Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates post-ischemic neuronal apoptosis through suppression of mitochondrial p53 translocation

Neuropharmacology

Volumn 85, Issue , 2014, Pages 508-516

  Liao, Juan ^a   Ye, Zhi ^a   Huang, Guoqing ^a   Xu, Chang ^a   Guo, Qulian ^a   Wang, E ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Cerebral ischemia; Diabetes; P53; Reactive oxygen species (ROS)

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; CYTOCHROME C; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN P53; PUMA PROTEIN; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; AMINOQUINOLINE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; NEUROPROTECTIVE AGENT; PUMA PROTEIN, RAT; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG DOSE COMPARISON; EVENING DOSAGE; MALE; METABOLIC INHIBITION; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MORNING DOSAGE; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; THERAPY DELAY; WESTERN BLOTTING; ANIMAL; BRAIN; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; TIME;

AMINOQUINOLINES; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN; CYTOCHROMES C; DIABETES MELLITUS, EXPERIMENTAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; PYRIMIDINES; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84903838501     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.06.008     Document Type: Article

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