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Volumn 25, Issue 7, 2014, Pages 735-744

Anticancer properties of Monascus metabolites

Author keywords

cancer; lovastatin; Monascus metabolites; red mold rice

Indexed keywords

ANTINEOPLASTIC AGENT; FUNGAL EXTRACT; MEVINOLIN; NATURAL PRODUCT; POLYSACCHARIDE; STEROID; BIOLOGICAL PRODUCT; RADIOSENSITIZING AGENT;

EID: 84903815139     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000102     Document Type: Review
Times cited : (24)

References (78)
  • 1
    • 0033672984 scopus 로고    scopus 로고
    • Constituents of red yeast rice, a traditional Chinese food and medicine
    • Ma J, Li Y, Ye Q, Li J, Hua Y, Ju D, et al. Constituents of red yeast rice, a traditional Chinese food and medicine. J Agric Food Chem 2000; 48: 5220-5225.
    • (2000) J Agric Food Chem , vol.48 , pp. 5220-5225
    • Ma, J.1    Li, Y.2    Ye, Q.3    Li, J.4    Hua, Y.5    Ju, D.6
  • 2
    • 37449014910 scopus 로고    scopus 로고
    • Biologically active components and nutraceuticals in the Monascus-fermented rice: A review
    • Lin YL, Wang TH, Lee MH, Su NW. Biologically active components and nutraceuticals in the Monascus-fermented rice: a review. Appl Microbiol Biotechnol 2008; 77:965-973.
    • (2008) Appl Microbiol Biotechnol , vol.77 , pp. 965-973
    • Lin, Y.L.1    Wang, T.H.2    Lee, M.H.3    Su, N.W.4
  • 4
    • 84878494408 scopus 로고    scopus 로고
    • Monascus secondary metabolites: Production and biological activity
    • Patakova P. Monascus secondary metabolites: production and biological activity. J Ind Microbiol Biotechnol 2013; 40:169-181.
    • (2013) J Ind Microbiol Biotechnol , vol.40 , pp. 169-181
    • Patakova, P.1
  • 5
    • 84857918181 scopus 로고    scopus 로고
    • Monascus purpureus-fermented products and oral cancer: A review
    • Hsu WH, Pan TM. Monascus purpureus-fermented products and oral cancer: a review. Appl Microbiol Biotechnol 2012; 93:1831- 1842.
    • (2012) Appl Microbiol Biotechnol , vol.93 , pp. 1831-1842
    • Hsu, W.H.1    Pan, T.M.2
  • 7
    • 2442687001 scopus 로고    scopus 로고
    • The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: A case-control study
    • DOI 10.1002/cncr.20271
    • Boudreau DM, Gardner JS, Malone KE, Heckbert SR, Blough DK, Daling JR. The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use a nd breast carcinoma risk among postmenopausal women: a case-control study. Cancer 2004; 100:2308-2316. (Pubitemid 38657877)
    • (2004) Cancer , vol.100 , Issue.11 , pp. 2308-2316
    • Boudreau, D.M.1    Gardner, J.S.2    Malone, K.E.3    Heckbert, S.R.4    Blough, D.K.5    Daling, J.R.6
  • 9
    • 80055075364 scopus 로고    scopus 로고
    • Thalidomide, dexamethasone and lovastati n with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma
    • Hus M, Grzasko N, Szostek M, Pluta A, Helbig G, Woszczyk D, et al. Thalidomide, dexamethasone and lovastati n with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma. Ann Hematol 2011; 90: 1161-1166.
    • (2011) Ann Hematol , vol.90 , pp. 1161-1166
    • Hus, M.1    Grzasko, N.2    Szostek, M.3    Pluta, A.4    Helbig, G.5    Woszczyk, D.6
  • 10
    • 0030010318 scopus 로고    scopus 로고
    • Phase i study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
    • Thibault A, Samid D, Tompk ins AC, Figg WD, Cooper MR, Hohl RJ, et al. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin Cancer Res 1996; 2:483-2491.
    • (1996) Clin Cancer Res , vol.2 , pp. 483-2491
    • Thibault, A.1    Samid, D.2    Tompk Ins, A.C.3    Figg, W.D.4    Cooper, M.R.5    Hohl, R.J.6
  • 11
    • 77956239562 scopus 로고    scopus 로고
    • Cytotoxicity of Monascus pigments and their derivatives to human cancer cells
    • Zheng Y, Xin Y, Shi X, Guo Y. Cytotoxicity of Monascus pigments and their derivatives to human cancer cells. J Agric Food Chem 2010; 58: 9523-9528.
    • (2010) J Agric Food Chem , vol.58 , pp. 9523-9528
    • Zheng, Y.1    Xin, Y.2    Shi, X.3    Guo, Y.4
  • 12
    • 15544376827 scopus 로고    scopus 로고
    • Ankaflavin f rom Monascus-fermented red rice exhibits selective cytotoxic effect and induces cell death on Hep G2 cells
    • Su NW, Lin YL, Lee MH, Ho CY. Ankaflavin f rom Monascus-fermented red rice exhibits selective cytotoxic effect and induces cell death on Hep G2 cells. J Agric Food Chem 2005; 53:1949-1954.
    • (2005) J Agric Food Chem , vol.53 , pp. 1949-1954
    • Su, N.W.1    Lin, Y.L.2    Lee, M.H.3    Ho, C.Y.4
  • 14
    • 84864330818 scopus 로고    scopus 로고
    • Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways
    • Chen RJ, Hung CM, Chen YL,Wu MD, Yuan GF,Wang YJ. Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways. J Agric Food Chem 2012; 60:7185-7193.
    • (2012) J Agric Food Chem , vol.60 , pp. 7185-7193
    • Chen, R.J.1    Hung, C.M.2    Chen, Y.L.3    Wu, M.D.4    Yuan, G.F.5    Wang, Y.J.6
  • 15
    • 84856148338 scopus 로고    scopus 로고
    • Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus pur pureus NTU 568
    • Hsu LC, Hsu YW, Liang YH, Liaw CC, Kuo YH, Pan TM. Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus pur pureus NTU 568. Molecules 2012; 17:664-673.
    • (2012) Molecules , vol.17 , pp. 664-673
    • Hsu, L.C.1    Hsu, Y.W.2    Liang, Y.H.3    Liaw, C.C.4    Kuo, Y.H.5    Pan, T.M.6
  • 16
    • 77954867227 scopus 로고    scopus 로고
    • Monaphilones A-C three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568
    • Hsu YW, Hsu LC, Liang YH, Kuo YH, Pan TM. Monaphilones A-C, three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568. J Agric Food Chem 2010; 58:8211-8216.
    • (2010) J Agric Food Chem , vol.58 , pp. 8211-8216
    • Hsu, Y.W.1    Hsu, L.C.2    Liang, Y.H.3    Kuo, Y.H.4    Pan, T.M.5
  • 17
    • 70349333821 scopus 로고    scopus 로고
    • The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells
    • Ho BY, Pan TM. The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells. J Agric Food Chem 2009; 57:8258-8265.
    • (2009) J Agric Food Chem , vol.57 , pp. 8258-8265
    • Ho, B.Y.1    Pan, T.M.2
  • 18
    • 0031784485 scopus 로고    scopus 로고
    • Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
    • DOI 10.1023/A:1006058409974
    • Alonso DF, Farina HG, Skilton G, Gabri MR, De Lorenzo MS, Gomez DE. Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis. Breast Cancer Res Treat 1998; 50:83-93. (Pubitemid 28438864)
    • (1998) Breast Cancer Research and Treatment , vol.50 , Issue.1 , pp. 83-93
    • Alonso, D.F.1    Farina, H.G.2    Skilton, G.3    Gabri, M.R.4    De Lorenzo, M.S.5    Gomez, D.E.6
  • 19
    • 33645790809 scopus 로고    scopus 로고
    • Action of lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines
    • Depasquale I,Wheatley DN, Action of lovastatin (Mevinolin) on an in vitro model of angiogenesis and its co-culture with malignant melanoma cell lines, Cancer Cell Int,2006,6,9-20.
    • (2006) Cancer Cell Int , vol.6 , pp. 9-20
    • Depasquale, I.1    Wheatley, D.N.2
  • 20
    • 33745894663 scopus 로고    scopus 로고
    • A comparative study on the antimutagenicity of atorvastatin and lovastatin against directly acting mutagens
    • DOI 10.1007/s10565-006-0064-6
    • Ajith TA, Soja M. A comparative study on the antimutagenicity of atorvastatin and lovastatin against directly acting mutagens. Cell Biol Toxicol 2006; 22:269-274. (Pubitemid 44050816)
    • (2006) Cell Biology and Toxicology , vol.22 , Issue.4 , pp. 269-274
    • Ajith, T.A.1    Soja, M.2
  • 21
    • 84863706653 scopus 로고    scopus 로고
    • Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation
    • Lee BH, Hsu WH, Liao TH, Pan TM. Inhibition of leukemia proliferation by a novel polysaccharide identified from Monascus-fermented dioscorea via inducing differentiation. Food Funct 2012; 3:758-764.
    • (2012) Food Funct , vol.3 , pp. 758-764
    • Lee, B.H.1    Hsu, W.H.2    Liao, T.H.3    Pan, T.M.4
  • 22
    • 79960443950 scopus 로고    scopus 로고
    • Cytotoxic steroids from Monascus purpureus-fermented rice
    • Shang XY, Li JJ, Liu MT, Li S, Liu Y, Wang YF, et al. Cytotoxic steroids from Monascus purpureus-fermented rice. Steroids 2011; 76: 1185-1189.
    • (2011) Steroids , vol.76 , pp. 1185-1189
    • Shang, X.Y.1    Li, J.J.2    Liu, M.T.3    Li, S.4    Liu, Y.5    Wang, Y.F.6
  • 23
    • 44649156402 scopus 로고    scopus 로고
    • Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells
    • DOI 10.1016/j.jnutbio.2007.05.012, PII S095528630700143X
    • Hong MY, Seeram NP, Zhang Y, Heber D. Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. J Nutr Biochem 2008; 19:448-458. (Pubitemid 351783405)
    • (2008) Journal of Nutritional Biochemistry , vol.19 , Issue.7 , pp. 448-458
    • Hong, M.Y.1    Seeram, N.P.2    Zhang, Y.3    Heber, D.4
  • 24
    • 84874108141 scopus 로고    scopus 로고
    • Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells
    • Lee CI, Lee CL, Hwang JF, Lee YH,Wang JJ. Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells. Appl Microbiol Biotechnol 2013; 97:1269-1278.
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 1269-1278
    • Lee, C.I.1    Lee, C.L.2    Hwang, J.F.3    Lee, Y.H.4    Wang, J.J.5
  • 25
    • 77954188167 scopus 로고    scopus 로고
    • Effects of Monascus-fermented rice extract on malignant cell-associated neovascularization and intravasation determined using the chicken embryo chorioallantoic membrane model
    • Ho BY, Wu YM, Hsu YW, Hsu LC, Kuo YH, Chang KJ, et al. Effects of Monascus-fermented rice extract on malignant cell-associated neovascularization and intravasation determined using the chicken embryo chorioallantoic membrane model. Integr Cancer Ther 2010; 9:204-212.
    • (2010) Integr Cancer Ther , vol.9 , pp. 204-212
    • Ho, B.Y.1    Wu, Y.M.2    Hsu, Y.W.3    Hsu, L.C.4    Kuo, Y.H.5    Chang, K.J.6
  • 26
    • 78349287736 scopus 로고    scopus 로고
    • Red mold dioscorea-induced G2/M arrest and apoptosis in human oral cancer cells
    • Hsu WH, Lee BH, Pan TM. Red mold dioscorea-induced G2/M arrest and apoptosis in human oral cancer cells. J Sci Food Agric 2010; 90: 2709-2715.
    • (2010) J Sci Food Agric , vol.90 , pp. 2709-2715
    • Hsu, W.H.1    Lee, B.H.2    Pan, T.M.3
  • 27
    • 0026039147 scopus 로고
    • Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin
    • Keyomarsi K, Sandoval L, Band V, Pardee AB. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 1991; 51:3602-3609.
    • (1991) Cancer Res , vol.51 , pp. 3602-3609
    • Keyomarsi, K.1    Sandoval, L.2    Band, V.3    Pardee, A.B.4
  • 28
    • 54849187000 scopus 로고    scopus 로고
    • BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: Analyses using a breast cancer cell line and tumoral xenograft model
    • Yu X, Luo Y, Zhou Y, Zhang Q,Wang J,Wei N, et al. BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model. Int J Oncol 2008; 33:555-563.
    • (2008) Int J Oncol , vol.33 , pp. 555-563
    • Yu, X.1    Luo, Y.2    Zhou, Y.3    Zhang, Q.4    Wang, J.5    Wei, N.6
  • 29
    • 80255131406 scopus 로고    scopus 로고
    • Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-reg ulation of p27 by interfering with the Rho/ROCK-mediated pathway
    • Zhong WB, Hsu SP, Ho PY, Liang YC, Chang TC, Lee WS. Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-reg ulation of p27 by interfering with the Rho/ROCK-mediated pathway. Biochem Pharmacol 2011; 82:1663-1672.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1663-1672
    • Zhong, W.B.1    Hsu, S.P.2    Ho, P.Y.3    Liang, Y.C.4    Chang, T.C.5    Lee, W.S.6
  • 30
    • 77949697998 scopus 로고    scopus 로고
    • A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells
    • Sane KM, Mynderse M, Lalonde DT, Dean IS,Wojtkowiak JW, Fouad F, et al. A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells. J Pharmacol Exp Ther 2010; 333:23-33.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 23-33
    • Sane, K.M.1    Mynderse, M.2    Lalonde, D.T.3    Dean, I.S.4    Wojtkowiak, J.W.5    Fouad, F.6
  • 31
    • 84855905371 scopus 로고    scopus 로고
    • Proteomics and bioinformatics analysis of lovastatin-induced differentiation in ARO cells
    • Shui HA, Hsia CW, Chen H M, Chang TC, Wang CY. Proteomics and bioinformatics analysis of lovastatin-induced differentiation in ARO cells. J Proteomics 2012; 75:1170-1180.
    • (2012) J Proteomics , vol.75 , pp. 1170-1180
    • Shui, H.A.1    Hsia, C.W.2    Chen, H.M.3    Chang, T.C.4    Wang, C.Y.5
  • 32
    • 36148976847 scopus 로고    scopus 로고
    • Proteome changes in Caco-2 cells treated with Monascus-fermented red mold rice extract
    • Lin WY, Hsu WY, Hish CH, Pan TM. Proteome changes in Caco-2 cells treated with Monascus-fermented red mold rice extract. J Agric Food Chem 2007; 55:8987-8994.
    • (2007) J Agric Food Chem , vol.55 , pp. 8987-8994
    • Lin, W.Y.1    Hsu, W.Y.2    Hish, C.H.3    Pan, T.M.4
  • 33
    • 79951745526 scopus 로고    scopus 로고
    • Anti-tumor and anti inflammatory properties of ankaflavin and monaphilone A from Monascus purpureus NTU 568
    • Hsu LC, Hsu YW, Liang YH, Kuo YH, Pan TM. Anti-tumor and anti inflammatory properties of ankaflavin and monaphilone A from Monascus purpureus NTU 568. J Agric Food Chem 2011; 59:1124-1130.
    • (2011) J Agric Food Chem , vol.59 , pp. 1124-1130
    • Hsu, L.C.1    Hsu, Y.W.2    Liang, Y.H.3    Kuo, Y.H.4    Pan, T.M.5
  • 34
    • 38949123783 scopus 로고    scopus 로고
    • In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent
    • Maksimova E, Yie TA, Rom WN. In vitro mechanisms of lovastatin on lung cancer cell lines as a potential chemopreventive agent. Lung 2008; 186: 45-54.
    • (2008) Lung , vol.186 , pp. 45-54
    • Maksimova, E.1    Yie, T.A.2    Rom, W.N.3
  • 36
    • 79957892969 scopus 로고    scopus 로고
    • Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP pr ostate cancer cells
    • Yang L, Egger M, Plattner R, Klocker H, Eder IE. Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP pr ostate cancer cells. Urology 2011; 77:e1-e7.
    • (2011) Urology , vol.77
    • Yang, L.1    Egger, M.2    Plattner, R.3    Klocker, H.4    Eder, I.E.5
  • 37
    • 70449574594 scopus 로고    scopus 로고
    • Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention
    • Guruswamy S, Rao CV. Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: implications for colon cancer prevention. Int J Oncol 2009; 35:1037-1043.
    • (2009) Int J Oncol , vol.35 , pp. 1037-1043
    • Guruswamy, S.1    Rao, C.V.2
  • 38
    • 67349105662 scopus 로고    scopus 로고
    • Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibit or in hepatocellular carcinoma
    • Kim W, Yoon JH, Kim JR, Jang IJ, Bang YJ, Kim YJ, et al. Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibit or in hepatocellular carcinoma. Cancer Chemother Pharmacol 2009; 64:497-507.
    • (2009) Cancer Chemother Pharmacol , vol.64 , pp. 497-507
    • Kim, W.1    Yoon, J.H.2    Kim, J.R.3    Jang, I.J.4    Bang, Y.J.5    Kim, Y.J.6
  • 39
    • 84887419206 scopus 로고    scopus 로고
    • Lovastatin-induced ap optosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal
    • Niknejad N, Gorn-Hondermann I, Ma L, Zahr S, Johnson-Obeseki S, Corsten M, et al. Lovastatin-induced ap optosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal. Int J Cancer 2014; 134:268-279.
    • (2014) Int J Cancer , vol.134 , pp. 268-279
    • Niknejad, N.1    Gorn-Hondermann, I.2    Ma, L.3    Zahr, S.4    Johnson-Obeseki, S.5    Corsten, M.6
  • 40
    • 56949083359 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state
    • Laezza C,Fiorentino L,Pisanti S,Gazzerro P,Caraglia M,Portella G,et al,Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state, J Mol Med (Berl),2008, 86,1341-1351.
    • (2008) J Mol Med (Berl) , vol.86 , pp. 1341-1351
    • Laezza, C.1    Fiorentino, L.2    Pisanti, S.3    Gazzerro, P.4    Caraglia, M.5    Portella, G.6
  • 41
    • 84866460606 scopus 로고    scopus 로고
    • Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: Implication for therapy
    • Shi Y, Felley-Bosco E, Marti TM, Stahel RA. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS One 2012; 7:e45354.
    • (2012) PLoS One , vol.7
    • Shi, Y.1    Felley-Bosco, E.2    Marti, T.M.3    Stahel, R.A.4
  • 44
    • 84867021493 scopus 로고    scopus 로고
    • Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squa mous cell carcinoma cells
    • Ma L, Niknejad N, Gorn-Hondermann I, Dayekh K, Dimitroulakos J. Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squa mous cell carcinoma cells. PLoS One 2012; 7:e46055.
    • (2012) PLoS One , vol.7
    • Ma, L.1    Niknejad, N.2    Gorn-Hondermann, I.3    Dayekh, K.4    Dimitroulakos, J.5
  • 45
    • 35648985077 scopus 로고    scopus 로고
    • Activation of the integrated stress response regulates lovastatin-induced apoptosis
    • DOI 10.1074/jbc.M705859200
    • Niknejad N, Morley M, Dimitroulakos J. Activation of the integrated stress response regulates lovastatin-induced apoptosis. J Biol Chem 2007; 282:29748-29756. (Pubitemid 350035248)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.41 , pp. 29748-29756
    • Niknejad, N.1    Morley, M.2    Dimitroulakos, J.3
  • 46
    • 79953691809 scopus 로고    scopus 로고
    • NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells
    • Savas S, Azorsa DO, Jarjanazi H, Ibrahim-Zada I, Gonzales IM, Arora S, et al. NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells. PLoS One 2011; 6:e18306.
    • (2011) PLoS One , vol.6
    • Savas, S.1    Azorsa, D.O.2    Jarjanazi, H.3    Ibrahim-Zada, I.4    Gonzales, I.M.5    Arora, S.6
  • 48
    • 0033557949 scopus 로고    scopus 로고
    • Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach
    • Dimitroulakos J, Nohynek D, Backway KL, Hedley DW, Yeger H, Freedman MH, et al. Increased sensitivity of acute mye loid leukemias to lovastatin-induced apoptosis: a potential therapeutic approach. Blood 1999; 93:1308-1318. (Pubitemid 29076146)
    • (1999) Blood , vol.93 , Issue.4 , pp. 1308-1318
    • Dimitroulakos, J.1    Nohynek, D.2    Backway, K.L.3    Medley, D.W.4    Yeger, H.5    Freedman, M.H.6    Minden, M.D.7    Penn, L.Z.8
  • 49
  • 50
    • 67649380732 scopus 로고    scopus 로고
    • Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras
    • Kang S, Kim ES, Moon A. Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep 2009; 21:1317-1322.
    • (2009) Oncol Rep , vol.21 , pp. 1317-1322
    • Kang, S.1    Kim, E.S.2    Moon, A.3
  • 51
    • 0036158675 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
    • Kusama T, Mukai M, Iwasaki T, Tatsuta M, Matsumoto Y, Akedo H, et al. 3-Hydroxy-3-methylglu taryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Gastroenterology 2002; 122:308-317. (Pubitemid 34116983)
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 308-317
    • Kusama, T.1    Mukai, M.2    Iwasaki, T.3    Tatsuta, M.4    Matsumoto, Y.5    Akedo, H.6    Inoue, M.7    Nakamura, H.8
  • 52
    • 28844433954 scopus 로고    scopus 로고
    • Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells
    • DOI 10.1016/j.bbrc.2005.11.075, PII S0006291X05025970
    • Lee J, Lee I, Park C, Kang WK. Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells. Biochem Biophys Res Commun 2006; 339:748-754. (Pubitemid 41772877)
    • (2006) Biochemical and Biophysical Research Communications , vol.339 , Issue.3 , pp. 748-754
    • Lee, J.1    Lee, I.2    Park, C.3    Kang, W.K.4
  • 53
    • 26944457329 scopus 로고    scopus 로고
    • Lovastatin suppresses invasiven ess of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling
    • Zhong WB, Liang YC, Wang CY, Chang TC, Lee WS. Lovastatin suppresses invasiven ess of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling. Endocr Relat Cancer 2005; 12:615-629.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 615-629
    • Zhong, W.B.1    Liang, Y.C.2    Wang, C.Y.3    Chang, T.C.4    Lee, W.S.5
  • 54
    • 57349135304 scopus 로고    scopus 로고
    • Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer
    • Horiuchi A, Kikuchi N, Osada R, Wang C, Hayashi A, Nikaido T, et al. Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer. Cancer Sci 2008; 99:2532-2539.
    • (2008) Cancer Sci , vol.99 , pp. 2532-2539
    • Horiuchi, A.1    Kikuchi, N.2    Osada, R.3    Wang, C.4    Hayashi, A.5    Nikaido, T.6
  • 55
    • 33645664011 scopus 로고    scopus 로고
    • Lovastatin and thalidomide have a combined effect on the rate of multiple myeloma cell apoptosis in short term cell cultures
    • Dmoszynska A, Podhor ecka M, Klimek P, Grzasko N. Lovastatin and thalidomide have a combined effect on the rate of multiple myeloma cell apoptosis in short term cell cultures. Eur J Clin Pharmacol 2006; 62: 325-329.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 325-329
    • Dmoszynska, A.1    Podhor Ecka, M.2    Klimek, P.3    Grzasko, N.4
  • 56
    • 78549272997 scopus 로고    scopus 로고
    • Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations
    • Park IH, Kim JY, Jung JI, Han JY. Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations. Invest New Drugs 2010; 28:791-799.
    • (2010) Invest New Drugs , vol.28 , pp. 791-799
    • Park, I.H.1    Kim, J.Y.2    Jung, J.I.3    Han, J.Y.4
  • 57
    • 79951768538 scopus 로고    scopus 로고
    • Lovastatin sensitizes lung cancer cells to ionizing radiation: Modulation of molecular pathways of radioresistance and tumor suppression
    • Sanli T, Liu C, Rashid A, Hopmans SN, Tsiani E, Schultz C, et al. Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. J Thorac Oncol 2011; 6:439-450.
    • (2011) J Thorac Oncol , vol.6 , pp. 439-450
    • Sanli, T.1    Liu, C.2    Rashid, A.3    Hopmans, S.N.4    Tsiani, E.5    Schultz, C.6
  • 58
    • 50649104814 scopus 로고    scopus 로고
    • Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status
    • Cemeus C, Zhao TT, Barrett GM, Lorimer IA, Dimitroulakos J. Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status. J Neuro oncol 2008; 90:9-17.
    • (2008) J Neuro Oncol , vol.90 , pp. 9-17
    • Cemeus, C.1    Zhao, T.T.2    Barrett, G.M.3    Lorimer, I.A.4    Dimitroulakos, J.5
  • 59
    • 77958520300 scopus 로고    scopus 로고
    • Lovastatin inhibits VEGFR and AKT activation: Synergistic cytotoxicity in combination with VEGFR inhibitors
    • Zhao TT, Trinh D, Addison CL, Dimitroulakos J. Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. PLoS One 2 010; 5:e12563.
    • (2010) PLoS One , vol.5
    • Zhao, T.T.1    Trinh, D.2    Addison, C.L.3    Dimitroulakos, J.4
  • 61
    • 84863630617 scopus 로고    scopus 로고
    • Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy
    • Chiu HW, Fang WH, Chen YL, Wu MD, Yuan GF, Ho SY, et al. Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy. PLoS One 2012; 7:e40462.
    • (2012) PLoS One , vol.7
    • Chiu, H.W.1    Fang, W.H.2    Chen, Y.L.3    Wu, M.D.4    Yuan, G.F.5    Ho, S.Y.6
  • 63
    • 84877267450 scopus 로고    scopus 로고
    • Preventive effects of Monascus on androgen-related diseases: Androgenetic alopecia, ben ign prostatic hyperplasia, and prostate cancer
    • Chiu HW, Chen MH, Fang WH, Hung CM, Chen YL, Wu MD, et al. Preventive effects of Monascus on androgen-related diseases: androgenetic alopecia, ben ign prostatic hyperplasia, and prostate cancer. J Agric Food Chem 2013; 61:4379-4386.
    • (2013) J Agric Food Chem , vol.61 , pp. 4379-4386
    • Chiu, H.W.1    Chen, M.H.2    Fang, W.H.3    Hung, C.M.4    Chen, Y.L.5    Wu, M.D.6
  • 64
    • 79959232583 scopus 로고    scopus 로고
    • Red mold rice mitigates oral carcinogenesis in 7,12-dimethyl-1,2- benzaanthracene-indu ced oral carcinogenesis in hamster
    • Tsai RL, Ho BY, Pan TM. Red mold rice mitigates oral carcinogenesis in 7,12-dimethyl-1,2-benzaanthracene-indu ced oral carcinogenesis in hamster. Evid Based Complement Alternat Med 2011; 2011: 245209.
    • (2011) Evid Based Complement Alternat Med , vol.2011 , pp. 245209
    • Tsai, R.L.1    Ho, B.Y.2    Pan, T.M.3
  • 65
    • 79955657286 scopus 로고    scopus 로고
    • Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model
    • Hsu WH, Lee BH, Pan TM. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food Chem Toxicol 2011; 49:1292-1297.
    • (2011) Food Chem Toxicol , vol.49 , pp. 1292-1297
    • Hsu, W.H.1    Lee, B.H.2    Pan, T.M.3
  • 66
    • 77953156481 scopus 로고    scopus 로고
    • Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidat ive potentials
    • Hsu WH, Lee BH, Pan TM. Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidat ive potentials. J Agric Food Chem 2010; 58:6715-6720.
    • (2010) J Agric Food Chem , vol.58 , pp. 6715-6720
    • Hsu, W.H.1    Lee, B.H.2    Pan, T.M.3
  • 67
    • 28844495629 scopus 로고    scopus 로고
    • Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies
    • DOI 10.1007/s00280-005-0013-8
    • Holstein SA, Knapp HR, Clamon GH, Murry DJ, Hohl RJ. Pharmacodynamic effects of high dose lovastatin in subjects with advanced malign ancies. Cancer Chemother Pharmacol 2006; 57:155-164. (Pubitemid 41779834)
    • (2006) Cancer Chemotherapy and Pharmacology , vol.57 , Issue.2 , pp. 155-164
    • Holstein, S.A.1    Knapp, H.R.2    Clamon, G.H.3    Murry, D.J.4    Hohl, R.J.5
  • 68
    • 20044366735 scopus 로고    scopus 로고
    • A phase i trial of prolonged administration of lovasta tin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix
    • Knox JJ, Siu LL, Chen E, Dimitroulakos J, Kamel-Reid S, Moore MJ, et al. A phase I trial of prolonged administration of lovasta tin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix. Eur J Cancer 2005; 41:523-1530.
    • (2005) Eur J Cancer , vol.41 , pp. 523-1530
    • Knox, J.J.1    Siu, L.L.2    Chen, E.3    Dimitroulakos, J.4    Kamel-Reid, S.5    Moore, M.J.6
  • 69
  • 71
    • 33646266975 scopus 로고    scopus 로고
    • Cytotoxic and antimitotic effects of N-containing Monascus metabolites studied using immortalized human kidney epithelial cells
    • Knecht A, Humpf HU. Cytotoxic and antimitotic effects of N-containing Monascus metabolites studied using immortalized human kidney epithelial cells. Mol Nutr Food Res 2006; 50:406-412.
    • (2006) Mol Nutr Food Res , vol.50 , pp. 406-412
    • Knecht, A.1    Humpf, H.U.2
  • 73
    • 23744501374 scopus 로고    scopus 로고
    • Study on red fermented rice with high concentration of monacolin K and low concentration of citrinin
    • DOI 10.1016/j.ijfoodmicro.2005.03.002, PII S0168160505001881
    • Chen F, Hu X. Study on red fermented rice with high concentration of monacolin K and low concentration of citrinin. Int J Food Microbiol 2005; 103:331-337. (Pubitemid 41138815)
    • (2005) International Journal of Food Microbiology , vol.103 , Issue.3 , pp. 331-337
    • Chen, F.1    Hu, X.2
  • 74
    • 34548041614 scopus 로고    scopus 로고
    • Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition
    • Lee CL, Hung HK,Wang JJ, Pan TM. Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem 2007; 55:6493-6502.
    • (2007) J Agric Food Chem , vol.55 , pp. 6493-6502
    • Lee, C.L.1    Hung, H.K.2    Wang, J.J.3    Pan, T.M.4
  • 75
    • 84857763616 scopus 로고    scopus 로고
    • Effect of amino acids on red pigments and citrinin production in Monascus ruber
    • Hajjaj H, Francois JM, Goma G, Blanc PJ. Effect of amino acids on red pigments and citrinin production in Monascus ruber. J Food Sci 2012; 77:M156-M159.
    • (2012) J Food Sci , vol.77
    • Hajjaj, H.1    Francois, J.M.2    Goma, G.3    Blanc, P.J.4
  • 76
    • 70449529310 scopus 로고    scopus 로고
    • Elimination of the mycotoxin citrinin production in the industrial important strain Monascus purpureus SM001
    • Jia XQ, Xu ZN, Zhou LP, Sung CK. Elimination of the mycotoxin citrinin production in the industrial important strain Monascus purpureus SM001. Metab Eng 2010; 12:1-7.
    • (2010) Metab Eng , vol.12 , pp. 1-7
    • Jia, X.Q.1    Xu, Z.N.2    Zhou, L.P.3    Sung, C.K.4
  • 77
    • 8444237432 scopus 로고    scopus 로고
    • Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture
    • Wang JJ, Lee CL, Pan TM. Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture. J Agric Food Chem 2004; 52:6977-6982.
    • (2004) J Agric Food Chem , vol.52 , pp. 6977-6982
    • Wang, J.J.1    Lee, C.L.2    Pan, T.M.3
  • 78
    • 78049264831 scopus 로고    scopus 로고
    • Marked variability of monacolin levels in commercial red yeast rice products: Buyer beware
    • Gordon RY, Cooperman T, Obermeyer W, Becker DJ. Marked variability of monacolin levels in commercial red yeast rice products: buyer beware! Arch Intern Med 2010; 170:1722 -1727.
    • (2010) Arch Intern Med , vol.170 , pp. 1722-1727
    • Gordon, R.Y.1    Cooperman, T.2    Obermeyer, W.3    Becker, D.J.4


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