-
1
-
-
84892590856
-
Antibodies to watch in 2014
-
PMID:24284914
-
Reichert JM. Antibodies to watch in 2014. MAbs 2013; 6:5-14; PMID:24284914
-
(2013)
MAbs
, vol.6
, pp. 5-14
-
-
Reichert, J.M.1
-
2
-
-
84872858296
-
Which are the antibodies to watch in 2013?
-
PMID:23254906
-
Reichert JM. Which are the antibodies to watch in 2013? MAbs 2013; 5:1-4; PMID:23254906; http://dx.doi.org/10.4161/mabs.22976
-
(2013)
MAbs
, vol.5
, pp. 1-4
-
-
Reichert, J.M.1
-
3
-
-
84862772871
-
Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics
-
PMID:22610647
-
Bumbaca D, Boswell CA, Fielder PJ, Khawli LA. Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics. AAPS J 2012; 14:554-8; PMID:22610647; http://dx.doi.org/10.1208/s12248-012-9369- y
-
(2012)
AAPS J
, vol.14
, pp. 554-558
-
-
Bumbaca, D.1
Boswell, C.A.2
Fielder, P.J.3
Khawli, L.A.4
-
4
-
-
34548229364
-
FcRn: The neonatal Fc receptor comes of age
-
PMID:17703228
-
Roopenian DC, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007; 7:715-25; PMID:17703228; http://dx.doi.org/10.1038/nri2155
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 715-725
-
-
Roopenian, D.C.1
Akilesh, S.2
-
5
-
-
0034042660
-
Multiple roles for the major histocompatibility complex class I- related receptor FcRn
-
PMID:10837074
-
Ghetie V, Ward ES. Multiple roles for the major histocompatibility complex class I- related receptor FcRn. Annu Rev Immunol 2000; 18:739-66; PMID:10837074; http://dx.doi.org/10.1146/annurev.immunol.18.1.739
-
(2000)
Annu Rev Immunol
, vol.18
, pp. 739-766
-
-
Ghetie, V.1
Ward, E.S.2
-
6
-
-
80052579373
-
Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies
-
PMID:22048692
-
Kacskovics I, Cervenak J, Erdei A, Goldsby RA, Butler JE. Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies. MAbs 2011; 3:431-9; PMID:22048692; http://dx.doi.org/10.4161/mabs.3.5.17023
-
(2011)
MAbs
, vol.3
, pp. 431-439
-
-
Kacskovics, I.1
Cervenak, J.2
Erdei, A.3
Goldsby, R.A.4
Butler, J.E.5
-
7
-
-
33745508741
-
Perspective - FcRn transports albumin: Relevance to immunology and medicine
-
PMID:16731041
-
Anderson CL, Chaudhury C, Kim J, Bronson CL, Wani MA, Mohanty S. Perspective - FcRn transports albumin: relevance to immunology and medicine. Trends Immunol 2006; 27:343-8; PMID:16731041; http://dx.doi.org/10.1016/j.it. 2006.05.004
-
(2006)
Trends Immunol
, vol.27
, pp. 343-348
-
-
Anderson, C.L.1
Chaudhury, C.2
Kim, J.3
Bronson, C.L.4
Wani, M.A.5
Mohanty, S.6
-
8
-
-
33644872801
-
Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces
-
PMID:16210471
-
Kim J, Bronson CL, Hayton WL, Radmacher MD, Roopenian DC, Robinson JM, Anderson CL. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces. Am J Physiol Gastrointest Liver Physiol 2006; 290:G352-60; PMID:16210471; http://dx.doi.org/10.1152/ajpgi.00286.2005
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Kim, J.1
Bronson, C.L.2
Hayton, W.L.3
Radmacher, M.D.4
Roopenian, D.C.5
Robinson, J.M.6
Anderson, C.L.7
-
9
-
-
76349123565
-
Enhanced antibody half-life improves in vivo activity
-
PMID:20081867
-
Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR. Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 2010; 28:157-9; PMID:20081867; http://dx.doi.org/10.1038/nbt.1601
-
(2010)
Nat Biotechnol
, vol.28
, pp. 157-159
-
-
Zalevsky, J.1
Chamberlain, A.K.2
Horton, H.M.3
Karki, S.4
Leung, I.W.5
Sproule, T.J.6
Lazar, G.A.7
Roopenian, D.C.8
Desjarlais, J.R.9
-
10
-
-
80052598705
-
Neonatal Fc receptor and IgG-based therapeutics
-
PMID:22048693
-
Kuo TT, Aveson VG. Neonatal Fc receptor and IgG-based therapeutics. MAbs 2011; 3:422-30; PMID:22048693; http://dx.doi.org/10.4161/mabs.3.5.16983
-
(2011)
MAbs
, vol.3
, pp. 422-430
-
-
Kuo, T.T.1
Aveson, V.G.2
-
11
-
-
0017166982
-
pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat
-
PMID:11223
-
Rodewald R. pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol 1976; 71:666-9; PMID:11223; http://dx.doi.org/10.1083/jcb.71.2.666
-
(1976)
J Cell Biol
, vol.71
, pp. 666-669
-
-
Rodewald, R.1
-
12
-
-
0035012654
-
Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: Mechanism of pH-dependent binding
-
PMID:11336709
-
Martin WL, West AP Jr., Gan L, Bjorkman PJ. Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. Mol Cell 2001; 7:867-77; PMID:11336709; http://dx.doi.org/10.1016/S1097-2765(01)00230-1
-
(2001)
Mol Cell
, vol.7
, pp. 867-877
-
-
Martin, W.L.1
West Jr., A.P.2
Gan, L.3
Bjorkman, P.J.4
-
13
-
-
0028089908
-
Crystal structure of the complex of rat neonatal Fc receptor with Fc
-
PMID:7969498
-
Burmeister WP, Huber AH, Bjorkman PJ. Crystal structure of the complex of rat neonatal Fc receptor with Fc. Nature 1994; 372:379-83; PMID:7969498; http://dx.doi.org/10.1038/372379a0
-
(1994)
Nature
, vol.372
, pp. 379-383
-
-
Burmeister, W.P.1
Huber, A.H.2
Bjorkman, P.J.3
-
14
-
-
0034663798
-
Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)
-
PMID:10933786
-
West AP Jr., Bjorkman PJ. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,). Biochemistry 2000; 39:9698-708; PMID:10933786; http://dx.doi.org/10.1021/ bi000749m
-
(2000)
Biochemistry
, vol.39
, pp. 9698-9708
-
-
West Jr., A.P.1
Bjorkman, P.J.2
-
15
-
-
0035794194
-
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R
-
PMID:11096108
-
Shields RL, Namenuk AK, Hong K, Meng YG, Rae J, Briggs J, Xie D, Lai J, Stadlen A, Li B, et al. High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 2001; 276:6591-604; PMID:11096108; http://dx.doi.org/10.1074/jbc.M009483200
-
(2001)
J Biol Chem
, vol.276
, pp. 6591-6604
-
-
Shields, R.L.1
Namenuk, A.K.2
Hong, K.3
Meng, Y.G.4
Rae, J.5
Briggs, J.6
Xie, D.7
Lai, J.8
Stadlen, A.9
Li, B.10
-
16
-
-
0033393536
-
Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn
-
PMID:10508256
-
Kim JK, Firan M, Radu CG, Kim CH, Ghetie V, Ward ES. Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn. Eur J Immunol 1999; 29:2819-25; PMID:10508256; http://dx.doi.org/10.1002/(SICI) 1521-4141(199909)29:09〈2819::AIDIMMU2819〉3.0.CO;2-6
-
(1999)
Eur J Immunol
, vol.29
, pp. 2819-2825
-
-
Kim, J.K.1
Firan, M.2
Radu, C.G.3
Kim, C.H.4
Ghetie, V.5
Ward, E.S.6
-
17
-
-
33845484193
-
Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies
-
PMID:17116867
-
Vaccaro C, Bawdon R, Wanjie S, Ober RJ, Ward ES. Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies. Proc Natl Acad Sci U S A 2006; 103:18709-14; PMID:17116867; http://dx.doi.org/10.1073/pnas.0606304103
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 18709-18714
-
-
Vaccaro, C.1
Bawdon, R.2
Wanjie, S.3
Ober, R.J.4
Ward, E.S.5
-
18
-
-
0035210960
-
Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
-
PMID:11717196
-
Ober RJ, Radu CG, Ghetie V, Ward ES. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 2001; 13:1551-9; PMID:11717196; http://dx.doi.org/10. 1093/intimm/13.12.1551
-
(2001)
Int Immunol
, vol.13
, pp. 1551-1559
-
-
Ober, R.J.1
Radu, C.G.2
Ghetie, V.3
Ward, E.S.4
-
19
-
-
84855341879
-
Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies
-
PMID:21939661
-
Magistrelli G, Malinge P, Anceriz N, Desmurs M, Venet S, Calloud S, Daubeuf B, Kosco-Vilbois M, Fischer N. Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies. J Immunol Methods 2012; 375:20-9; PMID:21939661; http://dx.doi.org/10.1016/j.jim. 2011.09.002
-
(2012)
J Immunol Methods
, vol.375
, pp. 20-29
-
-
Magistrelli, G.1
Malinge, P.2
Anceriz, N.3
Desmurs, M.4
Venet, S.5
Calloud, S.6
Daubeuf, B.7
Kosco-Vilbois, M.8
Fischer, N.9
-
20
-
-
11844275385
-
Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis
-
PMID:15644205
-
Zhou J, Mateos F, Ober RJ, Ward ES. Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. J Mol Biol 2005; 345:1071-81; PMID:15644205; http://dx.doi.org/10.1016/j.jmb.2004.11.014
-
(2005)
J Mol Biol
, vol.345
, pp. 1071-1081
-
-
Zhou, J.1
Mateos, F.2
Ober, R.J.3
Ward, E.S.4
-
21
-
-
77951156788
-
Cross-species binding analyses of mouse and human neonatal Fc receptor (FcRn) show dramatic differences in immunoglobulin G (IgG) and albumin binding
-
Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I. Cross-species binding analyses of mouse and human neonatal Fc receptor (FcRn) show dramatic differences in immunoglobulin G (IgG) and albumin binding. J Biol Chem 2010; 285:4826-36; http://dx.doi.org/10.1074/jbc.M109.081828
-
(2010)
J Biol Chem
, vol.285
, pp. 4826-4836
-
-
Andersen, J.T.1
Daba, M.B.2
Berntzen, G.3
Michaelsen, T.E.4
Sandlie, I.5
-
22
-
-
84877898507
-
Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities
-
PMID:23549129
-
Tam SH, McCarthy SG, Brosnan K, Goldberg KM, Scallon BJ. Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities. MAbs 2013; 5:1-9; PMID:23549129; http://dx.doi.org/10.4161/mabs.23836
-
(2013)
MAbs
, vol.5
, pp. 1-9
-
-
Tam, S.H.1
McCarthy, S.G.2
Brosnan, K.3
Goldberg, K.M.4
Scallon, B.J.5
-
23
-
-
80052008224
-
Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences
-
PMID:21610128
-
Wang W, Lu P, Fang Y, Hamuro L, Pittman T, Carr B, Hochman J, Prueksaritanont T. Monoclonal antibodies with identical Fc sequences can bind to FcRn differentially with pharmacokinetic consequences. Drug Metab Dispos 2011; 39:1469-77; PMID:21610128; http://dx.doi.org/10.1124/dmd.111.039453
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 1469-1477
-
-
Wang, W.1
Lu, P.2
Fang, Y.3
Hamuro, L.4
Pittman, T.5
Carr, B.6
Hochman, J.7
Prueksaritanont, T.8
-
24
-
-
84863304928
-
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life
-
PMID:22570488
-
Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I. Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. J Biol Chem 2012; 287:22927-37; PMID:22570488; http://dx.doi.org/10.1074/jbc.M112. 355131
-
(2012)
J Biol Chem
, vol.287
, pp. 22927-22937
-
-
Andersen, J.T.1
Foss, S.2
Kenanova, V.E.3
Olafsen, T.4
Leikfoss, I.S.5
Roopenian, D.C.6
Wu, A.M.7
Sandlie, I.8
-
25
-
-
67649207267
-
Engineering human IgG1 affinity to human neonatal Fc receptor: Impact of affinity improvement on pharmacokinetics in primates
-
PMID:19494290
-
Yeung YA, Leabman MK, Marvin JS, Qiu J, Adams CW, Lien S, Starovasnik MA, Lowman HB. Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates. J Immunol 2009; 182:7663-71; PMID:19494290; http://dx.doi.org/10.4049/jimmunol.0804182
-
(2009)
J Immunol
, vol.182
, pp. 7663-7671
-
-
Yeung, Y.A.1
Leabman, M.K.2
Marvin, J.S.3
Qiu, J.4
Adams, C.W.5
Lien, S.6
Starovasnik, M.A.7
Lowman, H.B.8
-
26
-
-
0033613146
-
Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution
-
PMID:10504233
-
Martin WL, Bjorkman PJ. Characterization of the 2:1 complex between the class I MHC-related Fc receptor and its Fc ligand in solution. Biochemistry 1999; 38:12639-47; PMID:10504233; http://dx.doi.org/10.1021/bi9913505
-
(1999)
Biochemistry
, vol.38
, pp. 12639-12647
-
-
Martin, W.L.1
Bjorkman, P.J.2
-
27
-
-
77951101786
-
Reduced elimination of IgG antibodies by engineering the variable region
-
PMID:20159773
-
Igawa T, Tsunoda H, Tachibana T, Maeda A, Mimoto F, Moriyama C, Nanami M, Sekimori Y, Nabuchi Y, Aso Y, et al. Reduced elimination of IgG antibodies by engineering the variable region. Protein Eng Des Sel 2010; 23:385-92; PMID:20159773; http://dx.doi.org/10.1093/protein/gzq009
-
(2010)
Protein Eng des Sel
, vol.23
, pp. 385-392
-
-
Igawa, T.1
Tsunoda, H.2
Tachibana, T.3
Maeda, A.4
Mimoto, F.5
Moriyama, C.6
Nanami, M.7
Sekimori, Y.8
Nabuchi, Y.9
Aso, Y.10
-
28
-
-
39149118917
-
A strategy for bacterial production of a soluble functional human neonatal Fc receptor
-
PMID:18155020
-
Andersen JT, Justesen S, Berntzen G, Michaelsen TE, Lauvrak V, Fleckenstein B, Buus S, Sandlie I. A strategy for bacterial production of a soluble functional human neonatal Fc receptor. J Immunol Methods 2008; 331:39-49; PMID:18155020; http://dx.doi.org/10.1016/j.jim.2007.11.003
-
(2008)
J Immunol Methods
, vol.331
, pp. 39-49
-
-
Andersen, J.T.1
Justesen, S.2
Berntzen, G.3
Michaelsen, T.E.4
Lauvrak, V.5
Fleckenstein, B.6
Buus, S.7
Sandlie, I.8
-
29
-
-
79551593709
-
Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays
-
PMID:21185301
-
Lu Y, Vernes JM, Chiang N, Ou Q, Ding J, Adams C, Hong K, Truong BT, Ng D, Shen A, et al. Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays. J Immunol Methods 2011; 365:132-41; PMID:21185301; http://dx.doi.org/10.1016/j.jim.2010.12.014
-
(2011)
J Immunol Methods
, vol.365
, pp. 132-141
-
-
Lu, Y.1
Vernes, J.M.2
Chiang, N.3
Ou, Q.4
Ding, J.5
Adams, C.6
Hong, K.7
Truong, B.T.8
Ng, D.9
Shen, A.10
-
30
-
-
84864117650
-
Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function
-
PMID:22723108
-
Kelley RF, Meng YG. Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function. Methods Mol Biol 2012; 901:277-93; PMID:22723108; http://dx.doi.org/10.1007/978-1-61779-931-0-18
-
(2012)
Methods Mol Biol
, vol.901
, pp. 277-293
-
-
Kelley, R.F.1
Meng, Y.G.2
-
31
-
-
29644434678
-
An engineered human IgG1 antibody with longer serum half-life
-
PMID:16365427
-
Hinton PR, Xiong JM, Johlfs MG, Tang MT, Keller S, Tsurushita N. An engineered human IgG1 antibody with longer serum half-life. J Immunol 2006; 176:346-56; PMID:16365427
-
(2006)
J Immunol
, vol.176
, pp. 346-356
-
-
Hinton, P.R.1
Xiong, J.M.2
Johlfs, M.G.3
Tang, M.T.4
Keller, S.5
Tsurushita, N.6
-
32
-
-
84875270732
-
Qualification of a homogeneous cellbased neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics
-
PMID:23384837
-
Mathur A, Arora T, Liu L, Crouse-Zeineddini J, Mukku V. Qualification of a homogeneous cellbased neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics. J Immunol Methods 2013; 390:81-91; PMID:23384837; http://dx.doi.org/10.1016/j.jim.2013.01. 011
-
(2013)
J Immunol Methods
, vol.390
, pp. 81-91
-
-
Mathur, A.1
Arora, T.2
Liu, L.3
Crouse-Zeineddini, J.4
Mukku, V.5
-
33
-
-
64149109989
-
Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors
-
PMID:19269032
-
Bertolotti-Ciarlet A, Wang W, Lownes R, Pristatsky P, Fang Y, McKelvey T, Li Y, Li Y, Drummond J, Prueksaritanont T, et al. Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors. Mol Immunol 2009; 46:1878-82; PMID:19269032; http://dx.doi.org/10.1016/j.molimm. 2009.02.002
-
(2009)
Mol Immunol
, vol.46
, pp. 1878-1882
-
-
Bertolotti-Ciarlet, A.1
Wang, W.2
Lownes, R.3
Pristatsky, P.4
Fang, Y.5
McKelvey, T.6
Li, Y.7
Li, Y.8
Drummond, J.9
Prueksaritanont, T.10
-
34
-
-
84455208902
-
Competition for FcRn-mediated transport gives rise to short halflife of human IgG3 and offers therapeutic potential
-
PMID:22186895
-
Stapleton NM, Andersen JT, Stemerding AM, Bjarnarson SP, Verheul RC, Gerritsen J, Zhao Y, Kleijer M, Sandlie I, de Haas M, et al. Competition for FcRn-mediated transport gives rise to short halflife of human IgG3 and offers therapeutic potential. Nat Commun 2011; 2:599; PMID:22186895; http://dx.doi.org/10.1038/ncomms1608
-
(2011)
Nat Commun
, vol.2
, pp. 599
-
-
Stapleton, N.M.1
Andersen, J.T.2
Stemerding, A.M.3
Bjarnarson, S.P.4
Verheul, R.C.5
Gerritsen, J.6
Zhao, Y.7
Kleijer, M.8
Sandlie, I.9
De Haas, M.10
-
35
-
-
0036839457
-
Increasing the affinity of a human IgG1 for the neonatal Fc receptor: Biological consequences
-
PMID:12391234
-
Dall'Acqua WF, Woods RM, Ward ES, Palaszynski SR, Patel NK, Brewah YA, Wu H, Kiener PA, Langermann S. Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences. J Immunol 2002; 169:5171-80; PMID:12391234
-
(2002)
J Immunol
, vol.169
, pp. 5171-5180
-
-
Dall'Acqua, W.F.1
Woods, R.M.2
Ward, E.S.3
Palaszynski, S.R.4
Patel, N.K.5
Brewah, Y.A.6
Wu, H.7
Kiener, P.A.8
Langermann, S.9
-
36
-
-
33747631571
-
Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)
-
PMID:16793771
-
Dall'Acqua WF, Kiener PA, Wu H. Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn). J Biol Chem 2006; 281:23514-24; PMID:16793771; http://dx.doi.org/10.1074/jbc.M604292200
-
(2006)
J Biol Chem
, vol.281
, pp. 23514-23524
-
-
Dall'Acqua, W.F.1
Kiener, P.A.2
Wu, H.3
-
37
-
-
33845930317
-
Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: Relationship to pharmacokinetics in mice and primates
-
PMID:17050651
-
Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ. Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates. Drug Metab Dispos 2007; 35:86-94; PMID:17050651; http://dx.doi.org/10.1124/dmd.106.011734
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 86-94
-
-
Datta-Mannan, A.1
Witcher, D.R.2
Tang, Y.3
Watkins, J.4
Jiang, W.5
Wroblewski, V.J.6
-
38
-
-
48549105161
-
Molecular engineering and design of therapeutic antibodies
-
PMID:18656541
-
Presta LG. Molecular engineering and design of therapeutic antibodies. Curr Opin Immunol 2008; 20:460-70; PMID:18656541; http://dx.doi.org/10.1016/j. coi.2008.06.012
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 460-470
-
-
Presta, L.G.1
-
39
-
-
77950265888
-
Pharmacokinetics of humanized monoclonal antitumor necrosis factor-alpha antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys
-
PMID:20071453
-
Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S. Pharmacokinetics of humanized monoclonal antitumor necrosis factor-alpha antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys. Drug Metab Dispos 2010; 38:600-5; PMID:20071453; http://dx.doi.org/10.1124/dmd.109.031310
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 600-605
-
-
Deng, R.1
Loyet, K.M.2
Lien, S.3
Iyer, S.4
DeForge, L.E.5
Theil, F.P.6
Lowman, H.B.7
Fielder, P.J.8
Prabhu, S.9
-
40
-
-
0014450553
-
Metabolism of immunoglobulins
-
PMID:4186070
-
Waldmann TA, Strober W. Metabolism of immunoglobulins. Prog Allergy 1969; 13:1-110; PMID:4186070
-
(1969)
Prog Allergy
, vol.13
, pp. 1-110
-
-
Waldmann, T.A.1
Strober, W.2
-
41
-
-
77951605086
-
Anti-p40 antibodies ustekinumab and briakinumab: Blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis
-
PMID:20430307
-
Gandhi M, Alwawi E, Gordon KB. Anti-p40 antibodies ustekinumab and briakinumab: blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis. Semin Cutan Med Surg 2010; 29:48-52; PMID:20430307; http://dx.doi.org/10.1016/j.sder.2010.02.001
-
(2010)
Semin Cutan Med Surg
, vol.29
, pp. 48-52
-
-
Gandhi, M.1
Alwawi, E.2
Gordon, K.B.3
-
42
-
-
77949884124
-
Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: A comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR
-
PMID:20083659
-
Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T, Yamaguchi T. Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR. J Immunol 2010; 184:1968-76; PMID:20083659; http://dx.doi.org/10.4049/jimmunol.0903296
-
(2010)
J Immunol
, vol.184
, pp. 1968-1976
-
-
Suzuki, T.1
Ishii-Watabe, A.2
Tada, M.3
Kobayashi, T.4
Kanayasu-Toyoda, T.5
Kawanishi, T.6
Yamaguchi, T.7
-
43
-
-
33847330766
-
Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor
-
PMID:17135257
-
Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ. Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. J Biol Chem 2007; 282:1709-17; PMID:17135257; http://dx.doi.org/10.1074/jbc.M607161200
-
(2007)
J Biol Chem
, vol.282
, pp. 1709-1717
-
-
Datta-Mannan, A.1
Witcher, D.R.2
Tang, Y.3
Watkins, J.4
Wroblewski, V.J.5
-
44
-
-
78149320579
-
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
-
PMID:20953198
-
Igawa T, Ishii S, Tachibana T, Maeda A, Higuchi Y, Shimaoka S, Moriyama C, Watanabe T, Takubo R, Doi Y, et al. Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization. Nat Biotechnol 2010; 28:1203-7; PMID:20953198; http://dx.doi.org/10.1038/nbt. 1691
-
(2010)
Nat Biotechnol
, vol.28
, pp. 1203-1207
-
-
Igawa, T.1
Ishii, S.2
Tachibana, T.3
Maeda, A.4
Higuchi, Y.5
Shimaoka, S.6
Moriyama, C.7
Watanabe, T.8
Takubo, R.9
Doi, Y.10
-
45
-
-
79955665534
-
Engineering the variable region of therapeutic IgG antibodies
-
PMID:21406966
-
Igawa T, Tsunoda H, Kuramochi T, Sampei Z, Ishii S, Hattori K. Engineering the variable region of therapeutic IgG antibodies. MAbs 2011; 3:243-52; PMID:21406966; http://dx.doi.org/10.4161/mabs.3.3.15234
-
(2011)
MAbs
, vol.3
, pp. 243-252
-
-
Igawa, T.1
Tsunoda, H.2
Kuramochi, T.3
Sampei, Z.4
Ishii, S.5
Hattori, K.6
-
46
-
-
84877897559
-
A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties
-
PMID:23571156
-
Tiller T, Schuster I, Deppe D, Siegers K, Strohner R, Herrmann T, Berenguer M, Poujol D, Stehle J, Stark Y, et al. A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties. MAbs 2013; 5:1-26; PMID:23571156; http://dx.doi.org/10. 4161/mabs.24218
-
(2013)
MAbs
, vol.5
, pp. 1-26
-
-
Tiller, T.1
Schuster, I.2
Deppe, D.3
Siegers, K.4
Strohner, R.5
Herrmann, T.6
Berenguer, M.7
Poujol, D.8
Stehle, J.9
Stark, Y.10
-
47
-
-
43049120226
-
Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet
-
PMID:18405656
-
Abdiche Y, Malashock D, Pinkerton A, Pons J. Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet. Anal Biochem 2008; 377:209-17; PMID:18405656; http://dx.doi.org/10.1016/j.ab.2008.03.035
-
(2008)
Anal Biochem
, vol.377
, pp. 209-217
-
-
Abdiche, Y.1
Malashock, D.2
Pinkerton, A.3
Pons, J.4
-
48
-
-
79951552251
-
Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
-
PMID:21256596
-
Wang W, Vlasak J, Li Y, Pristatsky P, Fang Y, Pittman T, Roman J, Wang Y, Prueksaritanont T, Ionescu R. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol 2011; 48:860-6; PMID:21256596; http://dx.doi.org/10.1016/j.molimm.2010.12.009
-
(2011)
Mol Immunol
, vol.48
, pp. 860-866
-
-
Wang, W.1
Vlasak, J.2
Li, Y.3
Pristatsky, P.4
Fang, Y.5
Pittman, T.6
Roman, J.7
Wang, Y.8
Prueksaritanont, T.9
Ionescu, R.10
-
49
-
-
42949139842
-
Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation
-
PMID:18407665
-
Liu D, Ren D, Huang H, Dankberg J, Rosenfeld R, Cocco MJ, Li L, Brems DN, Remmele RL Jr. Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation. Biochemistry 2008; 47:5088-100; PMID:18407665; http://dx.doi.org/10.1021/bi702238b
-
(2008)
Biochemistry
, vol.47
, pp. 5088-5100
-
-
Liu, D.1
Ren, D.2
Huang, H.3
Dankberg, J.4
Rosenfeld, R.5
Cocco, M.J.6
Li, L.7
Brems, D.N.8
Remmele Jr., R.L.9
-
50
-
-
33751211517
-
The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin
-
PMID:17048273
-
Andersen JT, Dee Qian J, Sandlie I. The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin. Eur J Immunol 2006; 36:3044-51; PMID:17048273; http://dx.doi.org/10.1002/eji.200636556
-
(2006)
Eur J Immunol
, vol.36
, pp. 3044-3051
-
-
Andersen, J.T.1
Dee Qian, J.2
Sandlie, I.3
-
51
-
-
33644817285
-
Development of new models for the analysis of Fc-FcRn interactions
-
PMID:16183124
-
Gurbaxani BM, Morrison SL. Development of new models for the analysis of Fc-FcRn interactions. Mol Immunol 2006; 43:1379-89; PMID:16183124; http://dx.doi.org/10.1016/j.molimm.2005.08.002
-
(2006)
Mol Immunol
, vol.43
, pp. 1379-1389
-
-
Gurbaxani, B.M.1
Morrison, S.L.2
-
52
-
-
27144465484
-
Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
-
PMID:16186811
-
Vaccaro C, Zhou J, Ober RJ, Ward ES. Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat Biotechnol 2005; 23:1283-8; PMID:16186811; http://dx.doi.org/10.1038/nbt1143
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1283-1288
-
-
Vaccaro, C.1
Zhou, J.2
Ober, R.J.3
Ward, E.S.4
-
53
-
-
84863912958
-
FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys
-
PMID:22584253
-
Datta-Mannan A, Chow CK, Dickinson C, Driver D, Lu J, Witcher DR, Wroblewski VJ. FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys. Drug Metab Dispos 2012; 40:1545-55; PMID:22584253; http://dx.doi.org/10.1124/dmd.112.045864
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 1545-1555
-
-
Datta-Mannan, A.1
Chow, C.K.2
Dickinson, C.3
Driver, D.4
Lu, J.5
Witcher, D.R.6
Wroblewski, V.J.7
-
54
-
-
84869840045
-
A strategy for risk mitigation of antibodies with fast clearance
-
PMID:23778268
-
Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, et al. A strategy for risk mitigation of antibodies with fast clearance. MAbs 2012; 4:753-60; PMID:23778268; http://dx.doi.org/10.4161/mabs.22189
-
(2012)
MAbs
, vol.4
, pp. 753-760
-
-
Hötzel, I.1
Theil, F.P.2
Bernstein, L.J.3
Prabhu, S.4
Deng, R.5
Quintana, L.6
Lutman, J.7
Sibia, R.8
Chan, P.9
Bumbaca, D.10
-
55
-
-
54349121015
-
A novel solid phase technology for high-throughput gene synthesis
-
PMID:18778261
-
Van den Brulle J, Fischer M, Langmann T, Horn G, Waldmann T, Arnold S, Fuhrmann M, Schatz O, O'Connell T, O'Connell D, et al. A novel solid phase technology for high-throughput gene synthesis. Biotechniques 2008; 45:340-3; PMID:18778261; http://dx.doi.org/10.2144/000112953
-
(2008)
Biotechniques
, vol.45
, pp. 340-343
-
-
Van Den Brulle, J.1
Fischer, M.2
Langmann, T.3
Horn, G.4
Waldmann, T.5
Arnold, S.6
Fuhrmann, M.7
Schatz, O.8
O'Connell, T.9
O'Connell, D.10
-
56
-
-
39149087988
-
The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies
-
PMID:18191144
-
Rothe C, Urlinger S, Löhning C, Prassler J, Stark Y, Jäger U, Hubner B, Bardroff M, Pradel I, Boss M, et al. The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies. J Mol Biol 2008; 376:1182-200; PMID:18191144; http://dx.doi.org/10.1016/j.jmb.2007.12.018
-
(2008)
J Mol Biol
, vol.376
, pp. 1182-1200
-
-
Rothe, C.1
Urlinger, S.2
Löhning, C.3
Prassler, J.4
Stark, Y.5
Jäger, U.6
Hubner, B.7
Bardroff, M.8
Pradel, I.9
Boss, M.10
-
57
-
-
0034905149
-
The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds
-
PMID:11483205
-
Schuurman J, Perdok GJ, Gorter AD, Aalberse RC. The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds. Mol Immunol 2001; 38:1-8; PMID:11483205; http://dx.doi.org/10.1016/S0161-5890(01) 00050-5
-
(2001)
Mol Immunol
, vol.38
, pp. 1-8
-
-
Schuurman, J.1
Perdok, G.J.2
Gorter, A.D.3
Aalberse, R.C.4
-
58
-
-
0034635335
-
Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
-
PMID:10656818
-
Knappik A, Ge L, Honegger A, Pack P, Fischer M, Wellnhofer G, Hoess A, Wölle J, Plückthun A, Virnekäs B. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides. J Mol Biol 2000; 296:57-86; PMID:10656818; http://dx.doi.org/10.1006/jmbi.1999.3444
-
(2000)
J Mol Biol
, vol.296
, pp. 57-86
-
-
Knappik, A.1
Ge, L.2
Honegger, A.3
Pack, P.4
Fischer, M.5
Wellnhofer, G.6
Hoess, A.7
Wölle, J.8
Plückthun, A.9
Virnekäs, B.10
-
59
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
PMID:1350088
-
Carter P, Presta L, Gorman CM, Ridgway JB, Henner D, Wong WL, Rowland AM, Kotts C, Carver ME, Shepard HM. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci U S A 1992; 89:4285-9; PMID:1350088; http://dx.doi.org/10.1073/pnas.89.10.4285
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
Ridgway, J.B.4
Henner, D.5
Wong, W.L.6
Rowland, A.M.7
Kotts, C.8
Carver, M.E.9
Shepard, H.M.10
-
60
-
-
0037227517
-
Biophysical properties of human antibody variable domains
-
PMID:12498801
-
Ewert S, Huber T, Honegger A, Plückthun A. Biophysical properties of human antibody variable domains. J Mol Biol 2003; 325:531-53; PMID:12498801; http://dx.doi.org/10.1016/S0022-2836(02)01237-8
-
(2003)
J Mol Biol
, vol.325
, pp. 531-553
-
-
Ewert, S.1
Huber, T.2
Honegger, A.3
Plückthun, A.4
-
61
-
-
0013261473
-
Establishment of a human somatic hybrid cell line for recombinant protein production
-
PMID:12432229
-
Cho MS, Yee H, Chan S. Establishment of a human somatic hybrid cell line for recombinant protein production. J Biomed Sci 2002; 9:631-8; PMID:12432229; http://dx.doi.org/10.1007/BF02254991
-
(2002)
J Biomed Sci
, vol.9
, pp. 631-638
-
-
Cho, M.S.1
Yee, H.2
Chan, S.3
|