20-Hydroxyecdysone Protects against Oxidative Stress-Induced Neuronal Injury by Scavenging Free Radicals and Modulating NF-κB and JNK Pathways

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Hu, Jun ^a   Luo, Chun Xia ^a   Chu, Wei Hua ^a   Shan, You An ^a   Qian, Zhong Ming ^a   Zhu, Gang ^a   Yu, Yan Bing ^b   Feng, Hua ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CALCIUM ION; CASPASE 3; ECDYSTERONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE 1; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME RELEASE; IN VITRO STUDY; IN VIVO STUDY; INFARCT VOLUME; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE POTENTIAL DISSIPATION; NERVE INJURY; NERVOUS SYSTEM PARAMETERS; NEUROLOGICAL DEFICIT SCORE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SCORING SYSTEM; SIGNAL TRANSDUCTION; TOTAL ANTIOXIDANT CAPABILITY;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; ECDYSTERONE; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; INFARCTION, MIDDLE CEREBRAL ARTERY; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84871116274     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050764     Document Type: Article

References (62)

1. Dirnagl U, Iadecola C, Moskowitz MA, (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22: 391-397.
2. Doyle KP, Simon RP, Stenzel-Poore MP, (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55: 310-318.
3. Allen CL, Bayraktutan U, (2009) Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int J Stroke 4: 461-470.
4. Sies H, (1997) Oxidative stress: oxidants and antioxidants. Exp Physiol 82: 291-295.
5. Love S, (1999) Oxidative stress in brain ischemia. Brain Pathol 9: 119-131.
6. Crack PJ, Taylor JM, (2005) Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 38: 1433-1444.
7. Friberg H, Wieloch T, Castilho RF, (2002) Mitochondrial oxidative stress after global brain ischemia in rats. Neurosci Lett 334: 111-114.
8. Murin R, Drgova A, Kaplan P, Dobrota D, Lehotsky J, (2001) Ischemia/Reper--fusion-induced oxidative stress causes structural changes of brain membrane proteins and lipids. Gen Physiol Biophys 20: 431-438.
9. Le Bras M, Clement MV, Pervaiz S, Brenner C, (2005) Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol Histopathol 20: 205-219.
10. Shen HM, Liu ZG, (2006) JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 40: 928-939.
11. Wang T, Gu J, Wu PF, Wang F, Xiong Z, et al. (2009) Protection by tetrahy--droxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med 47: 229-240.
12. Stetler RA, Cao G, Gao Y, Zhang F, Wang S, et al. (2008) Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling. J Neurosci 28: 13038-13055.
13. Li X, Ye X, Sun X, Liang Q, Tao L, et al. (2011) Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway. Brain Res.
14. Colasanti M, Suzuki H, (2000) The dual personality of NO. Trends Pharmacol Sci 21: 249-252.
15. Ridder DA, Schwaninger M, (2009) NF-kappaB signaling in cerebral ischemia. Neuroscience 158: 995-1006.
16. Sláma K, Lafont R, (1995) Insect hormones- ecdysteroids: their presence and actions in vertebrates. European Journal of Entomology 92: 355-377.
17. Matsuda H, Kawaba T, Yamamoto Y, (1970) [Pharmacological studies of insect metamorphotic steroids]. Nippon Yakurigaku Zasshi 66: 551-563.
18. Toth N, Szabo A, Kacsala P, Heger J, Zador E, (2008) 20-Hydroxyecdysone increases fiber size in a muscle-specific fashion in rat. Phytomedicine 15: 691-698.
19. Lafont R, Dinan L, (2003) Practical uses for ecdysteroids in mammals including humans: an update. J Insect Sci 3: 7.
20. Catalan RE, Martinez AM, Aragones MD, Miguel BG, Robles A, et al. (1985) Alterations in rat lipid metabolism following ecdysterone treatment. Comp Biochem Physiol B 81: 771-775.
21. Oehme I, Bosser S, Zornig M, (2006) Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death Differ 13: 189-201.
22. Chen Z, Zhu G, Tang WH, Liu Z, Zhang JH, et al. (2004) Effects of ecdysterone on injury of endothelial cells following experimental subarachnoid hemorrhage. Chin J Clin Pharmacol Ther 9: 540-543.
23. Kholodova Iu D, Tugai VA, Zimina VP, (1997) [Effect of vitamin D3 and 20-hydroxyecdysone on the content of ATP, creatine phosphate, carnosine and Ca2+ in skeletal muscles]. Ukr Biokhim Zh 69: 3-9.
24. Kuz'menko AI, Morozova RP, Nikolenko IA, Donchenko GV, (2001) [Vitamin D3 and 20-hydroxyecdysone - inhibitors of free radical lipid oxidation during D-hypervitaminosis]. Ukr Biokhim Zh 73: 44-50.
25. Kuzmenko AI, Morozova RP, Nikolenko IA, Korniets GV, Yu Kholodova D, (1997) Effects of vitamin D3 and ecdysterone on free-radical lipid peroxidation. Biochemistry (Mosc) 62: 609-612.
26. Cai YJ, Dai JQ, Fang JG, Ma LP, Hou LF, et al. (2002) Antioxidative and free radical scavenging effects of ecdysteroids from Serratula strangulata. Can J Physiol Pharmacol 80: 1187-1194.
27. Kuz'menko AI, Morozova RP, Nikolenko IA, Donchenko GV, (1999) Antioxidant effect of 20-hydroxyecdysone in a model system. Ukr Biokhim Zh 71: 35-38.
28. Tang WH, Chen Z, Liu Z, Zhang JH, Xi G, et al. (2008) The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo. Neurol Res 30: 571-580.
29. Liu Z, Zhu G, Zhang JH, Chen Z, Tang W-H, et al. (2008) Ecdysterone attenuates vasospasm following experimental subarachnoid haemorrhage in rabbits. Acta Neurochir Suppl 104: 297-302.
30. Hu J, Zhao TZ, Chu WH, Luo CX, Tang WH, et al. (2010) Protective Effects of 20-Hydroxyecdysone on CoCl2-Induced Cell Injury in PC12 Cells. Journal of Cellular Biochemistry 111: 1512-1521.
31. Benedi J, Arroyo R, Romero C, Martin-Aragon S, Villar AM, (2004) Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells. Life Sciences 75: 1263-1276.
32. Zhang F, Wang S, Signore AP, Chen J, (2007) Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 38: 2329-2336.
33. Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, et al. (2007) Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104: 13798-13803.
34. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, et al. (1990) A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 10: 290-293.
35. Ott M, Gogvadze V, Orrenius S, Zhivotovsky B, (2007) Mitochondria, oxidative stress and cell death. Apoptosis 12: 913-922.
36. Gulden M, Jess A, Kammann J, Maser E, Seibert H, (2010) Cytotoxic potency of H2O2 in cell cultures: Impact of cell concentration and exposure time. Free Radical Biology and Medicine 49: 1298-1305.
37. Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D, (2002) Antioxidant therapy in acute central nervous system injury: current state. Pharmacol Rev 54: 271-284.
38. Schaller B, (2005) Prospects for the future: the role of free radicals in the treatment of stroke. Free Radic Biol Med 38: 411-425.
39. Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, et al. (2005) Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis 18: 618-627.
40. Frantz MC, Wipf P, (2010) Mitochondria as a target in treatment. Environ Mol Mutagen.
41. Wang X, (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933.
42. Green DR, Reed JC, (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
43. Chinopoulos C, Adam-Vizi V, (2006) Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring theme. FEBS J 273: 433-450.
44. Starkov AA, Chinopoulos C, Fiskum G, (2004) Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium 36: 257-264.
45. Schild L, Reiser G, (2005) Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+. FEBS J 272: 3593-3601.
46. Perez-Asensio FJ, Hurtado O, Burguete MC, Moro MA, Salom JB, et al. (2005) Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia. Neurobiol Dis 18: 375-384.
47. Iadecola C, Zhang F, Casey R, Nagayama M, Ross ME, (1997) Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci 17: 9157-9164.
48. Zhao X, Haensel C, Araki E, Ross ME, Iadecola C, (2000) Gene-dosing effect and persistence of reduction in ischemic brain injury in mice lacking inducible nitric oxide synthase. Brain Res 872: 215-218.
49. Huang CY, Fujimura M, Noshita N, Chang YY, Chan PH, (2001) SOD1 down-regulates NF-kappaB and c-Myc expression in mice after transient focal cerebral ischemia. J Cereb Blood Flow Metab 21: 163-173.
50. Nurmi A, Lindsberg PJ, Koistinaho M, Zhang W, Juettler E, et al. (2004) Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke 35: 987-991.
51. Zhang W, Potrovita I, Tarabin V, Herrmann O, Beer V, et al. (2005) Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia. J Cereb Blood Flow Metab 25: 30-40.
52. Zhang JJ, Xu ZM, Zhang CM, Dai HY, Ji XQ, et al. (2010) Pyrrolidinedithiocarbamate inhibits nuclear factor-{kappa}B pathway activation, and regulates adhesion, migration, invasion and apoptosis of endometriotic stromal cells. Mol Hum Reprod.
53. Feng CY, Huang XR, Qi MX, (2012) [Effects of ecdysterone on the expression of NF-kappaB p65 in H2O2 induced oxidative damage of human lens epithelial cells]. Zhongguo Zhong Xi Yi Jie He Za Zhi 32: 76-79.
54. Sugawara T, Fujimura M, Noshita N, Kim GW, Saito A, et al. (2004) Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 1: 17-25.
55. Guan QH, Pei DS, Liu XM, Wang XT, Xu TL, et al. (2006) Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain Res 1092: 36-46.
56. Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94.
57. Tobiume K, Saitoh M, Ichijo H, (2002) Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer. J Cell Physiol 191: 95-104.
58. Takeda K, Matsuzawa A, Nishitoh H, Ichijo H, (2003) Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 28: 23-29.
59. Vosler PCJ, (2009) Potential molecular targets for translational stroke research. Stroke 40: 119-120.
60. Wang R, Zhang QG, Han D, Xu J, Lu Q, et al. (2006) Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J Neurochem 99: 1543-1554.
61. Longa EZ, Weinstein PR, Carlson S, Cummins R, (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91.
62. Chen J, Li Y, Wang L, Zhang Z, Lu D, et al. (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32: 1005-1011.