Pages 828-831

  Altay, Bariş ^a   Çetinkalp, Şevki ^a   Doǧanavşargil, Başak ^a   Hekimgil, Mine ^a   Semerci, Bülent ^a  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Adult rat; Diabetes mellitus; PCNA; Spermatogenesis

Indexed keywords

CELL NUCLEUS ANTIGEN; GLUCOSE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; EXPERIMENTAL RAT; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; OLIGOSPERMIA; PRIORITY JOURNAL; RAT; SEMINIFEROUS TUBULE; SPERMATOCYTE; SPERMATOGENESIS; TESTIS;

EID: 0141628337     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(03)00984-1     Document Type: Article

References (13)

1. Sexton W.F., Jarow J.P. Effect of diabetes mellitus upon male reproductive function. Urology. 47:1997;508-513.
2. Rossi G.L., Bestetti G. Morphological changes in the hypothalamic- hypophyseal-gonadal axis of male rats after twelve months of streptozotocin-induced diabetes. Diabetologia. 21:1981;476-481.
3. Kirchick H.J., Keyes P.L., Frye B.E. An explanation for anovulation in immature alloxan-diabetic rats treated with pregnant mare's serum gonadotropin: reduced response to gonadotropin-releasing hormone. Endocrinology. 105:1979;1343-1349.
4. Weisenberg L., Fridman O., Libertun C. Changes in nuclear translocation of estradiol-receptor complex in anterior pituitary and uterus of rats with streptozotocin diabetes. J Steroid Biochem. 19:1983;1737-1741.
5. Jackson F., Hutson J.C. Altered responses to androgen in diabetic male rats. Diabetes. 19:1983;819-824.
6. Seethalakshmi L., Menon M., Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J Urol. 138:1987;190-194.
7. Paz G., Homonnai Z.T., Drasnin N., Sofar A., Kaplan R., Kroicer P.F. Fertility of the streptozotocin-diabetic male rat. Andrologia. 10:1978;127.
8. Cameron D.F., Murray F.T., Drylie D.D. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men. Anat Rec. 213:1985;53-62.
9. Steger K., Aleithe I., Behre H., Bergman M. The proliferation of spermatogonia in normal and pathological human seminiferous epithelium: an immunohistochemical study using monoclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen. Mol Hum Reprod. 4:1998;227-233.
10. Zeng L., Kong X.T., Su J.W., Xia T.L., Na Y.Q., Guo Y.L. Evaluation of germ-cell kinetics in infertile patients with proliferating cell nuclear antigen proliferating index. Asian J Androl. 3:2001;63-66.
11. Faerman I., Vialr O., Rivarola M.A., Jadzinsky M.N., Fox D., Lloret A.P., et al. Impotence and diabetes. Studies of androgenic function in diabetic impotent males. Diabetes. 21:1972;23-30.
12. Wrobel K.H., Bickel D., Kujat R. Immunohistochemical study of seminiferous epithelium in adult bovine testis using monclonal antibodies against Ki-67 protein and proliferating cell nuclear antigen (PCNA). Cell Tissue Res. 283:1996;191-201.
13. Salama M., Tsuji M., Tamura M., Kagawa S. Impact of aging and diabetes mellitus on the expression of the proliferating cell nuclear antigen in rat testicular tissue. Arch Androl. 40:1998;95-107.