메뉴 건너뛰기




Volumn 19, Issue 7, 2014, Pages 845-858

Treating obesity: Is it all in the gut?

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE PLUS NALTREXONE; AMYLIN; ANTIOBESITY AGENT; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HORMONE RECEPTOR; LORCASERIN; OXYNTOMODULIN; PHENTERMINE PLUS TOPIRAMATE; POLYPEPTIDE; TYROSINE; GASTROINTESTINAL HORMONE;

EID: 84903787238     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.10.025     Document Type: Review
Times cited : (14)

References (116)
  • 1
    • 84903790988 scopus 로고    scopus 로고
    • Available at: http://www.who.int/mediacentre/factsheets/fs311/en
  • 2
    • 79953193199 scopus 로고    scopus 로고
    • The NHS Centre for Health and Social Care
    • M. Aresu et al. Health Survey for England 2010 The NHS Centre for Health and Social Care
    • (2010) Health Survey for England
    • Aresu, M.1
  • 3
    • 84903778892 scopus 로고    scopus 로고
    • Review: Orlistat and sibutramine are modestly effective for weight loss at 1 year
    • C.D. Byrne, and S. Wilde Review: orlistat and sibutramine are modestly effective for weight loss at 1 year ACP J. Club 142 2005 19
    • (2005) ACP J. Club , vol.142 , pp. 19
    • Byrne, C.D.1    Wilde, S.2
  • 4
    • 84903759918 scopus 로고    scopus 로고
    • New drug targets for the treatment of obesity
    • A.G. Powell et al. New drug targets for the treatment of obesity Clin. Pharmacol. Ther. 293 2011 43 53
    • (2011) Clin. Pharmacol. Ther. , vol.293 , pp. 43-53
    • Powell, A.G.1
  • 5
    • 84903763243 scopus 로고    scopus 로고
    • Available at: http://ir.vivus.com/releasedetail.cfm?ReleaseID=631582
  • 6
    • 84862122167 scopus 로고    scopus 로고
    • Gut hormones: The future of obesity treatment?
    • A.K. McGavigan, and K.G. Murphy Gut hormones: the future of obesity treatment? Br. J. Clin. Pharmacol. 74 2012 911 919
    • (2012) Br. J. Clin. Pharmacol. , vol.74 , pp. 911-919
    • McGavigan, A.K.1    Murphy, K.G.2
  • 7
    • 2642556637 scopus 로고    scopus 로고
    • Topiramate in migraine prophylaxis - Results from the placebo-controlled trial with propranol as an active control
    • H.C. Diener et al. Topiramate in migraine prophylaxis - results from the placebo-controlled trial with propranol as an active control J. Neurol. 251 2004 943 950
    • (2004) J. Neurol. , vol.251 , pp. 943-950
    • Diener, H.C.1
  • 8
    • 84903769060 scopus 로고    scopus 로고
    • Available at: http://ir.vivus.com/releasedetail.cfm?ReleaseID=650759
  • 9
    • 84901317398 scopus 로고    scopus 로고
    • Weight gain, sexual dysfunction, and bupropion
    • M.J. Menaster Weight gain, sexual dysfunction, and bupropion J. Clin. Psychiatry 66 2005 1335 1336
    • (2005) J. Clin. Psychiatry , vol.66 , pp. 1335-1336
    • Menaster, M.J.1
  • 10
    • 0037013589 scopus 로고    scopus 로고
    • Naltrexone in alcohol dependence: A randomised controlled trial of effectiveness in a standard clinical setting
    • N.C. Latt et al. Naltrexone in alcohol dependence: a randomised controlled trial of effectiveness in a standard clinical setting Med. J. Aust. 176 2002 530 534 (Pubitemid 34649401)
    • (2002) Medical Journal of Australia , vol.176 , Issue.11 , pp. 530-534
    • Latt, N.C.1    Jurd, S.2    Houseman, J.3    Wutzke, S.E.4
  • 11
    • 84903775084 scopus 로고    scopus 로고
    • Available at: http://ir.orexigen.com/phoenix.zhtml?c=207034&p=irol- newsArticle&ID=1432740&highlight
  • 12
    • 84903771867 scopus 로고    scopus 로고
    • Available at: http://ir.orexigen.com/phoenix.zhtml?c=207034&p=irol- newsArticle&ID=1771665&highlight
  • 13
    • 84903759186 scopus 로고    scopus 로고
    • Available at: http://invest.arenapharm.com/releasedetail.cfm?releaseid= 521977
  • 14
    • 84903757006 scopus 로고    scopus 로고
    • Available at: http://invest.arenapharm.com/releasedetail.cfm?releaseid= 597830
  • 15
    • 84903751480 scopus 로고    scopus 로고
    • Available at: http://invest.arenapharm.com/releasedetail.cfm?ReleaseID= 687182
  • 16
    • 84903764320 scopus 로고    scopus 로고
    • Available at: http://invest.arenapharm.com/releasedetail.cfm?releaseid= 645020
  • 17
    • 33646878552 scopus 로고    scopus 로고
    • A case-controlled matched-pair cohort study of laparoscopic Roux-en-Y gastric bypass and Lap-Band® patients in a single US center with three-year follow-up
    • DOI 10.1381/096089206776944913
    • D.R. Cottam et al. A case-controlled matched-pair cohort study of laparoscopic Roux-en-Y gastric bypass and Lap-Band patients in a single US centre with three year follow-up Obes. Surg. 16 2006 534 540 (Pubitemid 43781035)
    • (2006) Obesity Surgery , vol.16 , Issue.5 , pp. 534-540
    • Cottam, D.R.1    Atkinson, J.2    Anderson, A.3    Grace, B.4    Fisher, B.5
  • 19
    • 33746036883 scopus 로고    scopus 로고
    • Laparoscopic gastric bypass is superior to adjustable gastric band in super morbidly obese patients: A prospective, comparable analysis
    • W.B. Browne et al. Laparoscopic gastric bypass is superior to adjustable gastric band in super morbidly obese patients: a prospective, comparable analysis Obes. Surg. 141 2006 683 689
    • (2006) Obes. Surg. , vol.141 , pp. 683-689
    • Browne, W.B.1
  • 20
    • 84860136615 scopus 로고    scopus 로고
    • Bariatric surgery versus intensive medical therapy in obese patients with diabetes
    • P.R. Schauer et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes N. Engl. J. Med. 366 2012 1567 1576
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1567-1576
    • Schauer, P.R.1
  • 21
    • 84859419232 scopus 로고    scopus 로고
    • Bariatric surgery versus conventional medical therapy for type 2 diabetes
    • G. Mingrone et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes N. Engl. J. Med. 366 2012 1577 1585
    • (2012) N. Engl. J. Med. , vol.366 , pp. 1577-1585
    • Mingrone, G.1
  • 22
    • 0025340621 scopus 로고
    • Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty
    • J.M. Kellum et al. Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty Ann. Surg. 211 1990 763 770
    • (1990) Ann. Surg. , vol.211 , pp. 763-770
    • Kellum, J.M.1
  • 24
    • 33646411242 scopus 로고    scopus 로고
    • GLP-1 PYY, hunger and satiety after gastric bypass surgery in morbidly obese subjects
    • R. Morinigo et al. GLP-1 PYY, hunger and satiety after gastric bypass surgery in morbidly obese subjects J. Clin. Endocrinol. Metab. 91 2006 1735 1740
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1735-1740
    • Morinigo, R.1
  • 25
    • 25844495011 scopus 로고    scopus 로고
    • Medicinal chemical properties of successful central nervous system drugs
    • DOI 10.1602/neurorx.2.4.541
    • H. Pajoughesh, and G.R. Lenz Medicinal chemical properties of successful central nervous system drugs NeuroTherpeutics 2 2005 541 553 (Pubitemid 41393264)
    • (2005) NeuroRx , vol.2 , Issue.4 , pp. 541-553
    • Pajouhesh, H.1    Lenz, G.R.2
  • 26
    • 25844469583 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
    • DOI 10.1602/neurorx.2.4.554
    • M.S. Alavijeh et al. Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery NeuroTherpeutics 2 2005 554 571 (Pubitemid 41393265)
    • (2005) NeuroRx , vol.2 , Issue.4 , pp. 554-571
    • Alavijeh, M.S.1    Chishty, M.2    Qaiser, M.Z.3    Palmer, A.M.4
  • 27
    • 33845875966 scopus 로고    scopus 로고
    • Gut hormones and the regulation of energy homeostasis
    • DOI 10.1038/nature05484, PII NATURE05484
    • K.G. Murphy, and S.R. Bloom Gut hormones and the regulation of energy homeostasis Nature 444 2006 854 859 (Pubitemid 46024992)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 854-859
    • Murphy, K.G.1    Bloom, S.R.2
  • 28
    • 68949177102 scopus 로고    scopus 로고
    • Gut hormones: Implications for the treatment of obesity
    • R.L. Batterham, and M.T. Neary Gut hormones: implications for the treatment of obesity Br. J. Clin. Pharmacol. 124 2009 44 56
    • (2009) Br. J. Clin. Pharmacol. , vol.124 , pp. 44-56
    • Batterham, R.L.1    Neary, M.T.2
  • 29
    • 0025950606 scopus 로고
    • Co-secretion of amylin and insulin from cultured islet beta cells: Modulation by nutrient secretagogues, islet hormones and hypoglycemic agents
    • C.X. Moore, and G.J. Cooper Co-secretion of amylin and insulin from cultured islet beta cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents Biochem. Biophys. Res. Commun. 179 1991 1 9
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 1-9
    • Moore, C.X.1    Cooper, G.J.2
  • 31
    • 0029913870 scopus 로고    scopus 로고
    • 2, amylin, cholecystokinin, and other possible regulators of nutrient uptake
    • DOI 10.1016/S0026-0495(96)90192-4
    • A.A. Young et al. Dose responses for the slowing of gastric emptying in a rodent model by glucagonlike peptite (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake Metabolism 45 1996 1 3 (Pubitemid 26104260)
    • (1996) Metabolism: Clinical and Experimental , vol.45 , Issue.1 , pp. 1-3
    • Young, A.A.1    Gedulin, B.R.2    Rink, T.J.3
  • 32
    • 56149124659 scopus 로고    scopus 로고
    • Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity
    • S.R. Smith et al. Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity Diabetes Care 31 2008 1816 1823
    • (2008) Diabetes Care , vol.31 , pp. 1816-1823
    • Smith, S.R.1
  • 33
    • 69749086148 scopus 로고    scopus 로고
    • Enhanced weight loss with pramlintide/metreleptin: An integrated neurohormonal approach to obesity pharmacotherapy
    • S.R. Smith et al. Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy Obesity 17 2009 1736 1743
    • (2009) Obesity , vol.17 , pp. 1736-1743
    • Smith, S.R.1
  • 35
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
    • DOI 10.1016/j.cell.2008.01.017, PII S0092867408001177
    • J. Yang et al. Identification of the acyltransferase that octanoylates ghrelin, an appetite stimulating peptide hormone Cell 132 2008 387 396 (Pubitemid 351192001)
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 39
    • 29344464362 scopus 로고    scopus 로고
    • Effects of a fixed meal pattern on ghrelin secretion: Evidence for a learned response independent of nutrient status
    • DOI 10.1210/en.2005-0973
    • D.L. Drazen et al. Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status Endocrinology 147 2006 23 30 (Pubitemid 43004258)
    • (2006) Endocrinology , vol.147 , Issue.1 , pp. 23-30
    • Drazen, D.L.1    Vahl, T.P.2    D'Alessio, D.A.3    Seeley, R.J.4    Woods, S.C.5
  • 43
    • 0022398837 scopus 로고
    • Human distribution and release of a putative new gut hormone, peptide YY
    • T.E. Adrian et al. Human distribution and release of a putative gut hormone, peptide YY Gastroenterology 89 1985 1070 1077 (Pubitemid 16231572)
    • (1985) Gastroenterology , vol.89 , Issue.5 , pp. 1070-1077
    • Adrian, T.E.1    Ferri, G.L.2    Bacarese-Hamilton, A.J.3
  • 44
    • 58149522006 scopus 로고    scopus 로고
    • The influence of the resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin and peptide YY in healthy males
    • D.R. Broom et al. The influence of the resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin and peptide YY in healthy males Am. J. Physiol. Regul. Integr. Comp. Physiol. 296 2008 29 35
    • (2008) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.296 , pp. 29-35
    • Broom, D.R.1
  • 45
    • 66149150954 scopus 로고    scopus 로고
    • Subject standardization, acclimatization and sample processing affect gut hormone levels and appetite in humans
    • K. Chandarana et al. Subject standardization, acclimatization and sample processing affect gut hormone levels and appetite in humans Gastroenterology 136 2009 2115 2126
    • (2009) Gastroenterology , vol.136 , pp. 2115-2126
    • Chandarana, K.1
  • 46
    • 84903762805 scopus 로고
    • Low hepatic clearance of peptide YY in the perfused rat liver
    • K. Beckh et al. Low hepatic clearance of peptide YY in the perfused rat liver Regul. Pept. 76 1992 473 478
    • (1992) Regul. Pept. , vol.76 , pp. 473-478
    • Beckh, K.1
  • 47
    • 84903776843 scopus 로고    scopus 로고
    • Available at: http://www.7tm.com/News/News-Archive.aspx?M=News&PID= 45&NewsID=9
  • 48
    • 84903776665 scopus 로고    scopus 로고
    • Available at: http://www.news-medical.net/news/20100918/Emispheree28099s- SNAC-drug-successful-in-reducing-food-intake3b-increasing-satiety.aspx
  • 49
    • 84903774296 scopus 로고    scopus 로고
    • Available at: http://ir.emisphere.com/releasedetail.cfm?ReleaseID=508492
  • 50
    • 0028281773 scopus 로고
    • Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans
    • C. Orskov et al. Tissue and plasma concentrations of amidated and glycine rich glucagon-like peptide 1 in humans Diabetes 43 1994 535 539 (Pubitemid 24096293)
    • (1994) Diabetes , vol.43 , Issue.4 , pp. 535-539
    • Orskov, C.1    Rabenhoj, L.2    Wettergren, A.3    Kofod, H.4    Holst, J.J.5
  • 51
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • R. Mentlein et al. DPP-IV hydrolyses gastric inhibitory polypeptide, glucagon like peptide-1 (7-36) amide, peptide histidine methionine and is responsible for their degradation in human serum Eur. J. Biochem. 214 1993 829 835 (Pubitemid 23188160)
    • (1993) European Journal of Biochemistry , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 52
    • 0029765475 scopus 로고    scopus 로고
    • Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
    • C. Orskov et al. Secretion of the incretin hormones GLP-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day Scand. J. Gastroenterol. 31 1996 665 670 (Pubitemid 26290929)
    • (1996) Scandinavian Journal of Gastroenterology , vol.31 , Issue.7 , pp. 665-670
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 53
    • 18144381593 scopus 로고    scopus 로고
    • 3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • DOI 10.1016/j.brainres.2005.03.011
    • C.R. Abbott et al. The inhibitory effect of peripheral administration of peptide YY and GLP-1 on food intake are attenuated by the ablation of the vaga-brainstem-hypothalmic pathway Brain Res. 1044 2005 127 131 (Pubitemid 40616060)
    • (2005) Brain Research , vol.1044 , Issue.1 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5    Parkinson, J.R.C.6    Ghatei, M.A.7    Bloom, S.R.8
  • 54
    • 0032871230 scopus 로고    scopus 로고
    • GLP-1 slows solid gastric emptying and inhibits insulin, glucagon and PYY release in humans
    • E. Naslund et al. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon and PYY release in humans Am. J. Physiol. 277 1999 910 916
    • (1999) Am. J. Physiol. , vol.277 , pp. 910-916
    • Naslund, E.1
  • 55
    • 0034085701 scopus 로고    scopus 로고
    • Peripheral versus central effects of GLP-1 receptor agonists on satiety and body weight loss in Zucker obese rats
    • F. Rodriquez de Fonseca Peripheral versus central effects of GLP-1 receptor agonists on satiety and body weight loss in Zucker obese rats Metabolism 79 2000 709 711
    • (2000) Metabolism , vol.79 , pp. 709-711
    • Rodriquez De Fonseca, F.1
  • 56
    • 19344375318 scopus 로고    scopus 로고
    • Intravenous infusion of GLP-1 potently inhibits food intake, sham feeding, and gastric emptying in rats
    • P.K. Chelikani et al. Intravenous infusion of GLP-1 potently inhibits food intake, sham feeding, and gastric emptying in rats Am. J. Physiol. Regul. Integr. Comp. Physiol. 288 2005 1695 1706
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.288 , pp. 1695-1706
    • Chelikani, P.K.1
  • 57
    • 80455122696 scopus 로고    scopus 로고
    • The gut hormomes PKK (3-36) and GLP-1 (7-36 amide) reduce food intake and modulate brain activity in appetite centers in humans
    • A. De Silva et al. The gut hormomes PKK (3-36) and GLP-1 (7-36 amide) reduce food intake and modulate brain activity in appetite centers in humans Cell Metab. 14 2011 709 717
    • (2011) Cell Metab. , vol.14 , pp. 709-717
    • De Silva, A.1
  • 59
    • 0017043536 scopus 로고
    • Distribution and release of pancreatic polypeptide
    • T.E. Adrian et al. Distribution and release of pancreatic polypeptide Gut 17 1976 940 944
    • (1976) Gut , vol.17 , pp. 940-944
    • Adrian, T.E.1
  • 60
    • 0037338622 scopus 로고    scopus 로고
    • Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes
    • M.M. Berglund Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes Exp. Biol. Med. 228 2012 217 244
    • (2012) Exp. Biol. Med. , vol.228 , pp. 217-244
    • Berglund, M.M.1
  • 61
    • 0017723085 scopus 로고
    • Pancreatic polypeptide: A possible role in the regulation of food intake in the mouse
    • F. Malaise-Lagae et al. Pancreatic polypeptide: a possible role in the regulation of food intake in the mouse Hypothesis Cell Mol. Life Sci. 33 1977 915 917
    • (1977) Hypothesis Cell Mol. Life Sci. , vol.33 , pp. 915-917
    • Malaise-Lagae, F.1
  • 62
    • 0041882174 scopus 로고    scopus 로고
    • Pancreatic polypeptide reduces appetite and food intake in humans
    • R.L. Batterham et al. Pancreatic polypeptide reduces appetite and food intake in humans J. Clin. Endocrinol. Metab. 88 2003 2989 3992
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2989-3992
    • Batterham, R.L.1
  • 64
    • 84903772504 scopus 로고    scopus 로고
    • Available at: http://www.7tm.com/R-D.aspx
  • 65
    • 0019766354 scopus 로고
    • Bioactive enteroglucagon (oxyntomodulin): Present knowledge on its chemical structure and its biological activities
    • DOI 10.1016/0196-9781(81)90008-5
    • D. Bataille et al. Bioactivation enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities Peptides 2 1981 41 44 (Pubitemid 12118280)
    • (1981) Peptides , vol.2 , Issue.SUPPL. 2 , pp. 41-44
    • Bataille, D.1    Gespach, C.2    Tatemoto, K.3
  • 67
    • 0020509994 scopus 로고
    • Molecular forms for human enteroglucagon in tissue and plasma: Plasma responses to nutrient stimuli in health and in disorders of the upper GI tract
    • M.A. Gatei et al. Molecular forms for human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper GI tract J. Clin. Endocrinol. Metab. 57 1983 488 495
    • (1983) J. Clin. Endocrinol. Metab. , vol.57 , pp. 488-495
    • Gatei, M.A.1
  • 68
    • 0026718211 scopus 로고
    • Oxyntomodulin like immunoreactivity: Diurnal profile of a new potential enterogastrone
    • A. Le Quellec et al. Oxyntomodulin like immunoreactivity: diurnal profile of a new potential enterogastrone J. Clin. Endocrinol. Metab. 74 1992 1405 1409
    • (1992) J. Clin. Endocrinol. Metab. , vol.74 , pp. 1405-1409
    • Le Quellec, A.1
  • 71
    • 84903790266 scopus 로고    scopus 로고
    • Available at: http://www.thepharmaletter.com/file/85453/thiakis-obesity- drug-enters-first-clinical-trial.html
  • 72
    • 84903763555 scopus 로고    scopus 로고
    • Available at: http://www.pfizer.com/research/product-pipeline/product- pipeline
  • 75
    • 0016774924 scopus 로고
    • Identification of cholecystokinin-secreting cells
    • J.M. Polak et al. Identification of cholecystokinin-secreting cells Lancet 2 1975 1016 1018
    • (1975) Lancet , vol.2 , pp. 1016-1018
    • Polak, J.M.1
  • 76
    • 33644841711 scopus 로고    scopus 로고
    • Cholecystokinin and gastrin receptors
    • M. Dufrense et al. Cholecystokinin and gastrin receptors Physiol. Rev. 86 2006 508 847
    • (2006) Physiol. Rev. , vol.86 , pp. 508-847
    • Dufrense, M.1
  • 77
    • 0015701039 scopus 로고
    • Cholecystokinin decreases food intake in rats
    • J. Gibbs et al. Cholecystokinin decreases food intake in rats J. Comp. Physiol. Psychol. 84 1973 488 495
    • (1973) J. Comp. Physiol. Psychol. , vol.84 , pp. 488-495
    • Gibbs, J.1
  • 78
    • 0021433344 scopus 로고
    • Cholecystokinin persistently suppresses meal size but not food intake in free feeding rats
    • D.B. West et al. Cholecystokinin persistently suppresses meal size but not food intake in free feeding rats Am. J. Physiol. 246 1984 776 787
    • (1984) Am. J. Physiol. , vol.246 , pp. 776-787
    • West, D.B.1
  • 79
    • 38349104637 scopus 로고    scopus 로고
    • Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
    • J. Jordan et al. Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients Clin. Pharmacol. Ther. 83 2008 281 287
    • (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 281-287
    • Jordan, J.1
  • 80
    • 79955550099 scopus 로고    scopus 로고
    • Acute pancreatitis associated with Liraglutide
    • P.H. Lee et al. Acute pancreatitis associated with Liraglutide Ann. Pharmacother. 44 2011 22
    • (2011) Ann. Pharmacother. , vol.44 , pp. 22
    • Lee, P.H.1
  • 81
    • 77951523535 scopus 로고    scopus 로고
    • Association of pancreatitis with GLP-1 agonist use
    • S.L. Anderson et al. Association of pancreatitis with GLP-1 agonist use Ann. Pharmacother. 44 2010 904 909
    • (2010) Ann. Pharmacother. , vol.44 , pp. 904-909
    • Anderson, S.L.1
  • 82
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • M. Elashoff et al. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies Gastroenterology 141 2011 150 156
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1
  • 83
    • 84903787043 scopus 로고    scopus 로고
    • Available at: http://pdf.reuters.com/htmlnews/8knews.asp?i= 43059c3bf0e37541&u=urn:newsml:reuters.com:20130226:nBw 266992a
  • 86
    • 84903789017 scopus 로고    scopus 로고
    • Available at: http://www.aezsinc.com/en/page.php?p=60&q=323
  • 89
    • 84903772793 scopus 로고    scopus 로고
    • Available at: http://www.bloomberg.com/apps/news?pid=newsarchive&sid= aYbX4h8ZElu0
  • 94
    • 56849115949 scopus 로고    scopus 로고
    • Modulators of the Ghrelin system as potential treatments for obesity and diabetes
    • P.A. Carpino, and G. Ho Modulators of the Ghrelin system as potential treatments for obesity and diabetes Expert Opin. Ther. Pat. 18 2008 1253 1263
    • (2008) Expert Opin. Ther. Pat. , vol.18 , pp. 1253-1263
    • Carpino, P.A.1    Ho, G.2
  • 95
    • 84975911599 scopus 로고    scopus 로고
    • GPR119 agonists: A novel strategy for type 2 diabetes treatment
    • X. Zhu et al. GPR119 agonists: a novel strategy for type 2 diabetes treatment Diabetes Mellitus - Insights and Perspective 2013 59 82
    • (2013) Diabetes Mellitus - Insights and Perspective , pp. 59-82
    • Zhu, X.1
  • 96
    • 84903761112 scopus 로고    scopus 로고
    • The novel GPR119-receptor agonist PSN821 shows glucose lowering and decreased energy intake in patients with T2DM after 14 days treatment
    • A.A. Van Vliet et al. The novel GPR119-receptor agonist PSN821 shows glucose lowering and decreased energy intake in patients with T2DM after 14 days treatment 71st Annual Meeting and Scientific Sessions of the American Diabetes Association 2011
    • (2011) 71st Annual Meeting and Scientific Sessions of the American Diabetes Association
    • Van Vliet, A.A.1
  • 99
    • 84903785327 scopus 로고    scopus 로고
    • Available at: http://www.ttpharma.com/PressReleases/2012/ 20121101TransTechPharmaPressRelease/tabid/248/Default.aspx
  • 100
    • 84903760670 scopus 로고    scopus 로고
    • Beijing Hanmi Pharmaceutical: ChinaBio Partnering Forum 2013, May 29
    • Beijing Hanmi Pharmaceutical: ChinaBio Partnering Forum 2013, May 29. http://www.ebdgroup.com/cbpf/participants/index.php
  • 102
    • 33846477446 scopus 로고    scopus 로고
    • Small molecule agonists for the glucagon-like peptide-1 receptor
    • L.B. Knudsen et al. Small molecule agonists for the glucagon-like peptide-1 receptor Proc. Natl. Acad. Sci. U. S. A. 104 2006 937 942
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 937-942
    • Knudsen, L.B.1
  • 104
    • 78650038239 scopus 로고    scopus 로고
    • Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets
    • K.W. Sloop et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets Diabetes 59 2010 3099 3107
    • (2010) Diabetes , vol.59 , pp. 3099-3107
    • Sloop, K.W.1
  • 106
    • 84903767323 scopus 로고    scopus 로고
    • Discovery of triazolobenzodiazepinone derivatives as orally active, gut-selective CCK1 receptor agonists for the potential treatment of obesity
    • J.E. Chin et al. Discovery of triazolobenzodiazepinone derivatives as orally active, gut-selective CCK1 receptor agonists for the potential treatment of obesity 239th American Chemical Society National Meeting and Exposition 2010
    • (2010) 239th American Chemical Society National Meeting and Exposition
    • Chin, J.E.1
  • 108
    • 84903769870 scopus 로고    scopus 로고
    • Available at: http://www.evaluategroup.com/Universal/View.aspx?type= Story&id=63064
  • 111
    • 84903752405 scopus 로고    scopus 로고
    • Information meeting: February 2004
    • Sanofi Synthelabo (2004) Information meeting: February 2004. http://business.highbeam.com/436989/article-1G1-113441013/sr-146131- sanofisynthelabo-discontinued-europe
    • (2004) Sanofi Synthelabo
  • 114
    • 49849106067 scopus 로고    scopus 로고
    • 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity
    • R. Berger et al. 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity Bioorg. Med. Chem. Lett. 18 2008 4833 4837
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4833-4837
    • Berger, R.1
  • 115
    • 79955557574 scopus 로고    scopus 로고
    • Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists
    • L. Wang et al. Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists Bioorg. Med. Chem. Lett. 21 2011 2911 2915
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 2911-2915
    • Wang, L.1
  • 116
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • DOI 10.1016/S0169-409X(96)00423-1, PII S0169409X96004231
    • C.A. Lipinski et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 23 1997 3 25 (Pubitemid 27046991)
    • (1997) Advanced Drug Delivery Reviews , vol.23 , Issue.1-3 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.