Folding of an antibody variable domain in two functional conformations in vitro: Calorimetric and spectroscopic study of the anti-ferritin antibody VL domain

Protein Engineering, Design and Selection

Volumn 20, Issue 10, 2007, Pages 481-490

  Tsybovsky, Yaroslav ^a,c   Shubenok, Denis V ^a   Kravchuk, Zinaida I ^a   Martsev, Sergey P ^a,b  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

^b Ministry of Health Republic of Belarus   (Belarus)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Conformational stability; Conformers of folding; Protein refolding; Recombinant antibody; VL domain

Indexed keywords

ADSORPTION; BACTERIA; BIOMEDICAL ENGINEERING; DIALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; FLUORESCENCE;

ANTI-FERRITIN ANTIBODY; ANTIBODY VARIABLE DOMAIN; BACTERIAL INCLUSIONS; DISULFIDE BOND;

ANTIBODIES;

FERRITIN; FERRITIN ANTIBODY; RECOMBINANT ANTIBODY;

ARTICLE; BINDING SITE; DIFFERENTIAL SCANNING CALORIMETRY; FLUORESCENCE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEOMICS; SPECTROSCOPY;

ANIMALS; ANTIGENS; CALORIMETRY; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; CYTOPLASM; DISULFIDES; FERRITINS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INCLUSION BODIES; MICE; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SPLEEN; THERMODYNAMICS; ULTRAVIOLET RAYS;

BACTERIA (MICROORGANISMS);

EID: 36248987404     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzm034     Document Type: Article

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