Quinolone resistance mutations in Streptococcus pneumoniae gyrA and parC proteins: Mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 11, 2001, Pages 3140-3147

  Pan, X S ^a   Yague, G ^a   Fisher, L M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; PHENYLALANINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SERINE; SPARFLOXACIN; TYROSINE;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CHROMATOGRAPHY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GENE MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ALLELES; ANTI-INFECTIVE AGENTS; CULTURE MEDIA; DNA GYRASE; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE I; DNA, BACTERIAL; DNA, SUPERHELICAL; FLUOROQUINOLONES; MUTATION; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOCOCCUS PNEUMONIAE;

EID: 0034774996     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.11.3140-3147.2001     Document Type: Article

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