Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Chen, Lu ^a   Munõz Antonia, Teresita ^a   Cress, W Douglas ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE CELL ADHESION MOLECULE; PROTEIN TRIM28; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; REPRESSOR PROTEIN; TRIM28 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CANCER CELL LINE; CANCER STAGING; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; E CADHERIN GENE; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; METASTASIS; N CADHERIN GENE; ONCOGENE; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TGF BETA GENE; TRIM28 GENE; GENETICS; LUNG TUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

BIOMARKERS, TUMOR; CADHERINS; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; LUNG NEOPLASMS; REPRESSOR PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84903702736     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101040     Document Type: Article

References (36)

1. Yang J, Weinberg RA (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14: 818-829. (Pubitemid 351757205)
2. Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
3. Willis BC, Borok Z (2007) TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293: L525-534. (Pubitemid 47358808)
4. De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13: 97-110.
5. Byles V, Zhu L, Lovaas JD, Chmilewski LK, Wang J, et al. (2012) SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene 31: 4619-4629.
6. Dong C, Wu Y, Wang Y, Wang C, Kang T, et al. (2013) Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene 32: 1351-1362.
7. Dong C, Wu Y, Yao J, Wang Y, Yu Y, et al. (2012) G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest 122: 1469-1486.
8. Iyengar S, Farnham PJ (2011) KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem 286: 26267-26276.
9. Chen L, Chen DT, Kurtyka C, Rawal B, Fulp WJ, et al. (2012) Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions. J Biol Chem 287: 40106-40118.
10. Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, et al. (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 8: 870-876. (Pubitemid 44151591)
11. Fazzio TG, Huff JT, Panning B (2008) An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 134: 162-174. (Pubitemid 351905738)
12. Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, et al. (2010) TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner. Proc Natl Acad Sci U S A 107: 10926-10931.
13. Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, et al. (2007) A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest 117: 482-491. (Pubitemid 46203977)
14. Lin LF, Li CF, Wang WJ, Yang WM, Wang DD, et al. (2013) Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer. PLoS One 8: e73033.
15. Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, et al. (1996) KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev 10: 2067-2078. (Pubitemid 26346114)
16. Wang C, Rauscher FJ 3rd, Cress WD, Chen J (2007) Regulation of E2F1 function by the nuclear corepressor KAP1. J Biol Chem 282: 29902-29909. (Pubitemid 350035243)
17. Rambaud J, Desroches J, Balsalobre A, Drouin J (2009) TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77. J Biol Chem 284: 14147-14156.
18. Chang CJ, Chen YL, Lee SC (1998) Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression. Mol Cell Biol 18: 5880-5887.
19. Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ, 3rd (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16: 919-932. (Pubitemid 34408542)
20. Schultz DC, Friedman JR, Rauscher FJ 3rd (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev 15: 428-443. (Pubitemid 32187004)
21. Beer DG, Kardia SL, Huang CC, Giordano TJ, Levin AM, et al. (2002) Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med 8: 816-824.
22. Landi MT, Dracheva T, Rotunno M, Figueroa JD, Liu H, et al. (2008) Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PLoS One 3: e1651.
23. Hatakeyama S (2011) TRIM proteins and cancer. Nat Rev Cancer 11: 792-804.
24. Ho J, Kong JW, Choong LY, Loh MC, Toy W, et al. (2009) Novel breast cancer metastasis-associated proteins. J Proteome Res 8: 583-594.
25. Doyle JM, Gao J, Wang J, Yang M, Potts PR (2010) MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases. Mol Cell 39: 963-974.
26. Kokura K, Sun L, Bedford MT, Fang J (2010) Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J 29: 3673-3687.
27. Ma Y, Chen L, Wright GM, Pillai SR, Chellappan SP, et al. (2010) CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner. J Biol Chem 285: 9813-9822.
28. Kumar M, Allison DF, Baranova NN, Wamsley JJ, Katz AJ, et al. (2013) NF-kappaB Regulates Mesenchymal Transition for the Induction of Non-Small Cell Lung Cancer Initiating Cells. PLoS One 8: e68597.
29. Elliott RL, Blobe GC (2005) Role of transforming growth factor Beta in human cancer. J Clin Oncol 23: 2078-2093. (Pubitemid 46211385)
30. Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z (2005) TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 6: 56.
31. Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ (2008) Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol 38: 95-104.
32. Moreno-Bueno G, Peinado H, Molina P, Olmeda D, Cubillo E, et al. (2009) The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc 4: 1591-1613.
33. Tsuruma R, Ohbayashi N, Kamitani S, Ikeda O, Sato N, et al. (2008) Physical and functional interactions between STAT3 and KAP1. Oncogene 27: 3054-3059. (Pubitemid 351668002)
34. Herquel B, Ouararhni K, Khetchoumian K, Ignat M, Teletin M, et al. (2011) Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A 108: 8212-8217.
35. Yokoe T, Toiyama Y, Okugawa Y, Tanaka K, Ohi M, et al. (2010) KAP1 is associated with peritoneal carcinomatosis in gastric cancer. Ann Surg Oncol 17: 821-828.
36. Javelaud D, Alexaki VI, Dennler S, Mohammad KS, Guise TA, et al. (2011) TGF-beta/SMAD/GLI2 signaling axis in cancer progression and metastasis. Cancer Res 71: 5606-5610.