Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apoptosis by phosphorylation akt and GSK-3β

Neurochemical Research

Volumn 37, Issue 2, 2012, Pages 321-329

  Ye, Zhi ^a   Wang, Na ^a   Xia, Pingping ^a   Wang, E ^a   Yuan, Yajing ^a   Guo, Qulian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Akt glycogen synthase kinase 3 (GSK 3 ); Apoptosis; Cerebral ischemic reperfusion injury; Cyclooxygenase 2 (COX 2); Parecoxib

Indexed keywords

CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; PARECOXIB; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT; REPERFUSION INJURY; THERAPY DELAY; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CYCLOOXYGENASE 2 INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; IN SITU NICK-END LABELING; ISCHEMIA; ISOXAZOLES; MALE; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84856399966     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0615-y     Document Type: Article

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