Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain

Free Radical Biology and Medicine

Volumn 49, Issue 11, 2010, Pages 1804-1814

  Shan, Limei ^a   Li, Jianmin ^b   Wei, Meng ^c   Ma, Jian ^a,c   Wan, Li ^b   Zhu, Wei ^c   Li, Ying ^a   Zhu, Huaqing ^a   Arnold, J Malcolm O ^a   Peng, Tianqing ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Calpain; Diabetes; Free radicals; Ischemia; Rac1; Reactive oxygen species; Reperfusion

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; CALPAIN; CARBONYL DERIVATIVE; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HEART FUNCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; IN VIVO STUDY; INJURY SEVERITY; ISOLATED HEART; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CALPAIN; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; ENZYME ACTIVATION; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; MYOCARDIAL REPERFUSION INJURY; NEUROPEPTIDES; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; STREPTOZOCIN;

MUS; MUS MUSCULUS;

EID: 78049376598     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.09.018     Document Type: Article

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