Loss of ZBRK1 Contributes to the Increase of KAP1 and Promotes KAP1-Mediated Metastasis and Invasion in Cervical Cancer

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Lin, Li Fang ^a   Li, Chien Feng ^b   Wang, Wei Jan ^a   Yang, Wen Ming ^c   Wang, Dennis Ding Hwa ^e   Chang, Wen Chang ^a,d   Lee, Wen Hwa ^e   Wang, Ju Ming ^a,d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KRAB ZFP ASSOCIATED PROTEIN 1; NUCLEIC ACID BINDING PROTEIN; PROTEIN ZBRK1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KRAB DOMAIN; METASTASIS; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR INVASION; UTERINE CERVIX CANCER;

BRCA1 PROTEIN; CELL PROLIFERATION; FEMALE; HELA CELLS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 84882760435     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073033     Document Type: Article

References (26)

1. Sahai E, (2007) Illuminating the metastatic process. Nat Rev Cancer 7: 737-749. doi:10.1038/nrc2229. PubMed: 17891189.
2. Chen CF, Li S, Chen Y, Chen PL, Sharp ZD, et al. (1996) The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. J Biol Chem 271: 32863-32868. doi:10.1074/jbc.271.51.32863. PubMed: 8955125.
3. Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, et al. (2006) Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell 10: 13-24. doi:10.1016/j.ccr.2006.05.022. PubMed: 16843262.
4. Liao G, Huang J, Fixman ED, Hayward SD, (2005) The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor. J Virol 79: 245-256. doi:10.1128/JVI.79.1.245-256.2005. PubMed: 15596820.
5. Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, et al. (2000) Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain. J Biol Chem 275: 18000-18010. doi:10.1074/jbc.M001499200. PubMed: 10748030.
6. Peng H, Begg GE, Schultz DC, Friedman JR, Jensen DE, et al. (2000) Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J Mol Biol 295: 1139-1162. doi:10.1006/jmbi.1999.3402. PubMed: 10653693.
7. Schultz DC, Friedman JR, Rauscher FJ 3rd, (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev 15: 428-443. doi:10.1101/gad.869501. PubMed: 11230151.
8. Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd, (2002) SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16: 919-932. doi:10.1101/gad.973302. PubMed: 11959841.
9. Lechner MS, Begg GE, Speicher DW, Rauscher FJ 3rd, (2000) Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol Cell Biol 20: 6449-6465. doi:10.1128/MCB.20.17.6449-6465.2000. PubMed: 10938122.
10. Ryan RF, Schultz DC, Ayyanathan K, Singh PB, Friedman JR, et al. (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol Cell Biol 19: 4366-4378. PubMed: 10330177.
11. Wang C, Rauscher FJ 3rd, Cress WD, Chen J, (2007) Regulation of E2F1 function by the nuclear corepressor KAP1. J Biol Chem 282: 29902-29909. doi:10.1074/jbc.M704757200. PubMed: 17704056.
12. Yokoe T, Toiyama Y, Okugawa Y, Tanaka K, Ohi M, et al. (2010) KAP1 is associated with peritoneal carcinomatosis in gastric cancer. Ann Surg Oncol 17: 821-828. doi:10.1245/s10434-009-0795-8. PubMed: 19898899.
13. Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, et al. (2007) A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest 117: 482-491. doi:10.1172/JCI29544. PubMed: 17273560.
14. Lin LF, Chuang CH, Li CF, Liao CC, Cheng CP, et al. (2010) ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res 70: 192-201. doi:10.1158/1538-7445.AM10-192. PubMed: 19996286.
15. Lee YK, Thomas SN, Yang AJ, Ann DK, (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J Biol Chem 282: 1595-1606. PubMed: 17079232.
16. Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, et al. (2000) Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell 6: 757-768. doi:10.1016/S1097-2765(00)00075-7. PubMed: 11090615.
17. Yun J, Lee WH, (2003) Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. Mol Cell Biol 23: 7305-7314. doi:10.1128/MCB.23.20.7305-7314.2003. PubMed: 14517299.
18. Zhang Y, Fan S, Meng Q, Ma Y, Katiyar P, et al. (2005) BRCA1 interaction with human papillomavirus oncoproteins. J Biol Chem 280: 33165-33177. doi:10.1074/jbc.M505124200. PubMed: 15983032.
19. Burga LN, Tung NM, Troyan SL, Bostina M, Konstantinopoulos PA, et al. (2009) Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers. Cancer Res 69: 1273-1278. doi:10.1158/0008-5472.CAN-08-2954. PubMed: 19190334.
20. Friedman JR, Fredericks WJ, Jensen DE, Speicher DW, Huang XP, et al. (1996) KAP-1, a novel corepressor for the highly conserved KRAB repression domain. Genes Dev 10: 2067-2078. doi:10.1101/gad.10.16.2067. PubMed: 8769649.
21. Fair K, Anderson M, Bulanova E, Mi H, Tropschug M, et al. (2001) Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells. Mol Cell Biol 21: 3589-3597. doi:10.1128/MCB.21.10.3589-3597.2001. PubMed: 11313484.
22. Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, et al. (2005) MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J 24: 3279-3290. doi:10.1038/sj.emboj.7600791. PubMed: 16107876.
23. Kleer CG, Cao Q, Varambally S, Shen R, Ota I, et al. (2003) EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A 100: 11606-11611. doi:10.1073/pnas.1933744100. PubMed: 14500907.
24. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, et al. (2002) The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624-629. doi:10.1038/nature01075. PubMed: 12374981.
25. Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, et al. (2005) Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 434: 921-926. doi:10.1038/nature03452. PubMed: 15829968.
26. Jiménez-Palop M, Naredo E, Humbrado L, Medina J, Uson J, et al. (2010) Ultrasonographic monitoring of response to therapy in polymyalgia rheumatica. Ann Rheum Dis 69: 879-882. doi:10.1136/ard.2009.113555. PubMed: 19773289.