The alternatively spliced Kunitz protease inhibitor domain alters amyloid β protein precursor processing and amyloid β protein production in cultured cells

Journal of Biological Chemistry

Volumn 271, Issue 48, 1996, Pages 30929-30934

  Ho, Libin ^a,b   Fukuchi, Ken Ichiro ^c   Younkin, Steven G ^d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Moyo Clinic Jacksonville   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; APROTININ; PROTEIN PRECURSOR;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

ALTERNATIVE SPLICING; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APROTININ; CELLS, CULTURED; HUMANS; ISOENZYMES; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0029846435     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.48.30929     Document Type: Article

References (42)

1. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., and Younkin, S. G. (1992) Science 258, 126-129
2. Seubcrt, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, L, and Schenk, D. (1992) Nature 359, 325-327
3. Scheuner, D., Eckraan, C., Jensen, M., Song, X., Citron, M., Suzuki,.N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D., and Younkin, S. (1996)0. Med. 2, 864-870
4. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, L, Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
5. Busciglio, J., Gabuzda, D. H., Matsudaira, P., and Yankner, B. A. (1993) Proc. Natl. Acad. Sei. U. S. A. 90, 2092-2096
6. Wertkin, A. M., Turner, R. S., Pleasure, S. J., Golde, T. E., Younkin, S. G., Trojanowski, J. Q., and Lee, V. M.-Y. (1993) Proc. Natl. Acad. Sei. U. S. A. 90, 9513-9517
7. Seubert, P., Oltersdorf, T., Lee, M. G., Barbour, R., Blomquist, C., Davis, D. L., Bryant, K., Fritz, L. C., Galasko, D., Thal, L. J., Lieberburg, L, and Schenk, D. B. (1993) Nature 361, 260-263
8. Cheung, T., Ghiso, J., Shoji, M., Cai, X., Golde, T., Gandy, S., Frangione, B., and Younkin, S. (1994) Amyloid Int. J. Eip. Clin. Invest. I, 30-38
9. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., and Ward, P. J. (1990) Science 248,1122-1124
10. Goldgaber, D., Lerman, M. L, McBride, O. W., Saffiotti, U., and Gajdusek, D. C. (1987) Science 235, 877-880
11. Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K, and Müller-Hill, B. (1987) Nature 325, 733-736
12. Robakis, N. K., Wisniewski, H. M., Jenkins, E. C., Devine-Gage, E. A., Houck, G. E., Yao, X.-L., Ramakrishna, N., Wolfe, G., Silverman, W. P., and Brown, W. T. (1987) Lancet i, 384-385
13. Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St. George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., and Neve, R. L. (1987) Science 235, 880-884
14. Lemaire, H. G., Salbaum, J. M., Multhaup, G., Kang, J., Bayney, R. M., Unterbeck, A-, Beyreuther, K., and Müller-Hill, B. (1989) Nucleic Acids Res. 17, 517-522
15. Yoshikai, S.-i., Sasaki, H., Doh-ura, K., Furuya, H., and Sakaki, Y. (1990) Gene (Amst.) 87, 257-263
16. Golde, T. E., Estus, S., Usiak, M., Younkin, L. H., and Younkin, S. G. (1989) Neuron 4, 253-267
17. Kitaguchi, N., Takahashi, Y., Toushima, Y., Shiojiri, S., and Ito, H. (1988) Nature 331, 530-532
18. Ponte, P., Gonzalez-DeWhitt, P., Schilling, J., Miller, J., Hsu, D., Greenberg, B., Davis, K, Wallace, W., Lieberburg, L, Füller, F., and Cordeil, B. (1988) Nature 331, 525-527
19. Tanzi, R. E., McClatchey, A. L, Lamperti, E. D., Villa-Komaroff, L., Gusella, J. F., and Neve, R. L. (1988) Nature 331, 528-530
20. König, G., Monning, U., Czech, C., Prior, R., Banati, R., Schreiter-Gasser, U., Bauer, J., Masters, C. L., and Beyreuther, K. (1992) J. Biol. Chem. 267, 10804-10809
21. Oltersdorf, T. L., Fritz, L. C., Schenk, D. B., Lieberburg, L, Johnson-Wood, K. L., Beattie, E. C., Ward, P. J., Blachcr, R. W., Dovey, H. F., and Sinha, S. (1989) Nature 341,144-147
22. Van Nostrand, W. E., Wagner, S. L., Suzuki, M., Choi, B. H., Farrow, J. S., Geddes, J. W., Cotman, C. W., and Cunningham, D. D. (1989) Nature 341, 546-549
23. Van Nostrand, W. E., Wagner, S. L., Farrow, J. S., and Cunningham, D. D. (1990) J. Blol. Chem. 265, 9591-9594
24. Bhasin, R., Van Nostrand, W. E., Saitoh, T., Donets, M. A., Barnes, E. A., Quitschke, W. W-, and Goldgaber, D. (1991) Proc. Natl. Acad. Sei. U. S. A. 88, 10307-10311
25. Shimokawa, M., Nakamura, K-, Maruyama, K, Tagawa, K., Miyatake, T., Sugita, H., Ishiura, S., and Suzuki, K. (1993) Biochimie (Paris) 75,911-915
26. Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Jr., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264,1336-1340
27. Gravina, S. A., Ho, L., Eckman, C. B., Long, K. E., Otvos, L., Jr., Younkin, L. H., Suzuki, N., and Younkin, S. G. (1995) J. Biol. Chem. 270, 7013-7016
28. Niwa, H., Yamamura, K-i., and Miyazaki, J.-i. (1991) Gene (Amst.) 108, 193-200
29. Yamaguchi, F., Richards, S. J., Beyreuther, K., Salbaus, M., Carlson, G. A., and Dunnett, S. B. (1991) NeuroReport 2, 781-784
30. Cai, X.-D., Golde, T. E., and Younkin, S. G. (1993) Science 259, 514-516
31. Koo, E. H., and Squazzo, S. L. (1994) J. Biol. Chem. 269,17386-17389
32. Haass, C., Hung, A. Y., Selkoe, D. J., and Teplow, D. B. (1994) J. Biol. Chem. 269,17741-17748
33. Citron, M., Vigo-Pelfrey, C., Teplow, D. B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L., and Selkoe, D. J. (1994) Proc. Natl. Acad. Sei. U. S. A. 91,11993-11997
34. Tanaka, S., Liu, L., Kimura, J., Shiojiri, S., Takahashi, Y., Kitaguchi, N., Nakamura, S., and Ueda, K. (1992) Mol. Brain. Res. 15, 303-310
35. Tanaka, S., Nakamura, S., Kimura, J., and Ueda, K. (1993)Neurosci. Lett. 163, 19-21
36. Johnson, S. A., McNeill, T., Cordell, B., and Finch, C. E. (1990) Science 248, 854-857
37. Games, D., Adams, D., Alessandrini, R, Barbour, R., Berthelette, P., Blackwell, C., Can-, T., Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagopian, S., Johnson-Wood, K, Khan, K, Lee, M., Leibowitz, P., Lieberburg, L, Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B., and Zhao, J. (1995) Nature 373, 523-527
38. Quon, D., Wang, Y., Catalano, R., Scardania, J. M., Murakami, K., and Cordell, B. (1991) Nature 352, 239-241
39. Higgins, L. S., Catalano, R, Quon, D., and Cordell, B. (1993) Ann. N. Y. Acad. Sei. 695, 224-227
40. Higgins, L. S., Holtzman, D. M., Rabin, J., Mobley, W. C., and Cordell, B. (1994) Ann. Neural. 35, 598-607
41. Higgins, L. S., Rodems, J. M., Catalano, R, Quon, D., and Cordell, B. (1995) Proc. Natl. Acad. Sei. U. S. A. 92, 4402-4406
42. Morgan, P. M., Higgins, L. S., Cordell, B., and Moser, P. (1995) Proc. Natl. Acad. Sei. U. S. A. 92, 5341-5345