Defining Metabolically Healthy Obesity: Role of Dietary and Lifestyle Factors

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Phillips, Catherine M ^a   Dillon, Christina ^a   Harrington, Janas M ^a   McCarthy, Vera J C ^a   Kearney, Patricia M ^a   Fitzgerald, Anthony P ^a   Perry, Ivan J ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CALORIC INTAKE; CROSS-SECTIONAL STUDY; DISEASE CLASSIFICATION; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; HEALTH STATUS; HUMAN; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; MACRONUTRIENT; MAJOR CLINICAL STUDY; MALE; OBESITY; PHENOTYPE; PHYSICAL ACTIVITY; PREVALENCE; SMOKING;

AGED; ALCOHOL DRINKING; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; DIET; FEMALE; HEALTH BEHAVIOR; HUMANS; IRELAND; LIFE STYLE; MALE; MIDDLE AGED; OBESITY; PREVALENCE; QUALITY OF LIFE; SMOKING; TERMINOLOGY AS TOPIC;

EID: 84885571924     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076188     Document Type: Article

References (46)

1. Kelly T, Yang W, Chen CS, Reynolds K, He J, (2008) Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 32: 1431-1437. doi:10.1038/ijo.2008.102. PubMed: 18607383.
2. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, et al. (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289: 76-79. doi:10.1001/jama.289.1.76. PubMed: 12503980.
3. Van Gaal LF, Mertens IL, De Block CE, (2006) Mechanisms linking obesity with cardiovascular disease. Nature 444: 875-880. doi:10.1038/nature05487. PubMed: 17167476.
4. Flegal KM, Kit BK, Orpana H, Graubard BI, (2013) Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 309: 71-82. doi:10.1001/jama.2012.113905. PubMed: 23280227.
5. Karelis AD, Rabasa-Lhoret R, (2008) Inclusion of C-reactive protein in the identification of metabolically healthy but obese (MHO) individuals. Diabetes Metab 34: 183-184. doi:10.1016/j.diabet.2007.11.004. PubMed: 18329310.
6. Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, et al. (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168: 1609-1616. doi:10.1001/archinte.168.15.1609. PubMed: 18695074.
7. Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, et al. (2008) The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 168: 1617-1624. doi:10.1001/archinte.168.15.1617. PubMed: 18695075.
8. Blüher M, (2010) The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 21: 38-43. doi:10.1097/MOL.0b013e3283346ccc. PubMed: 19915462.
9. Karelis AD, Brochu M, Rabasa-Lhoret R, (2004) Can we identify metabolically healthy but obese individuals (MHO)? Diabetes Metab 30: 569-572. doi:10.1016/S1262-3636(07)70156-8. PubMed: 15671927.
10. Karelis AD, (2008) Metabolically healthy but obese individuals. Lancet 372: 1281-1283. doi:10.1016/S0140-6736(08)61531-7. PubMed: 18929889.
11. Ruderman NB, Schneider SH, Berchtold P, (1981) The "metabolically-obese," normal-weight individual. Am J Clin Nutr 34: 1617-1621. PubMed: 7270486.
12. Phillips CM, (2013) Metabolically healthy obesity: Definitions, determinants and clinical implications. Rev Endocr Metab Disord. PubMed: 23928851.
13. Wildman RP, (2009) Healthy obesity. Curr Opin Clin Nutr Metab Care 12: 438-443. doi:10.1097/MCO.0b013e32832c6db7. PubMed: 19474713.
14. Hankinson AL, Daviglus ML, Van Horn L, Chan Q, Brown I, et al. (2012) Diet composition and activity level of at risk and metabolically healthy obese American adults. Obesity (Silver Spring).
15. Pataky Z, Bobbioni-Harsch E, Golay A, (2010) Open questions about metabolically normal obesity. Int J Obes (Lond) 34 (Suppl 2):: S18-S23. doi:10.1038/ijo.2010.235. PubMed: 21151142.
16. Velho S, Paccaud F, Waeber G, Vollenweider P, Marques-Vidal P, (2010) Metabolically healthy obesity: different prevalences using different criteria. Eur J Clin Nutr 64: 1043-1051. doi:10.1038/ejcn.2010.114. PubMed: 20628408.
17. NHLBI Obesity Education Initiative Expert Panel on the Identification, Evaluation, and Treatment of Obesity in Adults (US) (1998) Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report Bethesda (MD): National Heart, Lung, and Blood Institute.
18. Janiszewski PM, Ross R, (2010) Effects of weight loss among metabolically healthy obese men and women. Diabetes Care 33: 1957-1959. doi:10.2337/dc10-0547. PubMed: 20573755.
19. Kantartzis K, Machann J, Schick F, Rittig K, Machicao F, et al. (2011) Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia 54: 864-868. doi:10.1007/s00125-010-2006-3. PubMed: 21174075.
20. Karelis AD, Messier V, Brochu M, Rabasa-Lhoret R, (2008) Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia 51: 1752-1754. doi:10.1007/s00125-008-1038-4. PubMed: 18504546.
21. Shin MJ, Hyun YJ, Kim OY, Kim JY, Jang Y, et al. (2006) Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (Lond) 30: 1529-1534. doi:10.1038/sj.ijo.0803304. PubMed: 16552406.
22. Kearney PM, Harrington JM, Mc Carthy VJ, Fitzgerald AP, Perry IJ, (2012) Cohort Profile: The Cork and Kerry Diabetes and Heart Disease Study. Int J Epidemiol. PubMed: 22984148.
23. Gómez-Ambrosi J, Silva C, Catalán V, Rodríguez A, Galofré JC, et al. (2012) Clinical usefulness of a new equation for estimating body fat. Diabetes Care 35: 383-388. doi:10.2337/dc11-1334. PubMed: 22179957.
24. Villegas R, Salim A, Collins MM, Flynn A, Perry IJ, (2004) Dietary patterns in middle-aged Irish men and women defined by cluster analysis. Public Health Nutr 7: 1017-1024. PubMed: 15548339.
25. Fung TT, Chiuve SE, McCullough ML, Rexrode KM, Logroscino G, et al. (2008) Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch Intern Med 168: 713-720. doi:10.1001/archinte.168.7.713. PubMed: 18413553.
26. International Physical Activity Questionnaire. Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ) Short and Long Forms.
27. Khaw KT, Wareham N, Bingham S, Welch A, Luben R, et al. (2008) Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study. PLOS Med 5: e12. doi:10.1371/journal.pmed.0050012. PubMed: 18184033.
28. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419. doi:10.1007/BF00280883. PubMed: 3899825.
29. Aguilar-Salinas CA, García EG, Robles L, Riaño D, Ruiz-Gomez DG, et al. (2008) High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab 93: 4075-4079. doi:10.1210/jc.2007-2724. PubMed: 18682512.
30. Lynch LA, O'Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, et al. (2009) Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient? Obesity 17: 601-605. doi:10.1038/oby.2008.565. PubMed: 19238145.
31. Meigs JB, Wilson PWF, Fox CS, Vasan RS, Nathan DM, et al. (2006) Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91: 2906-2912. doi:10.1210/jc.2006-0594. PubMed: 16735483.
32. Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, et al. (2008) The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering- Prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 168: 1617-1624. doi:10.1001/archinte.168.15.1617. PubMed: 18695075.
33. Landis JR, Koch GG, (1977) The measurement of observer agreement for categorical data. Biometrics 33: 159-174. doi:10.2307/2529310. PubMed: 843571.
34. Yoo HK, Choi EY, Park EW, Cheong YS, Bae RA, (2013) Comparison of Metabolic Characteristics of Metabolically Healthy but Obese (MHO) Middle-Aged Men According to Different Criteria. Korean J Fam Med 34: 19-26. doi:10.4082/kjfm.2013.34.1.19. PubMed: 23372902.
35. Phillips CM, (2013) Nutrigenetics and metabolic disease: current status and implications for personalised nutrition. Nutrients 5: 32-57. doi:10.3390/nu5010032. PubMed: 23306188.
36. Harrington J, Phillips CM, (2013) Nutrigenetics: Bridging two worlds to understand type 2 diabetes. Curr Diab Rep.
37. Hotamisligil GS, (2006) Inflammation and metabolic disorders. Nature 444: 860-867. doi:10.1038/nature05485. PubMed: 17167474.
38. Manu P, Ionescu-Tirgoviste C, Tsang J, Napolitano BA, Lesser ML, et al. (2012) Dysmetabolic Signals in "Metabolically Healthy" Obesity. Obes Res Clin Pract 6: e9-e20. doi:10.1016/j.orcp.2012.08.018. PubMed: 22368724.
39. Choi J, Se-Young O, Lee D, Tak S, Hong M, et al. (2012) Characteristics of diet patterns in metabolically obese, normal weight adults (Korean National Health and Nutrition Examination Survey III, 2005). Nutr Metab Cardiovasc Dis 22: 567-574. doi:10.1016/j.numecd.2010.09.001. PubMed: 21186103.
40. Pajunen P, Kotronen A, Korpi-Hyövälti E, Keinänen-Kiukaanniemi S, Oksa H, et al. (2011) Metabolically healthy and unhealthy obesity phenotypes in the general population: the FIN-D2D Survey. BMC Public Health 11: 754. doi:10.1186/1471-2458-11-754. PubMed: 21962038.
41. Ekelund U, Besson H, Luan J, May AM, Sharp SJ, et al. (2011) Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women. Am J Clin Nutr 93: 826-835. doi:10.3945/ajcn.110.006593. PubMed: 21346093.
42. Manson JE, Greenland P, LaCroix AZ, Stefanick ML, Mouton CP, et al. (2002) Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 347: 716-725. doi:10.1056/NEJMoa021067. PubMed: 12213942.
43. Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350. doi:10.1056/NEJM200105033441801. PubMed: 11333990.
44. Cena H, Fonte ML, Turconi G, (2011) Relationship between smoking and metabolic syndrome. Nutr Rev 69: 745-753. doi:10.1111/j.1753-4887.2011.00446.x. PubMed: 22133198.
45. Phillips CM, Tierney AC, Perez-Martinez P, Defoort C, Blaak EE, et al. (2013) Obesity and body fat classification in the metabolic syndrome: Impact on cardiometabolic risk metabotype. Obesity (Silver Spring) 21: E154-E161. doi:10.1002/oby.20263. PubMed: 2350519822739585.
46. Phillips C, Perry IJ, (2013) Does inflammation determine metabolic health status in obese and non-obese adults? J Clin Endocrinol Metab Aug 26.