APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis

Pathology International

Volumn 46, Issue 5, 1996, Pages 333-340

  Itoi, Takao ^a,b   Watanabe, Hidenobu ^a   Ajioka, Yoichi ^a   Oohashi, Yasuhiro ^a   Takei, Kazuo ^b   Nishikura, Ken ^a   Nakamura, Yusuke ^c   Horii, Akira ^d   Saito, Toshihiko ^b  

^a NIIGATA UNIVERSITY   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

APC; gall bladder carcinogenesis; K ras; p53

Indexed keywords

PROTEIN P53;

ADENOMA; ARTICLE; CANCER GENETICS; CARCINOGENESIS; GALLBLADDER CARCINOMA; GALLBLADDER TUMOR; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN TISSUE; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

EID: 0029901707     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1827.1996.tb03618.x     Document Type: Article

References (39)

1. Vogelstein B, Fearon ER, Hamilton SR et al. Genetic alterations during colorectal tumor development. N. Engl. J. Med. 1988; 319: 525-532.
2. Bos JL, Fearon ER, Hamilton SR et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987; 327: 293-297.
3. Forrester K, Almoguera C, Han K et al. Detection of high incidence of K-ras oncogenes during human colon carcinogenesis. Nature 1987; 327: 298-303.
4. Kinzler KW, Nilbert MC, Su LK et al. Identification of FAP locus genes from chromosome 5q21. Science 1991; 253: 661-665.
5. Nishisho I, Nakamura Y, Miyoshi Y et al. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991; 253: 665-669.
6. Miyoshi Y, Nagase H, Ando H et al. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region of the APC gene. Hum. Mol. Genet. 1992; 1: 229-233.
7. Nigro JM, Baker SJ, Preisenger AC et al. Mutations in the p53 gene occur in diverse human tumour types. Nature 1989; 342: 705-708.
8. Hollstein M, Sidransky D, Vogelstein B, Harris C. p53 mutations in human cancers. Science 1991; 253: 49-53.
9. Kinzler KW, Nilbert MC, Vogelstein B et al. Identification of a gene located at chromosome 5q21 that is mutated in colon cancers. Science 1991; 251: 1366-1370.
10. Fearon ER, Cho KR, Nigro JM et al. Identification of a chromosome 18q gene that is altered in human colorectal cancers. Science 1990; 247: 49-56.
11. Aoki T, Takeda S, Yanagisawa A et al. APC and p53 mutations in de novo colorectal adenocarcinomas. Hum. Mutat. 1994; 3: 342-346.
12. Fujimori T, Satonaka K, Yamamura IY et al. Non-involvement of ras mutations in flat colorectal adenomas and carcinomas. Int. J. Cancer 1994; 57: 51-55.
13. Albores-Saavedra J, Alcantara-Vazquez A, Cruz-Ortis H, Herrera-Geopfert H. The precursor lesions of invasive gallbladder carcinoma. Cancer 1980; 45: 919-927.
14. Latio M. Histogenesis of epithelial neoplasms of human gallbladder. I. Dysplasia. Pathol. Res. Pract. 1983; 178: 51-56.
15. Kijima H, Watanabe H, Iwafuchi M, Ishihara N. Histogenesis of gallbladder carcinoma from investigation of early carcinoma and microcarcinoma. Acta Pathol. Jpn. 1989; 39: 235-244.
16. Christensen AH, Ishak KG. Benign tumors and pseudotumors of the gallbladder. Arch. Pathol. 1970; 90: 423-432.
17. Yamaguchi K, Enjoji M. Carcinoma of the gallbladder: A clinicopathology of 103 patients and a newly proposed staging. Cancer 1988; 62: 1425-1432.
18. Wee A, Teh M, Raju GC. Clinical importance of p53 protein in gall-bladder carcinoma and its precursor lesions. J. Clin. Pathol. 1994; 47: 453-456.
19. Kamel D, Pääkkö P, Nurova K et al. p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gallbladder. J. Pathol. 1993; 170: 67-72.
20. Oohashi Y, Watanabe H, Ajioka Y, Hatakeyama K. p53 immunostaining distinguishes malignant from benign lesions of the gall-bladder. Pathol. Int. 1995; 45: 58-65.
21. Tada M, Omata M, Ohio M. Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing. Cancer 1990; 66: 930-935.
22. Imai M, Hoshi T, Ogawa K. K-ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis. Cancer 1994; 73: 2727-2733.
23. Watanabe M, Asaka M, Tanaka J et al. Point mutation of K-ras gene codon 12 in biliary tract tumors. Gastroenterology 1994; 107: 1147-1153.
24. Beahrs OH, Henson DE, Hutter RVP et al. eds. Manual for Staging of Cancer, 4th edn. JB Lippincott Co., Philadelphia, 1992.
25. Albores-Saavedra J, Henson DE, Sobin LH. Histological Typing of Tumors of the Gallbladder and Extrahepatic Bile Ducts. World Health Organization. Springer-Verlag, Berlin, 1991.
26. Watanabe H, Kijima H, Kurakaki I et al. Morphological diagnosis of gallbladder tumors. Pathol. Clin. Med. 1989; 7: 1184-1198 (in Japanese).
27. Watanabe H, Oohashi Y, Sato M et al. Histological grading of malignancy in carcinoma of the gallbladder. Kan Tan Sui 1991; 23: 659-668 (in Japanese).
28. Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissue: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. Histochem, Cytochem. 1991; 39: 741-748.
29. Bass IO, Mulder JWR, Offerhaus GJA et al. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasm. J. Pathol. 1994; 172: 5-12.
30. Wynford-Thomas D. p53 in tumour pathology: can we trust immunocytochemistry? J. Pathol. 1992; 166: 329-330.
31. Iggo R, Gatter K, Bartek J et al. Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 1990; 335: 675-679.
32. Yokoyama S, Kashima K, Inoue S et al. Biotin-containing intranuclear inclusions in endometrial glands during gestation and puerperium. Am. J. Clin. Pathol. 1993; 99: 13-17.
33. Ooshima S, Shimizu Y, Takahama M. Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung. Virchows Arch. 1994; 424: 129-134.
34. Finlay CA, Hinds PW, Tan TH et al. Activating mutations for transformation by p53 produce a gene product that forms an hsc700-p53 complex with an altered half-life. Mol. Cell Biol. 1988; 8: 531-539.
35. Dolcetti R, Doglioni C, Maestero R et al. p53 over-expression is an early event in the development of human squamous cell carcinoma of the larynx: genetic and prognostic implication. Int. J. Cancer 1992; 52: 172-182.
36. Esrig D, Spruck CH III, Nichols PW et al. p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer. Am. J. Pathol. 1993; 143: 1389-1397.
37. Kikuchi-Yanoshita R, Konishi M, Ito S et al. Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer Res. 1992; 52: 3965-3971.
38. Almoguera C, Shibata D, Forrester K et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53: 549-554.
39. Yanagisawa A, Ohtake K, Ohashi K et al. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasia of pancreas suffering from chronic inflammation. Cancer Res. 1993; 53: 953-956.