Engineered gene over-expression as a method of drug target identification

Biochemical and Biophysical Research Communications

Volumn 334, Issue 2, 2005, Pages 555-560

  Sugden, Christopher J ^a   Roper, Janine R ^a   Williams, Jeffrey G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Aminobisphosphonate; Bone resorption; Dictyostelium; Drug resistance; Drug target; FDP synthase; Gene over expression; Osteoclast

Indexed keywords

ALENDRONIC ACID; COMPLEMENTARY DNA; GERANYLTRANSFERASE;

ARTICLE; CELL GROWTH; CELL TRANSFORMATION; CROSS RESISTANCE; DICTYOSTELIUM; DRUG PROTEIN BINDING; DRUG TARGETING; GENE OVEREXPRESSION; GENETIC ENGINEERING; GENETIC VARIABILITY; PRIORITY JOURNAL; PROMOTER REGION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; DICTYOSTELIUM; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG RESISTANCE; GERANYLTRANSTRANSFERASE; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

DICTYOSTELIUM; MAMMALIA;

EID: 22144459408     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.06.117     Document Type: Article

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