Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 20, 2011, Pages 8212-8217

  Herquel, Benjamin ^a   Ouararhni, Khalid ^a   Khetchoumian, Konstantin ^b   Ignat, Mihaela ^a   Teletin, Marius ^a   Mark, Manuel ^a   Béchade, Guillaume ^c   Van Dorsselaer, Alain ^c   Sanglier Cianférani, Sarah ^c   Hamiche, Ali ^a   Cammas, Florence ^a   Davidson, Irwin ^a   Losson, Régine ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; TRANSCRIPTION COFACTOR TRIM24; TRANSCRIPTION COFACTOR TRIM28; TRANSCRIPTION COFACTOR TRIM33; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; HEPATOCYTES; LIVER NEOPLASMS; MICE; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEIN BINDING; RECEPTORS, RETINOIC ACID; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

MURINAE; MUS;

EID: 79957738075     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101544108     Document Type: Article

References (46)

1. Feo F, et al. (2006) Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition. Biochim Biophys Acta 1765:126-147.
2. Newell P, Villanueva A, Friedman SL, Koike K, Llovet JM (2008) Experimental models of hepatocellular carcinoma. J Hepatol 48:858-879.
3. Khetchoumian K, et al. (2007) Loss of TRIM24 (TIF1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet 39:1500-1506. (Pubitemid 350191338)
4. Le Douarin B, et al. (1995) The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J 14:2020-2033.
5. Teyssier C, Ou CY, Khetchoumian K, Losson R, Stallcup MR (2006) Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptorinteracting protein 1 nuclear receptor coactivators. Mol Endocrinol 20:1276-1286. (Pubitemid 43801230)
6. Miki T, et al. (1991) Development of a highly efficient expression cDNA cloning system: Application to oncogene isolation. Proc Natl Acad Sci USA 88:5167-5171. (Pubitemid 21914705)
7. Khetchoumian K, et al. (2008) TRIM24 (TIF1alpha): An essential "brake" for retinoic acid-induced transcription to prevent liver cancer. Cell Cycle 7:3647-3652.
8. Desmet VJ (2009) East-west pathology agreement on precancerous liver lesions and early hepatocellular carcinoma. Hepatology 49:355-357.
9. Le Douarin B, You J, Nielsen AL, Chambon P, Losson R (1998) TIF1alpha: A possible link between KRAB zinc finger proteins and nuclear receptors. J Steroid Biochem Mol Biol 65:43-50. (Pubitemid 28335589)
10. Venturini L, et al. (1999) TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. Oncogene 18:1209-1217. (Pubitemid 29085994)
11. Beckstead R, et al. (2001) Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Mol Cell 7:753-765. (Pubitemid 32436436)
12. Ransom DG, et al. (2004) The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. PLoS Biol 2:e237.
13. Khetchoumian K, et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem 279:48329-48341. (Pubitemid 39540989)
14. Cammas F, et al. (2000) Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development 127:2955-2963. (Pubitemid 30487613)
15. Cammas F, Herzog M, Lerouge T, Chambon P, Losson R (2004) Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): An essential role for progression through differentiation. Genes Dev 18:2147-2160. (Pubitemid 39166631)
16. Weber P, et al. (2002) Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse. Development 129:2329-2337. (Pubitemid 34863842)
17. He W, et al. (2006) Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell 125:929-941. (Pubitemid 43795187)
18. Dupont S, et al. (2005) Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121:87-99.
19. Rowe HM, et al. (2010) KAP1 controls endogenous retroviruses in embryonic stem cells. Nature 463:237-240.
20. Kim J, Kaartinen V (2008) Generation of mice with a conditional allele for Trim33. Genesis 46:329-333. (Pubitemid 352008882)
21. Ignat M, et al. (2008) Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci USA 105:2598-2603. (Pubitemid 351520559)
22. Doisne JM, et al. (2009) iNKT cell development is orchestrated by different branches of TGF-beta signaling. J Exp Med 206:1365-1378.
23. Tsai WW, et al. (2010) TRIM24 links a non-canonical histone signature to breast cancer. Nature 468:927-932.
24. Nielsen AL, et al. (1999) Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. Embo J 18:6385-6395. (Pubitemid 29533242)
25. Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ, 3rd (2002) SETDB1: A novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16:919-932. (Pubitemid 34408542)
26. Schultz DC, Friedman JR, Rauscher FJ, 3rd (2001) Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. Genes Dev 15:428-443. (Pubitemid 32187004)
27. Sripathy SP, Stevens J, Schultz DC (2006) The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol Cell Biol 26:8623-8638. (Pubitemid 44748593)
28. Matsui T, et al. Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature 464:927-931.
29. vom Baur E, et al. (1996) Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J 15:110-124.
30. Allton K, et al. (2009) TRIM24 targets endogenous p53 for degradation. Proc Natl Acad Sci USA 106:11612-11616.
31. AbrinkM, et al. (2001) Conserved interaction between distinct Kruppel-associated box domains and the transcriptional intermediary factor 1 beta. Proc Natl Acad Sci USA 98:1422-1426.
32. Dupont S, et al. (2009) FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 136:123-135.
33. Bai X, et al. (2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell 142:133-143.
34. Ouararhni K, et al. (2006) The histone variant mH2A1.1 interfereswith transcription by down-regulating PARP-1 enzymatic activity. Genes Dev 20:3324-3336. (Pubitemid 44904853)
35. Yan KP, et al. (2004) Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene. Gene 334:3-13.
36. Vincent DF, et al. (2009) Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas. PLoS Genet 5:e1000575.
37. Postic C, Magnuson MA (2000) DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 26:149-150. (Pubitemid 30158104)
38. Schuler M, Dierich A, Chambon P, Metzger D (2004) Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse. Genesis 39:167-172. (Pubitemid 39079514)
39. Frith CH, Terracini B, Turusov VS (1994) Tumors of the kidney, renal pelvis and ureter. IARC Sci Publ 357-381.
40. Remboutsika E, et al. (1999) The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J Cell Sci 112:1671-1683. (Pubitemid 29295044)
41. Vesselinovitch SD, Mihailovich N (1983) Kinetics of diethylnitrosamine hepatocarcinogenesis in the infant mouse. Cancer Res 43:4253-4259. (Pubitemid 13044048)
42. Peng H, et al. (2000) Reconstitution of the KRAB-KAP-1 repressor complex: A model system for defining the molecular anatomy of RING-B box-coiled-coil domainmediated protein-protein interactions. J Mol Biol 295:1139-1162.
43. Peng H, Feldman I, Rauscher FJ, 3rd (2002) Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: A potential mechanism for regulating the switch between coactivation and corepression. J Mol Biol 320:629-644.
44. Yang J, Moses MA (2009) Lipocalin 2: A multifaceted modulator of human cancer. Cell Cycle 8:2347-2352.
45. Yang J, et al. (2009) Lipocalin 2 promotes breast cancer progression. Proc Natl Acad Sci USA 106:3913-3918.
46. Morsut L, et al. (2010) Negative control of Smad activity by ectodermin/TIF1gamma patterns the mammalian embryo. Development 137:2571-2578.