The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

Nature Structural and Molecular Biology

Volumn 17, Issue 10, 2010, Pages 1266-1268

  Li, Qing ^a,b   Qi, Jianxun ^a   Zhang, Wei ^a,c   Vavricka, Christopher J ^a   Shi, Yi ^a,c   Wei, Jinhua ^a,c   Feng, Enguang ^d   Shen, Jingshan ^d   Chen, Jilong ^a   Liu, Di ^a   He, Jianhua ^e   Yan, Jinghua ^a   Liu, Hong ^d   Jiang, Hualiang ^d   Teng, Maikun ^b   Li, Xuebing ^a   Gao, George F ^a,b,c,f  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^e SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^f INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; NEURAMINIDASE N1; OSELTAMIVIR; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; VIRUS SIALIDASE; ZANAMIVIR;

ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; INFLUENZA A (H1N1); MUTATIONAL ANALYSIS; NONHUMAN; PANDEMIC INFLUENZA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; VIRUS STRAIN; VIRUS VIRULENCE;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; INFLUENZA A VIRUS, H1N1 SUBTYPE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

INFLUENZA A VIRUS;

EID: 77957767268     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1909     Document Type: Article

References (19)

1. Kobasa, D. et al. Nature 431, 703-707 (2004).
2. Tumpey, T.M. et al. Proc. Natl. Acad. Sci. USA 101, 3166-3171 (2004).
3. Novel Swine-Origin Infuenza A (H1N1) Virus Investigation Team. N. Engl. J. Med. 360, 2605-2615 (2009).
4. Wang, T.T. & Palese, P. Cell 137, 983-985 (2009).
5. Zhang, W. et al. Protein Cell 1, 459-467 (2010).
6. Xu, R. et al. Science 328, 357-360 (2010).
7. Yang, H., Carney, P. & Stevens, J. PLoS Curr. Infuenza RRN1152 (2010).
8. Wei, C.J. et al. Sci. Transl. Med. 2, 24ra21 (2010)
9. Colman, P.M. Protein Sci. 3, 1687-1696 (1994).
10. Russell, R.J. et al. Nature 443, 45-49 (2006)
11. von Itzstein, M. Nat. Rev. Drug Discov. 6, 967-974 (2007).
12. Xu, X., Zhu, X., Dwek, R.A., Stevens, J. & Wilson, I.A. J. Virol. 82, 10493-10501 (2008).
13. Luo, M. Nature 443, 37-38 (2006).
14. Mitrasinovic, P.M. Biophys. Chem. 140, 35-38 (2009).
15. Colman, P.M. Annu. Rev. Biochem. 78, 95-118 (2009).
16. Varghese, J.N., Laver, W.G. & Colman, P.M. Nature 303, 35-40 (1983).
17. Sun, Y. et al. Sci. China C Life Sci. 53, 633-642 (2010).
18. Gao, G.F. & Sun, Y. Sci. China C Life Sci. 53, 151-153 (2010).
19. Zhang, Y. et al. PLoS ONE 5, e9167 (2010).