Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 466-473

  Lou, Jun ^a   Yang, Xiaoyan ^a   Rao, Zhigang ^a   Qi, Wenwen ^a   Li, Jinhui ^a   Wang, Haiyu ^a   Li, Yuxi ^a   Li, Jinping ^a   Wang, Zhiming ^a   Hu, Xianming ^a   Liu, Peng ^a   Hong, Xuechuan ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

6 oxo 1,4,5,6 tetrahydropyrimidine 5 carboxylate derivatives; Anti influenza; Neuraminidase inhibitors; SAR

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ETHYL 2 ACETAMINO 4 (2 CHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (2 NITROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (2,4 DICHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (3,4 DIMETHOXYPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 BROMO 2 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 METHOXYPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 METHYLPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 NITROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 PHENYL 6 OXO 1,4,5, 6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (2 CHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (2 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (2 NITROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (2,4 DICHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIM DINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (3,4 DIMETHOXYPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 (DIMETHYLAMINO) PHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 BROMO 2 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 BROMOPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 CHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 FL UOROPHENYL) 6 OXO 1,4,5, 6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 METHOXYPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 METHYLPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 NITROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (FURAN 2 YL) 6 OXO 1,4,5 6 TETRAHYDROPYRIMIDINE 5 CARBOZYLATE; ETHYL 2 AMINO 4 ISOPROPYL 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 PHENYL 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; SIALIDASE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; 6-OXO-1,4,5,6-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE; ENZYME INHIBITOR; PYRIMIDINE DERIVATIVE; 2 ACETAMINO 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE DERIVATIVE; 2 AMINO 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE DERIVATIVE; ETHYL 2 ACETAMINO 4 (2 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 BROMO 4 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 BROMOPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (4 CHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 (FURAN 2 YL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 ISOPROPYL 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 PHENYL 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 ACETAMINO 4 [4 (DIMETHYLAMINO)PHENYL] 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (2,4 DICHLOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 2 AMINO 4 (4 FLUOROPHENYL) 6 OXO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 BROMOPHENYL) 6 OXO 2 (2,2,2 TRIFLUOROACETAMIDO) 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 4 (4 BROMOPHENYL) 6 OXO 2 PROPIONAMIDO 1,4,5,6 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; OSELTAMIVIR; VIRUS SIALIDASE;

ARTICLE; DRUG DESIGN; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INFLUENZA VIRUS A; NONHUMAN; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; SYNTHESIS; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; HYDROPHOBICITY; IC50; MICHAEL ADDITION; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; ENZYME INHIBITORS; INFLUENZA A VIRUS; MODELS, MOLECULAR; NEURAMINIDASE; PYRIMIDINES;

EID: 84903734164     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.059     Document Type: Article

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