Pro-oxidant induced DNA damage in human lymphoblastoid cells: Homeostatic mechanisms of genotoxic tolerance

Toxicological Sciences

Volumn 128, Issue 2, 2012, Pages 387-397

  Seager, Anna L ^a   Shah, Ume Kulsoom ^a   Mikhail, Jane M ^a   Nelson, Bryant C ^b   Marquis, Bryce J ^b   Doak, Shareen H ^a   Johnson, George E ^a   Griffiths, Sioned M ^a   Carmichael, Paul L ^c   Scott, Sharon J ^c   Scott, Andrew D ^c   Jenkins, Gareth J S ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

^c UNILEVER RESEARCH   (United Kingdom)

Author keywords

Antioxidants; DNA damage; DNA repair; Genotoxicology; Glutathione; OGG1; Pro oxidants; Reactive oxygen species; Thresholds.

Indexed keywords

DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; GLUTATHIONE; HYDROGEN PEROXIDE; MENADIONE; POTASSIUM BROMATE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; GENOTOXICITY; HOMEOSTASIS; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MALE; ONCOGENE; OXIDATIVE STRESS;

BLOTTING, WESTERN; BROMATES; CELL LINE; CHROMOSOME ABERRATIONS; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; HOMEOSTASIS; HUMANS; HYDROGEN PEROXIDE; LYMPHOCYTES; MALE; MUTAGENS; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; VITAMIN K 3;

EID: 84865399594     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs152     Document Type: Article

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