Genetic alterations in gallbladder adenoma, dysplasia and carcinoma

Cancer Letters

Volumn 169, Issue 1, 2001, Pages 59-68

  Kim, Yong Tae ^a,b   Kim, Jin ^a   Jang, Yoo Hyun ^a   Lee, Woo Jin ^a   Ryu, Ji Kon ^a   Park, Yoon Kyung ^a   Kim, Sun Whe ^a   Kim, Woo Ho ^a   Yoon, Yong Bum ^a   Kim, Chung Yong ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Adenoma; Dysplasia; Gallbladder carcinoma; K ras; Loss of heterozygosity; Microsatellite instability; p16; p53

Indexed keywords

PROTEIN P16; PROTEIN P53;

ADENOMA; ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSPLASIA; FEMALE; GALLBLADDER CARCINOMA; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; MUTATION RATE; ONCOGENE K RAS; PRIORITY JOURNAL; STAINING;

ADENOMA; ADULT; AGED; CARCINOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA, NEOPLASM; FEMALE; GALLBLADDER; GALLBLADDER NEOPLASMS; GENES, P16; GENES, P53; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; PRECANCEROUS CONDITIONS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035839308     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00562-6     Document Type: Article

References (28)

1. The histogenesis of adenocarcinoma of the gallbladder
2. Epidemiology
3. A clinical study of gallbladder carcinoma
4. Association of gallbladder carcinoma and anomalous pancreaticobiliary ductal union
5. Histological and genetic changes in malignant transformation of gallbladder adenoma
6. Mutations of p53 in gallbladder carcinomas in high-incidence areas of Japan and Chile
7. Losses of heterozygosity on chromosomes 17p and 9p/18q may play important roles in early and advanced phases of gallbladder carcinogenesis
8. Correlation of p53 protein expression with gene mutation in gall-bladder carcinomas
9. Point mutation of K-ras gene codon 12 in biliary tract tumors
10. Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile
11. K-ras gene mutation in gall bladder carcinomas and dysplasia
12. Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers
13. p53 protein overexpression in gallbladder carcinoma and its precursor lesions: An immunohistochemical study
14. K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct
15. p53 hot-spot mutational analysis in advanced Western gallbladder carcinoma
16. p53 and Ki-67 immunoreactivity and nuclear morphometry of 'carcinoma-in-adenoma' and adenoma of the gall-bladder
17. p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder
18. An immunohistochemical study of p53 protein in gallbladder and extrahepatic bile duct/ampullary carcinomas
19. p53 protein immunoreactivity in extrahepatic bile duct and gallbladder cancer: Correlation with tumor grade and survival
20. p53 immunostaining distinguishes malignant from benign lesions of the gall-bladder
21. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique
22. CDKN2A/p16 inactivation is related to pituitary adenoma type and size
23. Relation of adenoma to carcinoma of gallbladder
24. Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas
25. Clinical significance of anomalous pancreaticobiliary ductal union diagnosed by endoscopic retrograde cholangiopancreatography
26. Comparison of P53 protein overexpression with P53 mutation in bladder cancer: Clinical and biologic aspects
27. Loss of heterozygosity in dysplasia and carcinoma of the gallbladder