Comparing the genotoxic sensitivities of human peripheral blood lymphocytes and mucosa cells of the upper aerodigestive tract using the Comet assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 467, Issue 1, 2000, Pages 21-30

  Kleinsasser, Norbert H ^a   Wallner, Barbara C ^a   Kastenbauer, Ernst R ^a   Muenzenrieder, Ruth K ^a   Harréus, Ulrich A ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alkaline Comet assay; Genotoxicity; Lymphocytes; Mucosal cells; Nitrosamines; Phthalates

Indexed keywords

BENZO[A]PYRENE; DIETHYLNITROSAMINE; METHYLNITRONITROSOGUANIDINE; NITROSAMINE; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID ESTER;

ARTICLE; CARCINOGENESIS; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE; MALE; MUCOSA CELL; PRIORITY JOURNAL;

ADULT; ALCOHOL DRINKING; BENZO(A)PYRENE; COMET ASSAY; DIETHYLNITROSAMINE; DNA DAMAGE; FEMALE; HUMANS; LYMPHOCYTES; MALE; METHYLNITRONITROSOGUANIDINE; MIDDLE AGED; MUTAGENS; NASAL MUCOSA; OROPHARYNX; PHTHALIC ACIDS; SMOKING; XENOBIOTICS;

NICOTIANA TABACUM;

EID: 0034643489     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00022-X     Document Type: Article

References (24)

1. Rubin R.J., Ness P.M. What price progress? An update on vinyl plastic bags. Transfusion. 29.4:1989;358-361.
2. Kleinsasser N.H., Harréus U.A., Kastenbauer E.R. Genotoxicity of phthalates and nitrosodiethanolamine on human oropharyngeal mucosa. MMW, Res. Festival 98, München. 1998;453.
3. Kleinsasser N.H., Kastenbauer E.R., Weissacher H., Muenzenrieder R.K., Harréus U.A. Phthalates demonstrate genotoxicity on human mucosa of the upper aerodigestive tract. Environ. Mol. Mutagen. 35:2000;9-12.
4. Cloos J., Braakhuis B.J.M., Steen I., Copper M.P., De Vries N., Nauta J.J.P., Snow G.B. Increased mutagen sensitivity in head-and-neck squamous-cell carcinoma patients, particularly those with multiple primary tumors. Int. J. Cancer. 56:1994;816-819.
5. Moustacchi E. Molecular mechanisms of carcinogenesis: the role of systems of DNA repair. Bull. Acad. Natl. Med. 182.1:1998;33-46.
6. Cheng L., Eicher S.A., Guo Z., Hong W.K., Spitz M.R., Wei Q. Reduced DNA repair capacity in head and neck cancer patients. Cancer Epidemiol., Biomarkers Prev. 7.6:1998;465-468.
7. Hong J.Y., Yang C.S. Genetic polymorphism of cytochrome P450 as a biomarker of susceptibility to environmental toxicity. Environ. Health Perspect. 105.4:1997;759-762.
8. Kihara M., Kihara M., Kubota A., Furukawa M., Kimura H. GSTM1 gene polymorphism as a possible marker for susceptibility to head and neck cancers among Japanese smokers. Cancer Lett. 112:1997;257-262.
9. Matthias C., Jahnke V., Hand P., Fryer A.A., Strange R.C. Immunhistochemische und molekulargenetische Untersuchungen zum Einfluß von Gluthation-S-Transferasen auf die Entwicklung von Plattenepithelkarzinomen im Kopf-Hals-Bereich. Laryngol. Rhinol. Otol. 78:1999;182-188.
10. Copper M.P., Jovanovic A., Nauta J.J.P, Braakhuis B.J.M., de Vries N., van der Waal I., Snow G.B. Role of genetic factors in the etiology of squamous cell carcinoma of the head and neck. Arch. Otolaryngol., Head Neck Surg. 121:1995;157-160.
11. McKelvey-Martin V.J., Green M.H.L., Schmezer P., Pool-Zobel P.L., DeMeo M.P., Collins A. The single cell gel electrophoresis assay (Comet assay): a European review. Mutat. Res. 288:1993;47-63.
12. Olive P.L., Durand R.E., Le Riche J., Olivotto I.A., Jackson S.M. Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancer. Cancer Res. 53:1993;733-736.
13. IARC Monogr. Eval. Carcinog. Risks Hum. 7.67:1987.
14. N.H. Kleinsasser, H. Weissacher, E.R. Kastenbauer, P. Dirschedl, B. Wallner, U.A. Harréus, Altered genotoxicity in mucosal cells of head and neck cancer patients due to environmental pollutants, Eur. Arch. Otorhinolaryngol., in press.
15. Hanelt S., Helbig R., Hartmann A., Lang M., Seidel A., Speit G. A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (±)-anti-benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells. Mutat. Res. 390:1997;179-188.
16. Wei Q., Gu J., Cheng L., Bondy M.L., Jiang H., Hong W.K., Spitz M.R. Benzo[a]pyrene diol epoxide-induced chromosomal aberrations and risk of lung cancer. Cancer Res. 56:1996;3975-3979.
17. Huber W.W., Grasl-Kraupp B., Schulte-Hermann R. Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk. Crit. Rev. Toxicol. 26.4:1996;365-481.
18. Karle V.A., Short B.L., Martin G.R., Bulas D.I., Getson P.R., Luban N.L.C., O'Brien A.M., Rubin R.J. Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl)phthalate. Crit. Care Med. 25.4:1997;696-703.
19. Kleinsasser N.H., Harréus U.A. Genotoxic sensitivity to dibutylphthalate and diisobutylphthalate in non-tumor and patients with SCC of the head and neck. Cancer Res. Clin. Oncol. 125:1999;30-31.
20. Anderson D., Yu T.W., Hincal F. Effect of some phthalate esters in human cells in the comet assay. Teratog., Carcinog., Mutagen. 19.4:1999;275-280.
21. Richmond R.E., Carter J.H., Carter H.W., Daniel F.B., Deangelo A.B. Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl) phthalate (DHEP). Carcinogenesis. 17.8:1996;1647-1655.
22. Ward J.W., Peters J.M., Perella C.M., Gonzalez F.J. Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DHEP) in peroxisome proliferator-activated receptor α-null mice. Toxicol. Pathol. 26.2:1998;240-246.
23. Blom A., Ekman E., Johannisson A., Norrgren L., Pesonen M. Effects of xenoestrogenic environmental pollutants on the proliferation of a human breast cancer cell line (MCF-7). Arch. Environ. Contam. Toxicol. 34:1998;306-310.
24. Coutelle C., Ward P.J., Fleury B., Quatrocchi P., Chambrin H., Iron A., Couzigou P., Cassaigne A. Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione-S-transferase M1 polymorphisms. Hum. Genet. 99:1997;319-325.