메뉴 건너뛰기




Volumn 41, Issue 4, 2010, Pages 485-492

Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder

Author keywords

Cholangiocarcinoma; EGFR; FISH; HER 2 neu; Immunohistochemistry

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

EID: 77649339494     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.10.002     Document Type: Article
Times cited : (63)

References (50)
  • 1
    • 52949153589 scopus 로고    scopus 로고
    • Intrahepatic cholangiocarcinoma: a malignancy of increasing importance
    • Hammill C.W., and Wong L.L. Intrahepatic cholangiocarcinoma: a malignancy of increasing importance. J Am Coll Surg 207 (2008) 594-603
    • (2008) J Am Coll Surg , vol.207 , pp. 594-603
    • Hammill, C.W.1    Wong, L.L.2
  • 2
    • 57749170768 scopus 로고    scopus 로고
    • Evidence-based approach to cholangiocarcinoma: a systematic review of the current literature
    • Aljiffry M., Abdulelah A., Walsh M., Peltekian K., Alwayn I., and Molinari M. Evidence-based approach to cholangiocarcinoma: a systematic review of the current literature. J Am Coll Surg 208 (2009) 134-147
    • (2009) J Am Coll Surg , vol.208 , pp. 134-147
    • Aljiffry, M.1    Abdulelah, A.2    Walsh, M.3    Peltekian, K.4    Alwayn, I.5    Molinari, M.6
  • 3
    • 2942615272 scopus 로고    scopus 로고
    • The epidemiology of cholangiocarcinoma
    • Shaib Y., and El-Serag H.B. The epidemiology of cholangiocarcinoma. Semin Liver Dis 24 (2004) 115-125
    • (2004) Semin Liver Dis , vol.24 , pp. 115-125
    • Shaib, Y.1    El-Serag, H.B.2
  • 4
    • 34247560814 scopus 로고    scopus 로고
    • Diagnosis and surgical management of gallbladder cancer: a review
    • Reid K.M., Ramos-De la Medina A., and Donohue J.H. Diagnosis and surgical management of gallbladder cancer: a review. J Gastrointest Surg 11 (2007) 671-681
    • (2007) J Gastrointest Surg , vol.11 , pp. 671-681
    • Reid, K.M.1    Ramos-De la Medina, A.2    Donohue, J.H.3
  • 5
    • 16544366649 scopus 로고    scopus 로고
    • Cholangiocarcinoma: advocate an aggressive approach with adjuvant chemotherapy
    • Kelley S.T., Bloomston M., et al. Cholangiocarcinoma: advocate an aggressive approach with adjuvant chemotherapy. Am Surg 70 (2004) 743-748
    • (2004) Am Surg , vol.70 , pp. 743-748
    • Kelley, S.T.1    Bloomston, M.2
  • 6
    • 0037108106 scopus 로고    scopus 로고
    • Is post-operative chemotherapy useful for gallbladder carcinoma? A phase III multi-center prospective randomized controlled trial in patients with resectable pancreatobiliary carcinoma
    • Takada T., Amano H., Yasuda H., et al. Is post-operative chemotherapy useful for gallbladder carcinoma? A phase III multi-center prospective randomized controlled trial in patients with resectable pancreatobiliary carcinoma. Cancer 95 (2002) 1685-1695
    • (2002) Cancer , vol.95 , pp. 1685-1695
    • Takada, T.1    Amano, H.2    Yasuda, H.3
  • 7
    • 0036208350 scopus 로고    scopus 로고
    • Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line
    • Yoon J.H., Higuchi H., Werneburg N.W., Kaufmann S.H., and Gores G.J. Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. Gastroenterology 122 (2002) 985-993
    • (2002) Gastroenterology , vol.122 , pp. 985-993
    • Yoon, J.H.1    Higuchi, H.2    Werneburg, N.W.3    Kaufmann, S.H.4    Gores, G.J.5
  • 8
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 20 18 Suppl (2002) 1S-13S
    • (2002) J Clin Oncol , vol.20 , Issue.18 SUPPL
    • Mendelsohn, J.1
  • 9
    • 16844375378 scopus 로고    scopus 로고
    • Clinical experience with monoclonal antibodies to epidermal growth factor receptor
    • Calvo E., and Rowinsky E.K. Clinical experience with monoclonal antibodies to epidermal growth factor receptor. Curr Oncol Rep 7 (2005) 96-103
    • (2005) Curr Oncol Rep , vol.7 , pp. 96-103
    • Calvo, E.1    Rowinsky, E.K.2
  • 10
    • 66449117957 scopus 로고    scopus 로고
    • Recent advances relating to the clinical application of naked monoclonal antibodies in solid tumours
    • Argyriou A., and Kalofonos H.P. Recent advances relating to the clinical application of naked monoclonal antibodies in solid tumours. Mol Med 15 (2009) 183-191
    • (2009) Mol Med , vol.15 , pp. 183-191
    • Argyriou, A.1    Kalofonos, H.P.2
  • 12
    • 33748169241 scopus 로고    scopus 로고
    • Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib
    • Wiedmann M., Feisthammel J., Blüthner T., et al. Novel targeted approaches to treating biliary tract cancer: the dual epidermal growth factor receptor and ErbB-2 tyrosine kinase inhibitor NVP-AEE788 is more efficient than the epidermal growth factor receptor inhibitors gefitinib and erlotinib. Anticancer Drugs 17 (2006) 783-795
    • (2006) Anticancer Drugs , vol.17 , pp. 783-795
    • Wiedmann, M.1    Feisthammel, J.2    Blüthner, T.3
  • 13
    • 33748680142 scopus 로고    scopus 로고
    • Gemcitabine in combination with EGFR antibody (cetuximab) as a treatment of cholangiocarcinoma: a case report
    • Sprinzl M.F., Schimanski C.C., Moehler M., Schadmand-Fischer S., Galle P.R., and Kanzler S. Gemcitabine in combination with EGFR antibody (cetuximab) as a treatment of cholangiocarcinoma: a case report. BMC Cancer 6 (2006) 190
    • (2006) BMC Cancer , vol.6 , pp. 190
    • Sprinzl, M.F.1    Schimanski, C.C.2    Moehler, M.3    Schadmand-Fischer, S.4    Galle, P.R.5    Kanzler, S.6
  • 14
    • 37049013090 scopus 로고    scopus 로고
    • Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas
    • Paule B., Herelle M.O., Rage E., et al. Cetuximab plus gemcitabine-oxaliplatin (GEMOX) in patients with refractory advanced intrahepatic cholangiocarcinomas. Oncology 72 (2007) 105-110
    • (2007) Oncology , vol.72 , pp. 105-110
    • Paule, B.1    Herelle, M.O.2    Rage, E.3
  • 15
    • 33847699368 scopus 로고    scopus 로고
    • Effects of the anti-epidermal growth factor receptor cetuximab on cholangiocarcinoma of the liver
    • Huang T.W., Wang C.H., and Hsieh C.B. Effects of the anti-epidermal growth factor receptor cetuximab on cholangiocarcinoma of the liver. Onkologie 30 (2007) 129-131
    • (2007) Onkologie , vol.30 , pp. 129-131
    • Huang, T.W.1    Wang, C.H.2    Hsieh, C.B.3
  • 16
    • 33745970752 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with advanced biliary cancer
    • Philip P.A., Mahoney M.R., Allmer C., et al. Phase II study of erlotinib in patients with advanced biliary cancer. J Clin Oncol 24 (2006) 3069-3074
    • (2006) J Clin Oncol , vol.24 , pp. 3069-3074
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 17
    • 33645689431 scopus 로고    scopus 로고
    • Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma
    • Leone F., Cavalloni G., Pignochino Y., et al. Somatic mutations of epidermal growth factor receptor in bile duct and gallbladder carcinoma. Clin Cancer Res 12 (2006) 1680-1685
    • (2006) Clin Cancer Res , vol.12 , pp. 1680-1685
    • Leone, F.1    Cavalloni, G.2    Pignochino, Y.3
  • 18
    • 0023919568 scopus 로고    scopus 로고
    • Simultaneous detection of epidermal growth factor receptor, epidermal growth factor, and ras p21 in cholangiocarcinoma by an immunocytochemical method
    • Nonomura A., Ohta G., Nakanuma Y., et al. Simultaneous detection of epidermal growth factor receptor, epidermal growth factor, and ras p21 in cholangiocarcinoma by an immunocytochemical method. Liver 3 (1998) 157-166
    • (1998) Liver , vol.3 , pp. 157-166
    • Nonomura, A.1    Ohta, G.2    Nakanuma, Y.3
  • 19
    • 0035118561 scopus 로고    scopus 로고
    • Expression and clinical significance of the erbB family in intrahepatic cholangiocellular carcinoma
    • Ito Y., Takeda T., Sasaki Y., et al. Expression and clinical significance of the erbB family in intrahepatic cholangiocellular carcinoma. Pathol Res Pract 197 (2001) 95-100
    • (2001) Pathol Res Pract , vol.197 , pp. 95-100
    • Ito, Y.1    Takeda, T.2    Sasaki, Y.3
  • 20
    • 0142024103 scopus 로고    scopus 로고
    • Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours
    • Altimari A., Fiorentino M., Gabusi E., et al. Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours. Dig Liver Dis 35 (2003) 332-338
    • (2003) Dig Liver Dis , vol.35 , pp. 332-338
    • Altimari, A.1    Fiorentino, M.2    Gabusi, E.3
  • 21
    • 3042563755 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma
    • Jan Y.Y., Yeh T.S., Yeh J.N., et al. Expression of epidermal growth factor receptor, apomucins, matrix metalloproteinases, and p53 in rat and human cholangiocarcinoma: appraisal of an animal model of cholangiocarcinoma. Ann Surg 240 (2004) 89-94
    • (2004) Ann Surg , vol.240 , pp. 89-94
    • Jan, Y.Y.1    Yeh, T.S.2    Yeh, J.N.3
  • 22
    • 16244404256 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor, ErbB2, and matrix metalloproteinase-9 in hepatolithiasis and cholangiocarcinoma
    • Kim H.J., Kim J.S., Kang C.D., et al. Expression of epidermal growth factor receptor, ErbB2, and matrix metalloproteinase-9 in hepatolithiasis and cholangiocarcinoma. Korean J Gastro 45 (2005) 52-59
    • (2005) Korean J Gastro , vol.45 , pp. 52-59
    • Kim, H.J.1    Kim, J.S.2    Kang, C.D.3
  • 23
    • 21344438897 scopus 로고    scopus 로고
    • Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers
    • Nakazawa K., Dobashi Y., Suzuki S., et al. Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol 206 (2005) 356-365
    • (2005) J Pathol , vol.206 , pp. 356-365
    • Nakazawa, K.1    Dobashi, Y.2    Suzuki, S.3
  • 24
    • 38549139744 scopus 로고    scopus 로고
    • Clinicopathologic and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
    • Yoshikawa D., Ojima H., Iwasaki M., et al. Clinicopathologic and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer 98 (2008) 418-425
    • (2008) Br J Cancer , vol.98 , pp. 418-425
    • Yoshikawa, D.1    Ojima, H.2    Iwasaki, M.3
  • 25
    • 54749094335 scopus 로고    scopus 로고
    • EGFR expression in gallbladder carcinoma in North America
    • Kaufman M., Mehrotra B., Limaye S., et al. EGFR expression in gallbladder carcinoma in North America. Int J Med Sci 5 (2008) 285-291
    • (2008) Int J Med Sci , vol.5 , pp. 285-291
    • Kaufman, M.1    Mehrotra, B.2    Limaye, S.3
  • 26
    • 0036623359 scopus 로고    scopus 로고
    • Gene amplification and mRNA and protein overexpression of c-erbB-2 (HER-2/neu) in human intrahepatic cholangiocarcinoma as detected by fluorescence in situ hybridization, in situ hybridization, and immunohistochemistry
    • Ukita Y., Kato M., and Terada T. Gene amplification and mRNA and protein overexpression of c-erbB-2 (HER-2/neu) in human intrahepatic cholangiocarcinoma as detected by fluorescence in situ hybridization, in situ hybridization, and immunohistochemistry. J Hepatol 36 (2002) 780-785
    • (2002) J Hepatol , vol.36 , pp. 780-785
    • Ukita, Y.1    Kato, M.2    Terada, T.3
  • 27
    • 28644441429 scopus 로고    scopus 로고
    • FAT, e-cadherin, beta catenin, Her-2/neu, Ki-67 immunoexpression, and histologic grade in intrahepatic cholangiocarcinoma
    • Settakorn J., Kaewpila N., Burns G.S., and Leong S. FAT, e-cadherin, beta catenin, Her-2/neu, Ki-67 immunoexpression, and histologic grade in intrahepatic cholangiocarcinoma. J Clin Pathol 58 (2005) 1249-1254
    • (2005) J Clin Pathol , vol.58 , pp. 1249-1254
    • Settakorn, J.1    Kaewpila, N.2    Burns, G.S.3    Leong, S.4
  • 28
    • 34447301537 scopus 로고    scopus 로고
    • Gene amplification and protein overexpression of HER-2/neu in human extrahepatic cholangiocarcinoma as detected by chromogenic in situ hybridization and immunohistochemistry: its prognostic implication in node positive patients
    • Kim H.J., Yoo T.W., Park D.I., et al. Gene amplification and protein overexpression of HER-2/neu in human extrahepatic cholangiocarcinoma as detected by chromogenic in situ hybridization and immunohistochemistry: its prognostic implication in node positive patients. Ann Oncol 18 (2007) 892-897
    • (2007) Ann Oncol , vol.18 , pp. 892-897
    • Kim, H.J.1    Yoo, T.W.2    Park, D.I.3
  • 29
    • 0037429737 scopus 로고    scopus 로고
    • Epidermal growth factor receptor: mechanisms of activation and signaling
    • Jorissen R.N., Walker F., Pouliot N., et al. Epidermal growth factor receptor: mechanisms of activation and signaling. Exp Cell Res 284 (2003) 31-53
    • (2003) Exp Cell Res , vol.284 , pp. 31-53
    • Jorissen, R.N.1    Walker, F.2    Pouliot, N.3
  • 30
    • 0037229076 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage
    • Kari C., Chan T.O., Rocha de Quadros M., et al. Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. Cancer Res 63 (2003) 1-5
    • (2003) Cancer Res , vol.63 , pp. 1-5
    • Kari, C.1    Chan, T.O.2    Rocha de Quadros, M.3
  • 31
    • 1342281177 scopus 로고    scopus 로고
    • Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy
    • Marquez A., Wu R., Zhao J., et al. Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy. Diagn Mol Pathol 13 (2004) 1-8
    • (2004) Diagn Mol Pathol , vol.13 , pp. 1-8
    • Marquez, A.1    Wu, R.2    Zhao, J.3
  • 32
    • 0026324504 scopus 로고
    • A comparison of epidermal growth factor receptor (EGFR) and c-erbB-2 oncogene expression in head and neck squamous cell carcinomas
    • Kearsley J.H., Leonard J.H., Walsh M.D., et al. A comparison of epidermal growth factor receptor (EGFR) and c-erbB-2 oncogene expression in head and neck squamous cell carcinomas. Pathology 23 (1991) 189-194
    • (1991) Pathology , vol.23 , pp. 189-194
    • Kearsley, J.H.1    Leonard, J.H.2    Walsh, M.D.3
  • 33
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch F.R., Varella-Garcia M., Bunn Jr. P.A., et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 21 (2003) 3798-3807
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3
  • 34
    • 33745185990 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification
    • Alvarez G., Perry A., Tan B.R., et al. Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification. Mod Path 19 (2006) 942-949
    • (2006) Mod Path , vol.19 , pp. 942-949
    • Alvarez, G.1    Perry, A.2    Tan, B.R.3
  • 35
    • 33645116622 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma
    • Buckley A.F., Burgart L., and Kakar S. Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma. Hum Pathol 37 (2006) 410-414
    • (2006) Hum Pathol , vol.37 , pp. 410-414
    • Buckley, A.F.1    Burgart, L.2    Kakar, S.3
  • 36
    • 40449113855 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and gene copy number in conventional hepatocellular carcinoma
    • Buckley A.F., Burgart L., and Kakar S. Epidermal growth factor receptor and gene copy number in conventional hepatocellular carcinoma. Am J Clin Path 129 (2008) 245-251
    • (2008) Am J Clin Path , vol.129 , pp. 245-251
    • Buckley, A.F.1    Burgart, L.2    Kakar, S.3
  • 38
    • 34548202325 scopus 로고    scopus 로고
    • Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma
    • Buckley A.F., and Kakar S. Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma. Appl Immunohistochem Mol Morphol 15 (2007) 305-309
    • (2007) Appl Immunohistochem Mol Morphol , vol.15 , pp. 305-309
    • Buckley, A.F.1    Kakar, S.2
  • 39
    • 0035472540 scopus 로고    scopus 로고
    • Genetic alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    • Koo S.H., Ihm C.H., Kwon K.C., Park J.W., Kim J.M., and Kong G. Genetic alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Cancer Genet Cytogenet 130 (2001) 22-28
    • (2001) Cancer Genet Cytogenet , vol.130 , pp. 22-28
    • Koo, S.H.1    Ihm, C.H.2    Kwon, K.C.3    Park, J.W.4    Kim, J.M.5    Kong, G.6
  • 40
    • 0036362221 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dependence in human tumors: more than just expression?
    • Arteaga C.L. Epidermal growth factor receptor dependence in human tumors: more than just expression?. Oncologist 7 (2002) 31-39
    • (2002) Oncologist , vol.7 , pp. 31-39
    • Arteaga, C.L.1
  • 41
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung K.Y., Shia J., Kemeny N.E., et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 23 (2005) 1803-1810
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3
  • 42
    • 20444502086 scopus 로고    scopus 로고
    • Assessing epidermal growth factor expression in tumors: what is the value of current test methods?
    • Dei Tos A.P., and Ellis I. Assessing epidermal growth factor expression in tumors: what is the value of current test methods?. Eur J Cancer 41 (2005) 1383-1392
    • (2005) Eur J Cancer , vol.41 , pp. 1383-1392
    • Dei Tos, A.P.1    Ellis, I.2
  • 43
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: a cohort study
    • Moroni M., Veronese S., Benvenuti S., et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 6 (2005) 279-286
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3
  • 44
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and Gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F., Hirsch F.R., Rossi E., et al. Epidermal growth factor receptor gene and protein and Gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97 (2005) 643-655
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 45
    • 34250161814 scopus 로고    scopus 로고
    • Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial
    • Cappuzzo F., Ligorio C., Jänne P.A., et al. Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol 25 (2007) 2248-2255
    • (2007) J Clin Oncol , vol.25 , pp. 2248-2255
    • Cappuzzo, F.1    Ligorio, C.2    Jänne, P.A.3
  • 46
    • 64949187144 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma
    • Yoshikawa D., Ojima H., Kokubu A., et al. Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. Br J Cancer 100 (2009) 1257-1266
    • (2009) Br J Cancer , vol.100 , pp. 1257-1266
    • Yoshikawa, D.1    Ojima, H.2    Kokubu, A.3
  • 47
    • 27144523155 scopus 로고    scopus 로고
    • Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
    • Gwak G.Y., Yoon J.H., Shin C.M., et al. Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas. J Cancer Res Clin Oncol 131 (2005) 649-652
    • (2005) J Cancer Res Clin Oncol , vol.131 , pp. 649-652
    • Gwak, G.Y.1    Yoon, J.H.2    Shin, C.M.3
  • 48
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. New England J Med 350 (2004) 2129-2139
    • (2004) New England J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 49
    • 0036124041 scopus 로고    scopus 로고
    • c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma
    • Aishima S.I., Taguchi K.I., Sugimachi K., et al. c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma. Histopathology 40 (2002) 269-278
    • (2002) Histopathology , vol.40 , pp. 269-278
    • Aishima, S.I.1    Taguchi, K.I.2    Sugimachi, K.3
  • 50
    • 0031770247 scopus 로고    scopus 로고
    • c-erbB-2 protein is expressed in hepatolithiasis and cholangiocarcinoma
    • Terada T., Ashida K., Endo K., et al. c-erbB-2 protein is expressed in hepatolithiasis and cholangiocarcinoma. Histopathology 33 (1998) 325-331
    • (1998) Histopathology , vol.33 , pp. 325-331
    • Terada, T.1    Ashida, K.2    Endo, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.