Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 3, 2007, Pages 389-394

  Chang, Yu Ting ^a   Hsu, Chiun ^a   Jeng, Yung Ming ^a   Chang, Ming Chu ^a   Wei, Shu Chen ^a   Wong, Jau Min ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Bile duct carcinoma; Biliary tract carcinoma; CDX2; Survival

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GALLBLADDER CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TUMOR DIFFERENTIATION; UNIVARIATE ANALYSIS;

EID: 33846935522     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04487.x     Document Type: Article

References (25)

1. Shaib Y, El-Serag HB. The epidemiology of cholangiocarcinoma. Semin. Liver Dis. 2004; 24: 115-25.
2. Olnes MJ, Erlich R. A review and update on cholangiocarcinoma. Oncology 2004; 66: 167-79.
3. Wistuba II, Gazdar AF. Gallbladder cancer: lessons from a rare tumour. Nat. Rev. Cancer 2004; 4: 695-706.
4. de Groen PC, Gores GJ, LaRusso NF et al. Biliary tract cancers. N. Engl. J. Med. 1999; 341: 1368-78.
5. Silberg DG, Swain GP, Suh ER et al. Cdx1 and cdx2 expression during intestinal development. Gastroenterology 2000; 119: 961-71.
6. Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol. Cell. Biol. 1996; 16: 619-25.
7. Lorentz O, Duluc I, Arcangelis AD et al. Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation. J. Cell Biol. 1997; 139: 1553-65.
8. Bai YQ, Yamamoto H, Akiyama Y et al. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett. 2002; 176: 47-55.
9. Almeida R, Silva E, Santos-Silva F et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J. Pathol. 2003; 199: 36-40.
10. Silberg DG, Sullivan J, Kang E et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology 2002; 122: 689-96.
11. Mutoh H, Hakamata Y, Sato K et al. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem. Biophys. Res. Commun. 2002; 294: 470-9.
12. Eda A, Osawa H, Satoh K et al. Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. J. Gastroenterol. 2003; 38: 14-22.
13. Mizoshita T, Tsukamoto T, Nakanishi H et al. Expression of Cdx2 and the phenotype of advanced gastric cancers: relationship with prognosis. J. Cancer Res. Clin. Oncol. 2003; 129: 727-34.
14. Ishikawa A, Sasaki M, Ohira S et al. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Lab. Invest. 2004; 84: 629-38.
15. Phillips RW, Frierson HF Jr, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am. J. Surg. Pathol. 2003; 27: 1442-7.
16. Hansel DE, Maitra A, Lin JW et al. Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. J. Clin. Oncol. 2005; 23: 1811-18.
17. Mallo GV, Soubeyran P, Lissitzky JC et al. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J. Biol. Chem. 1998; 273: 14030-6.
18. Wu XS, Akiyama Y, Igari T et al. Expression of homeodomain protein CDX2 in gallbladder carcinomas. J. Cancer Res. Clin. Oncol. 2005; 131: 271-8.
19. Sergi C, Adam S, Kahl P et al. The remodeling of the primitive human biliary system. Early Hum. Dev. 2000; 58: 167-78.
20. Seno H, Oshima M, Taniguchi MA et al. CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications. Int. J. Oncol. 2002; 21: 769-74.
21. Matsumoto K, Mizoshita T, Tsukamoto T et al. Cdx2 expression in pancreatic tumors: relationship with prognosis of invasive ductal carcinomas. Oncol. Rep. 2004; 12: 1239-43.
22. Hong SM, Cho H, Moskaluk CA et al. CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma. Am. J. Clin. Pathol. 2005; 124: 361-70.
23. Hinoi T, Lucas PC, Kuick R et al. CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. Gastroenterology 2002; 123: 1565-77.
24. Hinoi T, Loda M, Fearon ER. Silencing of CDX2 expression in colon cancer via a dominant repression pathway. J. Biol. Chem. 2003; 278: 44608-16.
25. Lorentz O, Cadoret A, Duluc I et al. Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene 1999; 18: 87-92.