Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6- tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3381-3383

  Wang, Tiantian ^a   Liu, Jia ^a   Zhong, Hanyu ^a   Chen, Huan ^a   Lv, Zhiliang ^a   Zhang, Yikai ^a   Zhang, Mingfeng ^a   Geng, Dongping ^a   Niu, Chunjuan ^a   Li, Yongmei ^b   Li, Ke ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Anti tumor; Crystal structure; Domino reaction; Ethyl 4 oxo 3,3a,4,6 tetrahydro 1H furo 3,4 c pyran 3a carboxylate

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; ETHYL 3 ARYL 4 OXO 3,3A,4,6 TETRAHYDRO 1H FURO[3,4 C]PYRAN 3A CARBOXYLATE DERIVATIVE; FLUOROURACIL; MALONIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; ROOM TEMPERATURE; X RAY;

ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; FURANS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRANS;

EID: 79956158018     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.003     Document Type: Article

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32. 5: C, 62.28; H, 5.23; N, 4.84. Found: C, 62.42; H, 5.37; N, 4.77.