Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: An immunohistochemical and in situ hybridization study

Journal of Pathology

Volumn 188, Issue 1, 1999, Pages 30-37

  Yamato, Taro ^a   Sasaki, Motoko ^a   Watanabe, Yoh ^a   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Gall bladder carcinoma; MUC1; MUC2; Mucin core protein

Indexed keywords

KI 67 ANTIGEN; MESSENGER RNA; MUCIN;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DYSPLASIA; FEMALE; GALLBLADDER CARCINOMA; GOBLET CELL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; AGED; CA-15-3 ANTIGEN; CARCINOMA; CARCINOMA IN SITU; CHOLECYSTITIS; CHOLELITHIASIS; FEMALE; GALLBLADDER; GALLBLADDER NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; MUCINS; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 0032945706     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199905)188:1<30::AID-PATH291>3.0.CO;2-Q     Document Type: Article

References (40)

1. Lamont JT. Mucus: the front line of intestinal mucosal defense. Ann NY Acad Sci 1992; 664: 190-201.
2. Peat N, Gendler SJ, Lalani N, Duhig T, Taylor Papadimitriou J. Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res 1992; 52: 1954-1960.
3. Itzkowitz SH, Yuan M, Montgomery CK, et al. Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer. Cancer Res 1989; 49: 197-204.
4. Gendler SJ, Lancaster CA, Taylor Papadimitriou J, et al. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 1990; 265: 15286-15293.
5. Gum JR, Byrd JC, Hicks JW, et al. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem 1989; 264: 6480-6487.
6. Porchet N, Dufosse J, Audie JP, et al. Structural features of the core proteins of human airway mucins ascertained by cDNA cloning. Am Rev Respir Dis 1991; 144(3 Pt 2): S15-S18.
7. Bobek LA, Tsai H, Biesbrock AR, Levine MJ. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). J Biol Chem 1993; 268: 20563-20569.
8. Chang SK, Dohrman AF, Basbaum CB, et al. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology 1994; 107: 28-36.
9. Ajioka Y, Allison LJ, Jass JR. Significance of MUC1 and MUC2 mucin expression in colorectal cancer. J Clin Pathol 1996; 49: 560-564.
10. Blank M, Klussmann E, Kruger Krasagakes S, et al. Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types. Int J Cancer 1994; 59: 301-306.
11. Ho SB, Niehans GA, Lyftogt C, et al. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 1993; 53: 641-651.
12. Sasaki M, Nakanuma Y. Expression of mucin core protein of mammary type in primary liver cancer. Hepatology 1994; 20: 1192-1197.
13. Yamashita K, Yonezawa S, Tanaka S, et al. Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma. Int J Cancer 1993; 55: 82-91.
14. Hudson MJ, Stamp GW, Hollingsworth MA, Pignatelli M, Lalani EN MUC1 expressed in PanC1 cells decreases adhesion to type 1 collagen but increases contraction in collagen lattices. Am J Pathol 1996; 148: 951-960.
15. Osako M, Yonezawa S, Siddiki B, et al. Immunohistochemical study of mucin carbohydrates and core proteins in human pancreatic tumors. Cancer 1993; 71: 2191-2199.
16. Yonezawa S, Byrd JC, Dahiya R, et al. Differential mucin gene expression in human pancreatic and colon cancer cells. Biochem J 1991; 276: 599-605.
17. Dahiya R, Kwak KS, Byrd JC, et al. Mucin synthesis and secretion in various human epithelial cancer cell lines that express the MUC-1 mucin gene. Cancer Res 1993; 53: 1437-1443.
18. Yonezawa S, Sueyoshi K, Nomoto M, et al. MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. Hum Pathol 1997; 28: 344-352.
19. Sasaki M, Nakanuma Y, Young SK. Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: an immunohistochemical study. Hepatology 1996; 24: 1074-1078.
20. Albores Saavedra J, Henson DE, Sobin LH. Histolgocial Typing of Tumours of the Gallbladder and Extrahepatic Bile Ducts. World Health Organization International Histological Classification of Tumours. Berlin: Springer-Verlag, 1991.
21. Albores Saavedra J, Henson DE, Sobin LH The WHO Histological Classification of Tumors of the Gallbladder and Extrahepatic Bile Ducts. A commentary on the second edition. Cancer 1992; 70: 410-414.
22. Gendler SJ, Spicer AP Epithelial mucin gene. Annu Rev Physiol 1995; 57: 607-634.
23. Baeckstrom D, Karlsson N, Hannson GC Purification and characterization of sialyl-Le a-carrying mucins of human bile; evidence for the presence of MUC1 and MUC3 apoproteins. J Biol Chem 1994; 269: 14330-14337.
24. Keates AC, Nunes DP, Afdral NH, et al. Molecular cloning of a major human gall bladder mucin: complete c-terminal sequence and genomic organization of MUC5B. Biochem J 1997; 324: 295-303.
25. Toribara NW, Ho SB, Gum E, et al. The carboxyl-terminal sequence of the human secretory mucin, MUC6. J Biol Chem 1997; 272: 16398-16403.
26. Hsu S, Raine L, Fanger H. Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled (PAP) procedures. J Histochem Cytochem 1981; 29: 577-580.
27. Siddiqui J, Abe M, Hayes D, et al. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc Natl Acad Sci U S A 1988; 85: 2320-2323.
28. Kufe D, Inghirami G, Abe M, et al. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 1984; 3: 223-232.
29. Abe M, Kufe D. Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene. Proc Natl Acad Sci U S A 1993; 90: 282-286.
30. Sekine H, Ohno T, Kufe DW. Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas. J Immunol 1985; 135: 3610-3615.
31. Xing PX, Prenzoska J, Layton GT, Devine PL, McKenzie IF Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer. J Natl Cancer Inst 1992; 84: 669-703.
32. Cattoretti G, Becker MH, Key G, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992; 168: 357-363.
33. Shi SR, Key ME, Kalra KL Antigen retrieval in formalin-fixed, paraffinembedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991; 39: 741-748.
34. Szekeres G. Detection of the Ki-67 antigen in fixed proliferating cells (letter). Anal Cell Pathol 1993; 5: 249-250.
35. Curran RC, Gregory J. The unmasking of antigens in paraffin sections of tissue by tryspin. Experientia 1977; 33: 1400-1401.
36. Balague C, Audie JP, Porchet N, Real FX. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Gastroenterology 1995; 109: 953-964.
37. Sasaki M, Nakanuma Y, Kim YS. Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction. Hepatology 1998; 27: 54-61.
38. Koga A, Momii S, Eguchi M, Makino T. Ultrastructure of well-differentiated adenocarcinoma of the gall bladder. Ultrastruct Pathol 1991; 15: 41-48.
39. Regimbald LH, Pilarski LM, Longenecker BM, et al. The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res 1996; 56: 4244-4249.
40. Lee CS. Differences in cell proliferation and prognostic significance of proliferating cell nuclear antigen and Ki-67 antigen immunoreactivity in in situ and invasive carcinomas of the extrahepatic biliary tract. Cancer 1996; 78: 1881-1887.