Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux

Biochemical Pharmacology

Volumn 90, Issue 3, 2014, Pages 235-245

  Lorendeau, Doriane ^a,b   Dury, Lauriane ^a,b   Genoux Bastide, Estelle ^c   Lecerf Schmidt, Florine ^c   Simões Pires, Claudia ^d   Carrupt, Pierre Alain ^d   Terreux, Raphaël ^a,b   Magnard, Sandrine ^a,b   Di Pietro, Attilio ^a,b   Boumendjel, Ahcène ^c   Baubichon Cortay, Hélène ^a,b  

^a UNIVERSITÉ LYON 1   (France)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^c Université Joseph Fourier   (France)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Collateral sensitivity; Flavonoids; Glutathione; Multidrug resistance; Multidrug resistance protein 1

Indexed keywords

3 METHOXY CHRYSIN; 5 AMINOFLAVONE; 5 HYDROXY 7 ETHOXYFLAVONE; 5 HYDROXY 7 METHOXY 4' FLUOROFLAVONE; 5,7 DIHYDROXY 4' FLUOROFLAVONE; 5,7 DIMETHOXY 4' FLUOROFLAVONE; 6 AMINOFLAVONE; 6 GERANYL CHRYSIN; 6 HYDROXYFLAVONE; 6 PRENYL CHRYSIN; 7 HYDROXYFLAVONE; 7 METHOXYFLAVONE; 8 (1,1 DMA) 3 METHOXY CHRYSIN; 8 (1,1 DMA) GALANGIN; 8 GERANYL CHRYSIN; 8 PRENYL 3 METHOXY CHRYSIN; 8 PRENYL CHRYSIN; 8 PRENYL GALANGIN; APIGENIN; CHRYSIN; FLAVONE; FLAVONOID; GALANGIN; GLUTATHIONE; HYDROXYL GROUP; KAEMPFEROL; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; PRIMULETIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SCREENING;

CHRYSIN (PUBCHEM CID: 5281607); COLLATERAL SENSITIVITY; FLAVONOIDS; GALANGIN (PUBCHEM CID: 5281616); GLUTATHIONE; KAEMPFEROL (PUBCHEM CID: 5280863); MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE PROTEIN 1;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; APOPTOSIS; BIOLOGICAL TRANSPORT; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLAVONOIDS; GLUTATHIONE; HUMANS; INHIBITORY CONCENTRATION 50; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; UP-REGULATION;

EID: 84903879133     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.05.017     Document Type: Article

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