Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state

Journal of Molecular Medicine

Volumn 86, Issue 12, 2008, Pages 1341-1351

  Laezza, Chiara ^a,b   Fiorentino, Laura ^c   Pisanti, Simona ^c   Gazzerro, Patrizia ^c   Caraglia, Michele ^d   Portella, Giuseppe ^b   Vitale, Mario ^b   Bifulco, Maurizio ^c  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Farnesylation; Lovastatin; RAS; Thyroid

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN FARNESYLTRANSFERASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL CYCLE ARREST; CELL DEATH; CELL TYPE; CONTROLLED STUDY; DRUG EFFECT; IN VIVO STUDY; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; THYROID CELL; TREATMENT DURATION; TUMOR VOLUME; VIRUS ONCOGENE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENES, RAS; LOVASTATIN; MALE; MICE; MICE, NUDE; PRENYLATION; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THYROID GLAND;

EID: 56949083359     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0396-1     Document Type: Article

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