메뉴 건너뛰기




Volumn 464, Issue 1, 2000, Pages 123-128

Thresholds in genotoxicity responses

Author keywords

Aneuploidy; Homeostatic overload; In vitro artefacts; Risk assessment of genotoxins; Threshold mechanisms in genotoxicity

Indexed keywords

CELL PROLIFERATION; CHROMOSOME ABERRATION; CONFERENCE PAPER; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG SCREENING; ENZYME INHIBITION; GENOTOXICITY; IN VITRO STUDY; INTERMETHOD COMPARISON; MAXIMUM ALLOWABLE CONCENTRATION; MICRONUCLEUS TEST; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0033977140     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(99)00173-4     Document Type: Conference Paper
Times cited : (61)

References (25)
  • 1
    • 0032480026 scopus 로고    scopus 로고
    • Chromosome aberration testing in genetic toxicology - Past, present and future
    • Kirkland D. Chromosome aberration testing in genetic toxicology - past, present and future. Mutat. Res. 404:1998;173-185.
    • (1998) Mutat. Res. , vol.404 , pp. 173-185
    • Kirkland, D.1
  • 2
    • 0032565516 scopus 로고    scopus 로고
    • DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: Comparison of DNA-reactive and non-DNA-reactive clastogens
    • Galloway S.M., Miller J.E., Armstrong M.J., Bean C.L., Skopek T.R., Nichols W.W. DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-DNA-reactive clastogens. Mutat. Res. 400:1998;169-186.
    • (1998) Mutat. Res. , vol.400 , pp. 169-186
    • Galloway, S.M.1    Miller, J.E.2    Armstrong, M.J.3    Bean, C.L.4    Skopek, T.R.5    Nichols, W.W.6
  • 3
    • 0028978525 scopus 로고
    • Genotoxicity of gyrase- And mammalian topoisomerase II-inhibitors in prokaryotic an eukaryotic test systems
    • Albertini S., Chételat A., Miller B., Muster W., Pujadas E., Strobel R., Gocke E. Genotoxicity of gyrase- and mammalian topoisomerase II-inhibitors in prokaryotic an eukaryotic test systems. Mutagenesis. 10:1995;343-351.
    • (1995) Mutagenesis , vol.10 , pp. 343-351
    • Albertini, S.1    Chételat, A.2    Miller, B.3    Muster, W.4    Pujadas, E.5    Strobel, R.6    Gocke, E.7
  • 4
    • 0029956994 scopus 로고    scopus 로고
    • Comparative in vivo genotoxicty of antiviral nucleoside analogues; Penciclovir, acyclovir, ganciclovir and the xanthine analogue, caffeine, in the mouse bone marrow micronucleus assay
    • Haynes P., Lambert T.R., de Mitchell I.G. Comparative in vivo genotoxicty of antiviral nucleoside analogues; penciclovir, acyclovir, ganciclovir and the xanthine analogue, caffeine, in the mouse bone marrow micronucleus assay. Mutat. Res. 369:1996;65-74.
    • (1996) Mutat. Res. , vol.369 , pp. 65-74
    • Haynes, P.1    Lambert, T.R.2    De Mitchell, I.G.3
  • 5
    • 0028322120 scopus 로고
    • Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
    • Kunz B.A., Kohalmi S.E., Kunkel T.A., Mathews C.K., McIntosh E.M., Reidy J.A. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability. Mutat. Res. 318:1994;1-64.
    • (1994) Mutat. Res. , vol.318 , pp. 1-64
    • Kunz, B.A.1    Kohalmi, S.E.2    Kunkel, T.A.3    Mathews, C.K.4    McIntosh, E.M.5    Reidy, J.A.6
  • 6
    • 0343247805 scopus 로고    scopus 로고
    • The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea
    • Favor J., Neuhauser-Klaus A., Ehling U.H., Wulff A., van Zeeland A.A. The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea. Mutat. Res. 374:1997;193-199.
    • (1997) Mutat. Res. , vol.374 , pp. 193-199
    • Favor, J.1    Neuhauser-Klaus, A.2    Ehling, U.H.3    Wulff, A.4    Van Zeeland, A.A.5
  • 7
    • 0025338542 scopus 로고
    • A dose-response analysis of ethylnitrosourea-induced recessive specific-locus mutations in treated spermatogonia of the mouse
    • Favor J., Sund M., Neuhauser-Klaus A., Ehling E.U. A dose-response analysis of ethylnitrosourea-induced recessive specific-locus mutations in treated spermatogonia of the mouse. Mutat. Res. 231:1990;47-54.
    • (1990) Mutat. Res. , vol.231 , pp. 47-54
    • Favor, J.1    Sund, M.2    Neuhauser-Klaus, A.3    Ehling, E.U.4
  • 8
    • 0026056891 scopus 로고
    • Mutagenicity of Maillard reaction products from D-glucose amino acid mixtures and possible roles of active oxygens in the mutagenicity
    • Kim S.B., Kim I.S., Yeum D.M., Park Y.H. Mutagenicity of Maillard reaction products from D-glucose amino acid mixtures and possible roles of active oxygens in the mutagenicity. Mutat. Res. 254:1991;65-69.
    • (1991) Mutat. Res. , vol.254 , pp. 65-69
    • Kim, S.B.1    Kim, I.S.2    Yeum, D.M.3    Park, Y.H.4
  • 9
    • 0028305534 scopus 로고
    • The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA-damage in human lymphocytes in the Comet assay
    • Anderson D., Yu T.W., Phillips B.J., Schmezer P. The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA-damage in human lymphocytes in the Comet assay. Mutat. Res. 307:1994;261-271.
    • (1994) Mutat. Res. , vol.307 , pp. 261-271
    • Anderson, D.1    Yu, T.W.2    Phillips, B.J.3    Schmezer, P.4
  • 10
    • 0028148757 scopus 로고
    • Dose-response effects of malachite green on free-radical formation, lipid peroxidation and DNA damage in syrian hamster embryo cells and their modulation by antioxidants
    • Panandiker A., Maru C.B., Rao K.V.K. Dose-response effects of malachite green on free-radical formation, lipid peroxidation and DNA damage in syrian hamster embryo cells and their modulation by antioxidants. Carcinogenesis. 15:1994;2445-2448.
    • (1994) Carcinogenesis , vol.15 , pp. 2445-2448
    • Panandiker, A.1    Maru, C.B.2    Rao, K.V.K.3
  • 11
    • 0029791978 scopus 로고    scopus 로고
    • The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay)
    • Chételat A., Albertini S., Gocke E. The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay). Mutagenesis. 11:1996;497-504.
    • (1996) Mutagenesis , vol.11 , pp. 497-504
    • Chételat, A.1    Albertini, S.2    Gocke, E.3
  • 12
    • 34347276205 scopus 로고    scopus 로고
    • The genotoxicity and carcinogenicty of paracetamol: A regulatory (re)view
    • Bergman K., Müller L., Weberg Teigen S. The genotoxicity and carcinogenicty of paracetamol: a regulatory (re)view. Mutat. Res. 349:1996;263-288.
    • (1996) Mutat. Res. , vol.349 , pp. 263-288
    • Bergman, K.1    Müller, L.2    Weberg Teigen, S.3
  • 13
    • 45949118213 scopus 로고
    • Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity
    • Galloway S.M., Deasy D.A., Bean C.L., Kraynak A.R., Armstrong M.J., Bradley M.O. Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity. Mutat. Res. 189:1987;15-26.
    • (1987) Mutat. Res. , vol.189 , pp. 15-26
    • Galloway, S.M.1    Deasy, D.A.2    Bean, C.L.3    Kraynak, A.R.4    Armstrong, M.J.5    Bradley, M.O.6
  • 14
    • 45949118272 scopus 로고
    • Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK±cells
    • Cifone M.A., Myhr B., Eiche A., Bolcsfoldi G. Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK±cells. Mutat. Res. 189:1987;39-46.
    • (1987) Mutat. Res. , vol.189 , pp. 39-46
    • Cifone, M.A.1    Myhr, B.2    Eiche, A.3    Bolcsfoldi, G.4
  • 15
    • 0026718955 scopus 로고
    • Chromosomal aberration testing in vitro: Problems with protocol design and interpretation of results
    • Kirkland D. Chromosomal aberration testing in vitro: problems with protocol design and interpretation of results. Mutagenesis. 7:1992;95-106.
    • (1992) Mutagenesis , vol.7 , pp. 95-106
    • Kirkland, D.1
  • 17
    • 0027215247 scopus 로고
    • Induction of micronucleated erthrocytes by recombinant-human-erythropoietin
    • Yajima N., Kurata Y., Sawai T., Takeshita Y. Induction of micronucleated erthrocytes by recombinant-human-erythropoietin. Mutagenesis. 8:1993;221-229.
    • (1993) Mutagenesis , vol.8 , pp. 221-229
    • Yajima, N.1    Kurata, Y.2    Sawai, T.3    Takeshita, Y.4
  • 18
    • 0025943841 scopus 로고
    • Prior bleeding enhances the sensitivity of the in vivo micronucleus test
    • Hirai O., Miyame Y., Fujino Y., Izumi H., Miyamoto A., Noguchi H. Prior bleeding enhances the sensitivity of the in vivo micronucleus test. Mutat. Res. 264:1991;109-114.
    • (1991) Mutat. Res. , vol.264 , pp. 109-114
    • Hirai, O.1    Miyame, Y.2    Fujino, Y.3    Izumi, H.4    Miyamoto, A.5    Noguchi, H.6
  • 19
    • 0032574309 scopus 로고    scopus 로고
    • Transgenic rodent mutation/cancer bioassays: Cell cycle control, cell proliferation and apoptosis as modifiers of outcome
    • Roberts R.A. Transgenic rodent mutation/cancer bioassays: cell cycle control, cell proliferation and apoptosis as modifiers of outcome. Mutat. Res. 398:1998;189-195.
    • (1998) Mutat. Res. , vol.398 , pp. 189-195
    • Roberts, R.A.1
  • 20
    • 0342272944 scopus 로고
    • Results for the Big Blue transgenic assay using two genotoxins and a peroxisome proliferator
    • Ashby J., Tinwell H., Burnett K., LeFevre P.A. Results for the Big Blue transgenic assay using two genotoxins and a peroxisome proliferator. Environ. Mol. Mutagen. 21(S22):1993;4.
    • (1993) Environ. Mol. Mutagen. , vol.21 , Issue.S22 , pp. 4
    • Ashby, J.1    Tinwell, H.2    Burnett, K.3    Lefevre, P.A.4
  • 23
    • 0027468463 scopus 로고
    • Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay?
    • Gunz D., Shephard S.E., Lutz W.K. Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay? Environ. Mol. Mutagen. 21:1993;209-211.
    • (1993) Environ. Mol. Mutagen. , vol.21 , pp. 209-211
    • Gunz, D.1    Shephard, S.E.2    Lutz, W.K.3
  • 24
    • 0027468463 scopus 로고
    • Can "nongenotoxic" carcinogens be detected with the lacI transgenic mouse mutation assay?
    • Shephard S.E., Gunz D., Lutz W.K. Can "nongenotoxic" carcinogens be detected with the lacI transgenic mouse mutation assay? Environ. Mol. Mutagen. 21(S22):1993;64.
    • (1993) Environ. Mol. Mutagen. , vol.21 , Issue.S22 , pp. 64
    • Shephard, S.E.1    Gunz, D.2    Lutz, W.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.