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Volumn 8, Issue 7, 2013, Pages

NF-κB Regulates Mesenchymal Transition for the Induction of Non-Small Cell Lung Cancer Initiating Cells

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL1; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TWIST1; TRANSCRIPTION FACTOR ZEB2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84880989513     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068597     Document Type: Article
Times cited : (102)

References (60)
  • 1
    • 84862313154 scopus 로고    scopus 로고
    • Cancer-associated-fibroblasts and tumour cells: A diabolic liaison driving cancer progression
    • 10.1007/s10555-011-9340-x
    • Cirri P, Chiarugi P, (2012) Cancer-associated-fibroblasts and tumour cells: A diabolic liaison driving cancer progression. Cancer Metastasis Rev 31: 195-208 10.1007/s10555-011-9340-x.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 195-208
    • Cirri, P.1    Chiarugi, P.2
  • 2
    • 80053401068 scopus 로고    scopus 로고
    • Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    • 10.1172/JCI57099
    • Korkaya H, Liu S, Wicha MS, (2011) Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 121: 3804-3809 10.1172/JCI57099.
    • (2011) J Clin Invest , vol.121 , pp. 3804-3809
    • Korkaya, H.1    Liu, S.2    Wicha, M.S.3
  • 3
    • 84866334922 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial-mesenchymal transition: A link between cancer and inflammation
    • 10.1016/j.semcancer.2012.05.004
    • Fuxe J, Karlsson MC, (2012) TGF-beta-induced epithelial-mesenchymal transition: A link between cancer and inflammation. Semin Cancer Biol 22: 455-461 10.1016/j.semcancer.2012.05.004.
    • (2012) Semin Cancer Biol , vol.22 , pp. 455-461
    • Fuxe, J.1    Karlsson, M.C.2
  • 4
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 5
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • 10.1016/j.devcel.2008.05.009
    • Yang J, Weinberg RA, (2008) Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 14: 818-829 10.1016/j.devcel.2008.05.009.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 6
    • 81255168182 scopus 로고    scopus 로고
    • Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: Distinct, overlapping or same populations
    • 10.1038/onc.2011.184
    • Floor S, van Staveren WC, Larsimont D, Dumont JE, Maenhaut C, (2011) Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: Distinct, overlapping or same populations. Oncogene 30: 4609-4621 10.1038/onc.2011.184.
    • (2011) Oncogene , vol.30 , pp. 4609-4621
    • Floor, S.1    van Staveren, W.C.2    Larsimont, D.3    Dumont, J.E.4    Maenhaut, C.5
  • 7
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5
  • 8
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • 10.1371/journal.pone.0002888
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, et al. (2008) Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 3: e2888 10.1371/journal.pone.0002888.
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5
  • 9
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?
    • 10.1002/ijc.26311
    • Scheel C, Weinberg RA, (2011) Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer 129: 2310-2314 10.1002/ijc.26311.
    • (2011) Int J Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 10
    • 84862770017 scopus 로고    scopus 로고
    • Regulation of EMT by TGFbeta in cancer
    • 10.1016/j.febslet.2012.02.037
    • Heldin CH, Vanlandewijck M, Moustakas A, (2012) Regulation of EMT by TGFbeta in cancer. FEBS Lett 586: 1959-1970 10.1016/j.febslet.2012.02.037.
    • (2012) FEBS Lett , vol.586 , pp. 1959-1970
    • Heldin, C.H.1    Vanlandewijck, M.2    Moustakas, A.3
  • 11
    • 84857119664 scopus 로고    scopus 로고
    • Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression
    • 10.1007/s00441-011-1199-1
    • Wendt MK, Tian M, Schiemann WP, (2012) Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression. Cell Tissue Res 347: 85-101 10.1007/s00441-011-1199-1.
    • (2012) Cell Tissue Res , vol.347 , pp. 85-101
    • Wendt, M.K.1    Tian, M.2    Schiemann, W.P.3
  • 12
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • 10.1038/cr.2009.5
    • Xu J, Lamouille S, Derynck R, (2009) TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172 10.1038/cr.2009.5.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 13
    • 84859443939 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in tumor initiation, progression and therapy in breast cancer: An update
    • 10.1007/s00441-011-1225-3
    • Zu X, Zhang Q, Cao R, Liu J, Zhong J, et al. (2012) Transforming growth factor-beta signaling in tumor initiation, progression and therapy in breast cancer: An update. Cell Tissue Res 347: 73-84 10.1007/s00441-011-1225-3.
    • (2012) Cell Tissue Res , vol.347 , pp. 73-84
    • Zu, X.1    Zhang, Q.2    Cao, R.3    Liu, J.4    Zhong, J.5
  • 14
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    • 10.1091/mbc.E02-09-0583
    • Bates RC, Mercurio AM, (2003) Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 14: 1790-1800 10.1091/mbc.E02-09-0583.
    • (2003) Mol Biol Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 15
    • 84856463822 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells
    • 10.1093/jb/mvr136
    • Kawata M, Koinuma D, Ogami T, Umezawa K, Iwata C, et al. (2012) TGF-beta-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells. J Biochem 151: 205-216 10.1093/jb/mvr136.
    • (2012) J Biochem , vol.151 , pp. 205-216
    • Kawata, M.1    Koinuma, D.2    Ogami, T.3    Umezawa, K.4    Iwata, C.5
  • 16
    • 84867115486 scopus 로고    scopus 로고
    • Microenvironmental regulation of epithelial-mesenchymal transitions in cancer
    • 10.1158/0008-5472.CAN-12-1223
    • Gao D, Vahdat LT, Wong S, Chang JC, Mittal V, (2012) Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res 72: 4883-4889 10.1158/0008-5472.CAN-12-1223.
    • (2012) Cancer Res , vol.72 , pp. 4883-4889
    • Gao, D.1    Vahdat, L.T.2    Wong, S.3    Chang, J.C.4    Mittal, V.5
  • 17
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • 10.1016/j.cell.2011.04.029
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, et al. (2011) Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145: 926-940 10.1016/j.cell.2011.04.029.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5
  • 18
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
    • 10.1038/sj.onc.1209942
    • Basseres DS, Baldwin AS, (2006) Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene 25: 6817-6830 10.1038/sj.onc.1209942.
    • (2006) Oncogene , vol.25 , pp. 6817-6830
    • Basseres, D.S.1    Baldwin, A.S.2
  • 19
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-kappaB as the matchmaker
    • 10.1038/ni.2060
    • Ben-Neriah Y, Karin M, (2011) Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat Immunol 12: 715-723 10.1038/ni.2060.
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 20
    • 84860864158 scopus 로고    scopus 로고
    • NF-kappaB, stem cells and breast cancer: The links get stronger
    • Shostak K, Chariot A, (2011) NF-kappaB, stem cells and breast cancer: The links get stronger. Breast Cancer Res 13: 214 10.1186/bcr2886.
    • (2011) Breast Cancer Res , vol.13 , pp. 214
    • Shostak, K.1    Chariot, A.2
  • 21
    • 6044231839 scopus 로고    scopus 로고
    • Regulation of snail transcription during epithelial to mesenchymal transition of tumor cells
    • 10.1038/sj.onc.1207990
    • Barbera MJ, Puig I, Dominguez D, Julien-Grille S, Guaita-Esteruelas S, et al. (2004) Regulation of snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene 23: 7345-7354 10.1038/sj.onc.1207990.
    • (2004) Oncogene , vol.23 , pp. 7345-7354
    • Barbera, M.J.1    Puig, I.2    Dominguez, D.3    Julien-Grille, S.4    Guaita-Esteruelas, S.5
  • 22
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2
    • 10.1038/sj.onc.1209808
    • Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, et al. (2007) NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2. Oncogene 26: 711-724 10.1038/sj.onc.1209808.
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5
  • 23
    • 36349011403 scopus 로고    scopus 로고
    • Activation of NF-kappaB by akt upregulates snail expression and induces epithelium mesenchyme transition
    • 10.1038/sj.onc.1210546
    • Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, et al. (2007) Activation of NF-kappaB by akt upregulates snail expression and induces epithelium mesenchyme transition. Oncogene 26: 7445-7456 10.1038/sj.onc.1210546.
    • (2007) Oncogene , vol.26 , pp. 7445-7456
    • Julien, S.1    Puig, I.2    Caretti, E.3    Bonaventure, J.4    Nelles, L.5
  • 24
    • 34347358621 scopus 로고    scopus 로고
    • Upregulation of twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs
    • 10.1128/MCB.01219-06
    • Pham CG, Bubici C, Zazzeroni F, Knabb JR, Papa S, et al. (2007) Upregulation of twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugs. Mol Cell Biol 27: 3920-3935 10.1128/MCB.01219-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 3920-3935
    • Pham, C.G.1    Bubici, C.2    Zazzeroni, F.3    Knabb, J.R.4    Papa, S.5
  • 25
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    • 10.1016/j.ccr.2009.03.016
    • Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, et al. (2009) Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 15: 416-428 10.1016/j.ccr.2009.03.016.
    • (2009) Cancer Cell , vol.15 , pp. 416-428
    • Wu, Y.1    Deng, J.2    Rychahou, P.G.3    Qiu, S.4    Evers, B.M.5
  • 26
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S, (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 27
    • 30744458869 scopus 로고    scopus 로고
    • IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300
    • Hoberg JE, Popko AE, Ramsey CS, Mayo MW, (2006) IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol 26: 457-471.
    • (2006) Mol Cell Biol , vol.26 , pp. 457-471
    • Hoberg, J.E.1    Popko, A.E.2    Ramsey, C.S.3    Mayo, M.W.4
  • 28
    • 84867650919 scopus 로고    scopus 로고
    • Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-kappaB acetylation and transcription
    • 10.1073/pnas.1208468109
    • Allison DF, Wamsley JJ, Kumar M, Li D, Gray LG, et al. (2012) Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-kappaB acetylation and transcription. Proc Natl Acad Sci U S A 109: 16888-16893 10.1073/pnas.1208468109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 16888-16893
    • Allison, D.F.1    Wamsley, J.J.2    Kumar, M.3    Li, D.4    Gray, L.G.5
  • 29
    • 6344241039 scopus 로고    scopus 로고
    • SMRT derepression by the IkappaB kinase alpha: A prerequisite to NF-kappaB transcription and survival
    • Hoberg JE, Yeung F, Mayo MW, (2004) SMRT derepression by the IkappaB kinase alpha: A prerequisite to NF-kappaB transcription and survival. Mol Cell 16: 245-255.
    • (2004) Mol Cell , vol.16 , pp. 245-255
    • Hoberg, J.E.1    Yeung, F.2    Mayo, M.W.3
  • 30
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, et al. (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23: 2369-2380.
    • (2004) EMBO J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5
  • 31
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, et al. (2004) NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114: 569-581.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5
  • 32
    • 84864865194 scopus 로고    scopus 로고
    • Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity
    • 10.1038/cddis.2012.93
    • Akunuru S, James Zhai Q, Zheng Y, (2012) Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell Death Dis 3: e352 10.1038/cddis.2012.93.
    • (2012) Cell Death Dis , vol.3
    • Akunuru, S.1    James Zhai, Q.2    Zheng, Y.3
  • 33
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • 10.1158/0008-5472.CAN-06-3557
    • Ho MM, Ng AV, Lam S, Hung JY, (2007) Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 67: 4827-4833 10.1158/0008-5472.CAN-06-3557.
    • (2007) Cancer Res , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 34
    • 78649522166 scopus 로고    scopus 로고
    • Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties
    • Leung EL, Fiscus RR, Tung JW, Tin VP, Cheng LC, et al. (2010) Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties. PLoS One 5: e14062 10.1371/journal.pone.0014062.
    • (2010) PLoS One , vol.5
    • Leung, E.L.1    Fiscus, R.R.2    Tung, J.W.3    Tin, V.P.4    Cheng, L.C.5
  • 35
    • 42749084961 scopus 로고    scopus 로고
    • Characterization of a stem cell population in lung cancer A549 cells
    • 10.1016/j.bbrc.2008.04.038
    • Sung JM, Cho HJ, Yi H, Lee CH, Kim HS, et al. (2008) Characterization of a stem cell population in lung cancer A549 cells. Biochem Biophys Res Commun 371: 163-167 10.1016/j.bbrc.2008.04.038.
    • (2008) Biochem Biophys Res Commun , vol.371 , pp. 163-167
    • Sung, J.M.1    Cho, H.J.2    Yi, H.3    Lee, C.H.4    Kim, H.S.5
  • 36
    • 0037701271 scopus 로고    scopus 로고
    • Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types
    • 10.1002/bit.10655
    • Kelm JM, Timmins NE, Brown CJ, Fussenegger M, Nielsen LK, (2003) Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol Bioeng 83: 173-180 10.1002/bit.10655.
    • (2003) Biotechnol Bioeng , vol.83 , pp. 173-180
    • Kelm, J.M.1    Timmins, N.E.2    Brown, C.J.3    Fussenegger, M.4    Nielsen, L.K.5
  • 37
    • 77951631386 scopus 로고    scopus 로고
    • The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when?
    • 10.1371/journal.pone.0000537
    • Gilbert MT, Haselkorn T, Bunce M, Sanchez JJ, Lucas SB, et al. (2007) The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when? PLoS One 2: e537 10.1371/journal.pone.0000537.
    • (2007) PLoS One , vol.2
    • Gilbert, M.T.1    Haselkorn, T.2    Bunce, M.3    Sanchez, J.J.4    Lucas, S.B.5
  • 38
    • 45549107919 scopus 로고    scopus 로고
    • Invasion and metastasis models for studying RhoGDI2 in bladder cancer
    • 10.1016/S0076-6879(07)00417-X
    • Nitz MD, Harding MA, Theodorescu D, (2008) Invasion and metastasis models for studying RhoGDI2 in bladder cancer. Methods Enzymol 439: 219-233 10.1016/S0076-6879(07)00417-X.
    • (2008) Methods Enzymol , vol.439 , pp. 219-233
    • Nitz, M.D.1    Harding, M.A.2    Theodorescu, D.3
  • 39
    • 33444475794 scopus 로고    scopus 로고
    • Highly sensitive quantification of human cells in chimeric NOD/SCID mice by real-time PCR
    • Thulke S, Radonic A, Siegert W, Nitsche A, (2003) Highly sensitive quantification of human cells in chimeric NOD/SCID mice by real-time PCR. Haematologica 88: ELT18.
    • (2003) Haematologica , vol.88
    • Thulke, S.1    Radonic, A.2    Siegert, W.3    Nitsche, A.4
  • 42
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I, (2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14: 163-176.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 43
    • 49949111381 scopus 로고    scopus 로고
    • Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    • Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, et al. (2008) Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One 3: e2637 10.1371/journal.pone.0002637.
    • (2008) PLoS One , vol.3
    • Chen, Y.C.1    Hsu, H.S.2    Chen, Y.W.3    Tsai, T.H.4    How, C.K.5
  • 44
    • 84858341630 scopus 로고    scopus 로고
    • Sox2 expression in breast tumours and activation in breast cancer stem cells
    • 10.1038/onc.2011.338
    • Leis O, Eguiara A, Lopez-Arribillaga E, Alberdi MJ, Hernandez-Garcia S, et al. (2012) Sox2 expression in breast tumours and activation in breast cancer stem cells. Oncogene 31: 1354-1365 10.1038/onc.2011.338.
    • (2012) Oncogene , vol.31 , pp. 1354-1365
    • Leis, O.1    Eguiara, A.2    Lopez-Arribillaga, E.3    Alberdi, M.J.4    Hernandez-Garcia, S.5
  • 45
    • 75149117750 scopus 로고    scopus 로고
    • Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop
    • 10.1158/0008-5472.CAN-09-1102
    • Levina V, Marrangoni A, Wang T, Parikh S, Su Y, et al. (2010) Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res 70: 338-346 10.1158/0008-5472.CAN-09-1102.
    • (2010) Cancer Res , vol.70 , pp. 338-346
    • Levina, V.1    Marrangoni, A.2    Wang, T.3    Parikh, S.4    Su, Y.5
  • 46
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • 10.1016/j.cell.2007.11.019
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872 10.1016/j.cell.2007.11.019.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5
  • 47
    • 79955608022 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
    • 10.1038/onc.2010.591
    • Yu F, Li J, Chen H, Fu J, Ray S, et al. (2011) Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene 30: 2161-2172 10.1038/onc.2010.591.
    • (2011) Oncogene , vol.30 , pp. 2161-2172
    • Yu, F.1    Li, J.2    Chen, H.3    Fu, J.4    Ray, S.5
  • 48
    • 84866555389 scopus 로고    scopus 로고
    • EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
    • 73-4598-11-73 10.1186/1476-4598-11-73
    • Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, et al. (2012) EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Mol Cancer 11: 73-4598-11-73 10.1186/1476-4598-11-73.
    • (2012) Mol Cancer , vol.11
    • Singh, S.1    Trevino, J.2    Bora-Singhal, N.3    Coppola, D.4    Haura, E.5
  • 50
    • 0030612937 scopus 로고    scopus 로고
    • Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic ras
    • Mayo MW, Wang CY, Cogswell PC, Rogers-Graham KS, Lowe SW, et al. (1997) Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic ras. Science 278: 1812-1815.
    • (1997) Science , vol.278 , pp. 1812-1815
    • Mayo, M.W.1    Wang, C.Y.2    Cogswell, P.C.3    Rogers-Graham, K.S.4    Lowe, S.W.5
  • 51
    • 80053904142 scopus 로고    scopus 로고
    • Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
    • 10.1016/j.stem.2011.08.010
    • Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, et al. (2011) Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 9: 357-365 10.1016/j.stem.2011.08.010.
    • (2011) Cell Stem Cell , vol.9 , pp. 357-365
    • Dieter, S.M.1    Ball, C.R.2    Hoffmann, C.M.3    Nowrouzi, A.4    Herbst, F.5
  • 52
    • 0031883574 scopus 로고    scopus 로고
    • Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology
    • Kunz-Schughart LA, Kreutz M, Knuechel R, (1998) Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol 79: 1-23.
    • (1998) Int J Exp Pathol , vol.79 , pp. 1-23
    • Kunz-Schughart, L.A.1    Kreutz, M.2    Knuechel, R.3
  • 53
    • 79952000716 scopus 로고    scopus 로고
    • 3D models of epithelial-mesenchymal transition in breast cancer metastasis: High-throughput screening assay development, validation, and pilot screen
    • 10.1177/1087057110392995
    • Li Q, Chen C, Kapadia A, Zhou Q, Harper MK, et al. (2011) 3D models of epithelial-mesenchymal transition in breast cancer metastasis: High-throughput screening assay development, validation, and pilot screen. J Biomol Screen 16: 141-154 10.1177/1087057110392995.
    • (2011) J Biomol Screen , vol.16 , pp. 141-154
    • Li, Q.1    Chen, C.2    Kapadia, A.3    Zhou, Q.4    Harper, M.K.5
  • 54
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • 10.1038/nrm2236
    • Pampaloni F, Reynaud EG, Stelzer EH, (2007) The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8: 839-845 10.1038/nrm2236.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.3
  • 55
    • 84863349461 scopus 로고    scopus 로고
    • IL-6-induced epithelial-mesenchymal transition promotes the generation of breast cancer stem-like cells analogous to mammosphere cultures
    • 10.3892/ijo.2011.1275
    • Xie G, Yao Q, Liu Y, Du S, Liu A, et al. (2012) IL-6-induced epithelial-mesenchymal transition promotes the generation of breast cancer stem-like cells analogous to mammosphere cultures. Int J Oncol 40: 1171-1179 10.3892/ijo.2011.1275.
    • (2012) Int J Oncol , vol.40 , pp. 1171-1179
    • Xie, G.1    Yao, Q.2    Liu, Y.3    Du, S.4    Liu, A.5
  • 56
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • 10.1016/j.cell.2009.10.014
    • Iliopoulos D, Hirsch HA, Struhl K, (2009) An epigenetic switch involving NF-kappaB, Lin28, let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139: 693-706 10.1016/j.cell.2009.10.014.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 57
    • 76649113726 scopus 로고    scopus 로고
    • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    • 10.1172/JCI39397
    • Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, et al. (2010) CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest 120: 485-497 10.1172/JCI39397.
    • (2010) J Clin Invest , vol.120 , pp. 485-497
    • Ginestier, C.1    Liu, S.2    Diebel, M.E.3    Korkaya, H.4    Luo, M.5
  • 58
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, et al. (2009) IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15: 103-113.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5
  • 59
    • 84862806829 scopus 로고    scopus 로고
    • IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
    • 10.1016/j.molcel.2012.01.015
    • Rokavec M, Wu W, Luo JL, (2012) IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol Cell 45: 777-789 10.1016/j.molcel.2012.01.015.
    • (2012) Mol Cell , vol.45 , pp. 777-789
    • Rokavec, M.1    Wu, W.2    Luo, J.L.3
  • 60
    • 79551544182 scopus 로고    scopus 로고
    • Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer
    • 10.1371/journal.pone.0014593
    • Baird AM, Gray SG, O'Byrne KJ, (2011) Epigenetics underpinning the regulation of the CXC (ELR+) chemokines in non-small cell lung cancer. PLoS One 6: e14593 10.1371/journal.pone.0014593.
    • (2011) PLoS One , vol.6
    • Baird, A.M.1    Gray, S.G.2    O'Byrne, K.J.3


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