Nicotine and methyl methane sulfonate in mini organ cultures of human parotid gland tissue

Toxicology Letters

Volumn 197, Issue 2, 2010, Pages 69-74

  Ginzkey, Christian ^a   Friehs, Gudrun ^a   Koehler, Christian ^a   Hackenberg, Stephan ^a   Voelker, Hans Ullrich ^a   Richter, Elmar ^b   Kleinsasser, Norbert H ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Genotoxicity; Human study; Mini organ cultures; Nicotine; Parotid gland

Indexed keywords

AMYLASE; MESYLIC ACID METHYL ESTER; NICOTINE;

ACINAR CELL; ADULT; AGED; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ORGAN CULTURE; PAROTID GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 77953962614     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.04.032     Document Type: Article

References (45)

1. Anderson G., Jenkinson E.J. Investigating central tolerance with reaggregate thymus organ cultures. Methods Mol. Biol. 2007, 380:185-196.
2. Arabi M. Nicotinic infertility: assessing DNA and plasma membrane integrity of human spermatozoa. Andrologia 2004, 36:305-310.
3. Argentin G., Cicchetti R. Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts. Toxicol. Sci. 2004, 79:75-81.
4. Bals R., Gamarra F., Kaps A., Grundler S., Huber R.M., Welsch U. Secretory cell types and cell proliferation of human bronchial epithelial cells in an organ-culture system. Cell Tissue Res. 1998, 293:573-577.
5. Barrett L.A., McDowell E.M., Frank A.L., Harris C.C., Trump B.F. Long-term organ culture of human bronchial epithelium. Cancer Res. 1976, 36:1003-1010.
6. Bernstein C., Bernstein H., Payne C.M., Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 2002, 511:145-178.
7. Buehrlen M., Harréus U.A., Gamarra F., Hagen R., Kleinsasser N.H. Cumulative genotoxic and apoptotic effects of xenobiotics in a mini organ culture model of human nasal mucosa as detected by the alkaline single cell microgel electrophoresis assay and the annexin V-affinity assay. Toxicol. Lett. 2007, 169:152-161.
8. Chang M.-L., Sung K.-F., Sheen I.-S., Lin S.-M., Yeh C.-T. A liver slice culture-based ex vivo assay to predict the outcome of antiviral therapy for chronic hepatitis C. J. Viral Hepat. 2009, 16:359-366.
9. Chen M.-H., Chen Y.-J., Liao C.-C., Chan Y.-H., Lin C.-Y., Chen R.-S., Young T.-H. Formation of salivary acinar cell spheroids in vitro above a polyvinyl alcohol-coated surface. J. Biomed. Mater. Res. A 2009, 90:1066-1072.
10. Cooke J.P., Bitterman H. Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Ann. Med. 2004, 36:33-40.
11. Dasgupta P., Rizwani W., Pillai S., Kinkade R., Kovacs M., Rastogi S., Banerjee S., Carless M., Kim E., Coppola D., Haura E., Chellappan S. Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int. J. Cancer 2009, 124:36-45.
12. De Kanter R., Olinga P., de Jager M.H., Merema M.T., Meijer D.K.F., Groothius G.M.M. Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney. Toxicol. In Vitro 1999, 13:737-744.
13. Fjellbirkeland L., Bjerkvig R., Steinsvåg S.K., Laerum O.D. Nonadhesive stationary organ culture of human bronchial mucosa. Am. J. Respir. Cell. Mol. Biol. 1996, 15:197-206.
14. Freedman L.S., Oberman B., Sadetzki S. Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin's tumor risk. Am. J. Epidemiol. 2009, 170:1178-1185.
15. Ginzkey C., Kampfinger K., Friehs G., Köhler C., Hagen R., Richter E., Kleinsasser N.H. Nicotine induces DNA damage in human salivary glands. Toxicol. Lett. 2009, 184:1-4.
16. Glöckner R., Steinmetzer P., Drobner C., Müller D. Application of cryopreserved precision-cut liver slices in pharmacotoxicology-principles, literature data and own investigations with special reference to CYP1A1-mRNA induction. Exp. Toxicol. Pathol. 1998, 50:440-449.
17. Harréus U., Schmezer P., Kuchenmeister F., Maier H. Genotoxic effect on human mucous membrane biopsies of the upper aerodigestive tract. Laryngorhinootologie 1999, 78:176-181.
18. Heeschen C., Jang J.J., Weis M., Pathak A., Kaji S., Hu R.S., Tsao P.S., Johnson F.L., Cooke J.P. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat. Med. 2001, 7:833-839.
19. Hoffmann D., Adams J.D. Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers. Cancer Res. 1981, 41:4305-4308.
20. Horn-Ross P.L., Ljung B.M., Morrow M. Environmental factors and the risk of salivary gland cancer. Epidemiology (Cambridge, Mass) 1997, 8:414-419.
21. Joraku A., Sullivan C.A., Yoo J., Atala A. In-vitro reconstitution of three-dimensional human salivary gland tissue structures. Differentiation 2007, 75:318-324.
22. Kleinsasser N.H., Gamarra F., Bergner A., Wallner B.C., Harréus U.A., Juchhoff J., Kastenbauer E.R., Huber R.M. Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay. ORL 2001, 63:141-147.
23. Kleinsasser N.H., Juchhoff J., Wallner B.C., Bergner A., Harréus U.A., Gamarra F., Bührlen M.B., Huber R.M., Rettenmeier A.W. The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicology. Mutat. Res. 2004, 561:63-73.
24. Kleinsasser N.H., Sassen A.W., Semmler M.P., Harréus U.A., Licht A.-K., Richter E. The tobacco alkaloid nicotine demonstrates genotoxicity in human tonsillar tissue and lymphocytes. Toxicol. Sci. 2005, 86:309-317.
25. Kleinsasser N.H., Wallner B.C., Wagner C., Kastenbauer E.R., Harreus U.A. DNA repair capacity in lymphocytes of nasopharyngeal cancer patients. Eur. Arch. Otorhinolaryngol. 2005, 262:561-566.
26. Kleinsasser N.H., Harréus U.A., Gamarra F., Driemel O., Hagen R., Buehrlen M. Cytochrome P4502A6 stability in a mini organ culture model of human nasal mucosa for genotoxicology studies as detected by flow cytometry. Eur. Arch. Otorhinolaryngol. 2009, 266:385-389.
27. Lin R.-Z., Chang H.-Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol. J. 2008, 3:1172-1184.
28. Lindell G., Lunell E., Graffner H. Transdermally administered nicotine accumulates in gastric juice. Eur. J. Clin. Pharmacol. 1996, 51:315-318.
29. Minna J.D. Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer. J. Clin. Invest. 2003, 111:31-33.
30. Muscat J.E., Wynder E.L. A case/control study of risk factors for major salivary gland cancer. Otolaryngol. Head Neck Surg. 1998, 118:195-198.
31. Olive P.L., Durand R.E., Le Riche J., Olivotto I.A., Jackson S.M. Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Res. 1993, 53:733-736.
32. Parrish A.R., Gandolfi A.J., Brendel K. Precision-cut tissue slices: applications in pharmacology and toxicology. Life Sci. 1995, 57:1887-1901.
33. Richter E., Friesenegger S., Engl J., Tricker A.R. Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney. Toxicology 2000, 144:83-91.
34. Sassen A.W., Richter E., Semmler M.P., Harréus U.A., Gamarra F., Kleinsasser N.H. Genotoxicity of nicotine in mini-organ cultures of human upper aerodigestive tract epithelia. Toxicol. Sci. 2005, 88:134-141.
35. Shanabruch W.G., Rein R.P., Behlau I., Walker G.C. Mutagenesis, by methylating and ethylating agents, in mutH, mutL, mutS, and uvrD mutants of Salmonella typhimurium LT2. J. Bacteriol. 1983, 153:33-44.
36. Shin V.Y., Jin H.C., Ng E.K.O., Yu J., Leung W.K., Cho C.H., Sung J.J.Y. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: involvement of nicotinic acetylcholine receptor (nAChR) and β-adrenergic receptor signaling pathways. Toxicol. Appl. Pharmacol. 2008, 233:254-261.
37. Steinsvåg S.K., Strand M., Berg Ø., Miaguchi M., Olofsson J. Human respiratory mucosa in a nonadhesive stationary organ culture system. Laryngoscope 1991, 101:1323-1331.
38. Sudheer A.R., Muthukumaran S., Devipriya N., Menon V.P. Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine. Toxicology 2007, 230:11-21.
39. Sun T., Zhu J., Yang X., Wang S. Growth of miniature pig parotid cells on biomaterials in vitro. Arch. Oral Biol. 2006, 51:351-358.
40. Teneggi V., Squassante L., Iavarone L., Milleri S., Bye A., Gomeni R. Correlation and predictive performances of saliva and plasma nicotine concentration on tobacco withdrawal-induced craving. Br. J. Clin. Pharmacol. 2002, 54:407-414.
41. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
42. Umachandran M., Howarth J., Ioannides C. Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 2004, 34:771-780.
43. Wallner B.C., Harréus U.A., Gamarra F., Sassen A., Kleinsasser N.H. Miniorgankulturen humaner nasaler Mukosa-Ein Modell für ökogenotoxikologische Untersuchungen. HNO 2005, 53:1037-1046.
44. Yildiz D., Ercal N., Armstrong D.W. Nicotine enantiomers and oxidative stress. Toxicology 1998, 130:155-165.
45. Zeidler R., Albermann K., Lang S. Nicotine and apoptosis. Apoptosis 2007, 12:1927-1943.