Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent

Toxicological Sciences

Volumn 140, Issue 1, 2014, Pages 94-102

  Brüsehafer, Katja ^a   Rees, Benjamin James ^a   Manshian, Bella Barjouhi ^a   Doherty, Ann Teresa ^b   O'Donovan, Michael Richard ^b   Doak, Shareen Heather ^a   Jenkins, Gareth James Scott ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Cell cycle; Genomic instability; Micronucleus; p53; Threshold

Indexed keywords

CYTARABINE; MITOMYCIN; PROTEIN P53; MUTAGENIC AGENT;

ARTICLE; CELL ACTIVITY; CELL CYCLE PROGRESSION; CHROMOSOME BREAKAGE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CYTOKINESIS; CYTOTOXICITY; DNA DAMAGE; DOSE RESPONSE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC ANALYSIS; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOBLASTOID CELL LINE; M PHASE CELL CYCLE CHECKPOINT; MICRONUCLEUS; PROTEIN EXPRESSION; RISK ASSESSMENT; S PHASE CELL CYCLE CHECKPOINT; TOXICITY TESTING; CELL CYCLE; CELL SURVIVAL; CHEMICALLY INDUCED; CULTURE TECHNIQUE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; TOXICITY; TUMOR CELL LINE;

CELL CULTURE TECHNIQUES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CYTARABINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MITOMYCIN; MUTAGENS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84903843817     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu058     Document Type: Article

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