Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2911-2915

  Wang, Liping ^a   Hubert, James A ^a   Lee, Susan J ^a   Pan, Jie ^a   Qian, Su ^a   Reitman, Marc L ^a   Strack, Alison M ^a   Weingarth, Drew T ^a   MacNeil, Douglas J ^a   Weber, Ann E ^a   Edmondson, Scott D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Carboxamide; CCK1R agonists; Cholecycstokinin 1 receptor; Pyrimidine

Indexed keywords

AMIDE; CHOLECYSTOKININ; PYRAZINE 5 CARBOXAMIDE; PYRAZINE 6 CARBOXAMIDE; PYRIDINE 5 CARBOXAMIDE; PYRIMIDINE; PYRIMIDINECARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; SAPONIFICATION; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CELLS, CULTURED; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIMIDINES; RECEPTOR, CHOLECYSTOKININ A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955557574     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.069     Document Type: Article

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31. Assay protocols are provided in Supplementary data. Activation of the CCK1 and CCK2 receptors are reported relative to 100% receptor activation.