Nicotine causes genotoxic damage but is not metabolized during long-term exposure of human nasal miniorgan cultures

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 303-310

  Ginzkey, Christian ^a   Steussloff, Gudrun ^a   Koehler, Christian ^a   Hackenberg, Stephan ^a   Richter, Elmar ^b   Hagen, Rudolf ^a   Kleinsasser, Norbert H ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

CYP2A6; Genotoxicity; Metabolism; Miniorgan culture; Nasal mucosa; Nicotine

Indexed keywords

COTININE; CYTOCHROME P450 2A6; NICOTINE; NICOTINIC RECEPTOR;

ARTICLE; COMET ASSAY; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; DNA DAMAGE; DOWN REGULATION; EVALUATION STUDY; GENOTOXICITY; HUMAN; HUMAN TISSUE; LONG TERM EXPOSURE; MASS FRAGMENTOGRAPHY; METABOLISM; MINIORGAN CULTURE; MOLECULAR MECHANICS; NOSE MUCOSA; PRIORITY JOURNAL; SUPERNATANT; TISSUE CULTURE;

CYP2A6; GENOTOXICITY; METABOLISM; MINIORGAN CULTURE; NASAL MUCOSA; NICOTINE;

ADOLESCENT; ADULT; ARYL HYDROCARBON HYDROXYLASES; COMET ASSAY; COTININE; DNA DAMAGE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; METHYL METHANESULFONATE; MIDDLE AGED; MUTAGENS; NICOTINE; NICOTINIC AGONISTS; NOSE; ORGAN CULTURE TECHNIQUES; RECEPTORS, NICOTINIC; SMOKING; YOUNG ADULT;

EID: 84903713488     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.06.842     Document Type: Article

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