In vitro genoprotective and genotoxic effect of nicotine on human leukocytes evaluated by the comet assay

Drug and Chemical Toxicology

Volumn 37, Issue 3, 2014, Pages 322-328

  Sobkowiak, Robert ^a   Musidlak, Jakub ^a   Lesicki, Andrzej ^a  

^a ADAM MICKIEWICZ UNIVERSITY   (Poland)

Author keywords

Blood cells; DNA damage; DNA protection; Drug

Indexed keywords

DNA; NICOTINE; REACTIVE OXYGEN METABOLITE;

ARTICLE; BLOOD CELL; BLOOD LEVEL; CELL PROTECTION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE; SMOKING; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PATHOLOGY; TOXICITY;

COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IN VITRO TECHNIQUES; LEUKOCYTES; NICOTINE; REACTIVE OXYGEN SPECIES;

EID: 84901923671     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2013.851693     Document Type: Article

References (58)

1. Abreu-Villaca Y, Seidler FJ, Qiao D, et al. (2005). Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. Brain Res Dev Brain Res 154: 239-246. (Pubitemid 40221868)
2. Arabi M. (2004). Nicotinic infertility: assessing DNA and plasma membrane integrity of human spermatozoa. Andrologia 36:305-310. (Pubitemid 39389612)
3. Argentin G, Cicchetti R. (2004). Genotoxic and antiapoptotic effect of nicotine on human gingival fibroblasts. Toxicol Sci 79:75-81. (Pubitemid 38660250)
4. Arias HR, Richards VE, Ng D, et al. (2009). Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int J Biochem Cell Biol 41:1441-1451.
5. Attia SM. (2007a). Chromosomal composition of micronuclei in mouse bone marrow treated with rifampicin and nicotine, analyzed by multicolor fluorescence in situ hybridization with pancentromeric DNA probe. Toxicology 235:112-118. (Pubitemid 46669774)
6. Attia SM. (2007b). The genotoxic and cytotoxic effects of nicotine in the mouse bone marrow. Mutat Res 632:29-36. (Pubitemid 47031683)
7. Baron JA. (1996). Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious. Br Med Bull 52:58-73. (Pubitemid 26039049)
8. Benowitz NL, Hukkanen J, Jacob 3rd P. (2009). Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol 192: 29-60.
9. Collins AR. (2004). The comet assay for DNA damage and repair: principles, applications, and limitations. Mol Biotechnol 26:249-261. (Pubitemid 41490465)
10. Collins AR, Oscoz AA, Brunborg G, et al. (2008). The comet assay: topical issues. Mutagenesis 23:143-151.
11. DeMarini DM, Gudi R, Szkudlinska A, et al. (2008). Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates. Mutat Res 650:15-29.
12. Doolittle DJ, Winegar R, Lee CK, et al. (1995). The genotoxic potential of nicotine and its major metabolites. Mutat Res 344:95-102.
13. Faust F, Kassie F, Knasmuller S, et al. (2004). The use of the alkaline comet assay with lymphocytes in human biomonitoring studies. Mutat Res 566:209-229. (Pubitemid 38472028)
14. Ferger B, Spratt C, Earl CD, et al. (1998). Effects of nicotine on hydroxyl free radical formation in vitro and on MPTP-induced neurotoxicity in vivo. Naunyn Schmiedebergs Arch Pharmacol 358:351-359. (Pubitemid 28425492)
15. Ginzkey C, Kampfinger K, Friehs G, et al. (2009). Nicotine induces DNA damage in human salivary glands. Toxicol Lett 184:1-4.
16. Ginzkey C, Stueber T, Friehs G, et al. (2012). Analysis of nicotineinduced DNA damage in cells of the human respiratory tract. Toxicol Lett 208:23-29.
17. Gosselin RE, Smith RP, Hodge HC. (1988). Clinical toxicology of commercial products, 6th ed. Baltimore, MD: Williams & Wilkins.
18. Guan ZZ, Yu WF, Nordberg A. (2003). Dual effects of nicotine on oxidative stress and neuroprotection in PC12 cells. Neurochem Int 43: 243-249. (Pubitemid 36419525)
19. Gvozdjakova A, Kucharska J, Gvozdja'k J. (1992). Effect of smoking on the oxidative processes of cardiomyocytes. Cardiology 81:81-84. (Pubitemid 23052116)
20. Hall J, Bre'sil H, Donato F, et al. (1993). Alkylation and oxidative-DNA damage repair activity in blood leukocytes of smokers and nonsmokers. Int J Cancer 54:728-733. (Pubitemid 23228601)
21. Harris G, Holmes A, Sabovljev SA, et al. (1986). Sensitivity to X-irradiation of peripheral blood lymphocytes from ageing donors. Int J Radiat Biol Relat Stud Phys Chem Med 50:685-694. (Pubitemid 16026706)
22. Hartmann A, Elhajouji A, Kiskinis E, et al. (2001). Use of the alkaline comet assay for industrial genotoxicity screening: comparative investigation with the micronucleus test. Food Chem Toxicol 39: 843-858. (Pubitemid 32575252)
23. Hartmann A, Schumacher M, Plappert-Helbig U, et al. (2004). Use of the alkaline in vivo comet assay for mechanistic genotoxicity investigations. Mutagenesis 19:51-59. (Pubitemid 38088395)
24. Herman AI, Sofuoglu M. (2010). Comparison of available treatments for tobacco addiction. Curr Psychiatry Rep 12:433-440.
25. Hoffmann H, Speit G. (2005). Assessment of DNA damage in peripheral blood of heavy smokers with the comet assay and the micronucleus test. Mutat Res 581:105-114. (Pubitemid 40255899)
26. Hukkanen J, Jacob 3rd P, Benowitz NL. (2005). Metabolism and disposition kinetics of nicotine. Pharmacol Rev 57:79-115. (Pubitemid 40283970)
27. IARC (International Agency for Research on Cancer). (2004). IARC monographs on the evaluation of carcinogenic risks to humans: tobacco smoke and involuntary smoking, vol. 83. Lyon, France: IARC Scientific Publications.
28. IARC (International Agency for Research on Cancer). (2007). IARC monographs on the evaluation of carcinogenic risks to humans: smokeless tobacco and some tobacco-specific N-nitrosamines, vol. 89. Lyon, France: IARC Scientific Publications.
29. Idris AM, Ibrahim SO, Vasstrand EN, et al. (1998). The Swedish snus and the Sudanese toombak: are they different? Oral Oncol 34:558-566 Jarvik ME. (1991). Beneficial effects of nicotine. Br J Addict 86: 571-575.
30. Kleinsasser NH, Sassen AW, Semmler MP, et al. (2005). The tobacco alkaloid nicotine demonstrates genotoxicity in human tonsillar tissue and lymphocytes. Toxicol Sci 86:309-317. (Pubitemid 41418644)
31. Kohn KW, Bohr VA. (2002). Genomic instability and DNA repair. In: Alison M, ed. The cancer handbook. London: Nature Publishing Group, 87-106.
32. Koleva II, van Beek TA, Soffers AE, et al. (2012). Alkaloids in the human food chain - natural occurrence and possible adverse effects. Mol Nutr Food Res 56:30-52.
33. Konca K, Lankoff A, Banasik A, et al. (2003). A cross-platform public domain PC image-analysis program for the comet assay. Mutat Res 534:15-20. (Pubitemid 36015835)
34. Lee E, Oh E, Lee J, et al. (2004). Use of the tail moment of the lymphocytes to evaluate DNA damage in human biomonitoring studies. Toxicol Sci 81:121-132. (Pubitemid 39199870)
35. Leroy T, Van Hummelen P, Anard D, et al. (1996). Evaluation of three methods for the detection of DNA single-strand breaks in human lymphocytes: alkaline elution, nick translation, and single-cell gel electrophoresis. J Toxicol Environ Health 47:409-422.
36. Lovell DP, Omori T. (2008). Statistical issues in the use of the comet assay. Mutagenesis 23:171-182.
37. Matta SG, Balfour DJ, Benowitz NL, et al. (2007). Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl) 190:269-319. (Pubitemid 46156883)
38. Mizusaki S, Okamoto H, Akiyama A, Fukuhara Y. (1977). Relation between chemical constituents of tobacco and mutagenic activity of cigarette smoke condensate. Mutat Res 48:319-325. (Pubitemid 8107644)
39. Møller P. (2006). The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures. Basic Clin Pharmacol Toxicol 98:336-345.
40. Møller P, Knudsen LE, Loft S, Wallin H. (2000). The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 9:1005-1015.
41. Muthukumaran S, Sudheer AR, Nalini N, Menon VP. (2008). Effect of quercetin on nicotine-induced biochemical changes and DNA damage in rat peripheral blood lymphocytes. Redox Rep 13: 217-224.
42. Olive PL, Banath JP. (2006). The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 1:23-29.
43. Olive PL, Durand RE, Le Riche J, et al. (1993). Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. Cancer Res 53:733-736. (Pubitemid 23077852)
44. Pogocki D, Ruman T, Danilczuk M, et al. (2007). Application of nicotine enantiomers, derivatives and analogues in therapy of neurodegenerative disorders. Eur J Pharmacol 563:18-39. (Pubitemid 46604813)
45. Sassen AW, Richter E, Semmler MP, et al. (2005). Genotoxicity of nicotine in mini-organ cultures of human upper aerodigestive tract epithelia. Toxicol Sci 88:134-141. (Pubitemid 41548755)
46. Singh NP. (2000). Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat Res 455:111-127.
47. Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
48. Sobkowiak R, Lesicki A. (2009). Genotoxicity of nicotine in cell culture of Caenorhabditis elegans evaluated by the comet assay. Drug Chem Toxicol 32:252-257.
49. Sobkowiak R, Lesicki A. (2011). Cell signaling pathways activated by nicotine. Adv Cell Biol 38:581-596.
50. Soto-Otero R, Me'ndez-Alvarez E, Hermida-Ameijeiras A, et al. (2002). Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine- induced oxidative stress and neurotoxicity: relevance for Parkinson's disease. Biochem Pharmacol 64:125-135. (Pubitemid 34775183)
51. Speit G, Witton-Davies T, Heepchantree W, et al. (2003). Investigations on the effect of cigarette smoking in the comet assay. Mutat Res 542: 33-42. (Pubitemid 37486095)
52. Sudheer AR, Muthukumaran S, Devipriya N, Menon VP. (2007a). Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine. Toxicology 230: 11-21. (Pubitemid 46073326)
53. Sudheer AR, Muthukumaran S, Kalpana C, et al. (2007b). Protective effect of ferulic acid on nicotine-induced DNA damage and cellular changes in cultured rat peripheral blood lymphocytes: a comparison with N-acetylcysteine. Toxicol In Vitro 21:576-585. (Pubitemid 46550738)
54. Swan GE, Lessov-Schlaggar CN. (2009). Tobacco addiction and pharmacogenetics of nicotine metabolism. J Neurogenet 23: 262-271.
55. Turner DR, Griffith VC, Morley AA. (1982). Ageing in vivo does not alter the kinetics of DNA strand break repair. Mech Ageing Dev 19: 325-331. (Pubitemid 13249410)
56. Villablanca AC. (1998). Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol 84:2089-2098. (Pubitemid 28255971)
57. Wu HJ, Chi CW, Liu TY. (2005). Effects of pH on nicotine-induced DNA damage and oxidative stress. J Toxicol Environ Health A 68: 1511-1523.
58. Yildiz D, Ercal N, Armstrong DW. (1998). Nicotine enantiomers and oxidative stress. Toxicology 130:155-165. (Pubitemid 28488583)