메뉴 건너뛰기




Volumn 25, Issue 6, 2014, Pages 1086-1097

A genetic model for gallbladder carcinogenesis and its dissemination

Author keywords

Biology; Carcinogenesis; Dissemination; Gallbladder cancer; Genetic alteration; Therapeutics

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLOOXYGENASE 2; CYTOKERATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MUCIN; PROTEIN P16; TUMOR MARKER;

EID: 84903881283     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdu006     Document Type: Review
Times cited : (59)

References (127)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893-2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 3
    • 79959413832 scopus 로고    scopus 로고
    • Is gallbladder cancer decreasing in view of increasing laparoscopic cholecystectomy?
    • Le MD, Henson D, Young H et al. Is gallbladder cancer decreasing in view of increasing laparoscopic cholecystectomy? Ann Hepatol 2011; 10: 306-314.
    • (2011) Ann Hepatol , vol.10 , pp. 306-314
    • Le, M.D.1    Henson, D.2    Young, H.3
  • 4
    • 0032617274 scopus 로고    scopus 로고
    • Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas
    • Dhir V, Mohandas KM. Epidemiology of digestive tract cancers in India IV. Gall bladder and pancreas. Indian J Gastroenterol 1999; 18: 24-28.
    • (1999) Indian J Gastroenterol , vol.18 , pp. 24-28
    • Dhir, V.1    Mohandas, K.M.2
  • 5
    • 77953230266 scopus 로고    scopus 로고
    • Cholelithiasis in gallbladder cancer: coincidence, cofactor, or cause!
    • Shrikhande S, Barreto S, Singh S et al. Cholelithiasis in gallbladder cancer: coincidence, cofactor, or cause! Eur J Surg Oncol 2010; 36: 514-519.
    • (2010) Eur J Surg Oncol , vol.36 , pp. 514-519
    • Shrikhande, S.1    Barreto, S.2    Singh, S.3
  • 6
    • 39749154793 scopus 로고    scopus 로고
    • Cancer Incidence in Five Continents
    • IARC Scientific Publications
    • Curado M, Edwards B, Shin H et al. Cancer Incidence in Five Continents. IARC Scientific Publications, 2007; IX.
    • (2007) , pp. 9
    • Curado, M.1    Edwards, B.2    Shin, H.3
  • 7
    • 55149113853 scopus 로고    scopus 로고
    • A new scoring system for gallbladder cancer (aiding treatment algorithm): an analysis of 335 patients
    • Shukla PJ, Neve R, Barreto SG et al. A new scoring system for gallbladder cancer (aiding treatment algorithm): an analysis of 335 patients. Ann Surg Oncol 2008; 15: 3132-3137.
    • (2008) Ann Surg Oncol , vol.15 , pp. 3132-3137
    • Shukla, P.J.1    Neve, R.2    Barreto, S.G.3
  • 8
    • 2442423894 scopus 로고    scopus 로고
    • A phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gallbladder cancer
    • Doval D, Sekhon J, Gupta S et al. A phase II study of gemcitabine and cisplatin in chemotherapy-naive, unresectable gallbladder cancer. Br J Cancer 2004; 90: 1516-1520.
    • (2004) Br J Cancer , vol.90 , pp. 1516-1520
    • Doval, D.1    Sekhon, J.2    Gupta, S.3
  • 9
    • 84867847267 scopus 로고    scopus 로고
    • Gallbladder cancer: past, present and an uncertain future
    • Boutros C, Gary M, Baldwin K et al. Gallbladder cancer: past, present and an uncertain future. Surg Oncol 2012; 21: e183-191.
    • (2012) Surg Oncol , vol.21
    • Boutros, C.1    Gary, M.2    Baldwin, K.3
  • 10
    • 79959726051 scopus 로고    scopus 로고
    • Surgery for gallbladder cancer: the need to generate greater evidence
    • Shrikhande SV, Barreto SG. Surgery for gallbladder cancer: the need to generate greater evidence. World J Gastrointest Surg 2009; 1: 26-29.
    • (2009) World J Gastrointest Surg , vol.1 , pp. 26-29
    • Shrikhande, S.V.1    Barreto, S.G.2
  • 11
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E, Voglestein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.1    Voglestein, B.2
  • 12
    • 0017198648 scopus 로고
    • Early carcinoma of the gallbladder
    • Laitio M. Early carcinoma of the gallbladder. Beitr Pathol 1976; 158: 159-172.
    • (1976) Beitr Pathol , vol.158 , pp. 159-172
    • Laitio, M.1
  • 13
    • 0021058076 scopus 로고
    • Histogenesis of epithelial neoplasms of human gallbladder I. Dysplasia
    • Laitio M. Histogenesis of epithelial neoplasms of human gallbladder I. Dysplasia. Pathol Res Pract 1983; 178: 51-56.
    • (1983) Pathol Res Pract , vol.178 , pp. 51-56
    • Laitio, M.1
  • 14
    • 0018903177 scopus 로고
    • The precursor lesions of invasive gallbladder carcinoma. Hyperplasia, atypical hyperplasia and carcinoma in situ
    • Albores-Saavedra J, Alcántra-Vazquez A, Cruz-Ortiz H et al. The precursor lesions of invasive gallbladder carcinoma. Hyperplasia, atypical hyperplasia and carcinoma in situ. Cancer 1980; 45: 919-927.
    • (1980) Cancer , vol.45 , pp. 919-927
    • Albores-Saavedra, J.1    Alcántra-Vazquez, A.2    Cruz-Ortiz, H.3
  • 15
    • 0029967274 scopus 로고    scopus 로고
    • Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression
    • Roa I, Araya J, Villaseca M et al. Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression. Gastroenterology 1996; 111: 232-236.
    • (1996) Gastroenterology , vol.111 , pp. 232-236
    • Roa, I.1    Araya, J.2    Villaseca, M.3
  • 16
    • 33744951007 scopus 로고    scopus 로고
    • Preneoplastic lesions in gallbladder cancer
    • Roa I, Aretxabala XD, Roa J et al. Preneoplastic lesions in gallbladder cancer. J Surg Oncol 2006; 93: 615-623.
    • (2006) J Surg Oncol , vol.93 , pp. 615-623
    • Roa, I.1    Aretxabala, X.D.2    Roa, J.3
  • 17
    • 0023034719 scopus 로고
    • Intestinal metaplasia-dysplasia-carcinoma sequence of the gallbladder
    • Yamagiwa H, Tomiyama H. Intestinal metaplasia-dysplasia-carcinoma sequence of the gallbladder. Acta Pathol Jpn 1986; 36: 989-997.
    • (1986) Acta Pathol Jpn , vol.36 , pp. 989-997
    • Yamagiwa, H.1    Tomiyama, H.2
  • 18
    • 0027270797 scopus 로고
    • Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples
    • Duarte I, Llanos O, Domke H et al. Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples. Cancer 1993; 72: 1878-1884.
    • (1993) Cancer , vol.72 , pp. 1878-1884
    • Duarte, I.1    Llanos, O.2    Domke, H.3
  • 19
    • 0027421242 scopus 로고
    • Epithelial lesions associated with gallbladder carcinoma. A methodical study of 32 cases
    • Roa I, Araya J, Wistuba I et al. Epithelial lesions associated with gallbladder carcinoma. A methodical study of 32 cases. Rev Med Chil 1993; 121: 21-29.
    • (1993) Rev Med Chil , vol.121 , pp. 21-29
    • Roa, I.1    Araya, J.2    Wistuba, I.3
  • 20
    • 0029864322 scopus 로고    scopus 로고
    • p53 protein overexpression in gallbladder carcinoma and its precursor lesions: an immunohistochemical study
    • Wistuba I, Gazdar A, Roa I et al. p53 protein overexpression in gallbladder carcinoma and its precursor lesions: an immunohistochemical study. Hum Pathol 1996; 27: 360-365.
    • (1996) Hum Pathol , vol.27 , pp. 360-365
    • Wistuba, I.1    Gazdar, A.2    Roa, I.3
  • 21
    • 0034093568 scopus 로고    scopus 로고
    • Overexpression of p53 protein in gallbladder carcinoma in North India
    • Misra S, Chaturvedi A, Goel M et al. Overexpression of p53 protein in gallbladder carcinoma in North India. Eur J Surg Oncol 2000; 26: 164-167.
    • (2000) Eur J Surg Oncol , vol.26 , pp. 164-167
    • Misra, S.1    Chaturvedi, A.2    Goel, M.3
  • 22
    • 0020352386 scopus 로고
    • Relation of adenoma to carcinoma in the gallbladder
    • Kozuka S, Tsubone N, Yasui A et al. Relation of adenoma to carcinoma in the gallbladder. Cancer 1982; 50: 2226-2234.
    • (1982) Cancer , vol.50 , pp. 2226-2234
    • Kozuka, S.1    Tsubone, N.2    Yasui, A.3
  • 23
    • 0032776233 scopus 로고    scopus 로고
    • Histological and genetic changes in malignant transformation of gallbladder adenoma
    • Watanabe H, Date K, Itoi T et al. Histological and genetic changes in malignant transformation of gallbladder adenoma. Ann Oncol 1999; 10; 136-139.
    • (1999) Ann Oncol , vol.10 , pp. 136-139
    • Watanabe, H.1    Date, K.2    Itoi, T.3
  • 24
    • 0025294103 scopus 로고
    • Morphometrical analysis of gallbladder adenoma and adenocarcinoma with reference to histogenesis and adenoma- carcinoma sequence
    • Nakajo S, Yamamoto M, Tahara E. Morphometrical analysis of gallbladder adenoma and adenocarcinoma with reference to histogenesis and adenoma- carcinoma sequence. Virchows Arch A Pathol Anat Histopathol 1990; 417: 49-56.
    • (1990) Virchows Arch A Pathol Anat Histopathol , vol.417 , pp. 49-56
    • Nakajo, S.1    Yamamoto, M.2    Tahara, E.3
  • 25
    • 0034569572 scopus 로고    scopus 로고
    • Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings
    • Sasatomi E, Tokunaga O, Miyazaki K. Precancerous conditions of gallbladder carcinoma: overview of histopathologic characteristics and molecular genetic findings. J Hepatobiliary Pancreat Surg 2000; 7: 556-567.
    • (2000) J Hepatobiliary Pancreat Surg , vol.7 , pp. 556-567
    • Sasatomi, E.1    Tokunaga, O.2    Miyazaki, K.3
  • 26
    • 68749104995 scopus 로고    scopus 로고
    • Gallbladder cancer: a morphological and molecular update
    • Goldin R, Roa J. Gallbladder cancer: a morphological and molecular update. Histopathology 2009; 55: 218-229.
    • (2009) Histopathology , vol.55 , pp. 218-229
    • Goldin, R.1    Roa, J.2
  • 27
    • 79951937725 scopus 로고    scopus 로고
    • Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas
    • Pai RK, Mojtahed K. Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas. Appl Immunohistochem Mol Morphol 2011; 19: 133-140.
    • (2011) Appl Immunohistochem Mol Morphol , vol.19 , pp. 133-140
    • Pai, R.K.1    Mojtahed, K.2
  • 28
    • 34547927612 scopus 로고    scopus 로고
    • Is there a role for estrogen and progesterone receptors in gall bladder cancer?
    • Oxford
    • Shukla P, Barreto S, Gupta P et al. Is there a role for estrogen and progesterone receptors in gall bladder cancer? HPB (Oxford) 2007; 9: 285-288.
    • (2007) HPB , vol.9 , pp. 285-288
    • Shukla, P.1    Barreto, S.2    Gupta, P.3
  • 29
    • 39749123726 scopus 로고    scopus 로고
    • Simultaneous gallbladder and bile duct cancers: revisiting the pathological possibilities
    • Shukla P, Barreto S, Shrikhande S et al. Simultaneous gallbladder and bile duct cancers: revisiting the pathological possibilities. HPB (Oxford) 2008; 10: 48-53.
    • (2008) HPB (Oxford) , vol.10 , pp. 48-53
    • Shukla, P.1    Barreto, S.2    Shrikhande, S.3
  • 30
    • 0027231318 scopus 로고
    • Adenocarcinoma of the gallbladder associated with anomalous pancreaticobiliary ductal junction
    • Chijiiwa K, Tanaka M, Nakayama F. Adenocarcinoma of the gallbladder associated with anomalous pancreaticobiliary ductal junction. Am Surg 1993; 59: 430-434.
    • (1993) Am Surg , vol.59 , pp. 430-434
    • Chijiiwa, K.1    Tanaka, M.2    Nakayama, F.3
  • 31
    • 0033286023 scopus 로고    scopus 로고
    • Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma
    • Wistuba II, Albores-Saavedra J. Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma. J Hepatobiliary Pancreat Surg 1999; 6: 237-244.
    • (1999) J Hepatobiliary Pancreat Surg , vol.6 , pp. 237-244
    • Wistuba, I.I.1    Albores-Saavedra, J.2
  • 32
    • 4544297463 scopus 로고    scopus 로고
    • Gallbladder cancer: lessons from a rare tumour
    • Wistuba II, Gazdar AF. Gallbladder cancer: lessons from a rare tumour. Nat Rev Cancer 2004; 4: 695-706.
    • (2004) Nat Rev Cancer , vol.4 , pp. 695-706
    • Wistuba, I.I.1    Gazdar, A.F.2
  • 33
    • 77954672173 scopus 로고    scopus 로고
    • Genetic alterations in preneoplastic and neoplatic injuries of the gallbladder
    • Castillo J, Garcia P, Roa J. Genetic alterations in preneoplastic and neoplatic injuries of the gallbladder. Rev Med Chile 2010; 138: 596-604.
    • (2010) Rev Med Chile , vol.138 , pp. 596-604
    • Castillo, J.1    Garcia, P.2    Roa, J.3
  • 34
    • 0035013613 scopus 로고    scopus 로고
    • Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones
    • Tazuma S, Kajiyama G. Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones. Langenbecks Arch Surg 2001; 386: 224-229.
    • (2001) Langenbecks Arch Surg , vol.386 , pp. 224-229
    • Tazuma, S.1    Kajiyama, G.2
  • 35
    • 0032778114 scopus 로고    scopus 로고
    • Epithelial hyperplasia of the gallbladder in children with anomalous pancreaticobiliary ductal union
    • Tanno S, Obara T, Fujii T et al. Epithelial hyperplasia of the gallbladder in children with anomalous pancreaticobiliary ductal union. Hepatogastroenterology 1999; 46: 3068-3073.
    • (1999) Hepatogastroenterology , vol.46 , pp. 3068-3073
    • Tanno, S.1    Obara, T.2    Fujii, T.3
  • 36
    • 0029901357 scopus 로고    scopus 로고
    • Pathology and cellular kinetics of gallbladder with an anomalous junction of the pancreaticobiliary duct
    • Hanada K, Itoh M, Fujii K et al. Pathology and cellular kinetics of gallbladder with an anomalous junction of the pancreaticobiliary duct. Am J Gastroenterol 1996; 91: 1007-1011.
    • (1996) Am J Gastroenterol , vol.91 , pp. 1007-1011
    • Hanada, K.1    Itoh, M.2    Fujii, K.3
  • 37
    • 0033286201 scopus 로고    scopus 로고
    • Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct
    • Hanada K, Tsuchida A, Kajiyama G. Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct. J Hepatobiliary Pancreat Surg 1999; 6: 223-228.
    • (1999) J Hepatobiliary Pancreat Surg , vol.6 , pp. 223-228
    • Hanada, K.1    Tsuchida, A.2    Kajiyama, G.3
  • 38
    • 70350022551 scopus 로고    scopus 로고
    • Natural history of gallbladder cancer. Analysis of biopsy specimens
    • Roa EI, Munoz NS, Ibacache SG et al. Natural history of gallbladder cancer. Analysis of biopsy specimens. Rev Med Chil 2009; 137: 873-880.
    • (2009) Rev Med Chil , vol.137 , pp. 873-880
    • Roa, E.I.1    Munoz, N.S.2    Ibacache, S.G.3
  • 39
    • 20444414549 scopus 로고    scopus 로고
    • Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder
    • Roa JC, Roa I, Correa P et al. Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder. J Gastroenterol 2005; 40: 79-86.
    • (2005) J Gastroenterol , vol.40 , pp. 79-86
    • Roa, J.C.1    Roa, I.2    Correa, P.3
  • 40
    • 13544259874 scopus 로고    scopus 로고
    • Metastasis of primary gallbladder carcinoma in lymph node and liver
    • Lin HT, Liu GJ, Wu D et al. Metastasis of primary gallbladder carcinoma in lymph node and liver. World J Gastroenterol 2005; 11: 748-751.
    • (2005) World J Gastroenterol , vol.11 , pp. 748-751
    • Lin, H.T.1    Liu, G.J.2    Wu, D.3
  • 41
    • 84864287246 scopus 로고    scopus 로고
    • Adenomas of the gallbladder. Morphologic features, expression of gastric and intestinal mucins, and incidence of high-grade dysplasia/carcinoma in situ and invasive carcinoma
    • Albores-Saavedra J, Chable-Montero F, Gonzalez-Romo MA et al. Adenomas of the gallbladder. Morphologic features, expression of gastric and intestinal mucins, and incidence of high-grade dysplasia/carcinoma in situ and invasive carcinoma. Hum Pathol 2012; 43: 1506-1513.
    • (2012) Hum Pathol , vol.43 , pp. 1506-1513
    • Albores-Saavedra, J.1    Chable-Montero, F.2    Gonzalez-Romo, M.A.3
  • 42
    • 79551521139 scopus 로고    scopus 로고
    • p53: its alteration and gallbladder cancer
    • Rai R, Tewari M, Kumar M et al. p53: its alteration and gallbladder cancer. Eur J Cancer Prev 2011; 20: 77-85.
    • (2011) Eur J Cancer Prev , vol.20 , pp. 77-85
    • Rai, R.1    Tewari, M.2    Kumar, M.3
  • 43
    • 0031950070 scopus 로고    scopus 로고
    • Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile
    • Yokoyama N, Hitomi J, Watanabe H et al. Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile. Cancer Epidemiol Biomarkers Prev 1998; 7: 297-301.
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 297-301
    • Yokoyama, N.1    Hitomi, J.2    Watanabe, H.3
  • 44
    • 33644875437 scopus 로고    scopus 로고
    • TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma
    • Moreno M, Pimentel F, Gazdar AF et al. TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma. Ann Hepatol 2005; 4: 192-199.
    • (2005) Ann Hepatol , vol.4 , pp. 192-199
    • Moreno, M.1    Pimentel, F.2    Gazdar, A.F.3
  • 45
    • 0029008121 scopus 로고
    • Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile
    • Wistuba II, Sugio K, Hung J et al. Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile. Cancer Res 1995; 55: 2511-2515.
    • (1995) Cancer Res , vol.55 , pp. 2511-2515
    • Wistuba, I.I.1    Sugio, K.2    Hung, J.3
  • 46
    • 79960879899 scopus 로고    scopus 로고
    • The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathway
    • Feng Z, Chen J, Wei H et al. The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathway. Exp Mol Pathol 2011; 91: 569-577.
    • (2011) Exp Mol Pathol , vol.91 , pp. 569-577
    • Feng, Z.1    Chen, J.2    Wei, H.3
  • 47
    • 0035839308 scopus 로고    scopus 로고
    • Genetic alterations in gallbladder adenoma, dysplasia and carcinoma
    • Kim YT, Kim J, Jang YH et al. Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. Cancer Lett 2001; 169: 59-68.
    • (2001) Cancer Lett , vol.169 , pp. 59-68
    • Kim, Y.T.1    Kim, J.2    Jang, Y.H.3
  • 48
    • 0029782496 scopus 로고    scopus 로고
    • Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer
    • Saetta A, Lazaris AC, Davaris PS. Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer. Pathol Res Pract 1996; 192: 532-540.
    • (1996) Pathol Res Pract , vol.192 , pp. 532-540
    • Saetta, A.1    Lazaris, A.C.2    Davaris, P.S.3
  • 49
    • 0032976479 scopus 로고    scopus 로고
    • Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
    • Hanada K, Tsuchida A, Iwao T et al. Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct. Am J Gastroenterol 1999; 94: 1638-1642.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1638-1642
    • Hanada, K.1    Tsuchida, A.2    Iwao, T.3
  • 50
    • 0029876699 scopus 로고    scopus 로고
    • K-ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction
    • Matsubara T, Sakurai Y, Sasayama Y et al. K-ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction. Cancer 1996; 77: 1752-1757.
    • (1996) Cancer , vol.77 , pp. 1752-1757
    • Matsubara, T.1    Sakurai, Y.2    Sasayama, Y.3
  • 51
    • 0029901707 scopus 로고    scopus 로고
    • APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis
    • Itoi T, Watanabe H, Ajioka Y et al. APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis. Pathol Int 1996; 46: 333-340.
    • (1996) Pathol Int , vol.46 , pp. 333-340
    • Itoi, T.1    Watanabe, H.2    Ajioka, Y.3
  • 52
    • 33745312975 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions
    • Legan M, Luzar B, Marolt VF et al. Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. World J Gastroenterol 2006; 12: 3425-3429.
    • (2006) World J Gastroenterol , vol.12 , pp. 3425-3429
    • Legan, M.1    Luzar, B.2    Marolt, V.F.3
  • 53
    • 0037387182 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct
    • Fumino S, Tokiwa K, Ono S et al. Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct. J Pediatr Surg 2003; 38: 585-589.
    • (2003) J Pediatr Surg , vol.38 , pp. 585-589
    • Fumino, S.1    Tokiwa, K.2    Ono, S.3
  • 54
    • 0034321580 scopus 로고    scopus 로고
    • Cyclooxygenase expression in the gallbladder
    • Ghosh M, Kawamoto T, Koike N et al. Cyclooxygenase expression in the gallbladder. Int J Mol Med 2000; 6: 527-532.
    • (2000) Int J Mol Med , vol.6 , pp. 527-532
    • Ghosh, M.1    Kawamoto, T.2    Koike, N.3
  • 55
    • 0033760762 scopus 로고    scopus 로고
    • Microsatellite instability in gallbladder carcinoma: two independent genetic pathways of gallbladder carcinogenesis
    • Yoshida T, Sugai T, Habano W et al. Microsatellite instability in gallbladder carcinoma: two independent genetic pathways of gallbladder carcinogenesis. J Gastroenterol 2000; 35: 768-774.
    • (2000) J Gastroenterol , vol.35 , pp. 768-774
    • Yoshida, T.1    Sugai, T.2    Habano, W.3
  • 56
    • 84875377063 scopus 로고    scopus 로고
    • DCC (deleted in colorectal carcinoma) gene variants confer increased susceptibility to gallbladder cancer (Ref. No.: Gene-D-12-01446)
    • Rai R, Sharma KL, Tiwari S et al. DCC (deleted in colorectal carcinoma) gene variants confer increased susceptibility to gallbladder cancer (Ref. No.: Gene-D-12-01446). Gene 2013; 518: 303-309.
    • (2013) Gene , vol.518 , pp. 303-309
    • Rai, R.1    Sharma, K.L.2    Tiwari, S.3
  • 57
    • 84860288544 scopus 로고    scopus 로고
    • A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population
    • Cha PC, Zembutsu H, Takahashi A et al. A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. J Hum Genet 2012; 57: 235-237.
    • (2012) J Hum Genet , vol.57 , pp. 235-237
    • Cha, P.C.1    Zembutsu, H.2    Takahashi, A.3
  • 58
    • 0036080919 scopus 로고    scopus 로고
    • Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma
    • Wistuba II, Ashfaq R, Maitra A et al. Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma. Am J Pathol 2002; 160: 2073-2079.
    • (2002) Am J Pathol , vol.160 , pp. 2073-2079
    • Wistuba, I.I.1    Ashfaq, R.2    Maitra, A.3
  • 59
    • 0142028064 scopus 로고    scopus 로고
    • Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma
    • Koda M, Yashima K, Kawaguchi K et al. Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma. Cancer Lett 2003; 199: 131-138.
    • (2003) Cancer Lett , vol.199 , pp. 131-138
    • Koda, M.1    Yashima, K.2    Kawaguchi, K.3
  • 60
    • 0021879645 scopus 로고
    • Hereditary cancer, oncogenes, and antioncogenes
    • Knudson AG, Jr. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res 1985; 45: 1437-1443.
    • (1985) Cancer Res , vol.45 , pp. 1437-1443
    • Knudson Jr., A.G.1
  • 61
    • 0037068367 scopus 로고    scopus 로고
    • High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma
    • Wistuba II, Maitra A, Carrasco R et al. High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma. Br J Cancer 2002; 87: 432-440.
    • (2002) Br J Cancer , vol.87 , pp. 432-440
    • Wistuba, I.I.1    Maitra, A.2    Carrasco, R.3
  • 62
    • 0344132588 scopus 로고    scopus 로고
    • Loss of heterozygosity in dysplasia and carcinoma of the gallbladder
    • Chang HJ, Kim SW, Kim YT et al. Loss of heterozygosity in dysplasia and carcinoma of the gallbladder. Mod Pathol 1999; 12: 763-769.
    • (1999) Mod Pathol , vol.12 , pp. 763-769
    • Chang, H.J.1    Kim, S.W.2    Kim, Y.T.3
  • 63
    • 0032941343 scopus 로고    scopus 로고
    • Cancer risk in mutation carriers of DNAmismatch- repair genes
    • Aarnio M, Sankila R, Pukkala E et al. Cancer risk in mutation carriers of DNAmismatch- repair genes. Int J Cancer 1999; 81: 214-218.
    • (1999) Int J Cancer , vol.81 , pp. 214-218
    • Aarnio, M.1    Sankila, R.2    Pukkala, E.3
  • 64
    • 0036256948 scopus 로고    scopus 로고
    • Deficient expression of O(6)- methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma
    • Kohya N, Miyazaki K, Matsukura S et al. Deficient expression of O(6)- methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma. Ann Surg Oncol 2002; 9: 371-379.
    • (2002) Ann Surg Oncol , vol.9 , pp. 371-379
    • Kohya, N.1    Miyazaki, K.2    Matsukura, S.3
  • 65
    • 79958798502 scopus 로고    scopus 로고
    • Frequency of genetic alterations observed in cell cycle regulatory proteins and microsatellite instability in gallbladder adenocarcinoma: a translational perspective
    • Mishra PK, Raghuram GV, Jatawa SK et al. Frequency of genetic alterations observed in cell cycle regulatory proteins and microsatellite instability in gallbladder adenocarcinoma: a translational perspective. Asian Pac J Cancer Prev 2011; 12: 573-574.
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 573-574
    • Mishra, P.K.1    Raghuram, G.V.2    Jatawa, S.K.3
  • 66
    • 0033761713 scopus 로고    scopus 로고
    • Microsatellite instability meets gallbladder cancer
    • Matsuda Y. Microsatellite instability meets gallbladder cancer. J Gastroenterol 2000; 35: 798-799.
    • (2000) J Gastroenterol , vol.35 , pp. 798-799
    • Matsuda, Y.1
  • 67
    • 84858228461 scopus 로고    scopus 로고
    • Expression of HER2 and bradykinin B(1) receptors in precursor lesions of gallbladder carcinoma
    • Toledo C, Matus CE, Barraza X et al. Expression of HER2 and bradykinin B(1) receptors in precursor lesions of gallbladder carcinoma. World J Gastroenterol 2012; 18: 1208-1215.
    • (2012) World J Gastroenterol , vol.18 , pp. 1208-1215
    • Toledo, C.1    Matus, C.E.2    Barraza, X.3
  • 68
    • 0027253687 scopus 로고
    • p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder
    • Kamel D, Paakko P, Nuorva K et al. p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder. J Pathol 1993; 170: 67-72.
    • (1993) J Pathol , vol.170 , pp. 67-72
    • Kamel, D.1    Paakko, P.2    Nuorva, K.3
  • 69
    • 0035459383 scopus 로고    scopus 로고
    • Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas
    • Kim YW, Huh SH, Park YK et al. Expression of the c-erb-B2 and p53 protein in gallbladder carcinomas. Oncol Rep 2001; 8: 1127-1132.
    • (2001) Oncol Rep , vol.8 , pp. 1127-1132
    • Kim, Y.W.1    Huh, S.H.2    Park, Y.K.3
  • 70
    • 33744519888 scopus 로고    scopus 로고
    • Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582
    • Chaube A, Tewari M, Garbyal RS et al. Preliminary study of p53 and c-erbB-2 expression in gallbladder cancer in Indian patients manuscript id: 8962091628764582. BMC Cancer 2006; 6: 126.
    • (2006) BMC Cancer , vol.6 , pp. 126
    • Chaube, A.1    Tewari, M.2    Garbyal, R.S.3
  • 71
    • 0242584916 scopus 로고    scopus 로고
    • Expression of cytokeratin 7 and 20 in pathological conditions of the bile tract
    • Cabibi D, Licata A, Barresi E et al. Expression of cytokeratin 7 and 20 in pathological conditions of the bile tract. Pathol Res Pract 2003; 199: 65-70.
    • (2003) Pathol Res Pract , vol.199 , pp. 65-70
    • Cabibi, D.1    Licata, A.2    Barresi, E.3
  • 72
    • 4344647942 scopus 로고    scopus 로고
    • Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis
    • Chang HJ, Kim SW, Lee BL et al. Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis. Pathol Int 2004; 54: 576-584.
    • (2004) Pathol Int , vol.54 , pp. 576-584
    • Chang, H.J.1    Kim, S.W.2    Lee, B.L.3
  • 73
    • 33846935522 scopus 로고    scopus 로고
    • Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma
    • Chang YT, Hsu C, Jeng YM et al. Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma. J Gastroenterol Hepatol 2007; 22: 389-394.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 389-394
    • Chang, Y.T.1    Hsu, C.2    Jeng, Y.M.3
  • 74
    • 0033842916 scopus 로고    scopus 로고
    • Expression of cytokeratins 7 and 20 in carcinomas of the extrahepatic biliary tract, pancreas, and gallbladder
    • Duval JV, Savas L, Banner BF. Expression of cytokeratins 7 and 20 in carcinomas of the extrahepatic biliary tract, pancreas, and gallbladder. Arch Pathol Lab Med 2000; 124: 1196-1200.
    • (2000) Arch Pathol Lab Med , vol.124 , pp. 1196-1200
    • Duval, J.V.1    Savas, L.2    Banner, B.F.3
  • 75
    • 71749120396 scopus 로고    scopus 로고
    • EGFR and HER2 expression in advanced biliary tract cancer
    • Harder J, Waiz O, Otto F et al. EGFR and HER2 expression in advanced biliary tract cancer. World J Gastroenterol 2009; 15: 4511-4517.
    • (2009) World J Gastroenterol , vol.15 , pp. 4511-4517
    • Harder, J.1    Waiz, O.2    Otto, F.3
  • 76
    • 79957933905 scopus 로고    scopus 로고
    • Cytokeratin 7 and 20 expression in gallbladder carcinoma
    • Kalekou H, Miliaras D. Cytokeratin 7 and 20 expression in gallbladder carcinoma. Pol J Pathol 2011; 62: 25-30.
    • (2011) Pol J Pathol , vol.62 , pp. 25-30
    • Kalekou, H.1    Miliaras, D.2
  • 77
    • 54749094335 scopus 로고    scopus 로고
    • EGFR expression in gallbladder carcinoma in North America
    • Kaufman M, Mehrotra B, Limaye S et al. EGFR expression in gallbladder carcinoma in North America. Int J Med Sci 2008; 5: 285-291.
    • (2008) Int J Med Sci , vol.5 , pp. 285-291
    • Kaufman, M.1    Mehrotra, B.2    Limaye, S.3
  • 78
    • 0029594122 scopus 로고
    • Epidermal growth factor receptor immunoreactivity in gallbladder and extrahepatic biliary tract tumours
    • Lee CS, Pirdas A. Epidermal growth factor receptor immunoreactivity in gallbladder and extrahepatic biliary tract tumours. Pathol Res Pract 1995; 191: 1087-1091.
    • (1995) Pathol Res Pract , vol.191 , pp. 1087-1091
    • Lee, C.S.1    Pirdas, A.2
  • 79
    • 80052753558 scopus 로고    scopus 로고
    • Expression of CDX2 and hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic type and clinical outcome
    • Li QL, Yang ZL, Liu JQ et al. Expression of CDX2 and hepatocyte antigen in benign and malignant lesions of gallbladder and its correlation with histopathologic type and clinical outcome. Pathol Oncol Res 2011; 17: 561-568.
    • (2011) Pathol Oncol Res , vol.17 , pp. 561-568
    • Li, Q.L.1    Yang, Z.L.2    Liu, J.Q.3
  • 80
    • 79958170175 scopus 로고    scopus 로고
    • Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer
    • Moon WS, Park HS, Lee H et al. Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer. Cancer Res Treat 2005; 37: 171-176.
    • (2005) Cancer Res Treat , vol.37 , pp. 171-176
    • Moon, W.S.1    Park, H.S.2    Lee, H.3
  • 81
    • 21344438897 scopus 로고    scopus 로고
    • Amplification and overexpression of cerbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    • Nakazawa K, Dobashi Y, Suzuki S et al. Amplification and overexpression of cerbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol 2005; 206: 356-365.
    • (2005) J Pathol , vol.206 , pp. 356-365
    • Nakazawa, K.1    Dobashi, Y.2    Suzuki, S.3
  • 82
    • 61449126478 scopus 로고    scopus 로고
    • Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma
    • Ooi A, Suzuki S, Nakazawa K et al. Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma. Anticancer Res 2009; 29: 19-26.
    • (2009) Anticancer Res , vol.29 , pp. 19-26
    • Ooi, A.1    Suzuki, S.2    Nakazawa, K.3
  • 83
    • 33845338457 scopus 로고    scopus 로고
    • A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis
    • Sakamoto H, Mutoh H, Ido K et al. A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis. Hum Pathol 2007; 38: 66-71.
    • (2007) Hum Pathol , vol.38 , pp. 66-71
    • Sakamoto, H.1    Mutoh, H.2    Ido, K.3
  • 84
    • 0032826553 scopus 로고    scopus 로고
    • Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder
    • Sasaki M, Yamato T, Nakanuma Y et al. Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder. Pathol Int 1999; 49: 38-44.
    • (1999) Pathol Int , vol.49 , pp. 38-44
    • Sasaki, M.1    Yamato, T.2    Nakanuma, Y.3
  • 85
    • 77649339494 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder
    • Shafizadeh N, Grenert JP, Sahai V et al. Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder. Hum Pathol 2010; 41: 485-492.
    • (2010) Hum Pathol , vol.41 , pp. 485-492
    • Shafizadeh, N.1    Grenert, J.P.2    Sahai, V.3
  • 86
    • 20244377366 scopus 로고    scopus 로고
    • Expression of homeodomain protein CDX2 in gallbladder carcinomas
    • Wu XS, Akiyama Y, Igari T et al. Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol 2005; 131: 271-278.
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 271-278
    • Wu, X.S.1    Akiyama, Y.2    Igari, T.3
  • 87
    • 83555166091 scopus 로고    scopus 로고
    • Expressive levels of MUC1 and MUC5AC and their clinicopathologic significances in the benign and malignant lesions of gallbladder
    • Xiong L, Yang Z, Yang L et al. Expressive levels of MUC1 and MUC5AC and their clinicopathologic significances in the benign and malignant lesions of gallbladder. J Surg Oncol 2012; 105: 97-103.
    • (2012) J Surg Oncol , vol.105 , pp. 97-103
    • Xiong, L.1    Yang, Z.2    Yang, L.3
  • 88
    • 0032945706 scopus 로고    scopus 로고
    • Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gallbladder carcinoma: an immunohistochemical and in situ hybridization study
    • Yamato T, Sasaki M, Watanabe Y et al. Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gallbladder carcinoma: an immunohistochemical and in situ hybridization study. J Pathol 1999; 188: 30-37.
    • (1999) J Pathol , vol.188 , pp. 30-37
    • Yamato, T.1    Sasaki, M.2    Watanabe, Y.3
  • 89
    • 26444503642 scopus 로고    scopus 로고
    • MUC1 core protein as a marker of gallbladder malignancy
    • Ghosh M, Kamma H, Kawamoto T et al. MUC1 core protein as a marker of gallbladder malignancy. Eur J Surg Oncol 2005; 31: 891-896.
    • (2005) Eur J Surg Oncol , vol.31 , pp. 891-896
    • Ghosh, M.1    Kamma, H.2    Kawamoto, T.3
  • 90
    • 41949117297 scopus 로고    scopus 로고
    • Increased expression of mucin 5AC mRNA and decreased expression of epidermal growth-factor receptor mRNA in gallstone patients
    • Kim HJ, Kim SH, Chae GB et al. Increased expression of mucin 5AC mRNA and decreased expression of epidermal growth-factor receptor mRNA in gallstone patients. Tohoku J Exp Med 2008; 214: 139-144.
    • (2008) Tohoku J Exp Med , vol.214 , pp. 139-144
    • Kim, H.J.1    Kim, S.H.2    Chae, G.B.3
  • 91
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: a model for targeted therapy
    • Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 2006; 12: 5268-5272.
    • (2006) Clin Cancer Res , vol.12 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 93
    • 0033105361 scopus 로고    scopus 로고
    • Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression
    • Reis CA, David L, Correa P et al. Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Res 1999; 59: 1003-1007.
    • (1999) Cancer Res , vol.59 , pp. 1003-1007
    • Reis, C.A.1    David, L.2    Correa, P.3
  • 94
    • 84862627783 scopus 로고    scopus 로고
    • Mucin genes in gallstone disease
    • Chuang SC, Hsi E, Lee KT. Mucin genes in gallstone disease. Clin Chim Acta 2012; 413: 1466-1471.
    • (2012) Clin Chim Acta , vol.413 , pp. 1466-1471
    • Chuang, S.C.1    Hsi, E.2    Lee, K.T.3
  • 95
    • 34347233249 scopus 로고    scopus 로고
    • MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder
    • Finzi L, Barbu V, Burgel PR et al. MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder. Am J Pathol 2006; 169: 2031-2041.
    • (2006) Am J Pathol , vol.169 , pp. 2031-2041
    • Finzi, L.1    Barbu, V.2    Burgel, P.R.3
  • 96
    • 34249865020 scopus 로고    scopus 로고
    • Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation
    • Vilkin A, Nudelman I, Morgenstern S et al. Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation. Dig Dis Sci 2007; 52: 1613-1620.
    • (2007) Dig Dis Sci , vol.52 , pp. 1613-1620
    • Vilkin, A.1    Nudelman, I.2    Morgenstern, S.3
  • 97
    • 0141675097 scopus 로고    scopus 로고
    • Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma
    • Boonla C, Wongkham S, Sheehan J et al. Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma. Cancer 2003; 98: 1438-1443.
    • (2003) Cancer , vol.98 , pp. 1438-1443
    • Boonla, C.1    Wongkham, S.2    Sheehan, J.3
  • 98
    • 70349329737 scopus 로고    scopus 로고
    • Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact
    • Park S, Roh S, Kim Y et al. Expression of MUC1, MUC2, MUC5AC and MUC6 in cholangiocarcinoma: prognostic impact. Oncol Rep 2009; 22: 649-657.
    • (2009) Oncol Rep , vol.22 , pp. 649-657
    • Park, S.1    Roh, S.2    Kim, Y.3
  • 99
    • 17144400765 scopus 로고    scopus 로고
    • Cytokeratin is a superior marker for detection of micrometastatic biliary tract carcinoma
    • Natarajan S, Xu F, Gilchrist K et al. Cytokeratin is a superior marker for detection of micrometastatic biliary tract carcinoma. J Surg Res 2005; 125: 9-15.
    • (2005) J Surg Res , vol.125 , pp. 9-15
    • Natarajan, S.1    Xu, F.2    Gilchrist, K.3
  • 100
    • 0033121110 scopus 로고    scopus 로고
    • Immunohistochemical detection of lymph node micrometastases from gallbladder carcinoma using monoclonal anticytokeratin antibody
    • Yokoyama N, Shirai Y, Hatakeyama K. Immunohistochemical detection of lymph node micrometastases from gallbladder carcinoma using monoclonal anticytokeratin antibody. Cancer 1999; 85: 1465-1469.
    • (1999) Cancer , vol.85 , pp. 1465-1469
    • Yokoyama, N.1    Shirai, Y.2    Hatakeyama, K.3
  • 101
    • 0033195589 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of cytokeratin is useful for detecting micrometastatic foci from gallbladder carcinoma in regional lymph nodes
    • Tajima Y, Tomioka T, Ikematsu Y et al. Immunohistochemical demonstration of cytokeratin is useful for detecting micrometastatic foci from gallbladder carcinoma in regional lymph nodes. Jpn J Clin Oncol 1999; 29: 425-428.
    • (1999) Jpn J Clin Oncol , vol.29 , pp. 425-428
    • Tajima, Y.1    Tomioka, T.2    Ikematsu, Y.3
  • 102
    • 77957945965 scopus 로고    scopus 로고
    • Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma
    • Kim HS, Kim GY, Lim SJ et al. Reduced expression of Raf-1 kinase inhibitory protein is a significant prognostic marker in patients with gallbladder carcinoma. Hum Pathol 2010; 41: 1609-1616.
    • (2010) Hum Pathol , vol.41 , pp. 1609-1616
    • Kim, H.S.1    Kim, G.Y.2    Lim, S.J.3
  • 103
    • 84863989266 scopus 로고    scopus 로고
    • Immunohistochemical evidence of the prognostic value of hedgehog pathway components in primary gallbladder carcinoma
    • Li J, Wu T, Lu J et al. Immunohistochemical evidence of the prognostic value of hedgehog pathway components in primary gallbladder carcinoma. Surg Today 2012; 42: 770-775.
    • (2012) Surg Today , vol.42 , pp. 770-775
    • Li, J.1    Wu, T.2    Lu, J.3
  • 104
    • 67650485942 scopus 로고    scopus 로고
    • Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations
    • Li Q, Yang Z. Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. J Exp Clin Cancer Res 2009; 28: 65.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 65
    • Li, Q.1    Yang, Z.2
  • 105
    • 80051786943 scopus 로고    scopus 로고
    • Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma
    • Liu DC, Yang ZL. Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma. Pathol Res Pract 2011; 207: 472-478.
    • (2011) Pathol Res Pract , vol.207 , pp. 472-478
    • Liu, D.C.1    Yang, Z.L.2
  • 106
    • 84855457435 scopus 로고    scopus 로고
    • Identification of PEG10 and TSG101 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma
    • Liu DC, Yang ZL, Jiang S. Identification of PEG10 and TSG101 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma. Pathol Oncol Res 2011; 17: 859-866.
    • (2011) Pathol Oncol Res , vol.17 , pp. 859-866
    • Liu, D.C.1    Yang, Z.L.2    Jiang, S.3
  • 107
    • 83655184748 scopus 로고    scopus 로고
    • Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma
    • Wang W, Yang ZL, Liu JQ et al. Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma. Tumour Biol 2012; 33: 173-182.
    • (2012) Tumour Biol , vol.33 , pp. 173-182
    • Wang, W.1    Yang, Z.L.2    Liu, J.Q.3
  • 108
    • 80054741229 scopus 로고    scopus 로고
    • Expression of MK-1 and RegIV and its clinicopathological significances in the benign and malignant lesions of gallbladder
    • Yang L, Lan S, Liu J et al. Expression of MK-1 and RegIV and its clinicopathological significances in the benign and malignant lesions of gallbladder. Diagn Pathol 2011; 6: 100.
    • (2011) Diagn Pathol , vol.6 , pp. 100
    • Yang, L.1    Lan, S.2    Liu, J.3
  • 109
    • 81755176069 scopus 로고    scopus 로고
    • Expression of VHL and HIF-1alpha and their clinicopathologic significance in benign and malignant lesions of the gallbladder
    • Yang Z, Xiong L, Huang S et al. Expression of VHL and HIF-1alpha and their clinicopathologic significance in benign and malignant lesions of the gallbladder. Appl Immunohistochem Mol Morphol 2011; 19: 534-539.
    • (2011) Appl Immunohistochem Mol Morphol , vol.19 , pp. 534-539
    • Yang, Z.1    Xiong, L.2    Huang, S.3
  • 110
    • 84861215687 scopus 로고    scopus 로고
    • Expression levels of HMGA2 and CD9 and its clinicopathological significances in the benign and malignant lesions of the gallbladder
    • Zou Q, Xiong L, Yang Z et al. Expression levels of HMGA2 and CD9 and its clinicopathological significances in the benign and malignant lesions of the gallbladder. World J Surg Oncol 2012; 10: 92.
    • (2012) World J Surg Oncol , vol.10 , pp. 92
    • Zou, Q.1    Xiong, L.2    Yang, Z.3
  • 111
    • 78651225992 scopus 로고    scopus 로고
    • ERCC1 (excision repair crosscomplementing 1) expression in pT2 gallbladder cancer is a prognostic factor
    • Roa I, de Aretxabala X, Lantadilla S et al. ERCC1 (excision repair crosscomplementing 1) expression in pT2 gallbladder cancer is a prognostic factor. Histol Histopathol 2011; 26: 37-43.
    • (2011) Histol Histopathol , vol.26 , pp. 37-43
    • Roa, I.1    de Aretxabala, X.2    Lantadilla, S.3
  • 112
    • 79961004564 scopus 로고    scopus 로고
    • TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells
    • Hobbs SS, Goettel JA, Liang D et al. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2011; 301: G220-G229.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301
    • Hobbs, S.S.1    Goettel, J.A.2    Liang, D.3
  • 113
    • 3342951748 scopus 로고    scopus 로고
    • Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling
    • Gray T, Nettesheim P, Loftin C et al. Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol 2004; 66: 337-346.
    • (2004) Mol Pharmacol , vol.66 , pp. 337-346
    • Gray, T.1    Nettesheim, P.2    Loftin, C.3
  • 114
    • 0035721544 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor activation in regulating mucin synthesis
    • Nadel JA. Role of epidermal growth factor receptor activation in regulating mucin synthesis. Respir Res 2001; 2: 85-89.
    • (2001) Respir Res , vol.2 , pp. 85-89
    • Nadel, J.A.1
  • 115
    • 53549116464 scopus 로고    scopus 로고
    • IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population
    • Vishnoi M, Pandey SN, Choudhuri G et al. IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population. Cancer Genet Cytogenet 2008; 186: 63-68.
    • (2008) Cancer Genet Cytogenet , vol.186 , pp. 63-68
    • Vishnoi, M.1    Pandey, S.N.2    Choudhuri, G.3
  • 116
    • 0032815687 scopus 로고    scopus 로고
    • Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers
    • Sinicrope FA, Lemoine M, Xi L et al. Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. Gastroenterology 1999; 117: 350-358.
    • (1999) Gastroenterology , vol.117 , pp. 350-358
    • Sinicrope, F.A.1    Lemoine, M.2    Xi, L.3
  • 117
    • 3643084354 scopus 로고    scopus 로고
    • Reduced COX-2 protein in colorectal cancer with defective mismatch repair
    • Karnes WE, Jr., Shattuck-Brandt R, Burgart LJ et al. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res 1998; 58: 5473-5477.
    • (1998) Cancer Res , vol.58 , pp. 5473-5477
    • Karnes Jr., W.E.1    Shattuck-Brandt, R.2    Burgart, L.J.3
  • 119
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366: 883-892.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 120
    • 84859125350 scopus 로고    scopus 로고
    • Intratumor heterogeneity: seeing the wood for the trees
    • 127ps110
    • Yap TA, Gerlinger M, Futreal PA et al. Intratumor heterogeneity: seeing the wood for the trees. Sci Transl Med 2012; 4: 127ps110.
    • (2012) Sci Transl Med , vol.4
    • Yap, T.A.1    Gerlinger, M.2    Futreal, P.A.3
  • 121
    • 44949202465 scopus 로고    scopus 로고
    • The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome
    • Watson P, Vasen HF, Mecklin JP et al. The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer 2008; 123: 444-449.
    • (2008) Int J Cancer , vol.123 , pp. 444-449
    • Watson, P.1    Vasen, H.F.2    Mecklin, J.P.3
  • 122
    • 84860464922 scopus 로고    scopus 로고
    • Oncologic manifestations of neurofibromatosis type 1 in Korea
    • Kim ET, Namgung H, Shin HD et al. Oncologic manifestations of neurofibromatosis type 1 in Korea. J Korean Surg Soc 2012; 82: 205-210.
    • (2012) J Korean Surg Soc , vol.82 , pp. 205-210
    • Kim, E.T.1    Namgung, H.2    Shin, H.D.3
  • 124
    • 0037377931 scopus 로고    scopus 로고
    • Familial liver and gall bladder cancer: a nationwide epidemiological study from Sweden
    • Hemminki K, Li X. Familial liver and gall bladder cancer: a nationwide epidemiological study from Sweden. Gut 2003; 52: 592-596.
    • (2003) Gut , vol.52 , pp. 592-596
    • Hemminki, K.1    Li, X.2
  • 125
    • 84893391899 scopus 로고    scopus 로고
    • Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials
    • Subbiah IM, Subbiah V, Tsimberidou AM et al. Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials. Oncotarget 2013; 4: 156-165.
    • (2013) Oncotarget , vol.4 , pp. 156-165
    • Subbiah, I.M.1    Subbiah, V.2    Tsimberidou, A.M.3
  • 126
    • 84893391899 scopus 로고    scopus 로고
    • Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials
    • Subbiah IM, Subbiah V, Tsimberidou AM et al. Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials. Oncotarget 2013; 4: 153-162.
    • (2013) Oncotarget , vol.4 , pp. 153-162
    • Subbiah, I.M.1    Subbiah, V.2    Tsimberidou, A.M.3
  • 127
    • 84873732296 scopus 로고    scopus 로고
    • Recent advances in systemic therapies and radiotherapy for gallbladder cancer
    • Caldow Pilgrim CH, Groeschl RT, Quebbeman EJ et al. Recent advances in systemic therapies and radiotherapy for gallbladder cancer. Surg Oncol 2013; 22: 61-67.
    • (2013) Surg Oncol , vol.22 , pp. 61-67
    • Caldow Pilgrim, C.H.1    Groeschl, R.T.2    Quebbeman, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.