Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4379-4392

  Chand, P ^a   Montgomery, J A ^a   Kotian, P L ^a   Dehghani, A ^a   El Kattan, Y ^a   Lin, T H ^a   Hutchison, T L ^a   Babu, Y S ^a   Bantia, S ^a   Elliott, A J ^b  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

^b Magellan Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (ACETYLAMINO) 2 ETHYLBUTYL] 4 [[AMINO(IMINO)METHYL]AMINO]CYCLOPENTANECARBOXYLIC ACID; ANTIVIRUS AGENT; BUTYRONITRILE; CYCLOPENTANE DERIVATIVE; METHYL 4 [(TERT BUTOXYCARBONYL)AMINO]CYCLOPENT 2 ENE 1 CARBOXYLATE; N ACETYL 2,3 DIDEHYDRO 2 DEOXYNEURAMINIC ACID; NEURAMINIC ACID DERIVATIVE; OSELTAMIVIR; PERAMIVIR; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ZANAMIVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; INFLUENZA VIRUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOPENTANES; ENZYME INHIBITORS; GUANIDINES; INFLUENZA A VIRUS; MODELS, MOLECULAR; NEURAMINIDASE; PROTEIN BINDING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035818923     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010277p     Document Type: Article

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