The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury

Neuropharmacology

Volumn 85, Issue , 2014, Pages 427-439

  Tchantchou, Flaubert ^a   Tucker, Laura B ^a   Fu, Amanda H ^a   Bluett, Rebecca J ^b   McCabe, Joseph T ^a   Patel, Sachin ^b   Zhang, Yumin ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AEA; FAAH inhibition; Inflammation; Neuroprotection; TBI

Indexed keywords

ARGINASE 1; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CYCLOOXYGENASE 2; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; INDUCIBLE NITRIC OXIDE SYNTHASE; PF 3845; PROTEIN BCL 2; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; AMIDASE; CASP3 PROTEIN, MOUSE; CASPASE 3; FATTY-ACID AMIDE HYDROLASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; PIPERIDINE DERIVATIVE; PROTEIN KINASE B; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN NERVE CELL; CELL SURVIVAL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CONVALESCENCE; DENTATE GYRUS; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; MACROPHAGE; MALE; MICROGLIA; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRAUMATIC BRAIN INJURY; UPREGULATION; WORKING MEMORY; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; BRAIN INJURIES; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; IMMUNOMODULATION; MEMORY DISORDERS; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY;

AMIDOHYDROLASES; ANIMALS; ANXIETY; BRAIN; BRAIN INJURIES; CASPASE 3; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; MEMORY DISORDERS; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROIMMUNOMODULATION; NEUROPROTECTIVE AGENTS; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECOVERY OF FUNCTION;

EID: 84903547264     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.06.006     Document Type: Article

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